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| Changes of Serum Levels of OPG and IGF in Patients with Coronary Heart Disease and Heart Failure |
| SU Hai-feng%WEI Shi-gang%GAO Shan |
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Abstract [Objective]To explore the changes and significance of serum levels of osteoprotegerin (OPG ) and insulin-like growth factor-Ⅰ (IGF-Ⅰ) in patients with chronic heart failure(CHF) and coronary heart dis-ease(CHD) .[Methods]Enzyme-linked immunosorbent assay(ELISA) was used to determine serum levels of OPG and IGF-Ⅰ in 58 patients with CHF and CHD and 22 healthy subjects .Comparative analysis was taken .[Results]Serum OPG in CHF group was obviously higher than that in normal control groups ,and increased with the deterioration of cardiac function obviously ( P <0 .01) .Serum IGF-Ⅰin CHF group was obviously lower than that in normal control group ,and decreased with deterioration of cardiac function obviously ( P <0 .01) .Serum OPG was negatively related with IGF-Ⅰ( P<0 .01) .[Conclusion]OPG and IGF-Ⅰ conjointly participate in the occurrence and development of CHD and heart failure .Serum levels of OPG and IGF-Ⅰ can be used as the indicators for assessing the severity of heart failure .
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2014, Vol. 31 
