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Abstract [Objective]To observe serum level of galectin-3(Gal-3)in patients with different types of coro-nary heart disease and analyze its correlation with high-sensitivity C-reactive protein(hs-CRP)and monocyte chemokine protein-1(MCP-1),and to explore clinical value of Gal-3 in patients with coronary heart disease.[Methods]Totally 97 patients with coronary heart disease confirmed by coronary angiography were collected as coronary heart disease groups including stable angina pectoris group(group SA,n=31),unstable angina pec-toris group(group UA,n=35)and acute myocardial infarction(group AMI,n=31).Other 30 non-coronary heart disease patients with normal coronary angiography were collected as control group.General clinical data of all subjects were collected.Serum levels of Gal-3,MCP-1 and plasma hs-CRP were assayed.[Results]Ser-um Gal-3 level in coronary heart disease group was obviously higher that in control group(P<0.05).Serum Gal-3 levels in UA group and AMI group were markedly higher than those in SA group(P <0.05).Serum Gal-3 level in AMI group was higher than that in UA group,but there was significant difference(P>0.05). Serum Gal-3 level in patients with coronary heart disease was positively correlated with hs-CRP and MCP-1 significantly(P<0.05).[Conclusion]Serum Gal-3 level in patients with coronary heart disease is increased obviously,and may be a new biomarker for acute coronary syndrome,and has important clinical significance. Combined detection of Gal-3,hs-CRP and MCP-1 has important clinical significance in the early diagnosis,risk stratification and prognosis of coronary heart disease.
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2014, Vol. 31 
