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Quick Search     Adv Search 2014 Vol. 31, No. 11 Published: 2014-11-26   2081 Value of Combined Detection of Antinuclear Antibody,Antinuclear Antibody Profile and Anti-double Stranded DNA Antibody in the Diagnosis of Systemic Lupus Erythematosus ZENG Yan-kun%WU Jie Objective] To explore the value of antinuclear antibody(ANA) ,antinuclear antibody profile(ANAs) and anti‐double stranded DNA antibody (anti dsDNA antibody ) in the diagnosis of systemic lupus erythematosus (SLE) .[Methods] Totally 150 patients with SLE in a municipal hospital of Quanzhou city from Jan .2012 to Jan . 2014 were selected as SLE group ,and other 30 patients with rheumatic diseases were selected as disease control group ,and 30 health examination persons were selected as normal control group .Serum ANA was detected by indi‐rect immunofluorescence method .Serum ANAs and anti dsDNA antibody were measured by western blotting .[Re‐sults] The positive rates of serum ANA ,anti dsDNA antibody ,anti‐AHA ,anti‐nRNP ,anti‐AnuA and anti‐Sm in SLE group were significantly higher than those in disease control group and healthy control group( P <0 .01) .In SLE group ,only 5 .33% of patients had single positive antibody ,and the remaining 94 .67% of patients had two or more positive antibodies .After treatment ,the positive rates of ANA ,anti dsDNA antibody ,anti‐AHA ,anti‐Sm and anti‐SS‐A in SLE patients were decreased in different degree .The improvement rate of ANA ,anti‐dsDNA antibody and anti‐AHA were 23 .33% ,83 .33% and 63 .33% ,respectively .[Conclusion] The positive rates of ANA ,ANAs and anti ds‐DNA antibody in SLE patients is higher .The joint detection and dynamic observation of ANA ,ANAs and anti‐ds‐DNA antibody is of significance in the diagnosis and treatment of SLE . 2014 Vol. 31 (11): 2081-2083 [Abstract] ( 32 ) HTML (1 KB)  PDF  (0 KB)  ( 37 ) 2084 Significant of the Change of Human Beta-defensin-3 in Bronchoalveolar Lavage Fluid of Patients with Mycoplasma Pneumoniae Pneumonia Before and after Therapy Objective] To observe the level of human beta‐defensin‐3(hβD‐3) protein in bronchoalveolar lavage fluid(BALF) of patients with mycoplasma pneumoniae pneumonia(MPP) ,and to compare the change of hβD‐3 protein level in MPP patients before and after therapy ,and to explore the role of hβD‐3 in defending MPP infection .[Methods] ELISA was used to detect and compare the protein level of hβD‐3 in BALF of MPP patients ,non‐MPP patients and controls .The changes of hβD‐3 protein level in BALF of MMP patients before and after 7‐14 days of treatment therapy were compared .[Results]The protein level of hβD‐3 in BALF of MPP patients is lower than that of control group ,but upraised after treatment .[Conclusion]The decreasing of hβD‐3 is associated with epithelial cell damage ,which may participate in immune system damage of MPP . 2014 Vol. 31 (11): 2084-2086 [Abstract] ( 72 ) HTML (1 KB)  PDF  (0 KB)  ( 36 ) 2087 Study on the Turnover of 110 Patients with Impaired Glucose Regulation Interfered by Family Phy-sician Management Mode Intervention Objective] To explore the turnover of impaired glucose regulation(IGR) interfered by family physician management .[Methods] Totally 1353 adult residents were randomly collected from Meilong community health service center of Minhang district in Shanghai .IGR patients were selected for evaluating clinical baseline characteristics of IGR subgroups .Homeostasis model method(HOMA) was used to assess insulin resistance index(IR) and beta cell function in‐dex .After 1 year of health education by family physicians ,the 75g glucose tolerance test(OGTT) was reexamined .[Re‐sults]Among 1353 residents ,110 patients with IGR were detected and the detection rate was 8 .13% .IGR patients were divided into impaired fasting glucose group(IFG group ,n =15) ,impaired glucose tolerance group(IGT group ,n =87) and complex impaired glucose regulation group(CGI Group ,n=8) .There was no significant difference in age ,sex ,body mass index(BMI) ,waist/hip ratio ,blood pressure and lipids among subgroups( P >0 .05) .HOMA‐IR in CGI group was the highest and HOMA‐βin IFG group was the lowest( P<0 .01) .Among 110 patients with IGR ,57 patients re‐covered normal glucose tolerance ,and 45 patients were still IGR ,and 8 patients developed to diabetes mellitus .[Conclu‐sion]IGT is the main form of IGR .Under family physician management mode ,the rates of IGR turning to normal glucose tolerance ,IGR and diabetes mellitus are 51 .81% ,40 .9% and 7 .27% ,respectively . 2014 Vol. 31 (11): 2087-2089 [Abstract] ( 70 ) HTML (1 KB)  PDF  (0 KB)  ( 36 ) 2090 Value of Tei Index in the Evaluation of Cardiac Function of Myocardial Damage in Children with Infectious Mononucleosis Objective]To explore the value of Tei index in the evaluation of left heart function of myocar‐dial damage in children with infectious mononucleosis(IM ) .[Methods]Left ventricular ejection fraction(EF) , mitral valve early diastolic blood flow velocity peak(E)/late diastolic blood flow velocity peak(A) ratio ,left ventricular isovolumetric contraction time(ICT ) ,isovolumic relaxation time(IRT ) and ejection time(ET ) in 96 cases of IM with myocardial damage(observation group) and 40 normal subjects(control group) were measured and compared .Tei index was calculated .[Results]There was no significant difference in EF and E/A between observation group and control group( P >0 .05) .Compared with control group ,left ventricular Tei index in observation group was obviously increased[(0 .48 ± 0 .09) vs .(0 .39 ± 0 .08)]( P <0 .05) .Tei index was not significantly correlated with EF and E/A( P >0 .05) .[Conclusion]Pediatric patients with IM and myocardial damage have abnormal whole cardiac function .Tei index can conveniently and sensitively detect the change of cardiac function . 2014 Vol. 31 (11): 2090-2092 [Abstract] ( 28 ) HTML (1 KB)  PDF  (0 KB)  ( 37 ) 2093 Experimental Study of Thalidomide Combined with Epirubicin in the Treatment of Transplanted H22 Hepatoma in Mice Objective]To explore the efficacy of thalidomide combined with epirubicin in the treatment of transplanted H22 hepatoma in mice .[Methods]H22 tumor cells were cultured ,and 60 mice with transplanted H22 hepatoma were established .According to the different treatment methods ,mouse models were divided in‐to group A( n=20) ,group B( n=20) and group C( n=20) .The mice of group A received thalidomide com‐bined with epirubicin therapy .The mice of group B only received epirubicin treatment .The mice of group C received normal saline .Tumor diameter at d7 ,d14 ,d21 and d30 was measured .Death rate of mice in 3 groups after 12 months was calculated .[Results] The tumor diameter of group A at d14 was (11 .37+ 1 .03)mm , which was significantly lower than that of B group[(19 .32 ± 1 .12)mm]( t = -28 .62 ,P =0 .000) and group C[(28 .39+1 .19)mm]( t = -59 .23 ,P =0 .000) .The tumor diameter of group A at d30 was (9 .23 ± 1 .08) mm ,which was significantly lower than that of group B[(12 .23 ± 1 .04)mm]( t = -3 .22 ,P =0 .002) and group C[(29 .29 ± 1 .03)mm]( t = -67 .38 ,P =0 .000) .The death rat of group A was 10% (2/20) ,which was significantly lower than that of group B(45% ,9/20) and group C(80% ,16/20) .[Conclusion] Thalido‐mide combined with epirubicin for the treatment of H22 transplanted hepatoma in mice has satisfactory effect . 2014 Vol. 31 (11): 2093-2097 [Abstract] ( 78 ) HTML (1 KB)  PDF  (0 KB)  ( 38 ) 2095 Clinical Observation of Edaravone for the Treatment of Cerebral Infarction XING Yu%SHI Lei%HU Yang-qiong Objective] To explore clinical efficacy of edaravone for the treatment of cerebral infarction .[Methods] A total of 64 patients with cerebral infarction in our hospital form Jan .2012 to Dec .2013 were randomly selected .All patients were admitted to the hospital for the diagnosis and treatment within 24h of on‐set .These patients were randomly divided into experimental group( n=32) and control group( n =32) .The control group was given intravenous instillation with conventional Xuesaitong needle ,while the experimental group was given edaravone based on the treatment of control group .The treatment results of two groups were observed .[Results] In experimental group ,31 patients were effective treatment ,and 1 patient was invalid , and the effective rate was 96 .9% (31/32) .In control group ,30 patients were effective treatment ,and 2 pa‐tients were invalid ,and the effective rate was 93 .8% (30/32) .There is no significant difference in the total ef‐fective rate between two groups .Compared with before treatment ,NIHSS score and Bathel index of two groups after treatment were obviously improved(all P<0 .05) ,and those in experimental group were obvious‐ly better than the control group ,and there was significant difference(all P<0 .05) .[Conclusion]Edaravone for early treatment of cerebral infarction can improve the symptoms of neurologic impairment .Therefore ,it is worthy of clinical promotion . 2014 Vol. 31 (11): 2095-2097 [Abstract] ( 82 ) HTML (1 KB)  PDF  (0 KB)  ( 34 ) 2098 Effect of Obstructive Sleep Apnea on Restenosis and Plasma hsCRP in Patients with Acute Coro-nary Syndrome after Coronary Artery Stent Implantation Objective] To observe the effect of obstructive sleep apnea(OSA ) on restenosis and plasma high‐sensitivity C‐reactive protein(hsCRP) in patients with acute coronary syndrome(ACS) after successful coronary artery stent implantation .