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Quick Search     Adv Search 2014 Vol. 31, No. 4 Published: 2014-04-26   625 Study on the Correlation Between Metabolically Healthy Obese and Nonalcoholic Fatty Liver Disease [Objective] To explore the correlation between metabolically healthy obese(MHO) and nonal-coholic fatty liver disease(NAFLD) .[Methods] The data of physical examination subjects in our hospital from April 2006 to Jan .2010 were collected .All clinical indicators ,biochemical indexes and abdominal B-ultrasound results of subjects were recorded .There were 2830 cases excluding those with the missing data .According to the diagnostic criteria of obesity ,613 subjects including 261 cases of M HO and 352 cases of MS were enrolled in the study .General data such as blood pressure ,blood sugar ,lipids ,uric acid and white blood cell count (WBCC) in peripheral blood of 134 cases of M HO with NAFLD ,127 cases of M HO without NAFLD and 352 cases of MS were analyzed .Among them ,109 cases of MHO(including 62 cases of MHO with NAFLD) were followed up for 1~3 years .The incidence of MS in M HD with NAFLD was observed .[Results]Body mass in-dex(BMI),ageandsystolicbloodpressure(SBP)inthegroupofMHOwithoutNAFLDwerelowerthanthose in the group of M HO with NAFLD ,and there was significant difference( P<0 .05) .There was no significant difference in BMI and age between the group of MHO with NAFLD and the group of obesity with MS .SBP in the group of M HO with NAFLD was lower than that in the group of obesity with MS ,but higher than that in the group of MHO without NAFLD ,and there was significant difference ( P<0 .05) .The incidence of abnor-mal metabolic diseases in the group of M HO with NAFLD was higher than that in the group of M HO without NAFLD(59 .68% vs .29 .79% ,OR=3 .489 ,95% CI:1 .559~7 .804 ,P <0 .05) .[Conclusion] Clinical and biochemical features of the subjects with M HO and NAFLD is closer to those of the subjects with obesity and MS .NAFLD may be a risk factor of M HO developing to abnormal metabolic diseases . 2014 Vol. 31 (4): 625-630 [Abstract] ( 41 ) HTML (1 KB)  PDF  (0 KB)  ( 39 ) 628 Study on the Correlation Between Insulin Therapy and Secondary Malignant Tumor [Objective]To explore the correlation between insulin therapy and secondary malignant tumor in patients with type 2 diabetes mellitus(T2DM ) .[Methods] Clinical data of 8051 T2DM in first and second affiliated hospital of Shantou university from Jan .2003 to Dec .2007 were analyzed retrospectively .According to insulin therapy or not ,all patients were divided into case group(insulin therapy group ,n=792) and control group(non-insulin therapy group ,n=7259) .The prevalence of secondary malignant tumor was compared be-tween two groups .[Results] Among 8051 T2DM patients in the study ,the course of diabetic mellitus in case group was longer than that in control group ,while the incidence of malignant tumor was lower ,and there was significant difference between two groups(χ2 =6 .720 ,P <0 .01) .The prevalence risk of malignant tumor in T2DM patients was negatively related with male (OR= 0 .71 ,95% CI= 0 .50~0 .86) ,but positively related with age(OR=1 .72 ,95% CI=1 .39~1 .86) and smoking history(OR=2 .36 ,95% CI=1 .65~3 .82) ,and had no correlation with insulin therapy ( P=0 .72 ,OR=0 .71 ,95% CI为0 .52~1 .10) .[Conclusion] Insulin thera-py is not associated with the prevalence risk of secondary malignant tumor in T 2DM . 2014 Vol. 31 (4): 628-630 [Abstract] ( 22 ) HTML (1 KB)  PDF  (0 KB)  ( 29 ) 631 Impact of TGFβ1 on the Expression of MiR-29 in Human Embryonic Lung Fibroblasts FENG Tao%WA NG Yi-chun%GUO Qu-lian [Objective]To explore the impact of transforming growth factor beta-1(TGFβ1 ) on the expres-sion of micro-RNA-29(miR-29) in human embryonic lung fibroblasts(IMR90) .[Methods]The expression of miR-29a/b/c in IMR90 cell line treated with TGFβ1 was detected by fluorescence quantitative PCR (real-time PCR) assay normalized to the blank cell and U6 .[Results]When IMR90 cell line was treated with 1ng/mL , 2ng/mL and 4ng/mL TGFβ1 ,the expression of miR-29a/b/c was in turn decreased in comparison with control group ( P <0 .05) .When IMR90 cell line was treated with 2ng/mL TGFβ1 for 24 ,48 and 96h ,the relative expression of miR-29a/b/c was gradually decreased in comparison with the untreated group ( P < 0 .05) .[Conclusion] In IMR90 cell line ,TGFβ1 can inhibit the expression of miR-29 which indicates that TGFβ1-miR-29 pathway may play an important role in the formation of pulmonary interstitial fibrosis . 2014 Vol. 31 (4): 631-633 [Abstract] ( 34 ) HTML (1 KB)  PDF  (0 KB)  ( 40 ) 634 Impact of Intrauterine Hypoxia on Erythrocyte Osmotic Fragility in Newborns [Objective]To explore the impact of intrauterine hypoxia on erythrocyte osmotic fragility in newbo-rns .[Methods]Totally 27 newborns without neonatal asphyxia in department of neonatology of Xiangya hospital from 2012~2013 were selected .According to the history of intrauterine hypoxia before birth ,all patients were divided into control group( n=20) and intrauterine hypoxia group ( n=7) .Arterial blood samples were extracted within 1h after birth to detect blood gas ,lactic acid(LA) and minimal bilirubin(BIL) .Venous blood was drawn within 24h to detect erythrocyte osmotic fragility .[Results]There was no significant difference in Apgar score ,pH and PaCO2 between in-trauterine hypoxia group and control group ( P>0 .05) .PaO2 ,SaO2 and minimal BIL in intrauterine hypoxia group were obviously lower than those in control group ( P<0 .01~0 .05) ,but LA level in intrauterine hypoxia group was obviously higher than that in control group ( P<0 .01) .When hemolysis ratio was 20% ,50% ,80% and 90% re-spectively ,NaCl buffer solution concentration in intrauterine hypoxia group was lower than that in control group ( P<0 .05~0 .01) .When hemolysis ratio was 10% and 100% respectively ,there was no difference in NaCl buffer solu-tion concentration between intrauterine hypoxia group and control group ( P>0 .05) .[Conclusion]Intrauterine hypox-ia can decrease erythrocyte osmotic fragility in newborns . 2014 Vol. 31 (4): 634-639 [Abstract] ( 80 ) HTML (1 KB)  PDF  (0 KB)  ( 35 ) 637 Epidemiological Investigation of the Prevalence of Osteoporotic Fracture in Pingshan New Dis-trict of Shenzhen City [Objective] To explore the status of the prevalence of senile osteoporotic fracture of residents in Ping-shan new district of Shenzhen so as to provide the theoretical basic data for the primary prevention of senile osteoporo-sis .[Methods] Random cluster sampling and group technology was used to choose 300 elderly people in 2 neighbor-hood committees of Pingshan district .All persons received epidemiological questionnaire survey of senile osteoporotic fracture completed by the physicians in orthopedic and epidemiological department together .Uniform quality control , table retrieval and statistical analysis were performed by epidemiological experts .[Results] The incidence of senile os-teoporotic fracture in Pingshan new district was 11 .3% (34/300) .The incidence of male senile osteoporotic fracture was 10 .74% ,while that of female senile osteoporotic fracture was 11 .73% (21/179) ,but there was no significant difference between them( P>0 .05) .The incidence of senile osteoporotic fracture under 70 years old was 6 .92%(11/159) ,while that in persons over 70 years old was 16 .31% (23/141) ,and there was significant difference be-tween them( P<0 .05) .[Conclusion]The incidence of senile osteoporotic fracture in Pingshan new district of Shenz-hen region is lower than that in other areas of China .The incidence of senile osteoporotic fracture over 70 years old is obviously higher than that under 70 years old . 2014 Vol. 31 (4): 637-639 [Abstract] ( 28 ) HTML (1 KB)  PDF  (0 KB)  ( 34 ) 640 Discussion on Medication Compliance of Inpatients and the Influential Factors of Psychology and Society LI Hao-lun%WU Xi-lin%DENG Yun-long [Objective]To understand the status of medication compliance of inpatients in general hospital and the influential factors of psychology and society .[Methods] Totally 607 inpatients with somatological dis-eases in our hospital from Nov .2010 to Feb .2013 were surveyed by using 5:1 complete random sampling method .General questionnaire ,Morisky-4 compliance questionnaire ,medical coping mode questionnaire(MC-MQ) ,multi-dimensional mental health locus of control scale(MHLC) ,self-rating depression scale(SDS) and self-rating anxiety scale(SAS) were used to investigate 607 inpatients .[Results] The average compliance rate of inpatients was 42% ,and that of internal medicine patients was 40 .42% ,and that of surgical patients was 43 .44% ,but there was no significant difference between internal medicine patients and surgical patients (χ2 =0 .566 ,P =0 .452) .Male patients(χ2 =4 .565) ,fewer education years (8 .97 ± 4 .48 ,t =2 .365) ,employed patients(χ2 =4 .528) and patients with the history of hospitalization (χ2 =5 .372) had even higher compliance . The scores of depression ,anxiety and avoidance in low compliance group were significantly higher than those in high compliance group( t =3 .459 ,P =0 .001;t =4 .556 ,P =0 .001 ;t =3 .983 ,P =0 .001) .The scores of psychological manipulation mode of powerful others in high compliance group were higher than those in low compliance group( t = -2 .846 ,P = 0 .005) .[Conclusion] Social influential factors associated with compli-ance of inpatients are gender ,education level ,employment status and history of hospitalization .Psychological factors associated with compliance are depression ,anxiety ,avoidance coping style and locus of control of oth-ers . 2014 Vol. 31 (4): 640-643 [Abstract] ( 74 ) HTML (1 KB)  PDF  (0 KB)  ( 43 ) 644 Expression of Tumor-type M2-pyruvate Kinase in Patients with Bladder Cancer and Its Clinical Significance ZHOU Li%ZHAO Ya-Kun%ZHANG Chuan [Objective]To explore the expression of tumor type M2-pyruvate kinase(Tu M2-PK) in bladder cancer and its clinical significance .[Methods] Serum samples of 221 patients with bladder cancer and 220 healthy normal people from Jan .2009 to Jan .2012 were collected .Serum level of Tu M2-PK was detected by ELISA ,and compared between experimental group and control group .The correlation between Tu M2-PK and pathological type was analyzed .[Results]Serum levels of Tu M2-PK in patients with bladder cancer were ob-viously higher than those in control group[(39 .4 ± 3 .5)u/mL vs (7 .3 ± 2 .1)u/mL ,P <0 .05)] .There was significant difference in Tu M2-PK level among different pathological stages of bladder cancer .Tu M2-PK lev-els in stage T1 ,T2 and T3 were (32 .1 ± 6 .1)u/mL ,(34 .1 ± 4 .3)u/mL and (68 .2 ± 5 .9)u/mL ,respectively . There was no significant difference in Tu M2-PK level between stage T1 and stage T2 .Compared with stage T1 and T2 ,Tu M2-PK levels in stage T3 were increased obviously .[Conclusion] The monitoring of serum Tu M2-PK is helpful for the early diagnosis of bladder cancer .Meanwhile Tu M2-PK level can be also used as an important means for the monitoring and grading of the tumor . 