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Quick Search     Adv Search 2014 Vol. 31, No. 5 Published: 2014-05-26   833 Effect of Specific siRNA Inhibition of XIAP Expression on Cell Apoptosis of Human Endometri-al Carcinoma [Objective]To explore the effect of RNA interference(RNAi)targeting XIAP gene on cell ap-optosis of human endometrial carcinoma.[Methods]Specific small interference RNA(siRNA)of XIAP was de-signed and composed.Endometrial cancer cell line RL95-2 was transfected.The changes of mRNA and protein of XIAP after transfection were detected by real time RT-PCR and Western Blotting,respectively.MTT and flow cytometry method were used to detect cell proliferation and apoptosis.[Results]After transfection of XI-AP siRNA,the relative fold value of mRNA transcription volume and the relative protein expression volume in specific transfection group were (0.04±0.06)and (0.590±0.178)respectively,which were obviously lower than those in the control group(P<0.05).The cell growth inhibition rate in specific transduction group was (47.86±4.46)%,which was obviously higher than that in control group(P<0.05).[Conclusion]The ex-periment in vitro indicates that the composed siRNA can effectively inhibit the transcription and expression of XIAP in human endometrial cancer cell line RL95-2,and further promote cell apoptosis of endometrial carcino-ma significantly.The mechanism of promoting cell apoptosis still needs further investigation. 2014 Vol. 31 (5): 833-836 [Abstract] ( 79 ) HTML (1 KB)  PDF  (0 KB)  ( 31 ) 837 Clinical Analysis of the Time Between Pipeline Preshoot and On-line Hemodiafiltration for Pre-venting the First-use Syndrome SHEN Jian-qin%MIAOLi-ying%LIUJin-feng [Obj ective]To explore the clinical efficacy of the time between pipeline preshoot and on-line he-modiafiltration(HDF)for preventing the first-use syndrome(FUS).[Methods]Totally 187 patients(17,280 cases of on-line HDF)treated with on-line HDF in blood purification center of the third affiliated hospital of Soochow university from Jan.to Dec.2013 were enrolled in the study.According to the time between pipeline preshoot and on-line HDF(t),all patients were divided into observation group(t=0min),control group Ⅰ(0min30min).The incidence,type and features of FUS in 4 groups were recorded and statistically analyzed.[Results]The incidence of FUS in 17820 cases of on-line HDF was 721 cases(4.172%).The incidence of A-type FUS and B-type FUS was 1 case(0.012%)and 720 cases(4.170%).There was no significant difference in the incidence of A-type FUS a-mong 4 groups(χ2=1.248,P =0.742).There was significant difference in the incidence of B-type FUS a-mong 4 groups(χ2=531.604,P<0.001).[Conclusion]The shortening of the time between pipeline preshoot and on-line HDF is effective to decrease the incidence of B-type FUS. 2014 Vol. 31 (5): 837-840 [Abstract] ( 53 ) HTML (1 KB)  PDF  (0 KB)  ( 36 ) 840 Survey on Trainees'Status and the Efficacy of Job-Transfer Training for General Practitioners of Hunan Province in 2 0 1 2 [Objective]To investigate basic situation of trainees and the efficacy of job-transfer training for general practitioners in Hunan province so as to provide the basis for better training.[Methods]The trainees who participated in job-transfer training for general practitioners of Hunan province in 2012 were chosen as the subj ects.Questionnaires were used before and after the training.The basic situation and training will of the trainees were understood.The course arrangement and training efficacy of these training bases were evaluated.[Results]Totally 1238 questionnaires before the training were issued,and 1000 eligible ones were retrieved with an eligible retrieving rate of 80.78%.Totally 1238 questionnaires after the training were issued,and 1238 eligible ones were retrieved with an eligible retrieving rate of 100%.The age gap of doctors who attended the training was bigger,and most of them were middle-aged and young doctors.The male to female ratio difference was larger,and most of them were men.The professional title was lower and mainly primary title. The education history was not high and mainly college(all P<0.05).The mastery of knowledge of trainees af-ter training was higher than that before training(P<0.05).About 85.9% of trainees were satisfied with the training.[Conclusion]Job-transfer training for general practitioners in 2012 has obvious efficacy,and the students'satisfaction is high.The construction of teaching staff should be strengthened,and the teaching method should be improved in order to improve the training efficacy. 2014 Vol. 31 (5): 840-843 [Abstract] ( 54 ) HTML (1 KB)  PDF  (0 KB)  ( 39 ) 844 Study on the Characteristics of Pressure Ulcer in ICU and the Correlation of the Occurrence with Oxygenation and Perfusion Index ZHONGHui%ZHAOXiao-chun [Objective]To explore the characteristics of pressure ulcer in ICU and the correlation of the oc-currence with oxygenation with perfusion index.[Methods]Totally 1 1 3 patients in ICU were divided into pressure ulcer group(n=26)and non-pressure ulcer group(n=87).General information on admission,oxy-genation and perfusion index between two groups were compared.Meaningful indicators were taken for further logistic regression analysis to identify the correlation.[Results]Multiple sites of pressure ulcer were sacrococ-cygeal region,hip and scapular.Most patients with pressure ulcer were divided into stageⅠ and Ⅱ.The av-erage age and the proportion of hospital admission diagnosis of respiratory disease and trauma in pressure ulcer group were obviously higher than those in non-pressure ulcer group(P<0.05).There were significant differ-ence in pH,PaCO2 ,SBP,DBP,MAP and Braden score between two groups(P<0.05).Multivariate analy-sis showed that the advanced age(β= 1.637,OR= 5.140),respiratory diseases(β=1.592,OR=4.914)and trauma(β=1.748,OR=5.743)were risk factors for the occurrence of pressure ulcer in ICU patients,while high MAP(β=-1.528,OR=0.217),high Braden score (β= -1.705,OR=0.182)were protective factors.[Conclusion]The advanced age,respiratory diseases and trauma are risk factors for the occurrence of pressure ulcer in ICU patients,while high MAP and high Braden score are protective factors. 2014 Vol. 31 (5): 844-846 [Abstract] ( 66 ) HTML (1 KB)  PDF  (0 KB)  ( 36 ) 847 Study on the Correlation Between the Expression of mTOR/p70S6K Signaling Pathway and the Prognosis of Grade Ⅱ- Ⅲ Gliomas [Objective]To explore the expression of mTOR/p70S6K signaling pathway in gradeⅡ-Ⅲ glio-mas and its correlation with the prognosis of patients with gliomas.[Methods]Immunohistochemical method was used to detect the expression of mTOR and p70S6K in 148 patients with gliomas.The correlation between them was analyzed.The relationship of the expression of mTOR and p70S6K with progression-free survival (PFS)and overall survival(OS)was analyzed by using Kaplan-Meier method.Cox regression model was used to analyze the correlation between all clinical factors and prognosis.[Results]There was significant difference between the expression of mTOR and p70S6K between grade Ⅱ and Ⅲ gliomas(P<0.05).There was posi-tive correlation between mTOR and p70S6K expression(r=0.596,P <0.01).Cox regression analysis re-vealed that p70S6K was an independent prognostic factor of gliomas patients.The survival time of patients with high expression of p70S6K was shorter than that of patients with low expression of p70S6K(hazard ratio=3.606;95% confidence interval=1.066~12.201;P=0.039).The expression of mTOR was not associat-ed with the prognosis.[Conclusion]The expression of p70S6K is of clinical significance in predicting the prog-nosis of patients with gliomas and may be the potential target for gene therapy of glioma. 2014 Vol. 31 (5): 847-855 [Abstract] ( 18 ) HTML (1 KB)  PDF  (0 KB)  ( 30 ) 852 Detection of Serum Galectin-3 in Patients with Coronary Heart Disease and Its Clinical Signifi-cance [Objective]To observe serum level of galectin-3(Gal-3)in patients with different types of coro-nary heart disease and analyze its correlation with high-sensitivity C-reactive protein(hs-CRP)and monocyte chemokine protein-1(MCP-1),and to explore clinical value of Gal-3 in patients with coronary heart disease.[Methods]Totally 97 patients with coronary heart disease confirmed by coronary angiography were collected as coronary heart disease groups including stable angina pectoris group(group SA,n=31),unstable angina pec-toris group(group UA,n=35)and acute myocardial infarction(group AMI,n=31).Other 30 non-coronary heart disease patients with normal coronary angiography were collected as control group.General clinical data of all subjects were collected.Serum levels of Gal-3,MCP-1 and plasma hs-CRP were assayed.[Results]Ser-um Gal-3 level in coronary heart disease group was obviously higher that in control group(P<0.05).Serum Gal-3 levels in UA group and AMI group were markedly higher than those in SA group(P <0.05).Serum Gal-3 level in AMI group was higher than that in UA group,but there was significant difference(P>0.05). Serum Gal-3 level in patients with coronary heart disease was positively correlated with hs-CRP and MCP-1 significantly(P<0.05).[Conclusion]Serum Gal-3 level in patients with coronary heart disease is increased obviously,and may be a new biomarker for acute coronary syndrome,and has important clinical significance. Combined detection of Gal-3,hs-CRP and MCP-1 has important clinical significance in the early diagnosis,risk stratification and prognosis of coronary heart disease. 2014 Vol. 31 (5): 852-855 [Abstract] ( 91 ) HTML (1 KB)  PDF  (0 KB)  ( 38 ) 856 Construction and Identification of Adenovirus Vector of Promoter/Enhancer Sequences of ap2 and AQP7 cDNA BAI Xiao-su%LU Ze-yuan%SHAO Hao [Objective]To construct fusion protein expression vector pEGFP-ap2-AQP7 of promoter/enhancer sequences of ap2 and AQP7 cDNA.[Methods]The products of splicing promoter/enhancer of ap2 and AQP7 cDNA were cloned into pIRES2-EGFP.Adenovirus vector recombinant fusion protein was obtained.The infected 3T3 fat cell was used to determine the infextation effect.[Results]① The pEGFP-ap2-AQP7 fusion protein was expressed in the constructed cell strains stably.The enhanced green fluorescent protein was used as a marker.The positio-ning of AQP7 in 3T3 fat cells were observed.[Conclusion]The stable construction of 3T3 fat cell strains express-ing fusion protein pEGFP-ap2-AQP7 can provide the basis for intracellular localization and function research of AQP7 . 