[Methods] A total of 66 patients with ACS undergoing coronary artery stent implantation in cardiology department of our hospital from Jan .2008 to Dec .20100 CS) were selected . After polysomnography ,all patients were divided into OSA group( n = 21 ,ACS combined with OSA) and control group( n=45 ,ACS without OSA) .Blood samples were collected for detecting blood glucose ,lipids and hsCRP before operation .Blood glucose ,lipids and hsCRP were reexamined and coronary angiography was performed again at 6‐month follow up after operation .[Results]Compared with control group ,total cholester‐ol(TC) and low density lipoprotein(LDL) in OSA group at baseline were increased( P<0 .05) .There was no significant difference in TC and LDL between two groups at 6‐month follow up after lipid‐lowing treatment( P>0 .05) .Compared with control group ,hsCRP in OSA group at baseline and follow up was significantly in‐creased( P<0 .01) .Compared with control group ,the rate of stent restenosis in OSA group was obviously in‐creased at 6‐month follow‐up( P <0 .01) .AHI was positively correlated with stent restenosis and hsCRP ( P<0 .05) .hsCRP was positively correlated with stent restenosis( P<0 .05) .[Conclusion]OSA promotes coro‐nary stent restenosis of patients with ACS .The mechanism may be that hypoxemia caused by AHI in OSA pa‐tients promotes the increasing of plasma hsCRP ,which leads to aggravate vascular endothelial inflammation and raise the occurrence of in‐stent restenosis . 2014 Vol. 31 (11): 2098-2100 [Abstract] ( 59 ) HTML (1 KB)  PDF  (0 KB)  ( 30 ) 2101 Effect of Morphine Postconditioning on Myocardial Mitochondrial Permeability Transition Pore of Rats with Myocardial Ischemia-reperfusion Injury ZHANG Li%YUAN Jun%LI Jin Objective] To observe the effect of morphine postconditioning on myocardial mitochondrial permeability transition pore(MPTP) in male rats with myocardial ischemia‐reperfusion injury .[Methods]A total of 48 S‐D male rats with weight 170~260g were randomly divided into sham operation group(group C) , ischemia reperfusion group(I/R group) ,morphine postconditioning group(MP group) and morphine plus at‐ractyloside group(MAP group) with 12 rats in each group .Myocardial ischemia/reperfusion injury model was established by ligation of remus descendens anterior arteriae coronariae sinistrae for 30min and reperfusion for 90min .After reperfusion ,myocardial cell structure was observed by HE staining method .The percentage of myocardial infarction area/infarction ischemia area(IS/AAR) ,myocardial malondialdehyde(MDA) in myocar‐dium were measured .[Results] Compared with I/R group ,hemodynamics of MP group were markedly im‐proved ,and IS/AAR% and MDA content were markedly increased .[Conclusion] Morphine postconditioning can significantly attenuate myocardial ischemia‐reperfusion injury .MPTP may be the action pathway of mor‐phine postconditioning for protecting the myocardium . 2014 Vol. 31 (11): 2101-2107 [Abstract] ( 67 ) HTML (1 KB)  PDF  (0 KB)  ( 38 ) 2104 Analysis of the Correlation Between Insulin Resistance and the Incidence of Obesity-associated Nephropathy FENG Shao-ming%PEI Rong-guang%HAO Yu-jie Objective] To explore the correlation between insulin resistance and the incidence of obesity‐associated nephropathy(ORG) .[Methods]A total of 88 obese patients receiving routine renal function detection in our hospital from March 2010 to March 2014 were chosen .According to test results ,32 patients with nor‐mal renal function were taken as group A ,while 56 patients with kidney disease were taken as group B .Ac‐cording to treatment results after 8 weeks ,group B was divided into group B1( n=32 ,the group with signifi‐cantly improved renal function) and group B2( n=24 ,the group without obviously improved renal function) . The lipid related indicators ,renal function ,blood sugar and blood pressure of the two groups at medical exam‐ination and after 8 weeks of treatment were detected .[Results]Total cholesterol(TC) ,triglyceride(TG) ,24‐hour urinary protein excretion(24h‐UP) ,blood urea nitrogen(BUN) ,fasting blood glucose(FBG) ,2‐hour postprandial glucose(2h‐PBG) ,fasting insulin(FINS) ,insulin resistance index(HOMA‐IR) and mean arterial pressure (MAP) in group B were higher than those in group A ,while creatinine clearance rate (CCR) and high‐density lipoprotein cholesterol(HDL‐C) in group B were lower than those in group A ,and there were sig‐nificant differences( P <0 .05) .The TC ,TG ,24h‐UP ,BUN ,FBG ,HOMA‐IR and MAP in group B1 were lower than those in group B2 ,while CCR in group B1 was obviously higher than that in group B2 ,and there were significant differences( P <0 .05) .Pearson correlation analysis showed that HOMA‐IR and MAP of pa‐tients were positively correlated with 24h‐UP and BUN( P<0 .05) ,but negatively correlated with CCR( r =-0 .159 ,-0 .368 ,P <0 .05)[Conclusion]The increasing of HOMA‐IR and MAP is an important cause of ORG ,and may point out a new direction of the treatment of the disease . 2014 Vol. 31 (11): 2104-2107 [Abstract] ( 72 ) HTML (1 KB)  PDF  (0 KB)  ( 46 ) 2108 Analysis of the Relationship Between HBV cccDNA and HBV Replication Level in Liver Tissues HUA NG Wei-liang%XU Dan%XIE Yuan-lin Objective]To explore the relationship of hepatitis B virus(HBV) cccDNA with serum HBV DNA and HBeAg in liver tissues of patients with hepatitis B .[Methods]HBV cccDNA and serum HBV DNA in liver tis‐sues of patients with hepatitis B were detected by real‐time fluorescence quantitative polymerase chain reaction ,and serum HBeAg was detected by chemiluminescence method .[Results]HBV cccDNA in liver tissue was positively cor‐related with serum HBV DNA( r=0 .806 ,P<0 .01) ,but was not correlated with serum HBeAg( r=0 .219 ,P<0 .05) .[Conclusion]Virus replication in serum HBeAg positive group is more active than that in serum HBeAg nega‐tive group .Negative HBVDNA can not fully reflect HBV replication in liver tissues ,but the detection of HBV cccD‐NA in liver tissues can accurately reflect the replication of intrahepatic HBV . 2014 Vol. 31 (11): 2108-2110 [Abstract] ( 90 ) HTML (1 KB)  PDF  (0 KB)  ( 49 ) 2110 Significance of PLT-F Channel in the Determination of Low-count Platelet Objective] To explore the significance of PLT‐fluorescence(PLT‐F) channel in the determination of low‐count platelet .[Methods]Totally 103 patients with low‐count platelet(≤50 × 109/L) were analyzed by PLT‐F channel with XN‐1000 automated hematology analyzer .Meanwhile ,NE‐2100 hematology analyzer and hand‐made microscopic count method were used for the detection .The data were analyzed with straight line correlation regression analysis .[Results] The CV value of reproducibility of low‐count platelet in XE2100 PLT‐I ,PLT‐O and PLT‐F channels were 6 .7~16 .5% ,7 .1~15 .6% and 4 .9~9 .5% ,respectively .The coefficient correlation(r) of PLT‐I , PLT‐O and PLT‐F by hand‐made microscopic count reference method were 0 .900 ,0 .929 and 0 .959 ,respectively .[Conclusion] PLT‐F channel in the determination of low‐count platelet has good accuracy and high application value . 2014 Vol. 31 (11): 2110-2112 [Abstract] ( 87 ) HTML (1 KB)  PDF  (0 KB)  ( 36 ) 2113 Clinical Observation on Combined Treatment of Traditional Chinese Medicine and Western Medicine for the Treatment of Cesarean Scar Pregnancy WU Jing%GONG Ying-ping Objective]To explore clinical efficacy of combined treatment of traditional Chinese medicine and Western medicine for the treatment of cesarean scar pregnancy .[Methods]Clinical data of patients with unruptured cesarean scar pregnancy hospitalized in maternal and child health hospital of Hunan province from May 2010 to Dec . 2012 were analyzed retrospectively and divided into control group and observation group .The control group( n=24) underwent clearing the pericardium under hysteroscopy after simple MTX treatment .The observation group( n =101) underwent clearing the pericardium under hysteroscopy after traditional Chinese medicine combined with MTX treatment .The treatment success rate ,average decline speed of serum human chorionic gonadotropin(β‐HCG) and u‐terine heterogeneous echo volume and adverse reaction of two groups were compared and analyzed .[Results]The first success rate of clearing the pericardium in observation group was obviously higher than that in control group ,and there was significant difference( P<0 .05) .The rates of laparotomy or water sac compression for vaginal hemorrhea in observation during the operation were lower than those in control group ,and there was significant difference( P>0 .05) .The average decline speed ofβ‐HCG in observation group was obviously faster than that in control group( P<0 .05) .There was no significant difference in average decline speed of uterine heterogeneous echo volume between two groups( P>0 .05) .There was no significant difference in the incidence of adverse reaction between two groups( P>0 .05) .[Conclusion] The success rate and the average decline speed ofβ‐HCG in observation group receiving the combined treatment of traditional Chinese medicine and Western medicine are better than simple Western medicine treatment .Therefore ,the combined treatment of traditional Chinese and Western medicine is worthy to be popular‐ized . 