2014 Vol. 31 (4): 644-648 [Abstract] ( 62 ) HTML (1 KB)  PDF  (0 KB)  ( 29 ) 646 Study on the Relationship of Carotid Intima-media Thickness with Serum Interleukin-6 and High-sensitive C-reactive Protein in Patients with Type 2 Diabetes Mellitus [Objective]To explore the relationship of carotid intima-media thickness (IM T ) with serum inter-leukin-6(IL-6) and high-sensitive C-reactive protein(hs-CRP) in patients with type 2 diabetes mellitus(T2DM) .[Methods]Totally 201 patients with newly diagnosed T2DM were selected .According to carotid IMT ,all patients were divided into IMT increased group(IMT>0 .9mm ,n=99) and normal IMT group(IMT<0 .9mm ,n=102) . Fast blood samples were collected .Serum levels of IL-6 and hs-CRP were measured .Carotid IMT of the subjects in each group was detected by using color Doppler apparatus .[Results] Among T2DM subjects ,the levels of IL-6 and hs-CRP in IMT increased group were significantly higher than those in normal IMT group ( P < 0 .01) .In IMT increased group ,IL-6 and hs-CRP were positively correlated with IMT (r was 0 .73 and 0 .78 respectively ,P<0 .01) .In normal IM T group ,IL-6 and hs-CRP were also positively correlated with IM T (r was 0 .62 and 0 .59 respectively ,P <0 .01) .If T2DM patients were considered as the whole ,IL-6 was also related with hs-CRP(r was 0 .66 ,P <0 .01) .[Conclusion] IL-6 and hs-CRP are closely related with early atherosclerosis of T 2DM pa-tients . 2014 Vol. 31 (4): 646-648 [Abstract] ( 84 ) HTML (1 KB)  PDF  (0 KB)  ( 33 ) 649 Comparative Study of the Impact of Different Time Selection on the Efficacy of Walking Exer-cise for Patients with Ischemic Stroke XU Hong-xing%LV Shuang-xi%YA NG Wei-xin [Objective]To evaluate the impact of different time selection on walking exercise efficacy of pa-tients with ischemic stroke .[Methods]Totally 80 patients with ischemic stroke were chosen and randomly di-vided into observation group and control group with 40 patients in each group .While the affected limb had the standing balance grade ≥3 ,and could support over 75% of body weigh ,and had active flexion and extension function ,the control group received routine walking exercise .While muscular tension was normal and Ash-worth class I ,the observation group started walking exercise .Berg balance scale (BBS) ,Fugl-Meyer assess-ment(FMA) and functional ambulation category (FAC) were used for functional classification of two groups before ,1 month ,6 months and 1 year after rehabilitation .[Results] Compared with before exercise ,BBS , FMA and FAC scores of two groups were obviously improved with the prolongation of exercise time ( P <0 .05) ,and those of the observation group were improved more significantly than the control group ( P <0 .05) .[Conclusion]Compared with control group ,walking time selection in observation group is more help-ful for the recovery of walking ability . 2014 Vol. 31 (4): 649-653 [Abstract] ( 48 ) HTML (1 KB)  PDF  (0 KB)  ( 27 ) 651 Effect of Intravenous Penehyclidine Hydrochloride on Propofol Injection Pain MEI Yang%YANG Mi [Objective]To observe the effectiveness and safety of intravenous penehyclidine hydrochloride on eliminating propofol injection pain during anesthesia induction .[Methods]A total of 40 ASA Ⅰ ~ Ⅱ pa-tients scheduled for elective operation of otolaryngology under general anesthesia were randomly divided into group W(penehyclidine hydrochloride group) and group C (control group) with 20 patients in each group . Group C was given intravenous normal saline 0 .9% before anesthesia induction ,while group W was given in-travenous penehyclidine hydrochloride 0 .01mg/kg(diluted with 0 .9% normal saline into 10mL) and then intra-venous propofol 20mg/kg after 20min for 30s .Verbal rating scale(VRS) was used to evaluate and compared the propofol injection pain of patients .Blood pressure and heart rate of patients at entering the operation (T1 ) , 5min(T2 ) ,10min(T3 ) ,15min(T4 ) and 20min(T5 ) after the injection of penehyclidine hydrochloride or nor-mal saline were recorded .[Results]The pain score of patients in group W was obviously lower than that in group C(0 .9 ± 0 .7 vs .1 .7 ± 0 .9 ,P =0 .04) .The incidence of injection pain in group W was also lower than that in group C ,and there was significant difference between two groups (40% vs .90% ,P <0 .05) ,There was no significant difference in blood pressure and heart rate between two groups ( P > 0 .05) .[Conclusion]Penehyclidine hydrochloride can effectively alleviate propofol injection pain during anesthesia induction . 2014 Vol. 31 (4): 651-653 [Abstract] ( 25 ) HTML (1 KB)  PDF  (0 KB)  ( 34 ) 654 Analysis of the Correlation Between Clinical Symptom Features and Prognosis in 196 Cases of In-tracerebral Hemorrhage LI Hao-jun%LIU Ming%PAN Shu-ming [Objective] To explore the correlation between clinical symptom features and prognosis in intrace-rebral hemorrhage(ICH) .[Methods]A total of 196 patients with complete case history data in our hospital from Jan .2010 to Dec .2010 were enrolled .The cause ,clinical features and prognosis in different course ,age and sex were compared .[Results] The disease occurred mainly in patients aged 60~70 years old .The male patients were obviously more than female patients .The incidence was higher in autumn and winter than in spring and summer . The onset of the disease was rarely in sleep or wake state ,but mainly in exertion or agitation state .[Conclusion]The male patients with ICH are obviously more than the female patients .Hypertension is the most risk factors . The incidence of young men is far higher than that of young women .The age ,bleeding volume ,hemorrhage breaking into ventricles of brain ,blood pressure before and after the occurrence and complications are the main de-cisive factors of prognosis . 2014 Vol. 31 (4): 654-656 [Abstract] ( 71 ) HTML (1 KB)  PDF  (0 KB)  ( 37 ) 656 Correlation Between Serum Levels of TPOAb and TGAb in Patients with Graves Hyperthyroidism and the Incidence of Hypothyroidism after Subtotal Thyroidectomy [Objective]To measure serum levels of thyroid peroxidase antibody (TPOAb ) and thyroglobulin antibody (TGAb) in patients with Graves hyperthyroidism before surgery ,and to explore their correlation with the incidence of hy-pothyroidism after surgery .[Methods]According to the results of TPOAb and TGAb ,198 patients were divided into both negative TPOAb and TGAb group( n=12) ,positive TPOAb or TGAb group( n = 32) and both positive TPOAb and TGAb( n=154) .According to the titer levels of TPOAb and TGAb ,154 patients with both positive TPOAb and TGAb were also divided into group A ( n=79) ,group B( n=65) and group C( n=10) .The correlation of the titer levels of TPOAb and TGAb with hypothyroidism before the operation was further discussed .[Results] There was significant difference in the incidence of hypothyroidism after the operation among three groups ( P<0 .005) .Among 154 patients of both positive TPOAb and TGAb group ,the titer levels of TPOAb and TGAb were related with the incidence of hyperthy-roidism( P<0 .005) .[Conclusion] The detection of serum levels of TPOAb and TGAb is of significance for predicting the incidence of hypothyroidism after surgery . 2014 Vol. 31 (4): 656-658 [Abstract] ( 57 ) HTML (1 KB)  PDF  (0 KB)  ( 34 ) 659 Observation on the Efficacy of Endoluminal Therapy for 35 Diabetic Patients with Lower Ex-tremity Arterial Occlusive Disease YANG Yu%YU Yan%ZHANG Xue-dong [Objective]To explore the efficacy of endoluminal therapy for diabetes mellitus with peripheral arterial occlusive disease(PAOD) .[Methods]Clinical data of 35 PAOD patients with diabetes mellitus treated by endoluminal therapy for 48 times were analyzed retrospectively .[Results] Endoluminal operation success rate was 97 .1% 34/35) .No one died 30d after operation .Ankle/brachial index before operation was (0 .419 ± 0 .142) which was markedly higher than that after operation (0 .741 ± 0 .158) ,and there was significant difference( P < 0 .001) .Primary patency rate at 6 months ,12 months ,24 months and 36 months was 85 .2% ,61 .9% ,54 .3% ,and 46 .2% respectively ,and .secondary patency rate was 91 .5% ,83 .1% ,70 .2%and 63 .3% respectively ,and limb preservation rate was 94 .3% ,88 .6% ,85 .8% and 82 .9% ,respectively .[Conclusion] Percutaneous endoluminal therapy for diabetic patients with PAOD has advantages such high pa-tency and few complications ,and can better remain the integrity of the affected limbs . 2014 Vol. 31 (4): 659-662 [Abstract] ( 80 ) HTML (1 KB)  PDF  (0 KB)  ( 34 ) 662 Clinical Study of the Intensified Psychological Intervention after Total Hysterectomy for Allevia-ting Negative Mood and Improving Quality of Life ZHANG Yuan-ping [Objective]To explore the impact of the intensified psychological intervention after total hyster-ectomy for alleviating negative mood and improving quality of life .[Methods] Totally 200 patients undergoing total hysterectomy were chosen .According to admission time ,all patients were divided into two groups with 100 patients in each group .The control group was given routine nursing care ,while the observation group was given the directed psychological nursing intervention based on conventional care .Anxiety(SAS) and depression (SDS) self-rating scales were used to evaluate negative emotion .Female sexual function index(FSFI) was used to evaluate sexual function status of patients before and after intervention .[Results]After 6 months of inter-vention ,SAS(34 .38 ± 11 .26) and SDS(34 .21 ± 8 .76) in observation group were decreased significantly ,and the alleviation effect in observation group was better than control group [(40 .73 ± 11 .52) and (49 .73 ± 8 .88) , respectively ]( P <0 .05) .The total scores of FSFI and the scores of all dimensions in observation group were obviously better than control group ( P < 0 .05) .[Conclusion] Patients undergoing total hysterectomy have anxiety ,depression and other negative emotions .Psychological intervention can effectively relieve negative psychology and improve quality of life after operation . 2014 Vol. 31 (4): 662-664 [Abstract] ( 26 ) HTML (1 KB)  PDF  (0 KB)  ( 33 ) 665 Observation of the Efficacy of Qiliqiangxin Capsule in the Treatment of Chronic Heart Failure WANG Xining [Objective] To explore the effectiveness and safety of Qiliqiangxin capsule in the treatment of chronic contractive heart failure .[Methods]A total of 73 patients with chronic contractive heart failure were randomly divided into group A(Qiliqiangxin capsule observation group ,n =37) and group B(digoxin control group ,n=36) .The efficacy ,cardiac function and echocardiogram (ECG) parameters after 12 weeks were ob-served .The safety was evaluated .[Results]The total effective rate in group A and group B was 94 .59% and 75% respectively ,and that in group A was better than that in group B ( P < 0 .05) .Compared with before treatment ,SV ,CO ,LVEF and LVD in two groups after treatment were improved ( P<0 .01) .The improve-ment of LVEF and LVD in group A was better than that in group B ( P<0 .01) .[Conclusion]Qiliqiangxin cap-sule is effective and safe in the treatment of chronic contractive heart failure . 