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Abstract [Objective]To explore the expression of activated leukocyte cell adhesion molecule(ALCAM), matrix metalloproteinase-1(MMP-1)and matrix metalloproteinase-9(MMP-9)in human meningioma and its clinical significance.[Methods]A total of 80 patients with meningioma were analyzed retrospectively.Accord-ing to the pathology,all patients were divided into non-invasion group(n=44)and invasion group(n=36). Immunohistochemical method was used to detect the expression of ALCAM,MMP-1 and MMP-9 after opera-tion.[Results]The expressions of ALCAM,MMP-1 and MMP-9 in invasion group were higher than those in non-invasion group(P<0.01).There was correlation among the expressions of ALCAM,MMP-1 and MMP-9 in invasive meningioma.[Conclusion]ALCAM,MMP-1 and MMP-9 are correlated with the invasiveness of meningioma and can be used as the auxiliary indexes for evaluating the invasiveness and prognosis of meningio-ma.Immunohistochemical examination can determine the potential invasiveness of meningioma,guide clinical treatment and improve clinical efficacy.
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2014, Vol. 31 