2014 Vol. 31 (11): 2113-2115 [Abstract] ( 17 ) HTML (1 KB)  PDF  (0 KB)  ( 39 ) 2116 Analysis on the Correlation Between Homocysteine Level and Early Pregnancy Abortion Objective] To explore the correlation of homocysteine(HCY) level with polycystic ovary syn‐drome(PCOS) and early pregnancy abortion(EPL) .[Methods]Totally 123 patients with PCOS including 65 patients with one or more than one abortion within 12 weeks(PCOS abortion group) and 58 patients with nor‐mal pregnant history(PCOS non‐abortion group) were collected .Other 147 patients with one or more than one abortion within 12 weeks but without PCOS (non‐PCOS abortion group) were selected in the same period . HCY level was detected by enzymatic cycling method and compared among 3 groups .[Results] The level of HCY in PCOS abortion group was obviously higher than that in PCOS non‐abortion group and non‐PCOS abor‐tion group ,and that in non‐PCOS abortion group was markedly higher than that in PCOS non‐abortion group , and there was significant difference( P<0 .05) .[Conclusion]High HCY level is a risk factor for EPL and can be used as the indicator of early pregnancy outcome . 2014 Vol. 31 (11): 2116-2118 [Abstract] ( 54 ) HTML (1 KB)  PDF  (0 KB)  ( 40 ) 2118 Relationship Between Early-onset Preeclampsia and Pregnancy Outcome and the Analysis of the Related Factors Objective] To explore the relationship between early‐onset (< 34 weeks of gestation) pre‐eclampsia and pregnancy outcome in order to identify the associated factors of early‐onset preeclampsia .[Methods]Clinical data of 25360 pregnant and lying‐in women who were enrolled in the study of gynecological and obstetrical department in our hospital from Jan .2008 to Jan .2013 were analyzed retrospectively .The cor‐related factors of early‐onset preeclampsia were analyzed .The influence on pregnancy outcome was analyzed .[Results] There were 96 pregnant women with early‐onset preeclampsia(0 .37% ) .Among them ,12 women delivered after 34 weeks of gestation .The maternal age(≥35 years old ,P=0 .006 ,95% CI ,1 .309~5 .135) , primiparity( P ≤0 .001 ,95% CI ,2 .525~5 .052) ,diabetes mellitus( P ≤0 .001 ,95% CI ,2 .029~8 .669) , chronic hypertension( P ≤0 .001 ,95% CI ,9 .112~37 .303) and congenital anomalies( P ≤0 .001 ,95% CI , 2 .632~11 .222) were high risk factors of early‐onset preeclampsia .The poor outcome in women with early‐onset preeclampsia was severer than that in women without early‐onset preeclampsia .The factors associated with the fatality of neonates were fetal death ,small for gestational age infant and perinatal death .[Conclu‐sion]Based on the correlated factors and possible pregnancy outcome of early‐onset preeclampsia ,the condition of pregnant and lying‐in women can be distinguished as early as possible ,and the pregnancy outcome can be prevented and intervened . 2014 Vol. 31 (11): 2118-2120 [Abstract] ( 61 ) HTML (1 KB)  PDF  (0 KB)  ( 34 ) 2121 Effect of Morning Peak Blood Pressure on Carotid Atherosclerosis in Essential Hypertension Patients with Normal EF% and Its Correlation with Hcy and UmAlb Objective]To observe the effect of morning peak blood pressure on carotid atherosclerosis ,homocysteine(Hcy) and u‐rinary microalbumin(UmAlb) in essential hypertension patients with normal left ventricular ejection fraction(EF% ) ,and to explore the role of Hcy and UmAlb in carotid atherosclerosis caused by morning blood pressure .[Methods]The 24h ambulary blood pressure moni‐toring(ABPM) was used to monitor blood pressure in 190 cases of essential hypertension with normal EF% .According to morning peak blood pressure ,all patients were divided into group A(normal morning peak blood pressure ,n=90) and group B(increased morn‐ing peak blood pressure ,n=107) .Doppler ultrasound was performed in each patient to measure left and right sides of common carotid artery diameter(LCCAd and RCCAd) ,internal carotid artery diameter(LICAd and RICAd) ,common carotid artery intima‐media thick‐ness(LCA‐IMT and RCA‐IMT) and determine whether left and right carotid artery plaque was formed .The mean carotid artery diame‐ter(CCAdM) ,mean internal carotid artery diameter(ICAdM) ,mean common carotid artery intima‐media thickness(CCA‐IMTM) of two sides and the number of patients with carotid atherosclerosis plaque were calculated .The fasting venous blood of patients within 24h on admission was collected .OLYMPUS AU640 automatic biochemical analyzer was used to detect Hcy ,UmAlb ,blood lipids and other indicators .[Results]There was no significant difference in 24h‐,daytime and nighttime mean systolic blood pressure(SBP) and diastolic blood pressure(DBP) and 24h mean arterial pressure(MAP) between group A and group B( P>0 .05) .The carotid athero‐sclerosis parameters and number of patients with carotid atherosclerosis plaque in group B were obviously higher than those in group B , and there was significant differenc( P<0 .05) .The levels of Hcy and UmAlb in group B were obviously higher than those in group A , and there was significant difference( P<0 .05) .Morning peak blood pressure was significantly correlated with carotid atherosclerosis parameters ,Hcy and UmAlb( P<0 .05) .There was strongest correlation between morning peal blood pressure and CCA‐IMTM( r=0 .623 ,P=0 .000) .[Conclusion]Morning peak blood pressure is of great significance in carotid atherosclerosis in essential hyperten‐sion patients with normal EF% ,and closely correlated with Hcy and UmAlb .It suggests that the control of morning peak blood pres‐sure is an important process of the diagnosis and treatment of essential hypertension . 2014 Vol. 31 (11): 2121-2124 [Abstract] ( 51 ) HTML (1 KB)  PDF  (0 KB)  ( 36 ) 2125 Clinical Analysis of 46 Cases of Early-onset Preeclampsia ZHA NG Qian Objective]To explore clinical characteristics of early‐onset preeclampsia .[Methods]A total of 46 cases of early‐onset preeclampsia(onset gestational age<34 weeks)(group A) ,45 cases of late‐onset pre‐eclampsia(onset gestational age≥34 weeks)(group B) ,30 cases of normal pregnant women(gestational age<34 weeks)(group C) and 30 cases of normal pregnant women(gestational age≥34 weeks)(group D) were cho‐sen .Serum total protein(TP) ,hemoglobin(Hb) and haematocrit(HCT) in each group were examined and compared .[Results]TP ,Hb and HCT in group A were markedly lower than those in group B ,while those in group A were markedly lower than those in group C ,and there was significant different( P < 0 .05) .There was no significant difference in serum TP ,Hb and HCT between group C and group D( P >0 .05) .[Conclu‐sion]Early‐onset preeclampsia may be related to hypoproteinemia and anemia .Improving nutrition status can reduce the incidence of early‐onset preeclampsia . 2014 Vol. 31 (11): 2125-2129 [Abstract] ( 24 ) HTML (1 KB)  PDF  (0 KB)  ( 44 ) 2127 Observation on the Efficacy of Labor Analgesia with Intraspinal Anesthesia and DOULA Instru-ment in Maternal Delivery LI Xin-rong%HAN Gui-qin%TENG Ping Objective] To explore the application value of labor analgesia with intraspinal anesthesia and DOU‐LA instrument in maternal delivery .[Methods]Totally 364 pregnant women with single birth and normal full term and without high‐risk factors such as cephalopelvic disproportion in our hospital were chosen .According to the will , all pregnant women were divided into 3 groups .Among them ,122 pregnant women with intraspinal anesthesia were selected as spinal group ,and 118 pregnant women with DOULA instrument were selected as DOULA instrument group ,and 124 pregnant women without labor analgesia were selected as control group .The analgesia efficacy ,deliv‐ery method ,labor duration ,Apgar score and postpartum hemorrhage volume of parturients were observed .[Results]The vaginal normal rate of DOULA instrument group was 54 .23% (64/118) ,which was higher than that of spinal group(42 .62% ,52/122) and control group(41 .12% ,51/124)( P < 0 .05) .The vaginal delivery rate of spinal group was 24 .59% (30/122) ,which was higher than that of DOULA instrument group and control group( P <0 .05) .The cesarean section rate of control group was 44 .35% (55/124) ,which was higher than that of spinal group and DOULA instrument group( P<0 .05) .The active stage duration of first labor stage and second labor stage dura‐tion of DOULA instrument group were (105 .35 ± 31 .55)min and (39 .11 ± 16 .34)min respectively ,which were shorter than those of spinal group[(163 .42 ± 33 .2)min and (50 .06 ± 19 .39)min] and control group[(331 .25 ± 35 .40)min and (87 .96 ± 31 .50)min]( P <0 .05) .The active stage duration of first labor stage and second labor stage duration of spinal group were shorter than those of control group( P <0 .05) .The mean VAS score of spinal group was (3 .01 ± 0 .87) ,which was lower than that of DOULA instrument group[(4 .24 ± 0 .91)] and control group[(6 .13 ± 1 .03)] ,and that of DOULA instrument group was lower than that of control group( P <0 .05) .[Conclusion]Labor analgesia with intraspinal anesthesia and DOULA instrument have satisfactory efficacy and can promote spontaneous delivery and reduce the rate of cesarean section without any adverse effect for mother and infant . 