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Abstract [Objective]To explore the impact of intrauterine hypoxia on erythrocyte osmotic fragility in newbo-rns .[Methods]Totally 27 newborns without neonatal asphyxia in department of neonatology of Xiangya hospital from 2012~2013 were selected .According to the history of intrauterine hypoxia before birth ,all patients were divided into control group( n=20) and intrauterine hypoxia group ( n=7) .Arterial blood samples were extracted within 1h after birth to detect blood gas ,lactic acid(LA) and minimal bilirubin(BIL) .Venous blood was drawn within 24h to detect erythrocyte osmotic fragility .[Results]There was no significant difference in Apgar score ,pH and PaCO2 between in-trauterine hypoxia group and control group ( P>0 .05) .PaO2 ,SaO2 and minimal BIL in intrauterine hypoxia group were obviously lower than those in control group ( P<0 .01~0 .05) ,but LA level in intrauterine hypoxia group was obviously higher than that in control group ( P<0 .01) .When hemolysis ratio was 20% ,50% ,80% and 90% re-spectively ,NaCl buffer solution concentration in intrauterine hypoxia group was lower than that in control group ( P<0 .05~0 .01) .When hemolysis ratio was 10% and 100% respectively ,there was no difference in NaCl buffer solu-tion concentration between intrauterine hypoxia group and control group ( P>0 .05) .[Conclusion]Intrauterine hypox-ia can decrease erythrocyte osmotic fragility in newborns .
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2014, Vol. 31 