2014 Vol. 31 (4): 665-669 [Abstract] ( 60 ) HTML (1 KB)  PDF  (0 KB)  ( 47 ) 667 Observation on the Efficacy of Mycophenolate Mofetil Combined with Tacrolimus for the Treat-ment of Steroid-resistant Refractory Nephrotic Syndrome [Objective]To explore the efficacy and adverse reaction of mycophenolate mofetil (MMF) com-bined with tacrolimus(TAC) for the treatment of steroid-resistant nephrotic syndrome(SRNS) .[Methods]To-tally 74 SRNS patients were collected .Pathological types included 32 cases of minimal lesion(MCD) ,22 cases of local segmental glomerulosclerosis (FSGS ) and 20 cases of diffuse mesangial proliferation (DM P ) .All pa-tients were treated with MMF 1g/day and prednisolone 50mg(alternate day) for 6 months(first-step treat-ment) .For the patients without clinical remission after the first-step treatment automatically received the sec-ond-step treatment i .e .the withdrawal of steroids and then MMF 1g/day combined with TAC 3mg/day for 6 months .The efficacy of different therapy methods ,pathological types and adverse reaction were observed .[Results]In 74 SRNS patients receiving the first-step treatment ,24 patients(32 .4% ) got complete remission , and 4 patients(5 .4% ) got partial remission ,and the other 46 patients did not get clinical remission and then stopped steroids and received the second treatment .Among these 46 patients ,22 patients(47 .8% ) got com-plete remission and 4 patients(8 .7% ) got partial remission .There was significant difference in the remission rate among different pathological types ( P <0 .05) .The remission rate of MCD was the highest and that of FSGS was the lowest .No obvious adverse reaction was found in all patients during the therapy .[Conclusion]MMF combined with TAC for the treatment of SRNS has satisfactory effect ,so it is worthy of clinical promo-tion . 2014 Vol. 31 (4): 667-669 [Abstract] ( 26 ) HTML (1 KB)  PDF  (0 KB)  ( 27 ) 670 Clinical Observation of Microsurgery vs Open Surgery for the Treatment of Varicocele JU Lin-cheng%BU Ren-ge%SONG Yong-song [Objective]To compare clinical efficacy of microsurgery vs open surgery in the treatment of var-icocele .[Methods] Totally 149 patients with varicocele in our hospital from Dec .2011 to March 2013 were di-vided into microsurgery group( n =84) and open inguinal surgery group( n =65) .The operation time ,post-operative hospital stay ,the recurrence rate of postoperative varicocele ,the incidence of hydrocele and the im-provement of semen quality 3 months after surgery were compared between two groups .[Results]The opera-tion time in microsurgery group was longer than that in open surgery group(P<0 .05) ,while the postoperative hospital stay in microsurgery group was shorter than that in open surgery group ( P <0 .05) .The recurrence of postoperative varicocele and incidence of hydrocele in microsurgery group were lower than those in open sur-gery group( P <0 .05) .Compared with before surgery ,sperm concentration and motility in two groups after surgery were obviously improved( P <0 .05) .[Conclusion]Microsurgery for the treatment of varicocele can improve sperm concentration and mobility .Compared with open surgery ,microsurgery has advantages such as rapid recovery and fewer complications . 2014 Vol. 31 (4): 670-672 [Abstract] ( 43 ) HTML (1 KB)  PDF  (0 KB)  ( 40 ) 673 Value of Dual-source CT Angiography in the Diagnosis of Vertebral Artery Sulcus Ring [Objective] To explore the value of dual-source CT angiography (DSCTA ) in the diagnosis of vertebral artery sulcus ring .[Methods]Clinical data of 62 patients with vertebral artery sulcus ring diagnosed by DSCTA were col-lected .The types of whole-ring-type vertebral artery sulcus ring were analyzed .The diameter of vertebral artery was measured .[Results] The types of 62 patients with vertebral artery included Ⅳ type in 38 patients(61 .3% ) in which 25 patients were bilateral whole-ring type and 13 patients were unilateral whole-ring type(8 patients with right side and 4 pa-tients with left side) ,Ⅲ type in 6 patients (9 .7% ) which were bone breaking in curve bone bridge arch with both beak-like sides ,typeⅠandⅡ in 18 patients(29 .0% ) in which 3 patients were type I anterior semi-ring and 15 patients were typeⅡ posterior semi-ring .The upper and lower diameters of whole-ring type vertebral artery sulcus ring were 3 .1~8 .2 (4 .8 ± 0 .3)mm and anteroposterior diameters were 4 .2~9 .1(7 .10 .3)mm .The diameter of vertebral artery in atlas ver-tebral artery sulcus ring was 1 .8~5 .9(3 .7 ± 0 .8)mm .Local stenosis of vertebral artery was found in 15 patients ,and the stenosis rate was 10% ~30% .[Conclusion]DSCTA can accurately display the shape of atlas vertebral artery sulcus ring and stenosis caused by vertebral artery entrapment . 2014 Vol. 31 (4): 673-675 [Abstract] ( 50 ) HTML (1 KB)  PDF  (0 KB)  ( 32 ) 676 Expression and Significance of Serum PTP1B,Leptin and Adiponectin in Obesity Patients with Secondary Amenorrhea [Objective]To explore the serum levels of protein tyrosine phosphatase 1B(PTP1B) ,leptin and adiponectin in patients with secondary amenorrhea .[Methods]A total of 60 patients diagnosed as secondary a-menorrhea in second affiliated hospital of Harbin medical university including 30 patients with obesity and 30 patients without obesity were selected as case group .Other 60 patients with normal menstrual including 30 pa-tients with obesity and 30 patients without obesity were selected as control group .Serum levels of PTP1B , leptin and adiponectin were measured by enzyme linked immunosorbent assay (ELISA) .[Results]Serum levels of PTP1B and leptin in amenorrhea with obesity group were (86 .24 ± 17 .58)ng/L and (16 .14 ± 2 .67)ng/L re-spectively ,which were obviously higher than those in patients with obesity in control group [(54 .66 ± 13 .27) ng/L and (10 .10 ± 1 .93)ng/L ,respectively)](all P <0 .05) ,while serum level of adiponectin was obviously lower than that of patients with obesity in control group [(4 .71 ± 2 .64)mg/L vs .(10 .26 ± 3 .13)mg/L]( P<0 .05) .There was no significant difference in serum level of PTP1B between amenorrhea with obesity group and amenorrhea without obesity group[(73 .97 ± 10 .25)ng/L]( P>0 .05) ,while serum level of leptin was ob-viously increased[(6 .53 ± 3 .25) ng/L] and serum level of adiponectin was obviously decreased[(11 .76 ± 3 .58) mg/L](all P<0 .05) .Serum levels of leptin and adiponectin were related with obesity .PTP1B in amenorrhea with obesity patients was positively correlated with body mass index (BMI) and leptin ,but negatively correla-ted with adiponectin .[Conclusion] Serum levels of PTP1B ,leptin and adiponectin in obesity patients with a-menorrhea are of vital significance in promoting the occurrence and development of the disease . 2014 Vol. 31 (4): 676-679 [Abstract] ( 79 ) HTML (1 KB)  PDF  (0 KB)  ( 25 ) 679 Diagnosis and Treatment of Acute Hemorrhage of Cerebral Arteriovenous Malformation [Objective]To explore the diagnosis ,treatment experience and efficacy of intracranial arteriove-nous malformation(AVM ) with rupture hemorrhage .[Methods]Clinical data and efficacy of 48 patients with rupture hemorrhage of AVM treated by different therapy methods in acute phase from our hospital between May 1999 to Jan .2013 were analyzed retrospectively .[Results]Of 48 patients ,23 patients underwent one stage hematoma removal and AVM microsurgical resection ,and 12 patients underwent one stage hematoma re-moval and two stage AVM microsurgical resection ,and 8 patients underwent non-surgical therapy and AVM malformation mass resection ,and 2 patients underwent non-surgical therapy(or simple hematoma removal) andγ-knife therapy ,and 3 patients underwent simple hematoma removal .Two patients died .Severe disability oc-curred in 5 patients .Compared with before operation ,nerve function of 41 patients was improved at different degree .[Conclusion] Surgery strategies and microsurgical skills of AVM rupture hemorrhage should be grasped .One stage hematoma removal combined with lesion resection can obtain better prognosis . 2014 Vol. 31 (4): 679-681 [Abstract] ( 45 ) HTML (1 KB)  PDF  (0 KB)  ( 36 ) 682 Clinical Analysis of Vacuum Sealing Drainage for the Treatment of 87 Patients with Large Area of Cutaneous Defect XIAO Wan-an%LI Xiao-chuan%TIAN Li-jie [Objective] To observe the application effect of vacuum sealing drainage (VSD) in the dermato-plasty for large area of cutaneous defect during the operation .[Methods] Totally 45 patients with large area of cutaneous defect received VSD to cultivate the granulation before dermatoplasty for 7~14d ,and then continu-ously received VSD for 7~10d after dermatoplasty (VSD group) .Another 42 patients with cutaneous defect were given traditional dressing change ,simple skin grafting and conventional package and compression (tradi-tional group) . The survival rate of the grafted skin and hospitalization time were compared between two groups .[Results]In VSD group ,the successful rate of dermatoplasty was 88 .89% ,and the infection rate was 2 .22% ,and the hospitalization time was (30 .4 ± 3 .8)d .In traditional group ,the successful rate of dermato-plasty was 66 .67% ,and the infection rate was 19 .05% ,and the hospitalization time was (52 .8 ± 7 .2)d . There was significant difference in the successful rate of dermatoplasty between two groups (χ2 =4 .94 ,P <0 .05) .There was also significant difference in hospitalization time between two groups ( t=2 .45 ,P<0 .05) .[Conclusion] VSD applied in the dermatoplasty for repairing large area of skin defect wound during the opera-tion can promote the wound healing ,increase the successful rate ,reduce the infection rate and shorten the treatment duration . 2014 Vol. 31 (4): 682-687 [Abstract] ( 71 ) HTML (1 KB)  PDF  (0 KB)  ( 25 ) 685 Observation of Clinical Efficacy of Scopolamine Butylbromide Combined with Anesthetics Propofol in Gastrointestinal Endoscopy SUN Jing%SUN Ming-jun [Objective] To explore clinical efficacy and safety of scopolamine butylbromide combined with propofol in painless enteroscopy ,and calculate the comfort and satisfaction of patients .[Methods] Totally 400 cases with gastrointestinal endoscopy were divided into 4 groups with 100 cases in each group .Group A re-ceived conventional gastrointestinal endoscopy under intravenous anesthesia with scopolamine butylbromide and propofol intravenous anesthesia .Group B received conventional gastrointestinal endoscopy under intravenous anesthesia with scopolamine butylbromide .Group C received conventional gastrointestinal endoscopy under in-travenous anesthesia with propofol .Group D only received conventional gastrointestinal endoscopy .The mean arterial pressure(MAP) ,heart rate(HR) and pulse oxygen saturation(SpO2 ) of each group before treatment , during the operation and at consciousness were recorded .The adverse reactions of patients were observed dur-ing the operation .The comfort and satisfaction of patients were investigated ,and the operation time was also recorded after operation .