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Abstract Objective] To observe the effect of obstructive sleep apnea(OSA ) on restenosis and plasma high‐sensitivity C‐reactive protein(hsCRP) in patients with acute coronary syndrome(ACS) after successful coronary artery stent implantation .[Methods] A total of 66 patients with ACS undergoing coronary artery stent implantation in cardiology department of our hospital from Jan .2008 to Dec .20100 CS) were selected . After polysomnography ,all patients were divided into OSA group( n = 21 ,ACS combined with OSA) and control group( n=45 ,ACS without OSA) .Blood samples were collected for detecting blood glucose ,lipids and hsCRP before operation .Blood glucose ,lipids and hsCRP were reexamined and coronary angiography was performed again at 6‐month follow up after operation .[Results]Compared with control group ,total cholester‐ol(TC) and low density lipoprotein(LDL) in OSA group at baseline were increased( P<0 .05) .There was no significant difference in TC and LDL between two groups at 6‐month follow up after lipid‐lowing treatment( P>0 .05) .Compared with control group ,hsCRP in OSA group at baseline and follow up was significantly in‐creased( P<0 .01) .Compared with control group ,the rate of stent restenosis in OSA group was obviously in‐creased at 6‐month follow‐up( P <0 .01) .AHI was positively correlated with stent restenosis and hsCRP ( P<0 .05) .hsCRP was positively correlated with stent restenosis( P<0 .05) .[Conclusion]OSA promotes coro‐nary stent restenosis of patients with ACS .The mechanism may be that hypoxemia caused by AHI in OSA pa‐tients promotes the increasing of plasma hsCRP ,which leads to aggravate vascular endothelial inflammation and raise the occurrence of in‐stent restenosis .
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2014, Vol. 31 
