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| Value of Combined Detection of Antinuclear Antibody,Antinuclear Antibody Profile and Anti-double Stranded DNA Antibody in the Diagnosis of Systemic Lupus Erythematosus |
| ZENG Yan-kun%WU Jie |
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Abstract Objective] To explore the value of antinuclear antibody(ANA) ,antinuclear antibody profile(ANAs) and anti‐double stranded DNA antibody (anti dsDNA antibody ) in the diagnosis of systemic lupus erythematosus (SLE) .[Methods] Totally 150 patients with SLE in a municipal hospital of Quanzhou city from Jan .2012 to Jan . 2014 were selected as SLE group ,and other 30 patients with rheumatic diseases were selected as disease control group ,and 30 health examination persons were selected as normal control group .Serum ANA was detected by indi‐rect immunofluorescence method .Serum ANAs and anti dsDNA antibody were measured by western blotting .[Re‐sults] The positive rates of serum ANA ,anti dsDNA antibody ,anti‐AHA ,anti‐nRNP ,anti‐AnuA and anti‐Sm in SLE group were significantly higher than those in disease control group and healthy control group( P <0 .01) .In SLE group ,only 5 .33% of patients had single positive antibody ,and the remaining 94 .67% of patients had two or more positive antibodies .After treatment ,the positive rates of ANA ,anti dsDNA antibody ,anti‐AHA ,anti‐Sm and anti‐SS‐A in SLE patients were decreased in different degree .The improvement rate of ANA ,anti‐dsDNA antibody and anti‐AHA were 23 .33% ,83 .33% and 63 .33% ,respectively .[Conclusion] The positive rates of ANA ,ANAs and anti ds‐DNA antibody in SLE patients is higher .The joint detection and dynamic observation of ANA ,ANAs and anti‐ds‐DNA antibody is of significance in the diagnosis and treatment of SLE .
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| Cite this article: |
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ZENG Yan-kun%WU Jie. Value of Combined Detection of Antinuclear Antibody,Antinuclear Antibody Profile and Anti-double Stranded DNA Antibody in the Diagnosis of Systemic Lupus Erythematosus[J]. JOURNAL OF CLINICAL RESEARCH, 2014, 31(11): 2081-2083.
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| URL: |
| http://www.jcr.net.cn/EN/ OR http://www.jcr.net.cn/EN/Y2014/V31/I11/2081 |
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2014, Vol. 31 
