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Abstract Objective]To explore the sensitive index indicating organism nutrition of vitamin K ,and to an‐alyze the reasonable dosage of vitamin K for the treatment of infant vitamin K deficiency bleeding (VKDB) .[Methods]Prospective cohort study method was used from Sept .2009 to Sept .2013 .Venous blood of 106 in‐patients with VKDB was collected .Enzyme‐linked immunosorbent assay was used to determine prothrombin precursor protein (PIVKA‐Ⅱ ) . Prothrombin time (PT ) , activated partial thromboplastin time (APTT ) , thrombin time(TT) and fibrinogen(FIB) were examined by using sysmex CA‐1500 coagulation analyzer .Then all pediatric patients were divided into 2mg vitamin K1 treatment group and 5mg vitamin K1 treatment group . The above indicators at 24h ,3d and 5d after intravenous drip of vitamin K1 were examined again .The changes of the above indicators before and 5d after treatment were compared .The change of PIVKA‐Ⅱ between 2mg group and 5mg group was also compared .[Results] There were significant differences in the abnormal rates of PT ,APTT and PIVKA‐ Ⅱ between before and after treatment(72 .6 vs .13 .2 ,70 .8 vs .32 .1 ,98 .1 vs .8 .5 , P <0 .05) .There was no significant difference in the abnormal rates of TT and FIB between before and after treatment( P >0 .05) .There was significant difference in PIVKA‐ Ⅱ level between 2mg group and 5mg group 24h after intravenous drip of vitamin K1 ( P <0 .05) ,while there was no significant difference 3d and 5d after treatment( P >0 .05) .[Conclusion]After the supplementation of vitamin K for pediatric patients with VKDB , the levels and abnormal rates of PIVKA‐ Ⅱ ,PT and APTT are improved obviously .PIVK‐ Ⅱ is the most sensitive index of the diagnosis and the curative effect monitoring of VKDB .Intravenous drip of vitamin K1 2mg daily for continuous 5 days is effective in the treatment of VKDB .
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2014, Vol. 31 