[Results] Compared with group B ,group C and group D ,adverse reactions during surgery were fewer ,and whole vital signs were more stable ,and the operation time was shorter ,and postoper-ative satisfaction was higher in group A .[Conclusion] Scopolamine butylbromide combined with propofol ap-plied in the anesthesia of painless enteroscopy has even higher degree of comfort and satisfaction ,fewer adverse reactions and greater safety .Therefore ,it is worthy of clinical promotion . 2014 Vol. 31 (4): 685-687 [Abstract] ( 78 ) HTML (1 KB)  PDF  (0 KB)  ( 33 ) 688 Microsurgery Treatment of Patients with Hypertensive Intracerebral Hemorrhage Broken into Ventricles [Objective] To explore clinical efficacy of microsurgical operation in the treatment of hyperten-sive intracerebral hemorrhage broken into ventricles .[Methods]Totally 40 patients with hypertensive intrace-rebral hemorrhage broken into ventricles in neurological department and 40 patients with hypertensive intrace-rebral hemorrhage broken into ventricles in neurosurgical department of our hospital from Jan .2009 to Jan . 2013 were analyzed retrospectively .The 40 patients in neurological department were selected as conservation group ,while 40 patients undergoing microsurgical operation in neurosurgical department were selected as mi-crosurgery group .Hematoma elimination time ,hospitalization time and the incidence of hydrocephalus were compared between two groups .[Results] In microscopic group ,hematoma elimination time was (13 .7 ± 2 .6) d ,and the average hospitalization time was (18 .5 ± 3 .2)d ,and the incidence of hydrocephalus was 10% ,and the incidence of complications was 32 .5% .In conservative group ,hematoma elimination time was (23 .3 ± 3 .4)d ,and the average hospitalization time was (34 .1 ± 3 .9)d ,and the incidence of hydrocephalus was 42 .5% ,and the incidence of complications was 60% .There were significant differences between two groups ( P <0 .05) .[Conclusion] Microsurgical operation in the treatment of patients with hypertensive intracerebral hemorrhage broken into ventricles has more advantages and application value than conservation therapy .It can decrease the incidence of complications ,shorten the hematoma elimination time and alleviate the pain of pa-tients . 2014 Vol. 31 (4): 688-692 [Abstract] ( 77 ) HTML (1 KB)  PDF  (0 KB)  ( 30 ) 690 Value of Plasma Homocysteine in the Diagnosis of Coronary Heart Disease in Patients with Es-sential Hypertension LIU Li%LEI Ping [Objective] To explore the value of plasma homocysteine (Hcy) in the diagnosis of coronary heart dis-ease in patients with essential hypertension (ES) .[Methods] A total of 173 patients diagnosed as ES in our hospital from May 2011 to April 2013 underwent coronary angiography examination .According to coronary angiography ex-amination results ,all patients were divided into hypertension group (group A ,n =76) and hypertension combined with coronary heart disease group (group B ,n=97) .The levels of Hcy in two groups were measured and compared . When plasma Hcy (15μmol/L ) was taken as the cut-off value ,the probability of coronary heart disease in patients with different level of Hcy was compared .[Results]The level of Hcy in group B was 21 .1 ± 7 .9?mol/L ,which was obviously higher than that in group A (14 .0 ± 4 .5μmol/L) ,and there was significant difference between two groups ( P <0 .05) .When plasma Hcy(15μmol/L) was taken as the cut-off value ,the probability of coronary heart disease in patients with normal Hcy was 35 .1% ,which was obviously lower than that in high Hcy group (67 .7% ) ,and there was significant difference between two groups ( P<0 .05) .[Conclusion]Hcy level is valuable for predicting the probability of ES developing to coronary heart disease . 2014 Vol. 31 (4): 690-692 [Abstract] ( 24 ) HTML (1 KB)  PDF  (0 KB)  ( 41 ) 693 Expression and Significance of HIF-1α and VEGF in Laryngeal Carcinoma Tissue [Objective] To explore the expression of hypoxia-inducible factor-1α(HIF-1α) and vascular endothelial growth factor(VEGF)in laryngeal carcinoma and its clinical significance .[Methods] Immunohistochemical method was used to detect the expression of HIF-1αand VEGF in 62 cases of laryngeal carcinoma tissue and 46 cases of adjacent non-cancerous tissue .Clinicopathological parameters were also analyzed .[Results]The expression rates of HIF-1αand VEGF in laryngeal carcinoma tissue were 67 .74% and 62 .90% respectively ,which were higher than those in adjacent noncan-cerous tissue( P<0 .05) ,and there was a positive correlation between them ( P<0 .05) .The expression of HIF-1αwas associated with T stage and clinical stage ,and the expression of VEGF was associated with clinical stage and lymph node metastases( P<0 .05) .Survival analysis showed that there were significant differences in disease-free survival and overall survival between patients with positive expression of HIF-1αor VEGF and patients with negative expression ( P<0 .05) .[Conclusion] The expression of HIF-1αand VEGF may play an important role in the occurrence and development of la-ryngeal carcinoma ,and they have synergetic effect .HIF-1αmay promote tumor angiogenesis which leads to tumor inva-sion and lymph node metastasis by up-regulating VEGF expression .Both HIF-1αand VEGF can be used as important in-dicators to assess the biological behavior and prognosis of laryngeal carcinoma . 2014 Vol. 31 (4): 693-698 [Abstract] ( 60 ) HTML (1 KB)  PDF  (0 KB)  ( 37 ) 696 Evaluation of the Efficacy of Bifid Triple Viable Capsule Combined with Mesalazine in the Treat-ment of Ulcerative Colitis ZHANG Chen%ZOU Yi-you [Objective] To evaluate the efficacy of bifid triple viable capsule combined with mesalazine in the treatment of ulcerative colitis in many aspects of clinical manifestation ,colonoscopy and the changes of intestinal flora .[Methods]Totally 92 patients with ulcerative colitis patients in our hospital were divided into two groups by random digital table classification .The control group was given mesalazine only ,while the observation group was given mesalazine combined with bifid triple viable capsule .Clinical symptom scores ,intestinal flora and colonosco-py scores before and after the treatment were compared between two groups .[Results]The total effective rate of the observation group and control group was 89 .13% and 58 .7% ,respectively .The efficacy of observation group was obviously better than the control group ( P <0 .05) .After the treatment ,the decreasing degree of symptom scores and colonoscopy scores in observation group was larger than that in control group ( P<0 .05) .The number of lactobacillus and bifid bacterium in observation group after treatment were increased obviously ,but the number of Escherichia coli and Enterococcus were decreased obviously ( P<0 .05) .[Conclusion]Bifid triple viable capsule combined with mesalazine is benefit for the balance of intestinal flora ,and thus can inhibit the inflammation and significantly improve the curative effect . 2014 Vol. 31 (4): 696-698 [Abstract] ( 69 ) HTML (1 KB)  PDF  (0 KB)  ( 35 ) 699 Value of Phadiatop Detection in the Diagnosis of Bronchial Asthma in Children Aged under 5 Years Old [Objective] To explore the value of Phadiatop detection in the diagnosis of bronchial asthma in children .[Methods] Totally 267 patients with asthmatic suffocating pneumonia and suspected bronchial asth-ma who were detected by Phadiatop in pediatric medical center of Hunan provincial people's hospital were col-lected .The age was 2~3 years old .All patients were followed up by telephone and clinic service for 3 years . The occurrence and clinical manifestation of bronchial asthma in children were analyzed .[Results] In Phadi-atop-positive observation group( n =111) ,67 patients(60 .36% ) were bronchial asthma during follow up .In Phadiatop-negative observation group( n =156) ,29 patients(19 .59% ) were bronchial asthma during follow up .There was significant difference in the proportion of bronchial asthma between 2 groups( P < 0 .01) . There were significant differences in the incidence of recurrent asthma ,exercise-induced asthma ,hospitaliza-tion due to asthma ,asthma emergence ,allergic rhinitis ,eczema and asthma between two groups( P<0 .01) .[Conclusion] Long-term observation for Phadiatop-positive patients is of great value for the prediction and di-agnosis of bronchial asthma in children . 2014 Vol. 31 (4): 699-701 [Abstract] ( 52 ) HTML (1 KB)  PDF  (0 KB)  ( 36 ) 701 Study on the Expression of MVD and VEGF in Prostate Carcinoma and Their Correlation [Objective] To explore the expression of microvessel density (M VD ) and vascular endothelial growth factor(VEGF) in tissues of prostate cancer and its significance .[Methods] Totally 56 patients with prostate cancer in our hospital from 2007 to 2012 were selected as case group ,while 30 patients with benign prostatic hyperplasia were selected as control group .Immunohistochemical method was used to detect the ex-pression of VEGF and MVD .The correlation of MVD and VEGF with tumor metastasis was analyzed .[Re-sults] The expression of MVD and VEGF in prostate cancer was obviously higher than that in benign prostatic hyperplasia ,and there was significant difference between two groups ( P <0 .01) .There was also significant difference in the expression of MVD and VEGF between different TNM stage and lymphatic metastasis ( P <0 .05) .[Conclusion] VEGF participates in the angiogenesis of patients with prostate cancer ,and is closely re-lated with tumor growth and lymph node metastasis .VEGF and MVD may be the important reference indica-tors of the prognosis of prostate cancer . 2014 Vol. 31 (4): 701-704 [Abstract] ( 35 ) HTML (1 KB)  PDF  (0 KB)  ( 33 ) 705 Value of Fine Needle Biopsy Cytology in the Diagnosis of Papillary Thyroid Carcinoma and its Cervical Lymph Node Metastasis Carcinoma CHENG Zeng-xiong [Objective]To explore the value of cervical lymph node biopsy cytology in the diagnosis of pa-pillary thyroid carcinoma .[Methods] Totally 90 cases of papillary thyroid carcinomas with lymph node metas-tasis were selected and detected by using cervical lymph node biopsy cytology .Among them ,46 patients were detected by thyroid fine needle puncture cytology .The results were compared with postoperative pathological diagnosis results .[Results]The positive rate of cervical lymph node biopsy cytology was 90 .00% (81/90) . The sensitivity of cervical lymph node biopsy cytology was 89 .13% (41/46) ,and the missed diagnosis rate was 10 .87% (5/46) .The sensitivity of thyroid fine needle puncture cytology was 36 .96% (17/46) ,and the missed diagnosis rate was 63 .04% (29/46) .There was significant difference in the sensitivity between two methods ( P <0 .05) .[Conclusion]Cervical lymph node biopsy cytology in the diagnosis of cervical lymph node metas-tasis in patients with papillary thyroid carcinoma has significant advantages ,so it is worthy of clinical promo-tion . 2014 Vol. 31 (4): 705-709 [Abstract] ( 62 ) HTML (1 KB)  PDF  (0 KB)  ( 35 ) 707 Effect of Management for Hydrosalpinx on the Outcome of in Vitro Fertilization and Embryo Transfer [Objective]To explore the effect of different treatments for hydrosalpinx on the outcome of in vitro fertilization and embryo transfer(IVF-ET) .