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Abstract [Objective]To explore the correlation between insulin therapy and secondary malignant tumor in patients with type 2 diabetes mellitus(T2DM ) .[Methods] Clinical data of 8051 T2DM in first and second affiliated hospital of Shantou university from Jan .2003 to Dec .2007 were analyzed retrospectively .According to insulin therapy or not ,all patients were divided into case group(insulin therapy group ,n=792) and control group(non-insulin therapy group ,n=7259) .The prevalence of secondary malignant tumor was compared be-tween two groups .[Results] Among 8051 T2DM patients in the study ,the course of diabetic mellitus in case group was longer than that in control group ,while the incidence of malignant tumor was lower ,and there was significant difference between two groups(χ2 =6 .720 ,P <0 .01) .The prevalence risk of malignant tumor in T2DM patients was negatively related with male (OR= 0 .71 ,95% CI= 0 .50~0 .86) ,but positively related with age(OR=1 .72 ,95% CI=1 .39~1 .86) and smoking history(OR=2 .36 ,95% CI=1 .65~3 .82) ,and had no correlation with insulin therapy ( P=0 .72 ,OR=0 .71 ,95% CI为0 .52~1 .10) .[Conclusion] Insulin thera-py is not associated with the prevalence risk of secondary malignant tumor in T 2DM .
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2014, Vol. 31 