2014 Vol. 31 (5): 856-858 [Abstract] ( 61 ) HTML (1 KB)  PDF  (0 KB)  ( 35 ) 859 Assessment of Clinical Efficacy of Zoledronic Acid for the Treatment of Elderly Male Patients with Primary Osteoporosis XIONGMao-qiang%CHENYu%LUOZhan-biao [Objective]To evaluate clinical efficacy of zoledronic acid for the treatment of elderly male pa-tients with primary osteoporosis.[Methods]A total of 76 male patients with primary osteoporosis were ran-domly divided into 2 groups.The control group(n=39)was supplemented with calcium and vitamin D daily, while the treatment group(n=37)was given an intravenous drip infusion of zoledronic acid 5mg once based on the treatment of control group.The changes of bone mineral density and bone metabolism markers of all pa-tients were observed after 1 2 months of follow up.[Results]Bone mineral density of lumbar spine,total hip and femoral neck in treatment group was significantly higher than that in control group.Serum levels of bone metabolism markers such asβ-C-terminal telopeptide of type I collagen(β-CTx),procollagen type I N-terminal propeptide(PINP)and bone-specific alkaline phosphatase(BSAP)in treatment group were significantly lower than those in control group(P<0.05).The incidence of severe adverse reaction in two groups were 24.32%and 23.08% respectively,but there was no significant difference(P >0.05).[Conclusion]Zoledronic acid treatment for 1 year can markedly increase bone mineral density,decrease serum levels of bone metabolism markers and reduce the risk of fracture in elderly male patients with primary osteoporosis. 2014 Vol. 31 (5): 859-862 [Abstract] ( 76 ) HTML (1 KB)  PDF  (0 KB)  ( 35 ) 862 Expression and Significance of VEGF in Triple Negative Breast Cancer LIU Zhi-Chun%SUN Jing-wu%SUN Lei [Objective]To explore the expression and significance of VEGF in triple negative breast cancer (TNBC).[Methods]SP immunohistochemical method was used to detect the expression of VEGF in paraffin specimens from 50 cases of TNBC(TNBC group)and 50 cases of non-TNBC(non-TNBC group).The relation-ship between VEGF and clinical pathological factors of TNBC and the effect of VEGF on the prognosis were analyzed.[Results]The positive expression rate of VEGF in TNBC was 50.0%(25/50)which was markedly higher than that in non-TNBC group(30.0%,15/50),and there was significant difference between two groups(χ2=4.92,P<0.05).The expression of VEGF in TNBC tissues was closely associated with axillary lymph node metastasis and cancer embolus in vessels(P<0.05).The 5-year disease-free survival(DFS)and overall survival(OS)of patients with VEGF positive expression in TNBC group were 16.0%(4/25)and 76.6%(19/25)respectively,and those of patients with VEGF negative expression in TNBC group were 48.0%(12/25)and 96.0%(24/25)respectively,and there was significant difference between two groups(P<0.05).[Conclusion]VEGF plays an important role in the occurrence and development of TNBC.VEGF can improve the proliferation ability and metastasis potentials of tumor cells.The abnormal increasing of VEGF expression may predict the poor prognosis. 2014 Vol. 31 (5): 862-864 [Abstract] ( 79 ) HTML (1 KB)  PDF  (0 KB)  ( 46 ) 865 Survey on the Implementation Status of Hand Hygiene of Medical Staff at Time Points in Pedi-atric Surgery under JCI Standard [Objective]To investigate the implementation of hand hygiene of medical staff at time points in pediatric surgical ward under joint commission international(JCI)standard,and to analyze the effect of hand hygiene management system under JCI standard on implementation rate of hand hygiene of medical staff in ped-iatric surgery.[Methods]According to JCI standard,spot investigation was performed for 100 medical staff (25 doctors and 75 nurses)in 6 pediatric surgical departments including orthopedics,urinary surgery,general surgery and neonatal surgery of our hospital at 7 consecutive day work time in Jan.2013.With reference to hand hygiene directory for medical staff by WHO,handwashing behavior of all subjects at time points of hand hygiene was analyzed by statistical method,and compared with implementation rate of hand hygiene at the same period in 2012.[Results]The implementation status of hand hygiene was recorded for 835 times,and the actual implementation of hand hygiene was 586 times.The implementation rate was 70.18%,which was markedly higher than that at the same period in 2012(51.30%)(P<0.05).The total implementation rate of hand hygiene of nurses was 76.98%,which was higher than that of doctors(63.34%).There was significant difference in the implementation rate of hand hygiene at different time points between nurses and doctors(P<0.05).[Conclusion]Hand hygiene management system under JCI standard emphasizes the detail management and pays attention to training in order to further improve the knowledge of hand hygiene,standardize hand hy-giene behavior and promote the improvement of implementation rate of hand hygiene of medical staff. 2014 Vol. 31 (5): 865-867 [Abstract] ( 64 ) HTML (1 KB)  PDF  (0 KB)  ( 28 ) 868 Study on the Correlation Between-857C/T and -1031C/T Singe Nucleotide Polymorphism of Tumor Necrosis Factor-α Gene and Gestational Diabetes Mellitus TU Jiao%CHEN Jiang-li [Objective]To explore the association between singe nucleotide polymorphism(SNP)of two lo-ci -857C/T and -1031C/T of tumor necrosis factor-α(TNF-α)gene and gestational diabetes mellitus (GDM).[Methods]Totally 50 normal pregnant women(control group)and 50 pregnant women with GDM (group GDM)in Beijing aerospace general hospital from March 2012 to Feb 2013 were selected.Peripheral ve-nous blood was collected to extract DNA.Polymerase chain reaction(PCR)restriction enzyme fragment length was used to analyze -857C/T and -1031C/T.The sequencing was performed for the confirmation.Chi-square test was applied to confirm the Hardy-Weinberg equilibrium in genotype distribution.Statistical meth-ods involving t test and chi-square test were conducted to evaluate the statistical significance in all data.[Re-sults]There was significant difference in genotype distribution and allele frequency of-857C/T of TNF-αgene between GDM group and control group(P<0.05).The proportion of CT genotype and the frequency of allele genotype T in GDM group was significant higher than that in normal pregnant group(P<0.05).However, there was no significant difference in genotype distribution and allele frequency of -1031 C/T locus between GDM group and control group(P >0.05).[Conclusion]The -857C/T allele gene polymorphism of TNF-αgene is associated with the pathogenesis of GDM.Pregnant women with T locus are susceptible to have GDM. But -1031C/T polymorphism is not related with GDM. 2014 Vol. 31 (5): 868-872 [Abstract] ( 70 ) HTML (1 KB)  PDF  (0 KB)  ( 33 ) 873 Comparison of the Efficacy of Endoscopic vs.Percutaneous Transhepatic Biliary Metal Stent Place-ment for the Treatment of Malignant Extrahepatic Biliary Obstruction WUMing-hao [Objective]To explore the efficacy of different ways of metal stent placement for the treatment of advanced malignant obstructive jaundice in order to provide the basis for selecting better method for clinical treat-ment.[Methods]Clinical data of 80 patients with malignant extrahepatic biliary obstruction undergoing endoscopic biliary metal stent placement and 80 patients with malignant extrahepatic biliary obstruction undergoing percutane-ous transhepatic biliary metal stent placement in our hospital from Jan.2009 to Jan.2013 were analyzed retrospec-tively.The achievement ratio of operation,the incidence of postoperative complications,the unobstructed time of stents and the survival time of patients between two groups were compared.[Results]Liver function of two groups after operation was significantly improved.There was no significant difference in the decline of total bilirubin (TB),alkaline phosphatase(ALP)and gamma glutamyl transferase(GGT)between two groups.The achievement ratio of percutaneous transhepatic biliary metal stent placement was higher than that of endoscopic biliary metal stent placement,but the incidence of the complications of percutaneous transhepatic biliary metal stent placement was obviously higher than that of endoscopic biliary metal stent placement.There was no significant difference in the unobstructed time and survival time between two groups.[Conclusion]The first choice of treating the patients with malignant extrahepatic biliary obstruction is percutaneous transhepatic biliary metal stent placement.If the operation is failure,percutaneous transhepatic biliary stent placement by PTC can be considered. 2014 Vol. 31 (5): 873-875 [Abstract] ( 76 ) HTML (1 KB)  PDF  (0 KB)  ( 37 ) 876 Effect of Transcranial Magnetic Stimulation on Motor Function Recovery of Patients with Uni-lateral Spatial Neglect after Stroke WANGYong-hui%YANGGuang-jun%DONGLei [Objective]To explore the effect of transcranial magnetic stimulation(TMS)on motor function recovery of patients with unilateral spatial neglect after stroke.[Methods]A total of 60 outpatients or inpa-tients with unilateral spatial neglect after stroke were randomly divided into observation group and control group with 30 patients in each group.The observation group was treated with the joint repeated rTMS. Straight-line bisection test,line cancellation test,font copying test,clock drawing test and plane figure copy-ing test were performed before and after treatment.[Results]There was no significant difference in the degree of unilateral spatial neglect before treatment between two groups(P>0.05).After treatment,the degree of unilateral spatial neglect,movement and activities of daily living in two groups were improved obviously(P<0.05).The improvement of the observation group was markedly better than the control group(P<0.05).No obvious change was found in the control group(P>0.05).[Conclusion]The rTMS for the treatment of uni-lateral spatial neglect after stroke has significant efficacy and can improve the patient's condition of spatial neg-lect obviously. 2014 Vol. 31 (5): 876-878 [Abstract] ( 28 ) HTML (1 KB)  PDF  (0 KB)  ( 41 ) 879 Pathway analysis of the Effect of Personality Characteristics and Response Style on Comfort and Well-being of the Relatives of Patients with Schizophrenia LI Xue-Jing%GUO Yi%FU Chun-lian [Objective]To explore the effect of personality characteristics and response style on comfort and well-being of the relatives of patients with schizophrenia in order to provide the evidence for effective inter-vention.