2014 Vol. 31 (11): 2127-2129 [Abstract] ( 71 ) HTML (1 KB)  PDF  (0 KB)  ( 41 ) 2130 Observation on the Efficacy of Anterior Traction Therapy for Osseous Class Ⅲ Malocclusion in Children at Dental Transitional Period JING Yu-ying%ZHOU Yan-heng Objective] To explore the efficacy of anterior traction therapy for osseous class Ⅲ malocclusion in chil‐dren at dental transitional period .[Methods] A total of 80 pediatric patients with osseous class Ⅲ malocclusion in dental transitional period at orthodontic department were chosen .According to the severity ,all patients were divided into treat‐ment group and control group with 40 patients in each group .The treatment group underwent anterior traction therapy , while the control group was not given any therapy during the observation .X‐ray lateral projection of cranium was per‐formed in treatment group and control group .The relevant indexes of variables at mandible plane and sagittal level inclu‐ding upper dental alveolus bed(SNA) angle ,bottom dental alveolus bed(SNB) angle ,ANB angle(the difference between SAN angle and SNA angle) ,face angle(FH‐NP) ,vertical distance between AH point and palatal plane(FH‐PP) ,cross angle of upper central incisor long axis to subspinale line(U1/NA) ,the distance between upper central incisor border and the line of nasal point to subspinale(U1‐NA) ,cross angle of long axis of inferior central incisor and NB line(L1/NB) and the distance of long axis of inferior central incisor and NB line(L1‐NB) were measured .[Results]Compared with the con‐trol group ,the SNA angle in treatment group was increased by 1 .370( P < 0 .05) ,and SNB angle was decreased by 1 .800 ,and ANB angle was increased to 3 .390( P <0 .05) ,but FH‐NP and FH‐PP were decreased( P <0 .05) ,and U1/NA was increased by 2 .13mm and increased to 3 .03mm( P<0 .05) ,and L1/NB was reduced by 3 .890 and reduced to 0 .86mm( P<0 .05) .The average amount of rotation of the treatment group and control group was 0 .82 and -0 .66 , respectively .[Conclusion] After anterior traction therapy for patients with osseous class Ⅲ malocclusion in dental transi‐tional period ,the mandible of patients has clockwise rotation ,and the maxillary mandibular relation is more concordant , and facial appearance is greatly improved than before . 2014 Vol. 31 (11): 2130-2132 [Abstract] ( 23 ) HTML (1 KB)  PDF  (0 KB)  ( 31 ) 2133 Clinical Application of Pentazocine Combined with Flurbiprofen in Multimodal Analgesia after Laparoscopic Gynecologic Surgery Objective] To explore clinical application efficacy of pentazocine combined with flurbiprofen in multimodal analgesia after laparoscopic gynecologic surgery .[Methods]A total of 70 ASA Ⅰ ~ Ⅱ patients under‐going laparoscopic gynecologic surgery were randomly divided experimental group and control group .The experi‐mental group received intravenous continuous analgesia with pentazocine and flurbiprofen postoperatively . The control group only received intravenous continuous analgesia with pentazocine postoperatively .Visual analogue scale(VAS) score and Bruggrmann comfort scale(BCS) were used to assess the analgesia effect .The incidence of postoperative adverse reaction ,postoperative dose of pentazocine ,patients controlled analgesia(PCA) and compre‐hensive satisfaction score in two groups were compared .[Results]At 6~48h after operation ,VAS scores in two groups were gradually reduced with the time delay ,while BCS scores were gradually increased with the time delay . Compared with the control group ,the scores in the experimental group at each time point were markedly decreased or increased( P <0 .05) .The stage dose of pentazocine at 8h ,12h ,l6h ,20h and 24h and the total amount of pen‐tazocine at 0~12 ,0~24 ,0~36 and 0~48h in experimental group were less than those in control group( P <0 .05) .There was no significant difference in the incidence of adverse reaction between experimental group and control group .PCA satisfaction scores in experimental group were markedly higher than those in control group( P<0 .05) .[Conclusion]Pentazocine combined with flurbiprofen for multimodal analgesia after laparoscopic gyneco‐logic surgery is better than simple pentazocine .Multimodal analgesia can improve postoperative analgesia effect , reduce pentazocine consumption and increase hospitalization satisfaction of patients . 2014 Vol. 31 (11): 2133-2136 [Abstract] ( 72 ) HTML (1 KB)  PDF  (0 KB)  ( 29 ) 2136 Experience of Emergency Treatment for Patients with Diabetic Ketoacidosis Complicated with Hyperglycemic Hyperosmolar Status CAI Rui-yu Objective] To explore the methods of emergency treatment for patients with diabetic ketoaci‐dosis(DKA) complicated with hyperglycemic hyperosmolar status(HHS) .[Methods] The methods of emer‐gency treatment for 15 patients with DKA complicated with HHS were analyzed retrospectively .[Results]Af‐ter clinical treatment ,4 patients died of respiratory failure ,heart failure ,renal failure and myocardial infarc‐tion ,respectively .After effective treatment for 2~5 days ,the effective plasma osmotic pressure of 11 patients decreased to the normal range ,and urine acetone bodied became negative ,and dehydration was corrected ,and electrolytes recovered .After 1~3 day of treatment again ,the coma ,drowsiness and others symptoms had dis‐appeared and the condition of patients was stable .[Conclusion] Patients with DKA complicated with HHS should be diagnosed as early as possible .Active treatment is effective . 2014 Vol. 31 (11): 2136-2139 [Abstract] ( 20 ) HTML (1 KB)  PDF  (0 KB)  ( 33 ) 2140 Analysis of the Correlation Between Metabolic Syndrome and BPH in Middle and Old-aged Men ZHU Bo%LI Meng Objective] To explore the correlation between metabolic syndrome and benign prostatic hyperplasia (BPH) in middle and old‐aged men .[Methods] Totally 151 middle and old‐aged men(≥50 years old) in physical exami‐nation center of our hospital from May 2008 to July 2013 were chosen .The general examinations included age ,height , weight ,blood pressure ,past history and IPSS score .The laboratory tests included fasting blood glucose ,blood lipids and PSA .The image test was transrectal ultrasound for measuring prostate volume .Urine flow rate(QMax) was measured . The incidence of BPH between metabolic syndrome and non‐metabolic syndrome was compared .The correlation of factors in metabolic syndrome with BPH was analyzed .[Results]According to examination results ,all cases were divided into metabolic syndrome group( n =37) and non‐metabolic syndrome group( n =114) .The incidence of BPH in metabolic syndrome group and non‐metabolic syndrome was 32 .4% (12/37) and 12 .3% (14/114) ,respectively .There was signifi‐cant difference in IPSS ,prostate volume and PSA between two groups( P<0 .05) .There was no significant difference in QMax between two groups( P=0 .071) .Obesity ,hyperlipidemia and diabetes mellitus were the risk factors of BPH(OR=1 .72 ,3 .31 ,2 .07 ,P=0 .042 ,0 .029 ,0 .046) .[Conclusion]The morbidity of BPH in patients with metabolic syn‐drome is higher .IPSS ,prostate volume and PSA are the main influential factors of BPH patients .Obesity ,hyperlipi‐demia and diabetes are the risk factors of BPH . 2014 Vol. 31 (11): 2140-2142 [Abstract] ( 66 ) HTML (1 KB)  PDF  (0 KB)  ( 35 ) 2143 Changes of the Expression Profile of MicroRNA in Cardiomyocytes of Neonate Rats Induced by Hy-poxia Preconditioning Objective]To analyze the changes of miRNA expression profile in cardiomyocytes of neonate rats after hypoxia preconditioning ,and to explore the mechanism of hypoxia preconditioning and therapeutic target .[Methods]Pri‐mary cardiomyocytes of neonate rats were cultured .Survival rate of rat cardiomyocytes and lactate dehydrogenase(LDH) level were detected after hypoxia preconditioning and hypoxia reoxygenation .The expression profiles of miRNA in normal and hypoxia preconditioned cardiomyocytes were detected by miRNA genetic chip .The results were verified by real‐time quantitative polymerase chain reaction(PCR) ,and the biological function of miRNA significantly differentially expressed were analyzed .[Results]The successful establishment of hypoxia preconditioning models was verified by the results of sur‐vival rate of rat cardiomyocytes and LDH levels .The miRNA chip detection results showed that 6 miRNAs in hypoxia preconditioned cardiomyocytes were up‐regulated and 5 miRNAs were down‐regulated in comparison with normal cardio‐myocytes .The biological function of some miRNAs was related to cardiovascular function .[Conclusion]Hypoxia precon‐ditioning leads to the changes of miRNA expression profile which may serve as potential targets for the treatment of hy‐poxia reoxygenation injury . 2014 Vol. 31 (11): 2143-2146 [Abstract] ( 61 ) HTML (1 KB)  PDF  (0 KB)  ( 34 ) 2146 Relationship Between Infectious Mononucleosis and Various Pathogen Infection ZHAO Meng-hua%ZHONG Li-li Objective]To explore the relationship between clinical features of infectious mononucleosis(IM ) in chil‐dren and the diversity of pathogen infection .[Methods]A total of 211 pediatric patients diagnosed as IM in our hospital were analyzed retrospectively and divided into less than 3 years old group ,3~6 years old group and 6~13 years old group .[Results] Pediatric patients with age ≤ 3 years old ,3~6 years old 6~13 years old accounted for 63 .9% , 24 .2% and 11 .9% ,respectively .The 96 patients with single pathogen infection accounted for 45 .5% ,and 108 patients with mixed pathogen infection accounted for 51 .2% ,and 7 patients with unknown pathogen accounted for 3 .3% .The symptoms of pediatric patients with mixed pathogen infection were more and even severe .After antiviral and combination therapy ,all pediatric patients were cured and discharged from hospital .