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Abstract [Objective]To explore the correlation between DDR2 gene mutation and the occurrence of lung cancer in order to provide the theoretical basis for the targeted therapy of lung cancer.[Methods]Totally 200 patients with lung cancer and concurrent 100 cases of normal lung tissue samples in affiliated chest hospital of Shanghai Jiaotong university from May 2010 to May 2012 were selected and enrolled in observation group and control group,respectively.The difference in DDR2 gene sequencing results between two groups was ana-lyzed.The correlation between above indicators and the occurrence of lung cancer was discussed.[Results]DDR2 gene mutation rate in observation group and control group was 23.0%(46/200)and 1.0%(1/100),re-spectively.The mutation rate in observation group was markedly higher than that in control group,and there was significant difference between two groups(P <0.05).DDR2 gene mutation rate of lung squamous cell carcinoma was 51.4%(17/39)which was markedly higher than that of other pathological types such as lung adenocarcinoma and lung adeno-squamous carcinoma and,and there was significant difference between two groups(P<0.05).DDR2 gene mutation rate had no correlation with tumor stage(P>0.05).[Conclusion]DDR2 gene mutation is the key factor in the occurrence of lung squamous cell carcinoma,but has no obvious effect on the development of lung cancer.
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2014, Vol. 31 