[Methods]Totally 350 relatives of patients with schizophrenia were investigated by using response style questionnaire,Eysenck personality questionnaire(simplified Chinese edition)and comfort and well-being scale.[Results]Comfort and well-being(r=-0.279,P<0.01)had significantly negative correlation with psychoticism of personality characteristics(r=-0.267,P<0.01),and extraversion had significantly posi-tive correlation comfort and well-being(r=0.199,P<0.01).Rumination of response style had significantly positive correlation with psychoticism(r=0.242,P<0.01)and neuroticism(r=-0.358,P<0.01),but significantly negative correlation with comfort and well-being(r=-0.409,P<0.01).Detraction had nega-tive correlation with psychoticism(r=0.197,P<0.01)and neuroticism(r=0.163,P<0.05),but signifi-cantly positive correlation with extraversion(r=0.258,P<0.01).Detraction had significantly positive cor-relation with comfort and well-being(r=-0.213,P<0.01).Rumination and detraction of response style di-rectly affected comfort and well-being(pathway coefficients were -0.475 and 0.371).Psychoticism,neuroti-cism and extroversion of personality characteristics not only had direct influence(pathway coefficients were -0.147,-0.169 and 0.211),but also had indirect influence(pathway coefficients were -0.115,-0.153 and 0.107)through affecting response style.[Conclusion]Comfort and well-being of the relatives of patients with schizophrenia is influenced by personality characteristics and response style.Response style plays an important role in regulating the effect mode of personality characteristics on comfort and well-being. 2014 Vol. 31 (5): 879-881 [Abstract] ( 57 ) HTML (1 KB)  PDF  (0 KB)  ( 40 ) 882 Analysis of the Efficacy of Intraarticular Injection with Hyaluronate Sodium for the Treatment of Type 2 Diabetes Mellitus with Knee Osteoarthritis JING Shao-chun%LIANG Chun-yu [Objective]To explore clinical efficacy of intraarticular inj ection with hyaluronate sodium for the treatment of type 2 diabetes mellitus(T2DM)with knee osteoarthritis(KOA).[Methods]Totally 80 patients ac-cording with diagnosis criteria of moderate KOA were enrolled in the study.Among them,40 patients were simple KOA(group A)and 40 patients were T2DM with KOA(group B).All patients received intraarticular injection with hyaluronate sodium 2ml once a week.One course was 5 times.Knee joint function score standard(LKSS) was used to assess the efficacy.[Results]In group A,20 patients were excellent(50%),and 16 patients were good(40%),and 3 patients were fair(7.5%),and 1 patient was poor(2.5%),and the good and excellent rate was 90.0%.In group B,12 patients were excellent(30%),and 8 patients were good(20%),and 15 patients were fair (37.5%),and 5 patients were poor(12.5%),and the good and excellent rate was 50%.There was significant difference in the good and excellent rate between two groups(χ2=15.238,P<0.01).[Conclusion]Intraarticular inj ection with hyaluronate sodium for the treatment of moderate KOA has certain efficacy,but its efficacy is unsat-isfactory for T2DM with moderate KOA. 2014 Vol. 31 (5): 882-884 [Abstract] ( 80 ) HTML (1 KB)  PDF  (0 KB)  ( 38 ) 884 Analysis of High Risk Factors and Features of Pathogenic Bacteria Infection in Ventilator-associated Pneumonia LIChao-liang [Objective]To explore high risk factors,features of pathogenic bacteria infection and the relevant prevention of ventilator-associated pneumonia(VAP)in order to provide the reference for clinical intervention and improve the control level of hospital infection.[Methods]Clinical data of 1 1 7 patients given mechanic ventilation over 48 hours in ICU from Jan.2013 to Nov.2013 were analyzed retrospectively.Among them,53 patients accor-ded with the diagnosis of VAP and 64 patients had no VAP.High risk and features of pathogenic bacteria infection of 53 patients with VAP were analyzed.[Results]The 72 strains of pathogenic bacteria were isolated from airway secretions in VAP patients.The main bacterium was gram negative bacilli(69.44%,50/72).The first three pathogens were Pseudomonas aeruginosa(32.0%),Acinetobacter,Staphylococcus aureus and Escherichia coli. The drug sensitivity of Acinetobacter baumannii presented multidrug resistance.The rate of the mixed infection with fungi was higher(11.32%,6/53).The patients'age,long-time mechanical ventilation,the usage of sedatives and APACHEⅡ score were significantly correlated with the incidence of VAP.Corticosteroids were not the main risk factors of VAP.[Conclusion]The main pathogenic bacterium of VAP is gram negative bacilli.The incidence of VAP is correlated with multiple clinical factors.These factors should be controlled as for as possible in order to reduce the incidence and mortality of VAP. 2014 Vol. 31 (5): 884-886 [Abstract] ( 72 ) HTML (1 KB)  PDF  (0 KB)  ( 41 ) 887 Observation on the Efficacy of Different Drugs Combined with Nerve Block for the Treatment of Postherpetic Neuralgia ZHOULing-jun%YANGZhi-xiong%GUHui [Objective]To compare and analyze the efficacy and safety of pregabalin combined with nerve block vs.gabapentin combined with nerve block for the treatment of postherpetic neuralgia(PHN).[Meth-ods]Totally 100 patients with PHN were collected.According to the treatment methods,all patients were di-vided into two groups with 50 patients in each group.Group A was given oral pregabalin combined with nerve block,while group B was given oral gabapentin combined with nerve block for 3 weeks.Visual analog scale (VAS)and 24h sleep time were used to evaluate the therapeutic effect.The complications and adverse drug re-actions were also observed.[Results]Compared with before treatment,pain scores in two groups after treat-ment during 3 weeks of hospitalization were decreased with the time,while sleep time was increased(P <0.05).VAS scores of group A were decreased more than those in group B,while 24h sleep time in group A was increased more than that in group B(P<0.05).No complication and serious adverse reaction of drugs was found in two groups.[Conclusion]Pregabalin combined with nerve block or gabapentin combined with nerve block for the treatment of PHN can both quickly relieve pain and improve sleep quality,but the former is more effective than the latter. 2014 Vol. 31 (5): 887-890 [Abstract] ( 65 ) HTML (1 KB)  PDF  (0 KB)  ( 41 ) 890 Analysis of Clinical Features of 1 1 Cases of Incontinentia Pigmenti [Objective]To explore clinical features of incontinentia pigmenti(IP)in children in order to im-prove the awareness of the disease.[Methods]Clinical features of 1 1 pediatric patients with IP in our hospital from Jan.2004 to Dec.2013 were analyzed.[Results]Among 11 pediatric patients,10 patients were female and 1 patient was male.Two patients were premature twins.Eleven patients had skin involvement.Two pa-tients had nerve system involvement and convulsion.Two patients had eye involvement.The percentage of eo-sinophils in peripheral blood of 6 patients was obviously increased.Skin pathological biopsy of 4 patients showed a large of eosinophils in vesication to confirm the diagnosis.Gene deletion of nuclear factor kB essential regulator(NEMO)was detected in 1 patient.[Conclusion]IP is a rare x-linked dominant genetic disease.The dominant feature in neonatal period is skin lesion.It can be involve in multiple systems.Eye and nervous sys-tem lesions are serious.Skin pathology and chromosomal genetic analysis are the methods of definite diagno-sis.Pediatric patients should be followed up regularly. 2014 Vol. 31 (5): 890-892 [Abstract] ( 62 ) HTML (1 KB)  PDF  (0 KB)  ( 41 ) 893 Influence of the Temperature of Carbon Dioxide Gas on the Recovery of Patients after Laparo-scopic Gastrointestinal Operation PANGKe-hui%YUWen-hong [Objective]To explore the influence of the temperature of carbon dioxide(CO2 )gas on the re-covery of patients after laparoscopic gastrointestinal operation.[Methods]Totally 125 patients after laparo-scopic gastrointestinal operation were divided into 2 groups.In the experimental group(n=62),pneumoper-itoneum was established with CO2 gas heated to 37℃.In the control group(n=63),pneumoperitoneum was established with routine method.Body temperature before and after operation,tracheal extubation time,anal exhaust time and gastric extubation time in two groups were observed.Numerical rating scale(NRS)was used to evaluate the pain of surgical wound.[Results]There was no significant difference in body temperature be-fore operation between two groups (P>0.05).After operation,body temperature in the experimental group was obviously higher than in the control group(P<0.05).The tracheal extubation time,anal exhaust time, gastric extubation time and wound pain score in the experimental group were obviously lower than those in the control group,and there was significant difference(P<0.05).The incidence of postoperative complications was compared between two groups.Chills occurred in 6 cases(9.7%)of experimental group,which were sig-nificantly lower than those of control group(35 cases,55.6%),and there was significant difference between two groups(P<0.05).Gastrointestinal dysfunction occurred in 7 cases(11.3%)of experimental group, which were significantly lower than those of control group(26 cases,41.3%),and there was significant differ-ence between two groups(P<0.05).[Conclusion]Pneumoperitoneum established by CO2 gas heated to 37℃can promote the recovery of patients after laparoscopic gastrointestinal surgery. 2014 Vol. 31 (5): 893-897 [Abstract] ( 64 ) HTML (1 KB)  PDF  (0 KB)  ( 30 ) 895 Clinical Analysis of 3 2 Cases of Recessive and Dominant Umbilical Cord Prolapse HE Ji-ping [Objective]To explore the diagnosis of recessive and dominant umbilical cord prolapse and its effect on the outcome of perinatal children.[Methods]The diagnosis and treatment of 32 cases of umbilical cord prolapse in our hospital from Jan.2010 to June 2012 were analyzed.The cesarean rate and Apgar score of perinatal children between re-cessive group and dominant group was compared.The relationship between the ways of the diagnosis of umbilical cord prolapse and the prognosis of fetuses was observed.