[Conclusion] IM is commonly seen in children with age ≤ 3 years old .EB virus is the most common pathogen of IM in pediatric patients .The mixed pathogen infection is the majority and even severe .Combination therapy is effective for pediatric patients with mixed infection . 2014 Vol. 31 (11): 2146-2148 [Abstract] ( 53 ) HTML (1 KB)  PDF  (0 KB)  ( 37 ) 2149 Clinical Significance of Noninvasive Intracranial Pressure Monitoring in Moderate Brain Injury Objective] To explore clinical application value of noninvasive intracranial pressure monitoring in moderate brain injury .[Methods]A total of 29 patients with moderate brain injury receiving expectant treatment in our hospital were randomly divided into 2 groups .According to the condition after trauma ,the monitoring group( n=15) received intracranial pressure and mean arterial blood pressure monitoring per 6h in order to understand the change of cerebral perfusion pressure(CPP) ,and then were given mannitol with CPP at 60~80mmHg once per 6~8h according to intracranial pressure monitoring state .The dynamic change of intracranial pressure in monitoring group was recorded .Control group( n =14) received conventional therapy i .e .intravenous injection with 20 mannitol 125~250mL once per 6~8h ,and stopped mannitol according to clinical symptoms or was given CT or further therapy according to clinical symptoms and pupil change .[Results]In monitoring group ,the average hospitalization day was 12 .6 ± 2 .10d ,and the duration and dose of mannitol were 7 .6 ± 1 .59d and 5713 .3 ± 1291 .75ml ,respectively .In control group ,the average hospitalization day was 18 .71 ± 1 .33d ,and the duration and dose of mannitol were 15 ± 1 .22d and 9653 .57 ± 1371 .75 mL ,respectively .There were signifi‐cantly differences between two groups( P<0 .05) .The moderate disability rate in monitoring group and control group were 6 .67%and 28 .57% respectively ,and there was significant difference between two groups .No turnover below severe disability in two groups was found .Abnormal renal function rate in monitoring group and control group was 13 .30% and 21 .40% respectively ,but there was no significant difference between two groups( P>0 .05) .[Conclusion]Noninvasive intracranial pressure monitoring is helpful to guide physicians use mannitol reasonably .CPP at 60~80mmHg maintained by noninvasive intracranial pressure monitoring can improve the prognosis and shorten hospital stay of patients .Persistent noninvasive monitoring for patients with moderate brain injury is of vital sig‐nificance in guiding the treatment ,improving the prognosis and increasing the efficacy .Therefore ,it has high clinical value . 2014 Vol. 31 (11): 2149-2152 [Abstract] ( 26 ) HTML (1 KB)  PDF  (0 KB)  ( 49 ) 2153 Discussion on the Effect of COPD on Phrenic Nerve Discharge and Respiratory Motion in Rat GAO Rui Objective] To explore the effect of chronic obstructive pulmonary disease(COPD) on phrenic nerve discharge and respiratory movement in rat .[Methods]Totally 60 Wistar rats were randomly divided into two groups with 30 in each group .In experimental group ,COPD model was established by incense combined with porcine trypsin endotracheal instillation .In control group ,incense was not given ,but normal saline 20u/100g was instilled in trachea on d15 .The duration ,amplitude and interval of rats in each group were recorded and compared .[Results]Compared with control group ,the amplitude of phrenic nerve discharge in experimen‐tal group was increased ,and there was significant difference( P <0 .05) .There was no significant difference in the duration ,interval and area of phrenic nerve discharge between two groups ( P > 0 .05) .Inspiratory phase time was positively correlated with phrenic nerve discharge activity in two groups .[Conclusion] COPD can influence of phrenic nerve discharge and respiratory movement ,enhance phrenic nerve discharge activity in rat and has the phenomenon such as the increasing of inspiration driving in respiratory center ,which indicates that the activity of respiratory center in rat may be changed . 2014 Vol. 31 (11): 2153-2155 [Abstract] ( 78 ) HTML (1 KB)  PDF  (0 KB)  ( 47 ) 2155 Change and Significance of Thyroid Hormones in Children with Hand Foot Mouth Disease Infected by Enterovirus 71 Objective] To explore the change of serum triiodothyronine(T3 ) ,thyroxine(T4 ) ,thyroid stimulating hormone(TSH) ,free T3(FT3 ) and free T4(FT4 ) in children with hand foot mouth disease(HFMD) .[Methods]A total of 81 children with HFMD infected by enterovirus 71(EV71) in feces detected by RT‐PCR were divided into common type group( n=22) ,severe type group( n=19) and critically severe type group( n=40) .Serum levels of thyroid hormones T3 ,T4 ,FT3 ,FT4 and TSH of 3 groups were detected by chemiluminescence method .[Results]There was no significant difference in serum levels of T3 ,T4 ,FT4 ,FT3 and TSH among 3 groups( P>0 .05) .[Conclusion]Serum levels of thy‐roid hormones in children with HFMD infected by EV71 is not associated with the severity of disease . 2014 Vol. 31 (11): 2155-2156 [Abstract] ( 54 ) HTML (1 KB)  PDF  (0 KB)  ( 45 ) 2157 Comparison of the Long-term Efficacy of Simple Interbody Fusion vs .Metal Interbody Fusion in Elderly Patients with Lumbar Intervertebral Disc Protrusion Objective] To compare clinical efficacy of metal interbody fusion and bone graft(Cage) vs .interbody fu‐sion and bone graft for postoperative intervertebral stability of elderly lumbar intervertebral disc protrusion .[Methods]A total of 28 elderly patients with lumbar intervertebral disc protrusion were chosen .After discectomy ,15 patients (19 discs) underwent Cage implementation(group A) ,while 13 patients(17 discs) underwent simple interbody fusion and bone graft(group B) .X‐ray film and CT slice result of patients 1 week ,6 and 24 months after operation were followed up and compared .The change of segmental intervertebral height was measured .The intervertebral stability between two methods was compared .[Results]The maintenance of intervertebral height in group A at 6 months after operation was better than that in group B ,but intervertebral height in group A at 24 months after operation was lower than that in group B .The fusion rate of group B after 2 years(88 .24% ) was higher than that in group A(84 .21% ) ,and there was signifi‐cant difference( P<0 .05) .[Conclusion] The lumbar stability of Cage implantation within 6 months after operation is better than simple interbody fusion and bone graft ,but long‐term efficacy is poorer . 2014 Vol. 31 (11): 2157-2159 [Abstract] ( 72 ) HTML (1 KB)  PDF  (0 KB)  ( 38 ) 2160 Clinical Study of Selegiline for the Treatment of Sleep Disorder in Early Parkinson Disease Objective] To explore clinical efficacy and safety of selegiline for the treatment of sleep disor‐der in early Parkinson disease(PD) .[Methods] Totally 90 patients with early PD treated by trihexyphenidyl , amantadine and vitamin E were randomly divided into selegiline group and estazolam group .On the basis of the unchanged dose of original drugs ,the former was additionally given selegiline tablet 5mg/d ,while the latter was additionally given estazolam 1mg/d .The course was 4 weeks .All patients were surveyed by Pittsburg sleep quality index(PSQI) questionnaire .The sleep condition before and after treatment was analyzed .Mean‐while ,routine laboratory indexes were detected before and after the addition of the drugs .The incidence of ad‐verse reaction was analyzed and compared .[Results] After treatment ,the PSQI score was significantly im‐proved ,and there was significant difference between before and after treatment( P<0 .01) .There was no sig‐nificant difference in PSQI score after treatment between selegiline group and estazolam group( P > 0 .05) . There were significant differences in the scores of 3 factors(sleep quality ,daytime function and hypnotic drug) in PSQI after treatment between two groups( P <0 .05) .The incidence of adverse reaction in selegiline group and estazolam group was 17 .8% and 36 .9% respectively ,and there was significant difference between two groups( P <0 .05) .The incidence of drowsiness and orthostatic hypotension in selegiline group was signifi‐cantly lower than that in estazolam group( P<0 .01) .[Conclusion]Selegiline for the treatment of sleep disor‐der in PD is safe and effective .Selegiline for reducing hypnotic drug and improving sleep quality of PD patients is obviously superior to estazolam ,so it is worthy of clinical promotion . 2014 Vol. 31 (11): 2160-2162 [Abstract] ( 69 ) HTML (1 KB)  PDF  (0 KB)  ( 43 ) 2163 Arthroscopic Treatment with Keeping Coracoacromial Ligament for Subacromial Impingement Syn-drome Objective] To explore the clinical results of arthroscopic subacromial decompression with keeping cora‐coacromial ligament for the treatment of subacromial impingement syndrome .