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Abstract Objective]To explore the efficacy and safety of capecitabine combined with docetaxel in neoadju‐vant chemotherapy of locally advanced breast cancer .[Methods]On the basis of conventional therapy ,46 patients with locally advanced breast cancer in our hospital were given intravenous instillation with docetaxel 75mg/m2 on the first day ,and then oral capecitabine 1000mg/m2 twice daily in the next 2 weeks .The duration was 3~4 cycles with 3 weeks a cycle .The efficacy and safety were analyzed .[Results] The total effective rate of clinical efficacy was 84 .8% (39/46) .Among them ,5 patients(10 .9% ) were pathologic complete remission .Adverse reactions were neutropenia ,alopecia ,hand‐foot syndrome ,diarrhea and so on .[Conclusion] Capecitabine combined with docetaxel in neoadjuvant chemotherapy for breast cancer has good efficacy and high compliance ,so it is well ad‐vised for clinical reference .
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2014, Vol. 31 