[Results]The pediatric patients in two groups were labored success-fully,and no one died.The cesarean rate,neonatal 1min and 5min Apgar scores in recessive group were higher than those in dominant group(P<0.05).In the ways of diagnosis of umbilical cord prolapse,neonatal Apgar scores of prenatal ul-trasonography were higher,but there was no significant difference between prenatal ultrasonography and other ways(P>0.05).[Conclusion]Prenatal ultrasonography,fetal heart rate monitoring combined with vaginal examination are helpful for the early diagnosis of umbilical cord prolapse,especially for patients with recessive umbilical cord prolapse.Early in-tervention can significantly improve the prognosis of perinatal children. 2014 Vol. 31 (5): 895-897 [Abstract] ( 35 ) HTML (1 KB)  PDF  (0 KB)  ( 30 ) 898 Follow-up Study of Hepatotoxicity Induced by Antithyroid Drugs PENGBo%YUXiao-jing [Objective]To explore the incidence,the relative factors,treatment and prognosis of hepato-toxicity induced by antithyroid drugs(ATD).[Methods]Totally 184 patients diagnosed as hyperthyroidism and treated with thiamazole(MMI)(n=86)or propylthiouracil(PTU,n=80)in our hospital were followed up for 1 year.Liver and thyroid functions were examined before and after treatment once a month.[Results]Among all patients,166 patients were followed up for 1 year.Hepatic injury occurred in 38 patients(22.9%).The in-cidence of hepatic injury in MMI group was 6.9%(6/86),which was significantly lower than that in PTU group (40%,32/80).Hepatic injury was mainly subclinical hepatic injury(65.8%).Before treatment,FT3 level in hepatic inj ury group was significantly higher than that in non-hepatic inj ury group.After changing treatment protocols,the prognosis of patients with hepatic inj ury was good.The average recovery time of he-patic injury was 3.6 months.[Conclusion]Hepatotoxicity induced by ATD is commonly seen,especially for pa-tients with high level of FT3 .Because the incidence of hepatotoxicity induced by PTU is higher,MMI is rec-ommended to be preferentially used in the treatment hyperthyroidism.In the initial phase of treatment,hepatic function should be detected and treatment protocols should be regulated promptly. 2014 Vol. 31 (5): 898-902 [Abstract] ( 38 ) HTML (1 KB)  PDF  (0 KB)  ( 30 ) 900 Changes of Body Mass Index and Metabolic Indices in Obese Young and Middle-aged Men [Objective]To explore the changes of body mass index(BMI)and metabolic indexes in obese young and middle-aged men.[Methods]Totally 75 men aged 20~52 years old were chosen.According to BMI,all subjects were divided into obese group(n=25),overweight group(n=25)and control group(n=25).Metabolic indexes and basic human body parameters among 3 groups were measured and compared.[Results]There were significant difference in systolic blood pressure(SBP),diastolic blood pressure(DBP), total cholesterol(TC),triglyceride(TG),uric acid(UA),T,2 HPG,FINS,2 HINS and HOMA-IR among 3 groups(P<0.01 orP<0.05,respectively).There was no significant difference in HDL-C,LDL-C and FPG among 3 groups(P≥0.05).The factors of multiple linear regression analysis finally entering the regression e-quation were SBP,TC,T and FINS.[Conclusion]The related metabolic factors of early intervention leading to weight gain has the important significance in preventing the occurrence and development of metabolic syn-drome and the related diseases. 2014 Vol. 31 (5): 900-902 [Abstract] ( 67 ) HTML (1 KB)  PDF  (0 KB)  ( 51 ) 903 Clinical Significance of SIG in Patients with Acute Myocardial Infarction [Objective]To explore clinical significance of strong ion gap(SIG)in patients with acute myocardial in-farction(AMI).[Methods]Stewart-Figge methodology was used to calculate,compare and analyze the results of blood gas analysis of 83 patients with AMI in our hospital from March 2010 to Sept.2012.[Results]The indexes such as SIG, AG and potential HCO3- in effective treatment group were obviously lower than those in ineffective treatment group,and there was significant difference(P<0.05)Among the indexes,the change of SIG was the biggest,and that of AG was the second,and that of potential HCO3- was the smallest[Conclusion]In AMI patients,SIG can better reflect acid-base balance of AMI patients than AG and potential HCO3-,and has important clinical value in the detection of illness state and the assessment of short-time prognosis. 2014 Vol. 31 (5): 903-907 [Abstract] ( 63 ) HTML (1 KB)  PDF  (0 KB)  ( 37 ) 905 Analysis of the Efficacy of Eszopiclone Combined with Fluoxetine Hydrochloride for the Treat-ment of Post-stroke Depression XUELiang [Objective]To observe and analyze clinical efficacy of eszopiclone combined with fluoxetine hydrochloride for the treatment of post-stroke depression(PSD).[Methods]A total of 74 patients with PSD in our hospital from Dec.2009 to Oct.2013 were randomly divided into treatment group(n=39)and control group(n=35).The treatment group received eszopiclone combined with fluoxetine hydrochloride,while the control group was given antidepressive drug fluoxetine hydrochloride alone for continuous 6 weeks.The effica-cy was evaluated by using Hamilton depression scale(HAMD),national institute of health stroke scale(NIH-SS)and sleep dysfunction rating scale(SDRS).Treatment emergent symptom scale(TESS)was adopted to as-sess side effects.The assessment was performed before and 2,4 and 6 weeks after treatment.[Results]Com-pared with before treatment,the scores of HAMD,NIHSS and SDRS were decreased in both two groups after treatment(P<0.05).The improvement of HAMD and NIHSS scores in treatment group 2 weeks after treat-ment was better than control group,and there was significant difference(P<0.05).There was no significant difference in SDRS score at each time points between two groups(P>0.05).The total effective rate of treat-ment group was 94.9%,which was better than the control group(80.0%).There was no significant differ-ence in the incidence of adverse reaction(P >0.05).[Conclusion]Eszopiclone combined with fluoxetine hydrochloride for the treatment of PSD has obvious efficacy,rapid effect and good tolerance to adverse reac-tion.Therefore,it is worthy of clinical promotion. 2014 Vol. 31 (5): 905-907 [Abstract] ( 46 ) HTML (1 KB)  PDF  (0 KB)  ( 39 ) 908 Experimental Study of the Effect of Simulated Microgravity on the Differentiation of CD3 4+Cells [Objective]To explore the influence of simulated microgravity on differentiation of CD34+cells.[Methods]CD34+ cells were cultured by fluid medium in the simulated microgravity condition created by the rotary cell-culture systems(RCCS)and normal gravity condition.The same fluid medium in 1-g condition was taken as the culture group(1-g fluid group),while the standard methylcellulose semisolid medium was taken as control group(1-g methykcekkulose group).Flow cytometry was used to detect the percentage of spe-cific antigen of cells in each group.The effect of simulated microgravity on differentiation of CD34+ cells was analyzed.Meanwhile,propidium iodide(PI)cell apoptosis staining was performed.The effect of simulated mi-crogravity on apoptosis of CD34+ cells was analyzed.[Results]Flow cytometry showed that CD34+ cells in each group were less than 0.2%.The expression of erythroid cell(GlyA+)in RCCS group was obviously low-er than that in 1-g liquid control group(22.21%±3.02% vs.60.05%±3.08%,P<0.05),and the expres-sion levels of CD34+ in RCCS group and 1-g liquid control group were 52.12%±1.92% and 18.87%±1.41%respectively,and there was significant difference between two groups(P <0.05).The expression level of GlyA+(54.39%±2.86%)and CD34+(21.09%±3.19%)in 1-g liquid control group were similar to those in 1-g methylcellulose group,and there was no significant difference between two groups(P>0.05).The pro-portion of apoptotic cells in each group was less than 1%.[Conclusion]The simulated microgravity can inhibit the differentiation of CD34+ to all blood cells,especially inhibit the differentiation of CD34+ cells to erythroid cells. 2014 Vol. 31 (5): 908-913 [Abstract] ( 42 ) HTML (1 KB)  PDF  (0 KB)  ( 33 ) 911 Study on the Correlation Between Carotid Intima-media Thickness and Insulin Resistance in Elderly Patients with Type 2 Diabetes Mellitus [Objective]To explore the correlation between carotid intima-media thickness(IMT)and insulin resist-ance in elderly patients with type 2 diabetes mellitus(T2DM).[Methods]Totally 171 patients with diabetes mellitus or hy-pertension in our hospital were divided into hypertension group(n=61),T2DM group(n=48)and T2DM with hyper-tension group(n=62).Other 62 healthy people were selected as normal group.The biochemical indicators such as fast-ing plasma glucose(FPG),fasting insulin(FTINS),glycosylated hemoglobin(HBA1 c),uric acid(UA),blood lipids and IMT were measured.The above indexes combined with clinical data were analyzed.[Results]There was no significant difference in IMT between normal plasma glucose group and T2DM group(P>0.05)No matter that patients were com-plicated with or without T2DM,IMT of non-hypertension patients was significantly lower than that of hypertension pa-tients(P<0.01).Correlation analysis showed that IMT was not significantly associated with FPG,HBA1c,UA,plas-ma triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C)and low density lipoprotein cholesterol(LDL-C),but significantly associated with insulin resistance index(ISI)(coefficient was 0.293,P<0.05).[Conclusion]Insulin resistance is an independent risk factor of the increased carotid IMT in elderly patients with T2DM. 2014 Vol. 31 (5): 911-913 [Abstract] ( 49 ) HTML (1 KB)  PDF  (0 KB)  ( 38 ) 914 Comparison of the Efficacy of Different Doses of Omeprazole for the Treatment of Non-varicose Upper Gastrointestinal Hemorrhage [Objective]To explore compare the efficacy of different doses of omeprazole for the treatment of non-varicose upper gastrointestinal hemorrhage.[Methods]Totally 128 patients with non-varicose upper gastrointestinal hemorrhage in our hospital were chosen from June 2012 to July 2013.According to random in-formed consent principle,all patients were divided into treatment group and control group with 64 patients in each group.The treatment group was given large dose of omeprazole,while the control group was given nor-mal dose of omeprazole.Clinical efficacy was compared between two groups.The changes of each index of two groups before and after treatment were recorded and analyzed.Intragastric PH and the incidence of adverse re-actions in two groups were evaluated 74h after treatment.