[Methods]A total of 30 patients with sub‐acromial impingement syndrome received clinical therapy from Jan .2010 to June 2013 .Surgical procedure was as follows:subacromial bursa was removed with electric‐planer ,and the leading edge of acromion was grinded by burr ,and cora‐coacromial ligation was kept during the operation ,and acromioclavicular joint was explored and osteophytes were resected , and patients with the indication of rotator cuff tear was repaired with anchors .Shoulder function of patients was assessed with UCLA(university of California at Los Angeles) score .[Results] The mean follow‐up time was 16 .8 months(7~25 months) .All complete follow‐up data were collected .The mean preoperative and postoperative UCLA score was (16 .15 ± 2 .13) and (31 .85 ± 2 .57) ,respectively .The excellent and good rate was 89 .1% .There was significant difference in the scores between before and after operation( t=36 .09 ,P<0 .01) .[Conclusion]Arthroscopic subacromial decompres‐sion with keeping the coracoacromial ligament is an effective method for the treatment of subacromial impingement syn‐drome .It has the advantages such as simple operation ,low cost ,less bleeding ,small trauma ,good shoulder stability and fast recovery . 2014 Vol. 31 (11): 2163-2165 [Abstract] ( 22 ) HTML (1 KB)  PDF  (0 KB)  ( 39 ) 2166 Circumferential Approach Combined with Posthioplasty for the Treatment of Concealed Penis Objective]To explore the efficacy of circumferential approach combined posthioplasty for the treatment of concealed penis .[Methods]Clinical data of 29 patients with concealed penis undergoing circumfer‐ential approach combined posthioplasty from 2010 to 2013 were analyzed retrospectively .The age was 3~18 years old[(9 .2 ± 2 .7) years old] .The penile length was (1 .8 ± 0 .6)cm(0 .5~3 .2cm) before operation .A‐mong them ,13 patients were the severe degree and 16 patients were moderate degree .There were 23 patients with phimosis and 16 patients with obvious obesity .[Results] The penile length after circumferential approach combined posthioplasty was increased by (2 .5 ± 0 .3)cm .Balanus exposure was good .No refractory penile hydroderma was observed after operation .[Conclusion]The formation of concealed penis is related to congenital abnormality of superficial fascia of penis skin .Circumferential approach is simple method ,and posthioplasty is the key to prevent refractory penile hydroderma . 2014 Vol. 31 (11): 2166-2168 [Abstract] ( 63 ) HTML (1 KB)  PDF  (0 KB)  ( 37 ) 2168 Experience in Surgical Treatment of 12 Patients with Ankylosing Spondylitis and Spinal Fracture Objective] To explore the treatment method of ankylosing spondylitis combined with spinal fracture and its clinical efficacy .[Methods]Clinical data of 12 patients with ankylosing spondylitis and spinal fracture in our hospital from Jan .2010 to Dec .2012 were analyzed retrospectively .The 3 patients with lower cervical spinal fracture underwent the combination operation via anterior and posterior cervical vertebrae under general anesthesia .The 9 patients with thora‐columbar fracture underwent posterior incision and long segmental pedicle screw rod fixation .[Results]Among the 12 pa‐tients after rescue operation ,11 patients were treated successfully in which 1 patient died for invalid rescue ,and the mor‐tality rate was 8 .33% .More than 11 patients were followed up for 1 .5 years in which 1 patient died of respiratory fail‐ure ,and the 1 .5‐year survival rate was 90 .91% .The 10 patients received X‐ray examination 1 year after operation .Ac‐cording to Frankel classification ,neural function of 2 patients with grade D and 1 patient among 3 patients with grade C after operation recovered to the normal ,and 1 patient progressed to grade D ,and 1 patient with grade B progressed to grade C after operation .Preoperative VAS score was 7~9 points with an average of 8 .1 points ,and postoperative VAS score was 0~4 points with an average of 2 .3 points .X‐ray examination showed that bone graft site of all survival patients with fracture had fusion without obvious instability ,fixture loosening and breaking .[Conclusion] Surgical treatment of ankylosing spondylitis complicated with spinal fractures can achieve good efficacy ,so it is worthy of clinical promotion . 2014 Vol. 31 (11): 2168-2170 [Abstract] ( 63 ) HTML (1 KB)  PDF  (0 KB)  ( 47 ) 2171 Clinical Analysis of 106 Cases of Infant Vitamin K Deficiency Bleeding Objective]To explore the sensitive index indicating organism nutrition of vitamin K ,and to an‐alyze the reasonable dosage of vitamin K for the treatment of infant vitamin K deficiency bleeding (VKDB) .[Methods]Prospective cohort study method was used from Sept .2009 to Sept .2013 .Venous blood of 106 in‐patients with VKDB was collected .Enzyme‐linked immunosorbent assay was used to determine prothrombin precursor protein (PIVKA‐Ⅱ ) . Prothrombin time (PT ) , activated partial thromboplastin time (APTT ) , thrombin time(TT) and fibrinogen(FIB) were examined by using sysmex CA‐1500 coagulation analyzer .Then all pediatric patients were divided into 2mg vitamin K1 treatment group and 5mg vitamin K1 treatment group . The above indicators at 24h ,3d and 5d after intravenous drip of vitamin K1 were examined again .The changes of the above indicators before and 5d after treatment were compared .The change of PIVKA‐Ⅱ between 2mg group and 5mg group was also compared .[Results] There were significant differences in the abnormal rates of PT ,APTT and PIVKA‐ Ⅱ between before and after treatment(72 .6 vs .13 .2 ,70 .8 vs .32 .1 ,98 .1 vs .8 .5 , P <0 .05) .There was no significant difference in the abnormal rates of TT and FIB between before and after treatment( P >0 .05) .There was significant difference in PIVKA‐ Ⅱ level between 2mg group and 5mg group 24h after intravenous drip of vitamin K1 ( P <0 .05) ,while there was no significant difference 3d and 5d after treatment( P >0 .05) .[Conclusion]After the supplementation of vitamin K for pediatric patients with VKDB , the levels and abnormal rates of PIVKA‐ Ⅱ ,PT and APTT are improved obviously .PIVK‐ Ⅱ is the most sensitive index of the diagnosis and the curative effect monitoring of VKDB .Intravenous drip of vitamin K1 2mg daily for continuous 5 days is effective in the treatment of VKDB . 2014 Vol. 31 (11): 2171-2173 [Abstract] ( 58 ) HTML (1 KB)  PDF  (0 KB)  ( 24 ) 2174 Image Features of 295 Patients with Thyroid Nodules Undergoing the Surgery Objective] To explore the image features of 295 patients with benign and malignant thyroid nodules undergoing the surgery .[Methods]Clinical image data of 81 patients with thyroid cancer and 295 pa‐tients with benign thyroid nodules diagnosed by pathology after surgery were analyzed retrospectively .[Re‐sults] The incidence of microcalcification and calcification in 81 patients with thyroid cancer was obviously higher than that in patients with benign thyroid diseases( P<0 .05) .Among 109 patients with thyroid nodules and calcification ,the incidence of thyroid cancer in patients with age less than 45 years old was obviously high‐er than that in patients with age over 45 years old ,and there was significant difference( P<0 .05) .There was no significant difference in the calcification between male and female patients( P >0 .05) .There was signifi‐cant difference in malignant calcified nodules between single‐nodule patients and multiple‐nodule patients( P<0 .05) .[Conclusion] Thyroid nodules with microcalcification ,age less than 45 years old and single nodule have the high incidence of thyroid cancer . 2014 Vol. 31 (11): 2174-2178 [Abstract] ( 35 ) HTML (1 KB)  PDF  (0 KB)  ( 32 ) 2176 Observation on Clinical Efficacy of Nicorandil Combined with Isosorbide Mononitrate for the Treatment of Unstable Angina SHI Shun-hua%LIAO Chun-feng%FU Guang Objective] To explore clinical efficacy of nicorandil combined with isosorbide mononitrate for the treatment of unstable angina(UAP) .[Methods] A total of 76 patients with UAP in our hospital were ran‐domly divided into observation group( n =38) and control group( n =38) .All patients received conventional therapy including oral aspirin ,metoprolol tartrate tablets ,perindopril ,atorvastatin calcium tablets and so on . Moreover ,the control group received isosorbide mononitrate ,while the observation group was given nicorandil and isosorbide mononitrate based on the conventional therapy .Clinical efficacy ,dynamic electrocardiogram (ECG) changes and incidence of adverse reactions of 2 groups were observed .[Results] Total effective rate of observation group and control group was 94 .7% and 73 .7% respectively ,and there was significant difference between two groups( P <0 .05) .The improvement of ECG in observation group was higher than that in con‐trol group ,and there was significant difference( P>0 .05) .During the treatment ,light headache was found in 1 patient of observation group(2 .6% ) and 3 patients of control group(7 .89% ) ,but there was no significant difference( P > 0 .05) .During the treatment ,no obvious hypoglycemia and liver damage was found in two groups .[Conclusion]Nicorandil combined with isosorbide mononitrate for the treatment of patients with UAP is able to improve clinical symptoms and ECG ,and has good short‐term efficacy and safety . 2014 Vol. 31 (11): 2176-2178 [Abstract] ( 83 ) HTML (1 KB)  PDF  (0 KB)  ( 22 ) 2179 Relationship of Homocysteine and Serum Carbohydrate Antigen 125 Level with Atrial Fibrillation Objective] To investigate the correlation of homocysteine (Hcy ) and carbohydrate antigen 125 (Ca125) with left atrial diameter(LAD) in order to explore the role of Hcy and Ca125 in the occurrence and devel‐opment of atrial fibrillation(AF) .