[Methods] Totally 154 patients with infertility derived from tubal causes(102 patients with a history of hydrosalpinx ) undergoing IVF-ET were collected .According to dif-ferent treatments for hydrosalpinx before IVF-ET ,all patients were divided into group A (without treatment for hydrosalpinx ,n=16) ,group B(hydrosalpinx aspiration ,n=35) ,group C(laparoscopy resection of hydro-salpinx ,n=15) ,group D(proximal tubal ligation and distal tubal salpingostomy by laparoscopy ,n =36) and group E(control group of concurrent tubal obstruction without hydrosalpinx ,n=52 ) .The dose of gonadotro-pin(Gn) ,the duration of stimulation ,estradiol(E2 ) level on HCG day ,the number of retrieved oocytes and the transferred embryo ,the fertilization rate ,pregnancy rate ,abortion rate and ectopic pregnancy rate were compared among groups .[Results] There was no significant difference in Gn dosage ,the duration of stimula-tion ,E2 level on HCG day ,the number of the transferred embryo ,the fertilization rate and ectopic pregnancy rate among groups( P >0 .05) .The number of retrieved oocytes in group C was the lowest ,and there was significant difference between group C and other groups ( P <0 .05) .Clinical pregnancy rate of group A was lowest(25% ) and that of group D was highest (56% ) ,and there was significant difference between group A and group C ,D and E( P<0 .05) ,but there was no significant difference between group A and group B .The abortion rate of group A was highest(67% ) and that of group D was lowest(10% ) ,and there was significant difference between group A and group C ,D and E( P<0 .05) ,but there was no significant difference between group A and group B .[Conclusion] Hydrosalpinx may decrease the implantation rate of embryos and increase the abortion rate .Treatments for hydrosalpinx before IVF-ET are helpful for increasing embryo implantation rate and improving the pregnancy outcome .Proximal tubal ligation and distal tubal salpingostomy by laparos-copy can be considered for the suitable treatment of hydrosalpinx . 2014 Vol. 31 (4): 707-709 [Abstract] ( 58 ) HTML (1 KB)  PDF  (0 KB)  ( 29 ) 710 Changes of Serum Levels of OPG and IGF in Patients with Coronary Heart Disease and Heart Failure SU Hai-feng%WEI Shi-gang%GAO Shan [Objective]To explore the changes and significance of serum levels of osteoprotegerin (OPG ) and insulin-like growth factor-Ⅰ (IGF-Ⅰ) in patients with chronic heart failure(CHF) and coronary heart dis-ease(CHD) .[Methods]Enzyme-linked immunosorbent assay(ELISA) was used to determine serum levels of OPG and IGF-Ⅰ in 58 patients with CHF and CHD and 22 healthy subjects .Comparative analysis was taken .[Results]Serum OPG in CHF group was obviously higher than that in normal control groups ,and increased with the deterioration of cardiac function obviously ( P <0 .01) .Serum IGF-Ⅰin CHF group was obviously lower than that in normal control group ,and decreased with deterioration of cardiac function obviously ( P <0 .01) .Serum OPG was negatively related with IGF-Ⅰ( P<0 .01) .[Conclusion]OPG and IGF-Ⅰ conjointly participate in the occurrence and development of CHD and heart failure .Serum levels of OPG and IGF-Ⅰ can be used as the indicators for assessing the severity of heart failure . 2014 Vol. 31 (4): 710-714 [Abstract] ( 53 ) HTML (1 KB)  PDF  (0 KB)  ( 33 ) 712 Clinical Efficacy of Concurrent Chemoradiotherapy after Breast Conserving Surgery and Its Im-pact on Immunity of Patients ZHU Xue-jun%QIN Ting%ZHOU Guang-hua [Objective]To observe the efficacy of concurrent chemoradiotherapy for the treatment of early breast cancer after breast conserving surgery and its impact on T-lymphocyte subsets .[Methods]A total of 60 patients undergoing breast conserving surgery were randomly divided into observation group and control group with 30 patients in each group .The observation group was treated with radiotherapy and chemotherapy after operation ,while the control group only received radiotherapy .Clinical efficacy and the changes of peripheral blood CD3+ ,CD4+ and CD8+ cell percentage of two groups were observed .[Results]The local recurrence rate of observation group was obviously lower than that of control group ,and there was significant difference( P<0 .05) .There was no significant difference in peripheral blood CD3+ ,CD4+ percentage ,CD4+ /CD8+ ratio and adverse reactions between two groups ( P>0 .05) .[Conclusion]Concurrent chemoradiotherapy after early breast conserving surgery can obviously reduce the local recurrence rate of patients ,and be tolerated by pa-tients ,and it is safe and feasible .Therefore it is worthy of application . 2014 Vol. 31 (4): 712-714 [Abstract] ( 52 ) HTML (1 KB)  PDF  (0 KB)  ( 43 ) 715 Clinical Efficacy of Stomach Tube Injection of Pralidoxime Iodide and Mannitol Applied in Or-ganophosphorus Pesticide Poisoning YOU Jing%SHI Yong-Mei%SHI Hong-Mei [Objective] To explore clinical efficacy of stomach tube injection of pralidoxime iodide and mannitol applied in patients with organophosphorus pesticide poisoning .[Methods]Totally 60 patients with organophosphorus pesticide poisoning were randomly divided into observation group ( n=32) and control group( n =28) .The control group was given routine gastric lavage ,atropine ,pralidoxime iodide injection ,fluid infusion and symptomatic treat-ment .The observation group was given gastric lavage tube injection of pralidoxime iodide (or chlorophos) and manni-tol based on the above treatment .Clinical efficacy was compared between two groups .[Results] Atropine dosage and the frequency of bounce in observation group were obviously less than those in control group ( P<0 .01) ,while atro-pinization time ,hospitalization time ,curative rate and mortality in observation group were better than those in control group( P<0 .05) .[Conclusion]Early gastric lavage tube injection of pralidoxime iodide (or chlorophos ) and mannitol can obviously improve the rescue successful rate of organophosphorus pesticide poisoning . 2014 Vol. 31 (4): 715-717 [Abstract] ( 59 ) HTML (1 KB)  PDF  (0 KB)  ( 43 ) 717 Features of Coronary Artery Disease in Type 2 Diabetes Mellitus Patients with Coronary Heart Disease [Objective] To explore the features of coronary artery disease in patients with type 2 diabetes mellitus(T2DM ) .[Methods]Coronary angiography(CAG) was used to analyze the features of coronary artery disease in 394 coronary heart disease (CHD) patients with T2DM ( n = 124) and without diabetes mellitus (DM)( n=270) .Conventional ultrasonic echocardiogram(ECG) was used to analyze inner diameter of heart and cardiac function parameters .[Results] Left interior descending branch was mainly involved in T 2DM pa-tients with CHD ,and left circumflex branch was next ,and the right coronary artery was second next .There was no significant difference in inner diameter of heart between DM with and without CHD ( P>0 .05) .[Con-clusion]Coronary artery disease in T2DM patients with CHD is more severe .The effect of DM on cardiac function should be assessed systematically and comprehensively . 2014 Vol. 31 (4): 717-719 [Abstract] ( 75 ) HTML (1 KB)  PDF  (0 KB)  ( 34 ) 720 Comparison of Clinical Outcome Between Frozen-thawed Embryo Transfer and Fresh Embryo Transfer after the Improved Protocol of Antagonist for Ovarian Stimulation [Objective]To explore whether clinical outcome of frozen-thawed embryo transfer after the improved pro-tocol of antagonist for ovarian stimulation is better than that of fresh embryo transfer .[Methods]Clinical outcomes of 68 patients undergoing frozen-thawed embryo transfer following total embryo cryopreservation after the improved protocol of antagonist for ovarian stimulation (frozen-thawed embryo group ) and 82 concurrent patients undergoing fresh embryo transfer(fresh embryo group) in our center from June 2012 to Sept .2012 were analyzed retrospectively .[Results] The implantation rate and clinical pregnancy rate in frozen-thawed embryo group were 43 .38% and 66 .17% respectively , which were obviously higher than those in fresh embryo group (30 .98% and 42 .68% ,respectively)( P <0 .05) .There was no significant difference in the abortion rate (8 .89% vs .11 .43% ) and multiple pregnancy rate(31 .1% vs .34 .3% ) between two groups(all P>0 .05) .[Conclusion] Frozen-thawed embryo transfer following total embryo cryopreservation in the improved protocol of antagonist for ovarian stimulation can greatly improve the clinical pregnancy rate . 2014 Vol. 31 (4): 720-722 [Abstract] ( 71 ) HTML (1 KB)  PDF  (0 KB)  ( 33 ) 722 Epidemiological Investigation of the Causes of Knee Osteoarthritis in Sangzhi County of Hunan Province [Objective] To analyze the related risk factors and provide scientific basis for the prevention and treatment for local knee osteoarthritis(KOA) in patients through the epidemiological investigation of people over 40 years old with KOA in Sangzhi county of Hunan province .[Methods]Epidemiological investigation of KOA of 1296 people over 40 years old in 22 townships(concentrated population distribution) of Sangzhi county from Dec .9th 2012 were taken .The survey included name ,gender ,age ,ethnics ,diet habits ,course ,lesion location ,partial knee symptoms and special examinations such as tenderness place and floating patella test .The subjects were investigated by the trained medical staff through the questionnaire .All data was analyzed by chi-square test and univariate binary logistic regression analysis .Multivariate bi-nary logistic regression analysis was used to screen all the factors so as to find out the risk factors .[Results] The preva-lence rate of KOA in people over 40 years old was 25 .2% .There was no significant difference in the prevalence between male persons and female people ( P > 0 .05) .The prevalence rate in people aged 80 ~ 89 years old was the highest (37 .5% ) ,and that in people aged 40~49 year old was 12 .1% .The prevalence rate of Han nationality was the highest (31 .7% ) ,while that of Miao nationality was the lowest (11 .5% ) .The prevalence rate of wax diet was 35 .1% ,while that of spicy diet was 45 .1% .[Conclusion] People aged 60~69 years old in the region has the high incidence of KOA . Aging ,nationality ,wax and spicy diet are major risk factors of KOA . 2014 Vol. 31 (4): 722-724 [Abstract] ( 64 ) HTML (1 KB)  PDF  (0 KB)  ( 41 ) 725 Analysis of Electrocardiogram for 206 Senile Patients Aged over 60 Years Old MA Yan-xia%TA NG Shi-rong%HE Guan [Objective] To explore the characteristics of electrocardiogram (ECG) in elderly patients aged over 60 years old ,and to analyze the rule and causes of abnormal ECG .[Methods] Totally 260 elderly patients aged over 60 years old received physical examination by using 12-lead ECG .The relationship of abnormal ECG with age ,gender and basic diseases were analyzed .