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Abstract Objective]To observe the effect of morning peak blood pressure on carotid atherosclerosis ,homocysteine(Hcy) and u‐rinary microalbumin(UmAlb) in essential hypertension patients with normal left ventricular ejection fraction(EF% ) ,and to explore the role of Hcy and UmAlb in carotid atherosclerosis caused by morning blood pressure .[Methods]The 24h ambulary blood pressure moni‐toring(ABPM) was used to monitor blood pressure in 190 cases of essential hypertension with normal EF% .According to morning peak blood pressure ,all patients were divided into group A(normal morning peak blood pressure ,n=90) and group B(increased morn‐ing peak blood pressure ,n=107) .Doppler ultrasound was performed in each patient to measure left and right sides of common carotid artery diameter(LCCAd and RCCAd) ,internal carotid artery diameter(LICAd and RICAd) ,common carotid artery intima‐media thick‐ness(LCA‐IMT and RCA‐IMT) and determine whether left and right carotid artery plaque was formed .The mean carotid artery diame‐ter(CCAdM) ,mean internal carotid artery diameter(ICAdM) ,mean common carotid artery intima‐media thickness(CCA‐IMTM) of two sides and the number of patients with carotid atherosclerosis plaque were calculated .The fasting venous blood of patients within 24h on admission was collected .OLYMPUS AU640 automatic biochemical analyzer was used to detect Hcy ,UmAlb ,blood lipids and other indicators .[Results]There was no significant difference in 24h‐,daytime and nighttime mean systolic blood pressure(SBP) and diastolic blood pressure(DBP) and 24h mean arterial pressure(MAP) between group A and group B( P>0 .05) .The carotid athero‐sclerosis parameters and number of patients with carotid atherosclerosis plaque in group B were obviously higher than those in group B , and there was significant differenc( P<0 .05) .The levels of Hcy and UmAlb in group B were obviously higher than those in group A , and there was significant difference( P<0 .05) .Morning peak blood pressure was significantly correlated with carotid atherosclerosis parameters ,Hcy and UmAlb( P<0 .05) .There was strongest correlation between morning peal blood pressure and CCA‐IMTM( r=0 .623 ,P=0 .000) .[Conclusion]Morning peak blood pressure is of great significance in carotid atherosclerosis in essential hyperten‐sion patients with normal EF% ,and closely correlated with Hcy and UmAlb .It suggests that the control of morning peak blood pres‐sure is an important process of the diagnosis and treatment of essential hypertension .
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2014, Vol. 31 
