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Abstract [Objective]To compare the effects of anesthesia induction with different doses of remifentanil on mother and fe-tal delivery during caesarean section.[Methods]A total of 60 ASAⅠ~Ⅱ patients with contraindications of intraspinal anes-thesia undergoing elective caesarean section were chosen and randomly divided into 3 groups with 20 patients in each group. General anesthesia induction was performed with propofol 1.5mg/kg,vecuronium bromide 0.1mg/kg and remifentanil 1.0μg/kg(group A),1.5μg/kg(group B)and 2.0μg/kg(group C),respectively.Skin incision and operation were undertaken 20min after the assisted ventilation.Then tracheal intubation was taken for mechanical ventilation.Remifentanil 0.15μg/(kg·min) and propofol 4mg/(kg·h)were injected intravenously.Vecuronium 0.05mg/kg was injected intravenously for maintenance anesthesia.Systolic pressure(SP),diastolic pressure(DP),mean arterial pressure(MAP),heart rate(HR)and bleeding vol-ume before anesthesia(T0 ),skin incision at once(T1 )and tracheal intubation at once(T2 )were observed.Apgar score and treatment of neonates from anesthesia induction to fetal delivery(I-D),1min,5min and 10min were recorded.[Results]There was no significant difference in SP,DP,MAP and HR among 3 groups(P>0.05).Compared with group B and group C,SP, DP,MAP and HR in group A at T1 and T2 were obviously increased.Compared with T0,SP,DP,MAP and HR in group A at T1 and T2 were also obviously increased(P <0.05).There was no significant difference between group B and group C. There was no significant difference in bleeding volume at I-D among 3 groups(P<0.05).There was significant difference in neonate Apgar score at 1min between group C and group A or group B(P<0.05).There was no significant difference in neo-nate Apgar score at 5min and 10min among 3 groups(P>0.05).[Conclusion]Remifentanil 1.0μg/kg for anesthesia induction can maintain stable hemodynamics of parturients,and remifentanil 2.0μg/kg for anesthesia induction can reduce neonatal Apgar score at 1min.Therefore,remifentanile 1.5μg/kg used in general anesthesia induction has good efficacy,and can better inhibit the stress reaction of parturients without adverse effect on neonates.
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2014, Vol. 31 