[Results]Clinical efficacy of treatment group was better than control group(P<0.05),but the improvement of each index,intragastric PH and the incidence of adverse reaction were nearly to control group(P >0.05).[Conclusion]Large dose of omeprazole has good clinical efficacy in treating non-varicose upper gastrointestinal hemorrhage. 2014 Vol. 31 (5): 914-916 [Abstract] ( 62 ) HTML (1 KB)  PDF  (0 KB)  ( 37 ) 916 Analysis on the Efficacy of Fractionated Stereotactic Radiotherapy for the Treatment of Brain Metastasis of Non-small Cell Lung Cancer ZHANG Yu%XU Zi-hai%ZHOU Yan-hua [Objective]To explore the efficacy and adverse reaction of fractionated stereotactic radiothera-py(FSRT)for the treatment of brain metastasis of non-small cell lung cancer(NSCLS).[Methods]Totally 32 NSCLC brain metastasis patients with kaznofsky (KPS)>60 were treated with whole brain radiotherapy (WBRT)36~40Gy in advance and then received FSRT.Single dose around target region was 3~5Gy.Total radiation dose was 15~20Gy in 3~5 fractions with 50% of isodose curve planning target volume(PTV)cover-ing the target edge.The efficacy and adverse reaction was analyzed.[Results]All patients completed whole course of radiotherapy.No obvious adverse reaction and complication was found.Median overall survival was 11.6 months(95%CI:8.6~13.2).The 1-year and 2-year survival time were 30.4% and 11.2%,respective-ly.The remission rate of clinical symptoms was 82.6%.Local tumor control rate was 91.7%.Compared be-fore treatment,KPS scores 1 month after treatment were obviously improved,and there was significant differ-ence(P<0.05).[Conclusion]FSRT for disease progression patients with brain metastasis of lung cancer af-ter whole brain radiotherapy can improve the quality of life and prolong the survival time with good safety. 2014 Vol. 31 (5): 916-918 [Abstract] ( 63 ) HTML (1 KB)  PDF  (0 KB)  ( 41 ) 919 Features and Drug Resistance of Pathogenic Bacteria in Diabetic Foot Infection GUO Guan-fen%ZHANGXiu-wei%LI Chun-hua [Objective]To analyze the distribution and drug resistance of pathogenic bacteria in diabetic foot infection in order to provide a basis for reasonable application of antibiotics.[Methods]The data of pathogenic bacteria culture and drug sensitivity of 96 patients with diabetic foot infection in our hospital from Jan.2011 to June 2013 were analyzed retro-spectively.[Results]The 134 strains of pathogenic bacteria in 96 patients with diabetic foot infection were isolated.A-mong them,74 strains were Gram-positive bacteria(55.2%),and 55 strains were Gram-negative bacteria(41.0%),and 5 strains were fungi(3.7%).Common positive coccobacteria were staphylococcus aureus,staphylococcus epidermidis and enterococcus faecalis,while common negative bacteria were Escherichia coli,Klebsiella pneumoniae and pseudomonas aeruginosa.Positive coccobacteria were severely resistant to clarithromycin and erythromycin,while pseudomonas aerugi-nosa in negative bacteria were severely resistant to multiple antibiotics.[Conclusion]For patients with diabetic foot infec-tion,early and multiple etiological examination should be taken.Reasonable selection of antibiotics can control diabetic foot infection effectively. 2014 Vol. 31 (5): 919-921 [Abstract] ( 89 ) HTML (1 KB)  PDF  (0 KB)  ( 30 ) 921 Double Eyelid Plasty with Minimal-incision Orbicularis Muscle and Upper Eyelid Levator Muscle Aponeurosis Fixation [Objective]To explore clinical efficacy of 2 or 3mm minimal incision for double eyelid plasty.[Methods]Clinical data of 3 1 patients undergoing double eyelid plasty through orbicularis muscle and upper eyelid levator aponeurosis fixation with tiny incisions were analyzed retrospectively.[Results]At follow up for 1 year, 30 patients had natural and stable double eyelid without obvious scars after operation.Unilateral double eyelid line disappeared in only one patient who was revised by re-fixation.[Conclusion]Double eyelid plasty through orbicu-laris muscle and upper eyelid levator aponeurosis fixation with tiny incisions has smaller trauma,quicker recovery, minimal scar as well as natural and stable double eyelid line,and is especially suitable for young women.For pa-tients with fat and clumsy upper eyelid and slightly fiabby skin,the same satisfactory effect can be obtained. 2014 Vol. 31 (5): 921-923 [Abstract] ( 69 ) HTML (1 KB)  PDF  (0 KB)  ( 37 ) 924 Analysis of the Etiology for Symptomatic Epilepsy and the Study on the Time for the Genesis of Epilepsy LIUWan-ping%LIAOKe [Objective]To study the etiological distribution for symptomatic epilepsy,and to explore the characteristics of the time for the genesis of epilepsy.[Methods]More than 9200 patients with epilepsy from epilepsy center of first affiliated hospital of Chongqing medical university were investigated and followed up.A total of 1087 patients diagnosed as symptomatic epilepsy were selected.The data such as the type and age of the etiology and onset age of epilepsy were recorded in detail,and analyzed.[Results]The causes of symptom-atic epilepsy were traumatic brain inj ury,febrile seizures,intracranial infection,birth trauma,surgery,neo-natal hypoxic-ischemic encephalopathy,cerebrovascular disease and brain tumors by turns.The onset age of symptomatic epilepsy with different causes was different.Almost 59.71% patients with symptomatic epilepsy had seizure disorder within 5 years after suffering the pathogenic factors.The time for the genesis of epilepsy in symptomatic epilepsy with different causes was different.There was significant difference in the etiological age of symptomatic epilepsy caused by traumatic brain inj ury and febrile seizures which occurred in mature brain and immature brain,respectively.The time for the genesis of epilepsy in symptomatic epilepsy caused by traumatic brain inj ury and febrile seizures was different.[Conclusion]The first and second common causes of symptomatic epilepsy are traumatic brain inj ury and febrile seizures respectively,and the other causes are in-tracranial infection,birth trauma,surgery,neonatal hypoxic-ischemic encephalopathy,cerebrovascular disease and brain tumors by turns.The onset age of symptomatic epilepsy with different causes is different.Most pa-tients with symptomatic epilepsy have seizure disorder within 5 years after suffering the pathogenic factors. The time for the genesis of epilepsy in symptomatic epilepsy is different.The time for the genesis of epilepsy in symptomatic epilepsy caused by traumatic brain inj ury and febrile seizures is different,which may be associated with the different mechanism of the genesis of epilepsy occurring in mature brain and immature brain. 2014 Vol. 31 (5): 924-928 [Abstract] ( 69 ) HTML (1 KB)  PDF  (0 KB)  ( 26 ) 928 Expression and Significance of VEGF in Small Cell Neuroendocrine Carcinoma of Cervix [Objective]To explore the expression and significance of VEGF in small cell neuroendocrine carcinoma of cervix(SCNC).[Methods]The specimens of 23 patients with squamous carcinoma of cervix (SCC)(group SCC),23 SCNC patients(group SCNS)and 23 patients with normal cervix(control group)were collected.Immunohistochemistry method was used to detect the expression of VEGF in 3 groups.The correla-tion between VEGF expression and clinical pathological indexes of SCNC and survival time were analyzed.[Re-sults]The positive expression rates of VEGF in control group,SCC group and SCNC group were 0%,52.2%and 82.6% respectively,and there was significant difference among 3 groups(P<0.05).High expression of VEGF was correlated with clinical stage,pathological subtypes and muscular invasion(P<0.05).The 3-year survival rate of patients with negative expression of VEGF was 75%,which was markedly higher than that of patients with positive expression of VEGF (15.8%),and there was significant difference (P <0.05 ).[Conclusion]High expression of VEGF may be associated with biological characteristics such as the strong in-vasion,and can provide the evidence for the diagnosis and prognosis of SCNC. 2014 Vol. 31 (5): 928-930 [Abstract] ( 80 ) HTML (1 KB)  PDF  (0 KB)  ( 28 ) 931 Analysis of Clinical Risk Factors of Death in Children with Severe Pneumonia YANG Li-ping%LIU Wei-hong%LUO Fu-hua [Obj ective]To explore clinical risk factors of death in children with severe pneumonia.[Meth-ods]A total of 96 children with severe pneumonia were enrolled in the study.Among them,48 children died. Clinical risk factors of death in children with severe pneumonia were analyzed retrospectively.[Results]Univa-riate analysis showed that there were significant differences in age,hypoxemia,dehydration,abdominal disten-sion and hypotension between death group and non-death group(P <0.05).Multiple analysis showed that age,hypoxemia,dehydration,systolic hypotension were correlated with death of children with severe pneumo-nia(P<0.05).[Conclusion]Early identification of clinical changes of children with severe pneumonia can pre-vent the death. 2014 Vol. 31 (5): 931-933 [Abstract] ( 64 ) HTML (1 KB)  PDF  (0 KB)  ( 31 ) 933 Clinical Observation on the Efficacy of Immediate Post-abortion Insertion with Mirena in 5 6 Cases LI Jun%CUIChao-mei [Objective]To observe clinical efficacy of immediate post-abortion insertion with Mirena.[Meth-ods]Totally 1 1 2 women with reproductive age undergoing artificial abortion in maternal and child health hospital of Hunan province from Jan.2010 to Dec.2012 were randomly divided into control group and observation group with 5 6 cases in each group.The control group received immediate post-abortion insertion with T-intrauterine device, while the observation group received immediate post-abortion with Mirena .All patients were followed up after 3 months for 1 year.Clinical efficacy and adverse reaction in two groups were observed.[Results]The pregnancy rate with IUD in situ,expulsion rate and removal rate due to symptoms in observation group were lower than those in control group,and there was significant difference(P<0.05).Compared with control group,the incidence rate of adverse reactions,especially the incidence rate of menorrhagia increased(P <0.01).[Conclusion]Compared with traditional T-intrauterine device,Mirena ring is more effective,safe and reliable methods of intrauterine con-traception,and has little adverse reactions.Therefore,it is especially suitable for patients with menorrhagia. 