[Results] Among 260 elderly patients ,205 patients(227 cases) had abnormal ECG .The proportion of abnormal ECG increased with the age .The proportion of male patients with abnormal ECG in different age group was higher than that of female patients .ST segment change and cardiac arrhythmia in abnormal ECG were commonly seen .The most common basic diseases were hyper-tension ,coronary artery disease and cardiopulmonary disease .[Conclusion] The proportion of abnormal ECG and cardiovascular disease in elderly patients increases with the age .ECG examination should be a regularity health screening item for old people . 2014 Vol. 31 (4): 725-727 [Abstract] ( 40 ) HTML (1 KB)  PDF  (0 KB)  ( 36 ) 727 Univariate and Multivariate Analysis of the Efficacy of Surgical Treatment of Hepatocellular Carcinoma with Liver Cirrhosis CHEN Jie%QIAN Li-yuan [Objective]To explore the efficacy ,safety ,complication and prognosis of surgical treatment of hepatocellular carcinoma(HCC) with liver cirrhosis .[Methods] Totally 57 HCC patients with liver cirrhosis undergoing surgical treatment in our hospital from Jan .2001 to Aug .2008 were enrolled in the study .A ret-rospective analysis method was used to analyze all data of patients before and after surgery .The year survival rate was calculated .Univariate and multivariate regression method was used to analyze the influencing factors of year survival rate of patients .[Results] The 1-year ,2-year ,3-year and 5-year survival rate of patients after surgery was 63 .6% ,52 .1% ,34 .7% and 19 .3% ,respectively .Preoperative child grading ,preoperative platelet count ,preoperative alpha-fetoprotein(AFP) measurement ,tumor size and whether radical resection or not were all correlated with the prognosis ( P<0 .05) .Preoperative child grading and whether radical surgery or not was an independent risk factor ( P <0 .05) .[Conclusion]Surgery is the ideal method of radical treat-ment of HCC with liver cirrhosis ,but accurate preoperative assessment of patients'liver functional reserve and postoperative active adjuvant therapy is the key to improve survival rate and quality life of the patients . 2014 Vol. 31 (4): 727-729 [Abstract] ( 27 ) HTML (1 KB)  PDF  (0 KB)  ( 28 ) 730 Remote Ischemic Preconditioning to Reduce Liver Injury after Valve Replacement Surgery [Objective] To observe the effect of remote ischemic preconditioning (RIPer) for protecting the liver of patients undergoing valve replacement surgery .[Methods] Totally 40 patients scheduled for selective valve re-placement surgery under cardiopulmonary bypass were randomly divided into remote ischemic preconditioning is-chemic group(RIPer group ,n =20) and control group(group C ,n = 20) .Before anesthesia ,cuff-inflator was placed on lower left limb of patients .RIPer group was treated with three circles of 5-minute ischemia and 5-minute reperfusion for lower left limb immediately at the clamping of aorta ..Group C group was not treated .Carotid ve-nous blood was collected before anesthesia induction (d0 ) ,d1 ,d3 and d7 after operation .Serum alamine transami-nase(ALT) ,glutamate transaminase(AST) ,total bilirubin(TBIL) and total bile acid(TBA) were measured .Su-peroxide dismutase(SOD) activity 24h before and after RIPer .[Results]Serum ALT and AST in two groups after operation were increased in different degree .ALT level in RIPer group at d1 ,d3 and d7 after operation was lower than that in group C ( P <0 .05) .AST level in RIPer group at d2 and d3 after operation was lower than that in group C( P <0 .05) ,but there was no significant difference in AST level at d7 between two groups( P >0 .05) . There was no significant difference in TBIL and TBA level at d1 ,d3 and d7 after operation between two groups . Plasma SOD activity in RIPer group 24h after RIPer was obviously higher than that in control group .[Conclusion]RIPer can reduce acute liver injury after cardiopulmonary bypass ,but has little impact on liver reserve function . SOD might participate in the protective effect of RIPer . 2014 Vol. 31 (4): 730-732 [Abstract] ( 76 ) HTML (1 KB)  PDF  (0 KB)  ( 27 ) 733 Clinical Analysis of Arthroscopic Suture for Repairing 16 Patients with Rotator Cuff Injury [Objective] To explore the indications ,surgical skills and clinical efficacy of arthroscopic su-ture for repairing rotator cuff injury .[Methods] Totally 16 patients with rotator cuff injury from Jan .2012 to Dec .2013 underwent arthroscopic reconstruction of rotator cuff .American shoulder and elbow physician asso-ciation score(ASES) ,Constant-Murley score and simple shoulder test (SST ) questionnaires before operation and in the last follow up after operation were used to assess the functional recovery .[Results]All the 16 pa-tients were followed up for 3~21 months(average 12 months) .Mean ASES scores before and after operation were 72 .3 and 87 .1 ,respectively .SST scores before and after operation were 6 .1 and 10 .7 ,respectively . Mean forward flexion and elevation before and after treatment were 150 .3° and 173 .3° ,respectively .Mean ex-ternal rotation before and after operation were 28 .5° and 45 .2° ,respectively .Mean Constant-Murley scores before and after operation were 70 .9 and 85 .4 ,respectively .Compared with before operation ,the above inde-xes after operation were improved obviously ,and there were significant differences (all P <0 .05) .[Conclu-sion]Arthroscopic reconstruction of rotator cuff has advantages such as minimal injury and quick recovery of shoulder joint function ,so it is an effective method for the treatment of rotator cuff injury .Correct indication choice ,perfect arthroscopic operation skills and strict functional rehabilitation are the key for the successful operation . 2014 Vol. 31 (4): 733-735 [Abstract] ( 61 ) HTML (1 KB)  PDF  (0 KB)  ( 35 ) 736 Early Microsurgery for the Treatment of Ruptured Aneurysms of Anterior Communicating Ar-tery [Objective]To explore the efficacy of early microsurgical treatment of ruptured aneurysms of anterior communicating (ACOM ) artery .[Methods] Totally 50 patients with ruptured aneurysms of ACOM artery in our hospital underwent microsurgery through the pterional approach within 48 hours .The imaging characteristics and operation methods were discussed .[Results]The intraoperative diagnosis was consistent with preoperative diagnosis in 50 patients .Among them ,5 patients were multiple aneurysms ,and 3 patients were posterior communicating artery aneurysm ,and 1 patient was middle cerebral artery aneurysm ,which was ipsilateral and occluded by operation for one time ,and 1 patient was C2 segment aneurysm of bilateral carotid artery in which two aneurysms of major lateral carotid artery were occluded by operation for one time and con-tralateral C2 segment aneurysms were observed continuously .The ruptured aneurysms were middle and small aneurysms .After the operation for 6 months ,43 patients were Glasgow outcome scale(GOS) grade Ⅴ ,and 2 patients were grade Ⅳ ,and 1 patient was grade Ⅲ ,and 2 patients were grade Ⅱ ,and 2 patients were gradeⅠ .[Conclusion] Attention to the details and individual management are the critical for the success microsur-gery of ruptured aneurysms of ACOM artery .Early microsurgery for clearing hematocele and occluding aneu-rysms can achieve the satisfactory results . 2014 Vol. 31 (4): 736-739 [Abstract] ( 40 ) HTML (1 KB)  PDF  (0 KB)  ( 31 ) 740 Effect of Radix Paeoniae Rubra 801 on the Expression of NF-κB in Fibroblast-like Synoviocytes from Patients with Rheumatoid Arthritis PENG Ai-hong%CAI Yong%JIA NG Hong-min [Objective] To explore the location and expression changes of p65 and p50 protein in fibroblast-like synoviocyte(FLS) in patients with rheumatoid arthritis (RA) after Radix paeoniae rubra 801(P801) treat-ment .[Methods] FLS was isolated from synovial fluid through primary culture ,and then treated with 64 ,4 and 0μg/mL P801 for 24h .Immunocytochemistry method was used to analyze the location of p 65 and p50 in cells ,and then nuclear protein was drawn .Western blotting was used to detect the expression of p65 and p50 .[Results] Immunocytochemistry showed that the p65 and p50 were mainly expressed in cytoplasm of RA FLS treated by 0μg/mL P8010 .Compared with control group ,the expression of p65 or p50 had no change 24h af-ter 4μg/mL P801 treatment( P >0 .05) .The expression of p65 and p50 in nucleus 24h after 64μg/mL P801 treatment ,and there was significant difference between treatment group and control group ( P<0 .05) .West-ern blotting results showed that both p65 and p50 were detected in nucleus extract of RA FLS .Compared with control group ,the treatment with 4μg/mL P801 for 24h had no influence on the expression of p65 and p50( P>0 .05) .When the concentration of P801 reached 64μg/mL ,the expression of p65 and p50 increased signifi-cantly( P<0 .05) .[Conclusion]P801 can regulate the migration of p65 and p50 of RA FLS from cytoplasm to cell nuclear ,and induce their up-regulation . 2014 Vol. 31 (4): 740-745 [Abstract] ( 51 ) HTML (1 KB)  PDF  (0 KB)  ( 31 ) 743 Analysis of the Efficacy of Interventional Treatment of Diabetic Foot [Objective] To explore clinical efficacy of interventional methods such as balloon dilation and stent placement for the treatment of diabetic foot .[Methods] Totally 35 patients with diabetic foot received interventional treatment such as balloon dilation and stent placement based on comprehensive treatment such as controlling blood glucose ,regulating lipid ,dilating blood vessels ,controlling infection and improving circula-tion .The condition changes of diseased limbs after interventional therapy were observed .[Results]All patients completed interventional therapy successfully .Immediate blood flow was improved obviously .No acute ob-struction or vascular rupture hemorrhage occurred .After the treatment for 5~7 days ,the symptoms of 15 pa-tients were relieved obviously .Ankle/brachial index(ABI) was (0 .95 ± 0 .25) ,while toe/brachial index(TBI) was (0 .56 ± 0 .12) .One patient died for postoperative sudden myocardial infarction .One patient recovered af-ter interventional therapy for acute thrombus occlusion .Among 28 patients followed up for 1 year ,12 patients (42 .9% ) had restenosis .[Conclusion] Interventional treatment for diabetic foot can effectively relief the symptoms ,delay amputation time .The short-term efficacy is good .But many kinds of factor can affect the us-age of interventional treatment .The choice of appropriate cases should be fully considered . 2014 Vol. 31 (4): 743-745 [Abstract] ( 74 ) HTML (1 KB)  PDF  (0 KB)  ( 24 ) 746 Value of IL-18 and IL-33 in Pathogenesis of Asthma in Patients During Different Period AI Chun-y ing [Objective]To explore the expressions and significance of interleukin-18(IL-18) and interleukin-33 (IL-33) in bronchial asthma(asthma) .[Methods]Totally 125 patients with asthma(asthma group) were chosen . According to the patients'condition ,all patients were divided into asthma remission group ( n=48) ,acute asthma group( n=77) ,mild asthma group(n=32) ,moderate asthma group( n=25) and severe asthma group( n=20) . Other 48 normal subjects were selected as the control group .The levels of IL-18 and IL-33 in groups were meas-ured by immunosorbent method .Meanwhile ,the changes of the percentage of forced expiratory volume in one sec-ond(FEV1) of predictive value(FEV1% ) and eosinophils(EOS) were observed .