[Methods] A total of 68 AF patients were chosen .Among them ,28 patients were paroxysmal AF and 40 patients were persistent AF(including permanent AF) .Other 30 people were chosen as healthy adult group .The levels of Hcy and Ca125 in 3 groups were examined .Echocardiography was performed in all subjects .LAD was measured .[Results] The levels of Hcy and Ca125 in persistent AF group were higher than those in healthy adult group and paroxysmal AF group .The level of Hcy in paroxysmal AF group was higher than that in healthy adult group .There was no significant difference in Ca125 level between paroxysmal AF group and healthy adult group .The levels of Hcy and Ca125 in AF group were positively correlated with LAD .[Conclu‐sion] Hcy and Ca125 have closer relationship with AF . 2014 Vol. 31 (11): 2179-2181 [Abstract] ( 22 ) HTML (1 KB)  PDF  (0 KB)  ( 40 ) 2181 Comparison of Clinical Efficacy of Different Types of Laparoscopic Hysterectomy YE Xin-hong Objective] To explore clinical efficacy of two different methods laparoscopic total hysterectomy(TLH) and laparoscopic assisted vaginal hysterectomy (LAVH ) .[Methods]Totally 200 patients undergoing laparoscopic total hysterectomy in obstetrical and gynecological department of our hospital from Jan .2010 to Nov .2013 were selected and divided into TLH group( n=100) and LAVH group( n=100) .Operation time ,intraoperative blood loss ,postoperative anal gas passage time ,postoperative hospital stay ,the incidence and type of complications were recorded and compared between two groups .[Results] The operation time of TLH group was (126 .20 ± 8 .35)min ,which was obviously longer than that of LAVH group[(108 .03 ± 6 .58)min]( P<0 .05) .Blood loss of TLH group was (134 .08 ± 8 .36)mL ,which was obviously larger than that of LAVH group[(98 .50 ± 5 .68)mL] ,and there was significant difference( P <0 .05) . There was no significant difference in postoperative anal gas passage time ,postoperative hospital stay ,the incidence and type of complications between two groups( P>0 .05) .[Conclusion]Compared with TLH ,LAVH has higher superiority and worthy of clinical promotion . 2014 Vol. 31 (11): 2181-2183 [Abstract] ( 25 ) HTML (1 KB)  PDF  (0 KB)  ( 35 ) 2184 Observation on Clinical Efficacy of Methylprednisolone Pulse Therapy for Children with Electrical Status Epilepticus in Sleep ZHA NG Xiao-qing Objective] To explore the efficacy of methylprednisolone pulse therapy for children with electrical status epilepticus in sleep(ESES) .[Methods]A total of 31 pediatric patients with epilepsy and ESES in pediatric outpatient de‐partment of our hospital from May 2007 to April 2013 were chosen and randomly divided into treatment group( n=16) and control group( n=15) .The treatment group was given methylprednisolone pulse therapy ,oral prednisone and con‐ventional antiepileptics valproate .The control group was only given oral valproate .All patients were followed up for 6 months .The results were analyzed .[Results]In treatment group ,12 patients were effective ,and the efficiency was 75% ,and the incidence of drug adverse reaction was 25 .7% .In control group ,15 patients were effective ,and the effi‐ciency was 46 .6% ,and the incidence of drug adverse reaction was 22 .8% .There was significant difference in the effi‐ciency between two groups( P<0 .05) ,but there was no significant difference in the incidence of drug adverse reaction rate between two groups( P>0 .05) .[Conclusion]Compared with conventional antiepileptics ,methylprednisolone pulse therapy for pediatric patients with ESES has obvious efficacy ,but the side effect of hormone therapy on pediatric patients should be paid attention . 2014 Vol. 31 (11): 2184-2186 [Abstract] ( 23 ) HTML (1 KB)  PDF  (0 KB)  ( 34 ) 2186 Analysis of Clinical Characteristics and T Lymphocyte Subsets of Severe Adenovirus Pneumonia in Children LUO Li-yan%RAO Hua-ping Objective] To understand clinical characteristics and T lymphocyte subsets of severe adenovirus(ADV) pneumonia in children .[Methods]Clinical characteristics and immune‐related indicators of 101 pediatric patients with se‐vere ADV pneumonia and 122 pediatric patients with non‐severe ADV pneumonia from Jan .2013 to Dec .2013 were ana‐lyzed retrospectively .[Results] Among pediatric patients with severe ADV pneumonia ,male patients were more than fe‐male patients .Severe ADV pneumonia mainly occurred in winter and spring .There were significant differences in hospital day ,neutrophil ,c‐reactive protein(CRP) and procalcitonin(PCT) between severe ADV pneumonia group and non‐severe ADV pneumonia group( P<0 .05) .The constituent ratios of the decreasing of CD3 and CD4 in pediatric patients with severe ADV pneumonia were higher than those in pediatric patients with non‐severe ADV pneumonia ,and there was sig‐nificant difference( P<0 .05) .The constituent ratio of the increasing of CD8 in severe ADV pneumonia group was lower than that in non‐severe ADV pneumonia group ,and there was significant difference( P <0 .05) .[Conclusion]Pediatric patients with severe adenovirus pneumonia have strong inflammatory process ,the decreased immunologic responsiveness and immunity function disturbance .Early detection of the correlative indicators should be strengthened in clinical practice . Intervention and comprehensive treatment should be given to control the development of the disease . 2014 Vol. 31 (11): 2186-2188 [Abstract] ( 49 ) HTML (1 KB)  PDF  (0 KB)  ( 26 ) 2189 Application of Neuronavigation and Electrophysiological Monitoring in the Resection of Lesions near the Central Sulcus CHEN Han-min%WANG Wen-xin%LIAO Sheng-fang Objective]To explore the application of neuronavigation and electrophysiological monitoring in the resection of lesions near the central sulcus .[Methods]A total of 14 patients with lesions near the central sulcus in our hospital underwent microsurgical procedures assisted with neuronavigation and electrophysiological monito‐ring .Clinical efficacy was observed .[Results]In the group ,9 patients underwent total resection and 5 patients un‐derwent partial resection .After operation ,contralateral limb muscle strength impairment occurred in 2 patients af‐ter operation ,and hemiplegia occurred in 1 patient ,and limb muscle strength impairment was aggravated in 2 pa‐tients .The 3 patients with limb movement disorder got better about one month after operation .[Conclusion]The combination of intraoperative neuronavigation and electrophysiological monitoring is of great clinical practical value in the resection of lesions near the central sulcus . 2014 Vol. 31 (11): 2189-2194 [Abstract] ( 54 ) HTML (1 KB)  PDF  (0 KB)  ( 37 ) 2191 Clinical Observation on Posterior Pedicle Screw Fixation for the Treatment of Unstable Upper Thoracic Vertebrae Fractures Objective]To observe clinical efficacy of posterior pedicle screw fixation in the treatment of unstable upper thoracic fractures .[Methods]Clinical data of 21 patients with unstable upper thoracic fractures from March 2010 to April 2013 were analyzed retrospectively .T3 ~ T8 segmental fractures were high‐energy injury .All patients underwent posterior open reduction ,spinal decompression ,pedicle screw fixation ,pos‐terolateral fusion and bone graft .Conventional treatment and early rehabilitation intervention were given after operation .General condition ,radiographic evaluation(including pedicle screw position ,vertebral compression ratio and vertebral kyphosis angle) ,spinal nerve function classification(ASIA) and daily living activity(ADL) before and after operation were evaluated .[Results] All 21 patients successfully completed surgery ,and no postoperative complication occurred .The 20 patients got effective follow up ,and the follow up time was 12~49 months ,and the mean follow up time was (28 .78 ± 6 .25) months .Compared with before operation ,verte‐bral compression rate and vertebral kyphosis angle at 48h after operation and follow‐up were decreased( P <0 .01) .Compared with 24h after operation ,vertebral compression rate and vertebral kyphosis angle at follow‐up were increased( P<0 .05) .Spinal cord injury ASIA classification at 48h after operation had no change .At follow up ,spinal cord injury ASIA classification of 50 .0% of patients was recovered ,and ADL score was sig‐nificantly improved at follow up( P <0 .05) ,and increased by average (22 .11 ± 9 .64) points .[Conclusion]Posterior pedicle screw fixation is an effective method for the treatment of unstable thoracic fractures .The op‐eration combined with early postoperative rehabilitation intervention is the key of spinal function recovery . 2014 Vol. 31 (11): 2191-2194 [Abstract] ( 70 ) HTML (1 KB)  PDF  (0 KB)  ( 34 ) 2195 Observation of the Efficacy of Ureteroscopic Urethral Reunion Operation in the Treatment of U-rethral Injury (Report of 18 Cases) HU Jie-bin%LI Jin%LI Wen-ze Objective] To explore the methods and efficacy of ureteroscopic urethral reunion operation in the treatment of urethral injury .[Methods]Clinical data of 18 patients with urethral injury undergoing uretero‐scopic urethral reunion operation were analyzed retrospectively .