2014 Vol. 31 (5): 933-935 [Abstract] ( 20 ) HTML (1 KB)  PDF  (0 KB)  ( 41 ) 936 Analysis of the Difference Between Birth Canal Painless Labor and Spontaneous Labor WANG Li-xin%XUE Feng [Objective]To analyze the difference between birth canal painless labor and spontaneous labor.[Methods]Totally 400 full-term pregnant women in our hospital from Aug.2012 to Aug.2013 were enrolled in the study.According to the random number table,all these women were divided into observation group(n=200)and control group(n=200).The observation group was given painless labor,while the control group was given spontaneous labor.Clinical difference between two methods was analyzed.[Results]The pain in the observation group during the childbirth was obviously better than that in the control group,and there was sig-nificant difference(P<0.05).The time of first and second stage of childbirth in the observation group during the childbirth were obviously lower than those in the control group,and there was significant difference(P<0.05).Pulse,heart rate,partial pressure of oxygen and carbon dioxide in the observation group during the childbirth were obviously better than the control group and closer to normal mean value,and there was signifi-cant difference(P<0.05).[Conclusion]Birth canal painless labor has more significant analgesic effect than spontaneous labor.It can effectively improve the quality of childbirth and has good safety,so it is worthy of clinical popularization and application. 2014 Vol. 31 (5): 936-941 [Abstract] ( 74 ) HTML (1 KB)  PDF  (0 KB)  ( 33 ) 938 Effect of Ulinastatin on IL-1 7 in Brain Tissues of Rats with Cerebral Ischemia-reperfusion Inj u-ry REN Xiang%YANG Jie%LI li [Objective]To explore the protective effect and mechanism of ulinastatin(UTI)against cerebral ischemia-reperfusion injury.[Methods]A total of 72 male SD rats weighed 200~250g and aged 10~12 weeks were randomly divided into 3 groups including sham operation group,model group and UTI-treated group. The model of cerebral ischemia-reperfusion inj ury in model group and UTI-treated group were made by occlu-ding middle cerebral artery with thread,and ischemic time was 60min.Sham operation group only underwent neck surgery without occluding the vessel. UTI-treated group received intraperitoneal inj ection of UTI (10000U/kg)daily.The model group and sham group received the injection of isovolume normal saline daily. Petullo score was used to evaluate nervous function of 3 groups at 3d,7d and 14d after ischemia-reperfusion. Immunohistochemistry and Western blot were used to detect the expression of interleukin-17(IL-17)in rats of 3 groups at 3d,7d and 14d after ischemia-reperfusion.The effect of UTI on nervous function and IL-17 in brain tissues of rats with cerebral ischemia-reperfusion was observed.[Results]There were significant differ-ences in Petullo scores at d3 ,d7 and d14 between UTI-treated group and model group[(2.87±0.25)vs.(5.00 ±0.91),(2.20±1.52)vs.(4.87±0.62),(2.00±0.50)vs.(4.50±0.81)](P<0.05).Compared with the model group,the expression of IL-1 7 in UTI-treated group was obviously decreased,and there were signif-icant differences in the expression of IL-17 at d3 ,d7 and d 14 between two groups(P<0.05).[Conclusion]UTI may alleviate neurologic impairment after cerebral ischemia-reperfusion by decreasing the expression of IL-17. 2014 Vol. 31 (5): 938-941 [Abstract] ( 21 ) HTML (1 KB)  PDF  (0 KB)  ( 38 ) 942 Clinical Application of Two Methods of Breast Reduction WANGYan%ZHUWei-li [Objective]To compare clinical efficacy of two different methods of breast reduction and to explore the indications.[Methods]Totally 3 1 patients underwent surgical treatment.Among them,1 7 patients with mid-dle and serious giant breast were operated by single vertical pedicle method,and 14 patients with mild and middle giant breast were operated by double loop method.Blood supply and circulation of nipple and areola,sensation and breast contour in two groups after operation were observed.[Results]All patients recovered well.No necrosis of nipple and areola was observed.The contour of breast was satisfactory.The volume of the resection tissue of sin-gle vertical pedicle method was obviously more than that in double loop method(P<0.05).Patients with serious giant breast were mostly operated by single vertical pedicle method(P<0.05).[Conclusion]Single vertical pedi-cle method is suitable for middle and serious giant breast,while double loop method is suitable for mild and middle giant breast. 2014 Vol. 31 (5): 942-944 [Abstract] ( 65 ) HTML (1 KB)  PDF  (0 KB)  ( 34 ) 945 Study on the Correlation of Activated Leukocyte Cell Adhesion Molecule and Matrix Metallopro-teinases with Invasiveness of Meningiomas ZHANG Ai-hua%HE Qiang-hua%WANG Song-qing [Objective]To explore the expression of activated leukocyte cell adhesion molecule(ALCAM), matrix metalloproteinase-1(MMP-1)and matrix metalloproteinase-9(MMP-9)in human meningioma and its clinical significance.[Methods]A total of 80 patients with meningioma were analyzed retrospectively.Accord-ing to the pathology,all patients were divided into non-invasion group(n=44)and invasion group(n=36). Immunohistochemical method was used to detect the expression of ALCAM,MMP-1 and MMP-9 after opera-tion.[Results]The expressions of ALCAM,MMP-1 and MMP-9 in invasion group were higher than those in non-invasion group(P<0.01).There was correlation among the expressions of ALCAM,MMP-1 and MMP-9 in invasive meningioma.[Conclusion]ALCAM,MMP-1 and MMP-9 are correlated with the invasiveness of meningioma and can be used as the auxiliary indexes for evaluating the invasiveness and prognosis of meningio-ma.Immunohistochemical examination can determine the potential invasiveness of meningioma,guide clinical treatment and improve clinical efficacy. 2014 Vol. 31 (5): 945-947 [Abstract] ( 69 ) HTML (1 KB)  PDF  (0 KB)  ( 34 ) 947 Effect of MEBO Combined with Vaginal Bacteriostatic Adsorber on Wound Healing after Cervi-cal Loop Electrosurgical Excision Procedure ZHANG Jian-ping%LI juan [Objective]To explore clinical efficacy of Yunnanbaiyao powder plus MEBO combined with va-ginal adsorber for promoting wound healing after cervical loop electrosurgical excision procedure (Leep ).[Methods]Clinical data of 120 patients with cervical intraepithelial neoplasia(CIN)undergoing Leep in central hospital of the Turfan Basin from Aug.2012 to March 2014 were analyzed retrospectively.Among them,60 patients were given Yunnanbaiyao powder,MEBO and vaginal bacteriostatic adsorber(observation group),and other 60 patients were only given gauze oppression wound treatment(control group).Clinical efficacy between two groups was compared.[Results]The time of postoperative vaginal drainage,scab bleeding and acid bilges of waist in observation group were shorter than those in control group,but wound healing rate at early stage (less than 4 weeks)in observation group was higher than that in control group.The incidence of wound infec-tion and uterine neck adhesions in observational group was lower than that in control group.There were signif-icant differences(all P<0.05).[Conclusion]Yunnanbaiyao powder plus MEBO combined with vaginal bacteri-ostatic adsorber after cervical Leep can obviously reduce postoperative complications and has rapid recovery of patients,so it has important clinical application value. 2014 Vol. 31 (5): 947-949 [Abstract] ( 57 ) HTML (1 KB)  PDF  (0 KB)  ( 36 ) 950 Value of Trans-rectal Prostate Puncture in the Diagnosis of Prostatic Diseases [Objective]To explore the value of trans-rectal prostate puncture biopsy in the diagnosis of prostatic diseases.[Methods]Totally 105 patients with elevated PSA and abnormal prostates detected by trans-rectal ultrasonic examination(TRUS)underwent prostate puncture biopsy.Trans-rectal six-point punc-ture method was used to collect tissues for pathological examination.[Results]Among 105 patients,3 pa-tients were prostatitis,and 38 patients were prostatic hyperplasia,and 64 patients were prostate cancer.The success rate of tissue collection reached 100%.No severe complications such as hemospermia,prostate abscess and sepsis occurred.[Conclusion]Trans-rectal prostate puncture biopsy guided by ultrasonography is an im-portant method of diagnosing prostatic diseases.It is safe and accurate,and has high success rate,and can be effective in the differential and histological diagnosis of benign and malignant disease. 2014 Vol. 31 (5): 950-952 [Abstract] ( 21 ) HTML (1 KB)  PDF  (0 KB)  ( 32 ) 952 Observation on the Efficacy of 308nm Excimer Laser vs.Narrow-spectrum Midrange Ultraviolet Beam Local Radiation for the Treatment of Vitiligo [Objective]To explore the efficacy of 308nm excimer laser vs.narrow-spectrum midrange ultra-violet beam(NB-UVB)for the treatment of vitiligo.[Methods]Totally 63 patients(68 patches of skin lesion) with limited vitiligo were selected.Among them,36 patches were treated with 308nm excimer laser(laser group)and 32 patches were treated with NB-UVB twice a week for continuous 30 times(NB-UVB group). The effective rate,repigmentation rate and adverse reaction were compared between two groups.[Results]The repigmentation rate and total effective rate in laser group were 88.89% and 66.67% respectively,which were markedly higher than those in NB-UVB group(68.75% and 40.63%,respectively),and there was significant difference(P<0.05).No severe adverse reaction was found in two groups during the therapy.[Conclusion]The 308nm excimer laser for the treatment of vitiligo has good efficacy and advantages such as rapid effect and high safety. 2014 Vol. 31 (5): 952-954 [Abstract] ( 65 ) HTML (1 KB)  PDF  (0 KB)  ( 31 ) 955 Application of the Timed"Up-go"Test in the Assessment of Patients Undergoing Painless In-duced Abortion at Discharging from the Hospital MAYun-fei%LIYong-qing%LI Xiao-ying [Objective]To explore clinical application value of timed"up and go"test(TUGT)in the as-sessment of walking balance ability in patients undergoing painless induced abortion at discharging from the hospital.[Methods]A total of 60 patients undergoing painless induced abortion in our hospital from April 2013 to Oct.2013 were selected randomly.Postanesthetic discharge scoring system(PADSS)was taken as the ref-erence.TUGT was used to evaluate walking balance ability of patients.[Results]Preoperative TUGT of 60 patients was (7.12±1.16)s.When the postoperative PADSS was 9,TUGT was (12.87±2.1)s.When PADSS was10,TUGT was (11.10±1.19)s.TUGT≤11.0s was safe discharge standard.All 60 patients un-dergoing painless induced abortion discharged from the hospital safely.None had accident events such as post-anesthetic falling.