[Results]Compared with control group ,the levels of IL-18 ,IL-33 and EOS in asthma group were markedly increased ,while FEV1% was markedly decreased ,and there was significant difference( P<0 .05) .Compared with asthma remission group ,the levels of IL-18 ,IL-33 and EOS in acute asthma group were markedly increased ,while FEV1% was markedly decreased , and there was significant difference( P <0 .05) .Compared with mild and moderate asthma groups ,the levels of IL-18 ,IL-33 and EOS in severe asthma group were higher ,but FEV1% was lower ,and there was significant difference( P <0 .05) .The levels of IL-18 ,IL-33 and EOS in groups in acute period after treatment were lower than those before treatment ,while FEV1% after treatment was higher than that before treatment ,and there was significant difference( P<0 .05) .[Conclusion]IL-18 and IL-33 may play the proinflammatory role during acute at-tack of asthma attack ,and can strengthen airway reaction .For patients treated with hormone therapy ,IL-18 and IL-33 can effectively inhibit inflammation ,control airway reaction and promote the prognosis of patients . 2014 Vol. 31 (4): 746-748 [Abstract] ( 33 ) HTML (1 KB)  PDF  (0 KB)  ( 35 ) 749 Study on the Relationship Between Self-care Ability and Health Behavior in Patients with Breast Cancer Receiving Chemotherapy HUA NG Ji-ju [Objective]To explore the relationship between self-care ability and health behavior in patients with breast cancer receiving chemotherapy .[Methods] Totally 83 patients with breast cancer receiving chemo-therapy were collected .Self-care ability scale(ESCA) and health behavior scale(HPL) were used for assessing health behavior and self-care ability of all patients .The correlation between two scores were analyzed .[Re-sults] The ESCA and HPL scores in breast cancer patients receiving chemotherapy were (106 .54 ± 9 .53) and (122 .15 ± 12 .45) ,respectively .The ESCA scores were positively correlated with HPL scores .[Conclusion]When breast cancer patients receiving chemotherapy are given the nursing interventions ,the mental health and stress mediation of patients should be paid attention ,and the health behaviors of patients should be improved , and the training of self-care skills should be strengthened ,and the self-care ability should be increased . 2014 Vol. 31 (4): 749-753 [Abstract] ( 34 ) HTML (1 KB)  PDF  (0 KB)  ( 29 ) 751 Analysis of the Efficacy of Individualized Pain Management on Perioperative Pain in Patients with Hip Replacement SONG Yong-qing%ZENG Heng [Objective] To explore the efficacy of individualized pain management for perioperative pain in patients with hip replacement .[Methods] Totally 90 patients with hip replacement complicated by periopera-tive pain were selected .According to the order of hospitalization ,all patients were divided into observation group and control group with 45 patients in each group .Control group was given conventional treatment , while the observation group was given individualized pain management .Visual analogue scale(VAS) pain scores and sleep time at 4h ,12h ,24h ,48h and 72h after operation were compared between two groups .The satisfaction of patients in two groups was evaluated .[Results]VAS pain scores in observation group at 4h , 12h ,24h and 48h after operation were obviously lower than those in control group ,and there was significant difference( P <0 .05) .There was no significant difference in VAS pain scores at 72h after operation between two groups( P >0 .05) .Sleep time in observation group at 4h ,12h ,24h ,48h and 72h after operation was ob-viously better than that in control group ,and there was significant difference( P <0 .05) .The satisfaction of patients in observation group was 88 .9% ,which was markedly higher than that in control group (66 .7% ) , and there was significant difference( P <0 .01) .[Conclusion] Individualized pain management can effectively alleviate perioperative pain symptoms of patients with hip replacement ,so it is of clinical significance for im-proving the satisfaction of patients and worthy of clinical application . 2014 Vol. 31 (4): 751-753 [Abstract] ( 54 ) HTML (1 KB)  PDF  (0 KB)  ( 40 ) 754 Effect of Early Cluster Treatment Strategies on the Prognosis of Patients with Severe Heatstroke FENG Shi-jun%XU Dao-miao [Objective] To explore the effect of early cluster treatment strategies on the prognosis of patients with severe heatstroke .[Methods]Clinical data of 36 cases of severe heatstroke in our hospital were analyzed retro-spectively .All patients were divided into the group with admission time less than 2h and the group with admission time more than 6h .All patients received cluster treatment strategies including "early rapid cooling ,rapid expansion , early anticoagulation ,active organ function support ,nutritional support".The severity of the disease (APACHE-Ⅱscore) and mortality were compared between two groups .[Results] The average temperature of 36 patients was 40 .8℃ .The later the clinical time ,the higher the mortality ( P<0 .05) .There was significant difference in PCT ,CK-MB ,PLT ,ALT ,and APACHE-Ⅱ between two groups(P<0 .05) .The later clinical time of severe heatstroke ,the more serious the organ damage .[Conclusion]The prognosis of patients with severe heatstroke is associated with clin-ical time .Early cluster treatment strategies can improve the prognosis of patients . 2014 Vol. 31 (4): 754-758 [Abstract] ( 55 ) HTML (1 KB)  PDF  (0 KB)  ( 33 ) 756 Comparative Analysis of Conservative Treatment vs .Surgical Treatment for Ectopic Pregnancy XUE Feng%WA NG Li-xin [Objective]To compare the effect of conservative treatment and surgical treatment for Ectopic preg-nancy .[Methods] Among 180 patients with ectopic pregnancy ,90 patients(observation group) underwent laparo-scopic surgery and 90 patients(control group) received drug conservation therapy .The treatment efficacy was com-pared between two groups .[Results]After treatment ,hospitalization time and blood β-HCG level at discharge in observation group were obviously better than those in control group( P <0 .05) ,while the cost of hospitalization in observation group was obviously higher than that in control group( P<0 .05) .Serumβ-HCG decreasing to nor-mal time ,pregnancy mass disappearance time and tubal re-canalization rate in observation group were obviously better than those in control group( P<0 .05) .Re-intrauterine pregnancy and re-ectopic pregnancy rate in observa-tion group were obviously better than those in control group (P<0 .05) .The incidence of pelvic inflammation in observation group after treatment was obviously lower than that in control group ( P<0 .05) .[Conclusion]Laparo-scopic surgery for the treatment of ectopic pregnancy has advantages such fast efficacy and short hospital stay ,and can greatly increase postoperative re-intrauterine pregnancy and reduce re-ectopic pregnancy rate ,and is helpful for the quality of life .Therefore ,it is worthy of clinical application . 2014 Vol. 31 (4): 756-758 [Abstract] ( 59 ) HTML (1 KB)  PDF  (0 KB)  ( 40 ) 759 Observation on Postoperative Pulmonary Infection of Senile Acute Abdomen and Analysis of the Relative Risk Factors NING Wei-min%ZHU Li-tao [Objective] To observe the incidence of postoperative pulmonary infection in senile acute abdomen and to analyze the associated risk factors in order to reduce the incidence of postoperative pulmonary infection in se-nile acute abdomen .[Methods]Totally 114 senile patients with acute abdomen undergoing surgery were analyzed respectively .The incidence of postoperative pulmonary infection was calculated .The associated risk factors were tested by single factor χ2 test and multi-factor Logistic regression analysis .[Results] Among the 114 patients ,30 patients had postoperative pulmonary infection ,and the incidence rate was 26 .32% .The multi-factor Logistic test showed that age(OR= 2 .356 ,95% CI 1 .845~3 .009) ,the combined pulmonary diseases(OR= 3 .526 ,95% CI 2 .346~5 .300) ,general anesthesia(OR= 3 .410 ,95% CI 2 .469~ 4 .710) ,sputum excretion by oneself (OR=0 .472 ,95% CI 0 .335~0 .665) ,sputum excretion by others (OR=0 .503 ,95% CI 0 .394~0 .642) ,mouth clean (OR=0 .481 ,95% CI 0 .369~0 .627) ,anemia(OR=1 .821 ,95% CI 1 .632~2 .032) ,poor immune function(OR=2 .526 ,95% CI 1 .887~3 .381) and hospital stay (OR=1 .793 ,95% CI 1 .421~2 .262) were the risk factors for postoperative pulmonary infection .[Conclusion] The incidence of postoperative pulmonary infection is high in eld-erly patients with acute abdomen ,and is associated with a variety of factors .On the basis of the relevant risk fac-tors ,the prevention ,treatment and nursing during the operation should be strengthened . 2014 Vol. 31 (4): 759-761 [Abstract] ( 64 ) HTML (1 KB)  PDF  (0 KB)  ( 36 ) 761 Clinical Analysis of PFNA for the Treatment of Intertrochanteric Femoral Fracture DEN He-sheng [Objective] To explore the efficacy of proximal femoral nail antirotation(PFNA) for the treatment of intertrochanteric femoral fracture .[Methods]Totally 54 patients with intertrochanteric femoral fracture were treated with PFNA from Jan .2008 to Jan .2012 .All patients were followed up after operation .The efficacy was evaluated .[Results] All the patients were followed up after operation .The follow up time was for 10~37 months with 13 .8 months in average .The fractures of patients were all healed .According to Harris score standard ,28 patients were excellent ,and 21 patients were good ,and 5 patients were fair .The good and excellent rate was 90 .7% .[Conclusion] PFNA is simple operation ,minimal trauma ,stable fixation and little impact on blood sup-ply ,so it is good treatment of intertrochanteric femoral fracture . 2014 Vol. 31 (4): 761-763 [Abstract] ( 57 ) HTML (1 KB)  PDF  (0 KB)  ( 36 ) 764 Study on the Safety and Effectiveness of Evidence-based Nutrition Support for Elderly Inpatients LI Kai-lai%XU Lin-lin%YANG Jun-nan [Objective] To observe the safety and effectiveness of individual nutritional intervention on eld-erly patients with nutritional risk .[Methods] Totally 129 elderly inpatients(age≥65 years old) in department of cadre care of our hospital from Sept .2011 to March 2012 were enrolled in the study .Nutritional risk screening 2002(NRS 2002) standard was performed to find the patients with nutritional risk .The patients with nutritional risk were given individual nutrition intervention .Liver and kidney function ,blood lipids and proteins before ,2 weeks and 1 month after nutrition intervention were examined .The nutrition status was compared between before and after intervention .[Results] The research results showed that NRS of 32 pa-tients in 120 patients were equal or over 3 points ,and the incidence of nutritional risk was 24 .8% (32/129) . The indicators such as liver and kidney function and blood lipids 2 weeks and 1 month after nutritional inter-vention had no change ,while serum levels of total protein ,albumin and hemoglobin were obviously increased , and there was significant difference between before and after intervention ( P<0 .05) .