[Results] Among 18 patients ,11 patients were bulbar urethral injury and underwent the operation successfully ,and 7 patients were membranous ure‐thral injury in which 6 patients underwent the operation successfully and 1 patient failed .All patients were fol‐lowed up for 6 to 36 months .Two patients with membranous urethral injury developed urethral injury .Two patients appeared erection dysfunction .[Conclusion] Urethral reunion operation with ureteroscope has advan‐tages such as small injury ,less complication ,rapid recovery and simple procedure .Therefore ,it is an effective method for urethral injury . 2014 Vol. 31 (11): 2195-2196 [Abstract] ( 43 ) HTML (1 KB)  PDF  (0 KB)  ( 40 ) 2197 Analysis on the Efficacy and Safety of Capecitabine Combined with Docetaxel for Neoadjuvant Chemotherapy of Locally Advanced Breast Cancer XIE Jin-long Objective]To explore the efficacy and safety of capecitabine combined with docetaxel in neoadju‐vant chemotherapy of locally advanced breast cancer .[Methods]On the basis of conventional therapy ,46 patients with locally advanced breast cancer in our hospital were given intravenous instillation with docetaxel 75mg/m2 on the first day ,and then oral capecitabine 1000mg/m2 twice daily in the next 2 weeks .The duration was 3~4 cycles with 3 weeks a cycle .The efficacy and safety were analyzed .[Results] The total effective rate of clinical efficacy was 84 .8% (39/46) .Among them ,5 patients(10 .9% ) were pathologic complete remission .Adverse reactions were neutropenia ,alopecia ,hand‐foot syndrome ,diarrhea and so on .[Conclusion] Capecitabine combined with docetaxel in neoadjuvant chemotherapy for breast cancer has good efficacy and high compliance ,so it is well ad‐vised for clinical reference . 2014 Vol. 31 (11): 2197-2202 [Abstract] ( 78 ) HTML (1 KB)  PDF  (0 KB)  ( 49 ) 2199 Surveillance of Pathogenic Bacterium and Analysis of Bacterial Resistance in Changsha Maternal and Child Health Hospital in 2013 Objective] To understand the resistance of clinical isolates obtained from Changsha maternal and child health hospital in 2013 to commonly used antimicrobial agents .[Methods]Kirby‐Bauer(K‐B) method was used for anti‐bacterial drug susceptibility test of 1882 stains of bacteria isolated from our hospital in 2013 .According to 2013 national committee for clinical and laboratory standards institute(CLSI) ,the results were analyzed .[Results] A total of 1882 pathogenic strains were clinically isolated and included 557 Gram‐positive bacteria(29 .60% ) ,803 Gram‐negative bacteria (42 .67% ) and 522 fungi(27 .73% ) .Among Gram‐positive bacteria ,the detection rate of methicillin resistant staphylo‐coccus aureus(MASA) was 32 .94% ,and vancomycin and linezolid‐resistant staphylococcus aureus were not found ,and the sensitivity of staphylococcus epidermidis to oxacillin was high(90 .32% ) ,and the Enterococcus faecalis was sensitive to ampicillin and the resistant rate was 6 .25% ,and the sensitivity of Streptococcus agalactiae to ampicillin was 100% .A‐mong Gram‐negative bacteria ,Escherichia coli and Klebsiella pneumonia producing the extended spectrum beta‐lactamases (ESBLs) were not found ,and the sensitivity of Moraxelle catarrhalis to Ampicillin and Sulbactam was 100% ,and the re‐sistance rate of Haemophilus influenzae to Ampicillin and Sulbactam was 8 .51% .[Conclusion] Regular surveillance of bacterial drug resistance is helpful to understand the transition of bacterial drug resistance and can provide a theoretical ba‐sis for rational administration . 2014 Vol. 31 (11): 2199-2202 [Abstract] ( 20 ) HTML (1 KB)  PDF  (0 KB)  ( 38 ) 2203 Observation on the Efficacy of Atorvastatin for the Treatment of Coronary Heart Disease with Chronic Heart Failure Objective]To observe the effect of atorvastatin on the levels of hypersensitive C‐reactive pro‐tein(hsCRP) ,hypersensitive cardiac troponin T (hs‐cTnT ) and the prognosis in patients with coronary heart diease(CHD) and chronic heart failure(CHF) .[Methods]Totally 100 patients with CHD and CHF were ran‐domly divided into observation group( n=50) and control group( n =50) .The control group was given con‐ventional medication of anti‐heart failure strategies ,while the observation group received additional atorvasta‐tin 20mg daily based on the conventional treatment .hsCRP and hs‐cTnT were determined before and after 1 month of treatment .The incidence of major adverse cardiovascular events(MACE) and rehospitalization rate were recorded during 1‐year follow up after treatment .[Results]Compared with control group ,the levels of hsCRP and hs‐cTnT in observation group were decreased more significantly after treatment for 1 month[(3 .02 ± 0 .53)mg/L vs .(3 .88 ± 0 .64)mg/L ,(0 .018 ± 0 .009)ng/mL vs .(0 .029 ± 0 .008)ng/mL ,both P<0 .05] . Compared with control group ,MACE and rehospitalization rate in observation group during 1‐year follow up were even decreased[15 .6% vs .21 .7% ,26 .7% vs .37 .0% ,both P<0 .05] .[Conclusion]Atorvastatin can reduce the levels of inflammatory factors and myocardial injury ,and improve the prognosis of patients with CHD and CHF . 2014 Vol. 31 (11): 2203-2205 [Abstract] ( 53 ) HTML (1 KB)  PDF  (0 KB)  ( 35 ) 2206 Value of the Combination Detection of Four Urine Micro-proteins in Early Diagnosis of Non-diabet-ic Hypertensive Renal Damage YA NG Yu-xia Objective] To explore the value of the combination detection of four urine micro‐proteins urine trace albumin(mAlb) ,urinary transferrin(TRF) ,urine alpha 1 microglobulin(α1‐MG) and urine immunoglobulin (IgG) in early diagnosis of non‐diabetic hypertensive renal injury .[Methods]Four urine micro‐proteins of 100 pa‐tients confirmed as non‐diabetic hypertension(observation group) and 100 healthy physical examination persons (control group) were examined .Blood biochemical indicators were detected .The test results were analyzed statis‐tically .[Results] Urine micro‐proteins in observation group were higher than those in control group .The mAlb in 35 patients(35% ) ,TRF in 24 patients(24% ) ,α1‐MG in 32 patients(32% ) and IgG in 15 patients(15% ) were positive .The positive rate of the combination detection of four micro‐proteins was 55% .Hypertension ,obesity , high CRP ,low and high‐density lipoproteins in observation group had correlation with urine micro‐proteins .[Con‐clusion] The combination detection of mAlb ,TRF ,α1‐MG and IgG can improve early diagnostic rate of non‐dia‐betic hypertensive renal injury . 2014 Vol. 31 (11): 2206-2208 [Abstract] ( 20 ) HTML (1 KB)  PDF  (0 KB)  ( 26 ) 2208 Analysis of Variation Degree of the Implementation of Clinical Pathway for Patients with Correc-tion of Kyphosis in Ankylosing Spondylitis CH EN Su-Jun Objective] To analyze the variation degree of the implement of clinical pathway in correction of ky‐phosis in ankylosing spondylitis in order to find out the shortage of clinical pathway and provide some measures to improve the clinical pathway .[Methods]The data of 350 patients with the indication of correction of kyphosis in ankylosing spondylitis from Jan .2012 to Dec .2013 were collected .According to the criteria and type of variation , the data were analyzed by statistical method .[Results] Among 350 patients ,290 patients had 16 types of varia‐tions mainly including negative variation ,patients'condition variation and uncontrollable variation .[Conclusion]In the clinical pathway of correction of kyphosis on ankylosing spondylitis ,the operational process should be im‐proved ,the detailed inclusive and exclusive criterion should be made ,and the transition of diagnosis and treatment of community hospital and convalescent hospital should be enforced so as to better carry out clinical pathway of correction of kyphosis in ankylosing spondylitis ,and then raise the quality of treatment and care ,decrease hospital stay and reduce hospitalization cost . 2014 Vol. 31 (11): 2208-2211 [Abstract] ( 57 ) HTML (1 KB)  PDF  (0 KB)  ( 36 ) 2212 Effect of Additional Lamotrigine Therapy on Serum IL-2,TNF-αand Cognitive Function in Pediat-ric Patients with Intractable Epilepsy YA NG Li-ming%CHEN Bo%NING Ze-shu Objective]To observe the effect of additional lamotrigine therapy on interleukin‐2(IL‐2) ,tumor necrosis factor‐alpha(TNF‐α) and cognitive function in pediatric patients with intractable epilepsy .[Methods]A total of 35 pediat‐ric patients with intractable epilepsy were selected as observation group and given additional lamotrigine therapy .Mean‐while 35 healthy children were selected as control group .Serum levels of IL‐2 ,TNF‐αand Chinese Wechsler intelligence scale for children (C‐WISC) score in observation group before and after treatment were observed and compared with the control group .[Results]There was no significant difference in serum levels of IL‐2 and TNF‐α,verbal intelligence quo‐tient(VIQ) ,performance intelligence quotient(PIQ) and full intelligence quotient(FIQ) in observation group between be‐fore and after treatment( P>0 .05) ,but the knowledge score was increased significantly( P<0 .05) .[Conclusion]Addi‐tional lamotrigine therapy can improve the cognitive function of pediatric patients with intractable epilepsy partially ,but has no obvious effect on serum levels of IL‐2 and TNF‐α. 2014 Vol. 31 (11): 2212-2214 [Abstract] ( 22 ) HTML (1 KB)  PDF  (0 KB)  ( 34 )

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