[Conclusion]TUGT can effectively assess walking balance ability of patients undergoing painless induced abortion at discharging from the hospital.The risk of postoperative falling should be preven-ted.TUGT is simple and worthy of clinical promotion. 2014 Vol. 31 (5): 955-957 [Abstract] ( 73 ) HTML (1 KB)  PDF  (0 KB)  ( 27 ) 958 Assessment of the Efficacy of Psychological Nursing Intervention for Mental Disorder in Elderly Patients after Orthopedic Operation HUMin-juan%HUZhi-hui%XIEWei [Objective]To explore the implementation efficacy of comprehensive nursing intervention for mental disorder in elderly patients after orthopedic operation.[Methods]Totally 60 elderly patients scheduled for selective operation in orthopedics department were randomly divided into observation group and control group with 30 patients in each group.The control group was given conventional nursing care in perioperative period of orthopedics,while the observation group was given psychological nursing intervention for mental dis-orders on the basis of routine care.Self-rating depression scale(SDS),self-rating anxiety scale(SAS)score and the incidence of depression and anxiety incidence before and 7d after surgery were compared between two groups.[Results]Compared with control group,SDS and SAS scores in observation group 7d after operation were decreased significantly(P<0.05).The incidence rate of depression and anxiety incidence in observation group was 10.00%(3/30)and 16.67%(5/30)respectively,which was markedly lower than that in control group[30%(9/30)and 40%(12/30)],and there was significant difference(P<0.05).[Conclusion]Imple-mentation of psychological nursing intervention for elderly patients in orthopedics department has important application value for preventing and reducing the incidence of postoperative depression and anxiety. 2014 Vol. 31 (5): 958-963 [Abstract] ( 81 ) HTML (1 KB)  PDF  (0 KB)  ( 34 ) 960 Analysis of the Correlative Risk Factors of Early Diabetic Nephropathy in Type 2 Diabetes Mel-litus [Objective]To explore the risk factors of early diabetic nephropathy(EDN)in type 2 diabetes mellitus(T2DM)in order to provide the scientific evidence for early prevention and treatment of type 2 diabetic nephropathy (DN).[Methods]According to 24h urinary albumin level,566 T2DM patients were divided into EDN group(EN group,urinary albumin was 30~300mg/24h)and simple T2DM group(DM group,urinary albumin<30mg/24 h).The history of hypertension,fatty liver disease and smoking,the duration of diabetes mellitus,body mass index(BMI),triglyceride(TG),total cholesterol(TC),high density lipoprotein cholester-ol(HDL-C),low density lipoprotein cholesterol(LDL-C),uric acid(UA),glucosylated hemoglobin(HBA1C), fasting C-peptide(FCP),half an hour C-peptide(0.5hPCP)and 2 hour C-peptide(2hPCP)were compared be-tween two groups.[Results]There were significant differences in duration,the percentage of hypertension , the percentage of smoking,BMI,HDL-C,TG and UA levels between EN group and DM group(P<0.05), but there was no significant difference in the incidence of fatty liver disease,HBA1C,FCP,0.5hPCP,2hPCP and LDL-C between two groups(P>0.05).The duration,BMI,TG and UA in EN group were lower.Lo-gistical regression analysis showed that the duration of diabetes mellitus,the hypertension,high BMI and high LDL-C were the influencing factors of DN.[Conclusion]Long duration of diabetes mellitus,hypertension, high BMI and high LDL-C are the risk factors of EDN.Diabetic patients should stop smoking,strictly control blood pressure,blood sugar and body weight,regularly monitor UA and blood lipids and actively correct lipid metabolism disorders in order to prevent the occurrence and development of DN. 2014 Vol. 31 (5): 960-963 [Abstract] ( 73 ) HTML (1 KB)  PDF  (0 KB)  ( 30 ) 964 Influence of Behavior Conversion Mode on the Efficacy of Health Education in Patients with Di-abetes Mellitus [Objective]To explore the influence of behavior conversion mode on the efficacy of health edu-cation in patients with diabetes mellitus.[Methods]A total of 120 patients with diabetes mellitus were collect-ed and intervened by the staged behavior conversion mode of health education.Self efficacy,quality of life and medication compliance of patients were compared before and after health education.[Results]After health edu-cation,the self efficacy score,quality of life score and medication compliance rates of patients were significant-ly higher than those before health education,and there were significant differences(P<0.05).[Conclusion]Application of behavior conversion mode for health education in patients with diabetes mellitus can effectively improve the patient's self-efficacy level and life quality,and increase medication compliance.Therefore,it is worthy of clinical promotion. 2014 Vol. 31 (5): 964-969 [Abstract] ( 74 ) HTML (1 KB)  PDF  (0 KB)  ( 40 ) 966 Comparison of the Efficacy of Sustaining Plate vs.Locking Plate for the Treatment of Tibial Plateau Fracture [Objective]To compared and analyze the efficacy of sustaining plate(SP)vs.locking plate(LP) for the treatment of tibial plateau fracture.[Methods]A total of 44 patients tibial plateau fracture were col-lected.Among them,19 patients underwent SP internal fixation(SP group),while 25 patients underwent LP internal infixation(LP group).The age,gender,inj ury status,type,operation time,blood loss,postoperative wound drainage volume,length of hospital stay,healing time of fracture and the rating results of knee joint function in 2 groups were compared and analyzed.[Results]There was no significant difference in gender con-stitution,average age,the combined inj ury,fracture type,hospitalization time and postoperative drainage vol-ume between two groups(P>0.05).Compared with LP group,intraoperative blood loss was more,and op-eration time and healing time were longer in SP group.The good and excellent rate in LP group was markedly higher than that in SP group(92.00% vs.78.94%),and there was significant difference(P<0.05).[Con-clusion]LP for the treatment of tibial plateau fracture is better than SP.The main indexes are intraoperative blood loss,operation time,healing time of fracture and knee joint function score,etc. 2014 Vol. 31 (5): 966-969 [Abstract] ( 76 ) HTML (1 KB)  PDF  (0 KB)  ( 32 ) 970 Study on the Relationship of Complicated Ischemic Stroke with Carotid Artery Intima-media Thick-ness and Retinopathy in Elderly Patients with Type 2 Diabetes Mellitus [Objective]To explore the correlation of complicated ischemic stroke with the degree of carotid stenosis and retinopathy in elderly patients with type 2 diabetes mellitus(T2DM).[Methods]Among 161 elderly patients with T2DM,58 patients were complicated with stroke(stroke group)and 103 patients were not complicated with stroke(non-stroke group).Carotid intima-media thickness(IMT)of patients in 2 groups was detected by ultrasonography.Fundus examination was performed in all patients.[Results]Carotid atherosclerotic plaques of patients in 2 groups mainly oc-curred at the site near the bifurcation of common carotid artery.The detection rate of instable carotid plaque and carotid IMT in stroke group were significantly higher than those in non-stroke group(P<0.05).Carotid IMT of patient with simple diabetic retinopathy(NPDR)and proliferative diabetic retinopathy(PDR)in stroke group was significantly higher than that in non-stroke group(P<0.05).Correlation analysis showed that IMT was significantly associated with fundus lesion(r=0.5509,P<0.05).[Conclusion]Carotid IMT and the degree of retinopathy are related with complicated is-chemic stroke in elderly patients with TDM. 2014 Vol. 31 (5): 970-974 [Abstract] ( 23 ) HTML (1 KB)  PDF  (0 KB)  ( 34 ) 972 Expression and Significance of ERCC1 and AKT2 in Gastric Carcinoma YANG An%LIU Ping%DONGYuan-yuan [Obj ective]To explore the expression of excision repair cross complementing 1 (ERCC1 )and pro-tein kinase B(AKT2)in gastric carcinoma and its significance.[Methods]The expressions of ERCC1 and AKT2 in 76 cases of gastric carcinoma tissues were detected by using SP immunohistochemical method,and compared with those in 42 cases of normal gastric mucosa tissues.[Results]The expression of ERCC1 and AKT2 in gastric carcinoma tissue was located in nucleus and plasma.The positive expression of ERCC1 in gastric carcinoma tissue was obviously lower than that in normal gastric mucosa tissue,while the positive expression of AKT2 in gastric carcinoma tissue was obviously higher than that in normal gastric mucosa tissue(P<0.05).The expressions of ERCC1 and AKT2 were related with lymph node metastasis and pathological stage(P<0.05).There was no ob-vious correlation between the expression of ERCC1 and AKR2.The prognosis of patients receiving postoperative chemotherapy with negative expression of ERCC1 and AKT2 was better than that of patients with positive expres-sion of ERCC1 and AKT2.[Conclusion]ERCC1 and AKT2 are closely related with the prognosis and resistance of gastric carcinoma.The detection of the changes of ERCC1 and AKT2 is helpful to understand malignant degree of patients with gastric cancer,instruct the setting of individualized treatment protocol and assess the prognosis. 2014 Vol. 31 (5): 972-974 [Abstract] ( 68 ) HTML (1 KB)  PDF  (0 KB)  ( 29 ) 975 Influence of the Change of Bladder Volume on the Radiotherapy of Cervical Cancer [Objective]To explore the influence of the change of bladder volume on the radiotherapy of cervical cancer.[Methods]When bladder was empty,half full or full,22 patients with cervical cancer in our hospital received CT scan for 3 times.The changes of the displacement of cervix and uterine body were com-pared.[Results]The mean displacement of cervix and uterine body for empty-full group in anterior,superior and inferior directions was the largest(0.7~1.0cm and 0.8~0.9cm).The mean maximal displacement of cer-vix and uterine body for empty-half full group in 6 directions was less than 0.6cm and 0.5cm,respectively. The mean maximal displacement of cervix and uterine body for half full-full group in 6 directions was less than 0.8cm and 0.6,respectively.[Conclusion]The position of uterine body and cervix changes with bladder vol-ume,and the maximal displacement alteration is positively related with bladder volume. 