[Conclusion]Individual nutritional intervention is safe and effective for elderly patients with nutrition risk . 2014 Vol. 31 (4): 764-770 [Abstract] ( 59 ) HTML (1 KB)  PDF  (0 KB)  ( 40 ) 767 Study on Viral Pathogen in Hospitalized Children with Acute Lower Respiratory Tract Infection from 2011 to 2012 in Hunan Province [Objective] To understand the viral pathogen in hospitalized children with acute lower respira-tory tract infection(ALRTI) from 2011 to 2012 in Hunan province .[Methods]A total of 727 nasopharyngeal aspirate samples in hospitalized children due to ALRTI from April 2011 to March 2012 were collected .Reverse transcription polymerase chain reaction (RT-PCR) and Nest-PCR were used to detect 13 kinds of common re-spiratoryvirusesincludinghumanbocavirus(HBoV),adenovirus(ADV),respiratory syncytialvirus(RSV), human rhinovirus(HRV) ,parainfluenza 1-4(PIV1-4) ,influenza virus A(IFVA) ,influenza virus B(IFVB) , human metapneumovirus (HMPV) ,human coronaviruses NL63 (HCoV-NL63) and human coronaviruses HKU1(HCoV-HKU1) .The positive amplification products were confirmed by gene sequencing .[Results]Vi-ruses were detected in 504 of 727 specimens ,and the total detection rate was 69 .3% (504/727) .The first three viruses were RSV(26 .3% ) ,HRV(18 .7% ) and ADV(18 .6% ) .The high detection rate of viruses was found in spring and summer and children aged less than 3 years old ,and there was significant difference . There was no significant difference in the detection rate of viruses between males and females .The mixed in-fection rate of two or more than two kinds of viruses was 38 .9% .[Conclusion]During the study period ,respir-atory syncytial virus and rhinovirus are the main pathogens in hospitalized children with ALRTI of Hunan province .Compared with former years ,the detection rate of adenovirus is obviously increased ,and becomes the third common virus ,and has important significance .The mixed infection rate of viruses is high . 2014 Vol. 31 (4): 767-770 [Abstract] ( 90 ) HTML (1 KB)  PDF  (0 KB)  ( 27 ) 771 Application of Pedicle Screw Fixation in Atlantoaxial Fracture [Objective]To explore clinical efficacy of pedicle screw in the treatment of atlantoaxial fracture .[Methods] Clinical data of 26 patients with atlantoaxial fracture undergoing posterior pedicle screw fixation form Aug .2008 to Nov .2012 were analyzed retrospectively .Among them ,8 patients were odontoid fracture , and 13 patients were atlas fracture ,and 5 patients were atlantoaxial complex fracture .All patients complained of neck pain ,limitation of activity ,limb numbness and weakness .Preoperative JOA scores ranged from 5 to 12 points(mean 8 .5 points)[Results]A total of 52 atlas pedicle screws and 52 axis pedicle screws were insert-ed .All patients were followed up for an average of 18 months .Postoperative JOA scores were 12~16 points (mean 14 .5 points) .During the follow up ,all pedicle screws were verified to be fixed in a proper position , and cervical vertebra arrangement was normal .In the last follow up ,all patients had bone union and nearly normal motion of neck .[Conclusion] Atlantoaxial pedicle screw fixation for the treatment of atlantoaxial frac-ture has certain efficacy and can maintain most of motor function . 2014 Vol. 31 (4): 771-773 [Abstract] ( 58 ) HTML (1 KB)  PDF  (0 KB)  ( 36 ) 774 Surveillance Analysis of Infection Status and Resistance of Multi-drug Resistant Bacteria in Ma-ternal and Child Health Hospital in 5 Years CHEN Min%MAO An-hua%TAN Hao [Objective]To understand the detection status of multidrug-resistant bacteria(MDRB) and the trend of drug resistance in order to provide experimental data for prevention and therapy of clinical infection .[Methods]The results of MDRB identification and drug sensitive test in maternal and child health hospital of Hunan province from Jan .2008 to Dec .2012 were analyzed retrospectively .[Results]Totally 1648 strains of MDRB were isolated in 5 years and the detection rate showed the rising trend year by year ( P<0 .05) .Among them ,Gram-negative bacteria accounted for 59 .64% ,which was higher than that of Gram-positive bacteria (40 .36% )( P <0 .05) .In Gram-negative bacteria of MDRB ,Enterobacteriaceae bacteria were highly sensitive to meropenem ,while pseudomonas aeruginosa and Baumannii acinetobacter were widespread multidrug-resist-ance .Vancomycin resistant strains were not found in methicillin-resistant staphylococcus aureus (MRS) of Gram-positive bacteria of MDRB .[Conclusion]The detection of MDRB in collection samples of the hospital in recent 5 years .Gram-negative bacteria account for the higher proportion and reveal serious drug resistance . Since infant and child patients have immature immune function and pregnant women have weakened immune function in maternal and child health hospital ,regular monitoring of bacterial resistance are more important for the prevention and treatment of clinical infection . 2014 Vol. 31 (4): 774-779 [Abstract] ( 72 ) HTML (1 KB)  PDF  (0 KB)  ( 40 ) 777 Value of Color Doppler Ultrasound Used in the Diagnosis of Gallbladder Carcinoma LI Jun%SUN Ke-ying%ZHOU Jie [Objective]To explore the value of color Doppler ultrasound used in the diagnosis of gallbladder carcinoma .[Methods]Color Doppler ultrasound was used for the differential diagnosis of 24 patients with gallblad-der carcinoma diagnosed by CT ,MRI ,pathology and follow up .The tumor size ,boundary ,shape ,echo feature , blood flow signal and its location and character and hemodynamic parameters were examined and compared with those of gallbladder wall of 20 patients without gallbladder disease .[Results]Color Doppler ultrasonic manifesta-tions showed that peak systolic velocity (PSV) ,end diastolic velocity(EDV) of artery ,mean velocity(Vmean) and resistance index (RI) in gallbladder carcinoma group were (30 .4 ± 4 .3)cm/s ,(8 .8 ± 6 .1)cm/s ,(14 .6 ± 5 .2)cm/s and (0 .71 ± 0 .21) respectively ,which were obviously higher than those in normal control group[(14 .3 ± 2 .7)cm/s ,(4 .4 ± 3 .8)cm/s ,(6 .1 ± 3 .4)cm/s and (0 .46 ± 0 .23) ,respectively] ,and there were significant differences( P<0 .01) .The differential diagnosis indicator was gallbladder artery PSV ≥0 .20cm/s .The sensitivity ,specificity , accuracy ,positive predictive value ,negative predictive value and Youden index were 87 .5% ,95 .0% ,90 .91% , 95 .45% ,86 .36% and 0 .825 ,respectively .[Conclusion] Blood flow signal showed by Color Doppler ultrasound combined with ultrasonogram in the diagnosis of patients with gallbladder has an important useful value . 2014 Vol. 31 (4): 777-779 [Abstract] ( 75 ) HTML (1 KB)  PDF  (0 KB)  ( 35 ) 780 Clinical Analysis of Vena Cava Filter Implantation for the Treatment of 11 Patients with Upper Extremity Deep Venous Thrombosis CHEN Ke-qin%PENG Han-wu%HU Xian-ming [Objective]To explore the efficacy of vena cava filter in the treatment of upper extremity deep venous thrombosis(UEDVT) .[Methods]Clinical data of 11 patients with UEDVT treated with thrombolysis after vena cava filter implantation in our hospital from July 2008 to Dec .2013 were analyzed retrospectively .[Results] All 11 patients were implanted with vena cava filter successfully .The catheters of 4 patients compli-cated with floating thrombus around the catheter were smoothly removed after thrombolysis therapy for some time ,and then the filters were smoothly removed 12d after operation .No pulmonary embolism occurred .All patients were followed up for 24 months after operation .No complications such as filter migration ,thrombosis along the filter and perforation of vena cava were found .[Conclusion]Vena cava filter implantation for the treatment of UEDVT is safe and effective ,so it is worthy of clinical promotion . 2014 Vol. 31 (4): 780-784 [Abstract] ( 47 ) HTML (1 KB)  PDF  (0 KB)  ( 35 ) 782 Study on the Relationship of Chronic Atrophic Gastritis and Peptic Ulcer with Helicobacter Pylori Infection [Objective] To explore the relationship of chronic atrophic gastritis and peptic ulcer with Helico-bacter pylori(HP) infection .[Methods] Totally 200 patients with chronic atrophic gastritis and 200 patients with peptic ulcer in our hospital from Jan .2012 to Dec .2013 were enrolled in the study .All patients received endosco-py ,gastric biopsy and HP detection .The relationship of the type ,onset age and sex of chronic atrophic gastritis and peptic ulcer with HP infection was analyzed .[Results] The prevalence of HP-positive patients with chronic a-trophic gastritis was obviously higher than that of HP-negative patients ,and there was significant difference(χ2 =36 .805 ,P <0 .05) .The prevalence of HP-positive gastric ulcer patients with chronic atrophic gastritis was obvi-ously higher than that of HP-positive duodenal ampulla ulcer patients ,and there was significant difference(χ2 =12 .394 ,P<0 .05) .The prevalence of HP-positive male patients was obviously higher than that of HP-positive fe-male patients(χ2 =18 .330 ,P <0 .05) .The prevalence of HP-positive patients in middle age group was obviously higher than that in younger age group and older group(χ2 =15 .240 ,P<0 .05 ;χ2 =33 .374 ,P<0 .05) .The prev-alence of HP-positive patients in younger group was obviously higher than that in older age group ,and there was significant difference(χ2 =18 .591 ,P<0 .05) .[Conclusion] HP infection is one of the important causes of patho-genesis of chronic atrophic gastritis and peptic ulcer .The incidence of HP in patients at different gender and age is various . 2014 Vol. 31 (4): 782-784 [Abstract] ( 58 ) HTML (1 KB)  PDF  (0 KB)  ( 44 ) 785 Clinical Observation of Longdan Xiegan Pills Combined with Western Medicine for the Treat-ment of 30 Patient with Herpes Zoster [Objective] To observe clinical efficacy of Longdan Xiegan pills (LXP) combined with western medicine for the treatment of herpes zoster .[Methods] A total of 60 patients were randomly divided into ob-servation group and control group with 30 patients in each group .The control group was treated with normal western medicine ,while the observation group was given LXP combined with western medicine .The duration was 10 days .The disappearance time of clinical symptoms of two groups was observed .Adverse reactions were recorded .The efficacy was evaluated .[Results] The time of stopping vesication ,incrustation time and analgesia time in observation group were shorter than those in control group ( P <0 .05) .The total effective rate of observation group and control group was 93 .33% and 73 .33% respectively ,and there was significant difference( P<0 .05) .The incidence of neuralgia in observation group was lower than that in control group ( P<0 .05) .There was no significant difference in the incidence of adverse reaction between two groups ( P >0 .05) .[Conclusion] LXP combined with western medicine for the treatment of herpes zoster is safe ,effective and convenient to take ,so it is worthy of clinical application . 2014 Vol. 31 (4): 785-787 [Abstract] ( 86 ) HTML (1 KB)  PDF  (0 KB)  ( 40 )

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