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Abstract Objective] To explore the correlation between insulin resistance and the incidence of obesity‐associated nephropathy(ORG) .[Methods]A total of 88 obese patients receiving routine renal function detection in our hospital from March 2010 to March 2014 were chosen .According to test results ,32 patients with nor‐mal renal function were taken as group A ,while 56 patients with kidney disease were taken as group B .Ac‐cording to treatment results after 8 weeks ,group B was divided into group B1( n=32 ,the group with signifi‐cantly improved renal function) and group B2( n=24 ,the group without obviously improved renal function) . The lipid related indicators ,renal function ,blood sugar and blood pressure of the two groups at medical exam‐ination and after 8 weeks of treatment were detected .[Results]Total cholesterol(TC) ,triglyceride(TG) ,24‐hour urinary protein excretion(24h‐UP) ,blood urea nitrogen(BUN) ,fasting blood glucose(FBG) ,2‐hour postprandial glucose(2h‐PBG) ,fasting insulin(FINS) ,insulin resistance index(HOMA‐IR) and mean arterial pressure (MAP) in group B were higher than those in group A ,while creatinine clearance rate (CCR) and high‐density lipoprotein cholesterol(HDL‐C) in group B were lower than those in group A ,and there were sig‐nificant differences( P <0 .05) .The TC ,TG ,24h‐UP ,BUN ,FBG ,HOMA‐IR and MAP in group B1 were lower than those in group B2 ,while CCR in group B1 was obviously higher than that in group B2 ,and there were significant differences( P <0 .05) .Pearson correlation analysis showed that HOMA‐IR and MAP of pa‐tients were positively correlated with 24h‐UP and BUN( P<0 .05) ,but negatively correlated with CCR( r =-0 .159 ,-0 .368 ,P <0 .05)[Conclusion]The increasing of HOMA‐IR and MAP is an important cause of ORG ,and may point out a new direction of the treatment of the disease .
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2014, Vol. 31 