2014 Vol. 31 (5): 975-977 [Abstract] ( 21 ) HTML (1 KB)  PDF  (0 KB)  ( 32 ) 977 Study on the Relationship Between DDR2 Gene Mutation and the Occurrence and Development of Lung Cancer [Objective]To explore the correlation between DDR2 gene mutation and the occurrence of lung cancer in order to provide the theoretical basis for the targeted therapy of lung cancer.[Methods]Totally 200 patients with lung cancer and concurrent 100 cases of normal lung tissue samples in affiliated chest hospital of Shanghai Jiaotong university from May 2010 to May 2012 were selected and enrolled in observation group and control group,respectively.The difference in DDR2 gene sequencing results between two groups was ana-lyzed.The correlation between above indicators and the occurrence of lung cancer was discussed.[Results]DDR2 gene mutation rate in observation group and control group was 23.0%(46/200)and 1.0%(1/100),re-spectively.The mutation rate in observation group was markedly higher than that in control group,and there was significant difference between two groups(P <0.05).DDR2 gene mutation rate of lung squamous cell carcinoma was 51.4%(17/39)which was markedly higher than that of other pathological types such as lung adenocarcinoma and lung adeno-squamous carcinoma and,and there was significant difference between two groups(P<0.05).DDR2 gene mutation rate had no correlation with tumor stage(P>0.05).[Conclusion]DDR2 gene mutation is the key factor in the occurrence of lung squamous cell carcinoma,but has no obvious effect on the development of lung cancer. 2014 Vol. 31 (5): 977-979 [Abstract] ( 92 ) HTML (1 KB)  PDF  (0 KB)  ( 38 ) 980 Observation on Operation Time and Efficacy of Cholecystectomy for Acute Calculous Cholecysti-tis Patients Complicated with Acute Pancreatitis WANJun%WUHe-ming [Objective]To explore the operation time and clinical efficacy of cholecystectomy for patients of acute calculous cholecystitis(ACC)accompanied by acute pancreatitis(AP).[Methods]According to the opera-tion time,49 ACC patients with AP in our hospital from Jan.2011 to Dec.2013 were divided into group A and group B.Group A(n=11)underwent surgical treatment within 72 hours at admission(blood amylase still higher than normal level during the operation).Group B(n=38)received non-surgical treatment in advance, and then underwent the operation until body temperature and blood amylase returned to normal level(5~16d). The operation condition and clinical indexes were compared between two groups.[Results]Laparoscopy rate, laparotomy rate and conversion rate of laparotomy in group A were 81.82%,9.09% and 9.09% respectively, and those in group B were 92.11%,5.26% and 2.63% respectively,but there was no significant difference between two groups(P>0.05).There was no significant difference in the time of placing drainage tube be-tween two groups(P>0.05).Hospital stay and the time of blood amylase,urine amylase and white blood cell returning to normal in group B were shorter than those in group A(P <0.05).There was no significant difference in the incidence of complications between two groups(9.09% vs.2.63%,P>0.05).All patients were followed up for 6 months.No recurrence was found in 49 patients.[Conclusion]Cholecystectomy for ACC complicated with AP has good prognosis.The first choice of treatment is non-surgical treatment in ad-vance and then the operation until body temperature and blood amylase return to normal level. 2014 Vol. 31 (5): 980-982 [Abstract] ( 83 ) HTML (1 KB)  PDF  (0 KB)  ( 32 ) 983 Effect of Safflower Yellow Injection on High Sensitivity C-reactive Protein and Platelet Aggrega-tion Rate in Patients With non-ST Elevation Acute Myocardial Infarction [Objective]To explore the effect of safflower yellow inj ection on high sensitivity C reactive protein(hsCRP)and platelet aggregation rate in patients with non-ST elevation acute myocardial infarction (NSTEAMI).[Methods]Totally 7 1 NSTEAMI patients were randomly divided into safflower yellow inj ection treatment group and routine control group.On the basis of the treatment of control group,the treatment group was additionally given safflower yellow injection 100mg once a day for 14 days.The hsCRP and platelet aggregation rate in two groups before and after treatment.[Results]Compared with the control group,hsCRP and platelet aggregate rate in the treatment group decreased significantly(P<0.05).[Conclusion]Safflower yellow inj ection can improve the prognosis of patients with NSTEAMI,and can be used as the adj uvant thera-py of acute myocardial infarction. 2014 Vol. 31 (5): 983-987 [Abstract] ( 48 ) HTML (1 KB)  PDF  (0 KB)  ( 33 ) 985 Analysis of the Feasibility of Strain Rate Imaging Combined with Tissue Doppler Imaging in the Assessment of Left Atrial Function of Patients with Rheumatic Mitral Stenosis GUO Yan%ZHAO Zhen-xing%CHEN Lei [Objective]To explore the feasibility of strain rate imaging(SRI)combined with tissue Doppler imaging(TDI)in the assessment of left atrial function in patients with rheumatic mitral stenosis.[Methods]A total of 50 patients with rheumatic mitral stenosis were chosen and divided into sinus group and atrial fibrilla-tion group with 25 patients in each group.Other 25 healthy subjects were selected as control group.TDI was used to measure in the velocity of mitral ring in atrioventricular j unction area and lateral wall at apical four-chamber view(S for ventricular systole,E for ventricular diastole and A for atrial systole).SRI was used to measure ventricular systolic strain rate(Ssr),early ventricular diastolic strain rate(Esr)and atrial systolic strain rate(Asr)in interatrial septum and left atrium wall.[Results]There was significant difference in TDI S, E and A peak values between sinus or atrial fibrillation groups and control group(P<0.05).There was sig-nificant differences in S and E values of mitral ring side wall and S value of mitral ring interval side between at-rial fibrillation group and sinus group(P<0.05).There was significant difference in Ssr,Esr and Asr at each sampling point between sinus or atrial fibrillation groups and control group(P<0.05).There was significant difference in Ssr at each sampling point and Esr of atrial interval top between atrial fibrillation group and sinus group(P<0.05).[Conclusion]The systolic and diastolic function of left atrial in patients with rheumatic mi-tral stenosis are significantly decreased.SRI and TDI technology can be used to assess the left atrial function in patients with rheumatic mitral stenosis. 2014 Vol. 31 (5): 985-987 [Abstract] ( 19 ) HTML (1 KB)  PDF  (0 KB)  ( 35 ) 988 Clinical Comparative Study of Yanhuning Combined with Cimetidine vs. Ribavirin for the Treatment of Mumps XIAOYue-bing [Objective]To observe the efficacy and safety of yanhuning combined with cimetidine or ribavi-rin for the treatment of mumps in order to provide the basis for clinical optimal medication.[Methods]A total of pediatric patients with mumps were randomly divided into observation group(n=33)and control group(n=32).All patients in two groups were treated with yanhuning 10mg/(kg·d)by intravenous drip.The ob-servation group was additionally treated with cimetidine 15~20mg/(kg·d),while the control group was addi-tionally treated with ribavirin 10~15mg/(kg·d).Clinical efficacy and safety of two groups 5d after treatment were observed.[Results]The fever clearance time and swollen extinction time in observation group were shor-ter than those in control group,and there was significant difference(P<0.05).Clinical total effective rate of observation group was 93.94%,which was higher than that of control group(75.00%)(P <0.05).There was no significant difference in the complication rate between two groups(P>0.05).No obvious adverse re-action occurred.[Conclusion]Yanhuning combined cimetidine for the treatment of mumps is more safe and ef-fective than yanhuning combined with ribavirin,so it is worthy of clinical application. 2014 Vol. 31 (5): 988-992 [Abstract] ( 71 ) HTML (1 KB)  PDF  (0 KB)  ( 30 ) 990 Effect of Different Doses of Remifentanil for Anesthesia Induction on Mothers and Fetal Delivery During Cae-sarean Section [Objective]To compare the effects of anesthesia induction with different doses of remifentanil on mother and fe-tal delivery during caesarean section.[Methods]A total of 60 ASAⅠ~Ⅱ patients with contraindications of intraspinal anes-thesia undergoing elective caesarean section were chosen and randomly divided into 3 groups with 20 patients in each group. General anesthesia induction was performed with propofol 1.5mg/kg,vecuronium bromide 0.1mg/kg and remifentanil 1.0μg/kg(group A),1.5μg/kg(group B)and 2.0μg/kg(group C),respectively.Skin incision and operation were undertaken 20min after the assisted ventilation.Then tracheal intubation was taken for mechanical ventilation.Remifentanil 0.15μg/(kg·min) and propofol 4mg/(kg·h)were injected intravenously.Vecuronium 0.05mg/kg was injected intravenously for maintenance anesthesia.Systolic pressure(SP),diastolic pressure(DP),mean arterial pressure(MAP),heart rate(HR)and bleeding vol-ume before anesthesia(T0 ),skin incision at once(T1 )and tracheal intubation at once(T2 )were observed.Apgar score and treatment of neonates from anesthesia induction to fetal delivery(I-D),1min,5min and 10min were recorded.[Results]There was no significant difference in SP,DP,MAP and HR among 3 groups(P>0.05).Compared with group B and group C,SP, DP,MAP and HR in group A at T1 and T2 were obviously increased.Compared with T0,SP,DP,MAP and HR in group A at T1 and T2 were also obviously increased(P <0.05).There was no significant difference between group B and group C. There was no significant difference in bleeding volume at I-D among 3 groups(P<0.05).There was significant difference in neonate Apgar score at 1min between group C and group A or group B(P<0.05).There was no significant difference in neo-nate Apgar score at 5min and 10min among 3 groups(P>0.05).[Conclusion]Remifentanil 1.0μg/kg for anesthesia induction can maintain stable hemodynamics of parturients,and remifentanil 2.0μg/kg for anesthesia induction can reduce neonatal Apgar score at 1min.Therefore,remifentanile 1.5μg/kg used in general anesthesia induction has good efficacy,and can better inhibit the stress reaction of parturients without adverse effect on neonates. 2014 Vol. 31 (5): 990-992 [Abstract] ( 20 ) HTML (1 KB)  PDF  (0 KB)  ( 37 )

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