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Quick Search     Adv Search 2014 Vol. 31, No. 6 Published: 2014-06-26   1041 Relationship Between P2 1 Gene rs1059234 Polymorphisms and the Risk of Endometrial Cancer among Northeastern Han Women [Objective]To explore the correlation between p21 gene rs1059234 polymorphisms and endome-trial cancer in Han women from northeast China.[Methods]The sequencing and PCR-restriction fragment length polymorphism(PCR-RFLP)were used for the genotyping of p21 gene rs1059234 in peripheral blood DNA of 263 patients with endometrial cancer(observation group)and 315 healthy subjects(control group). The correlation between the genotypes and endometrial cancer was analyzed.[Results]Compared with control group,the C allele frequency of rs1059234 in observation group was increased obviously(P=0.039),and the CC genotype frequency of rs1059234 in observation group had obvious increasing trend(0.335 vs.0.219,P=0.045).The CC genotype could increase the risk of endometrial cancer(OR=1.589,95%CI:1.010~2.502). After correction with regression analysis,the CC genotype didn't increase the risk of endometrial cancer(OR=1.623,95% CI:0.720~3.659,P =0.243).[Conclusion]Among Han women from northeast China,the rs1059234 polymorphism of p21 gene is not associated with the risk of endometrial cancer. 2014 Vol. 31 (6): 1041-1044 [Abstract] ( 54 ) HTML (1 KB)  PDF  (0 KB)  ( 33 ) 1044 Observation on the Efficacy of Pedicle Screw Placement in Single Segment of the Injured Verte-bral by Quadrant System for the Treatment of Thoracolumbar Fracture [Obj ective]To explore the efficacy of pedicle screw placement in single segment of the inj ured verte-bra by posterior Quadrant system for the treatment of thoracolumbar fracture.[Methods]Totally 50 patients with tho-racolumbar fracture were collected.After localization by C-arm fluoroscopy,all patients underwent pedicellscrew placement in single segment,internal fixation and bone graft infusion by posterior QUADRANT system.ASIA clas-sification of nerve function,vertebra height and Cobb angle before and after operation were analyzed and compared.[Results]All patients were followed up.The mean incision length was 3 .5 cm.The average operation time was 53min.The average bleeding volume was 125mL.One patient with incision skin edge necrosis was cured by symp-tomatic treatment.All patients after operation had bony fusion.ASIA grade C neural function of 2 patients recovered to normal.Postoperative X-ray examination showed that the inj ured vertebral height recovered to 9 5 .9%.During the follow up,the vertebral height only lost 0.4mm,and the lost rate was 1.4%.The Cobb angle recovered from preop-erative e 19.5°(12.6°~26.4°)to postoperative 4.1°(1.5°~6.3°).No internal fixation loosening,shift and breakage fracture were found.[Conclusion]Pedicle screw placement in single segment of the inj ured vertebra by posterior Quadrant system for the treatment of thoracolumbar fracture is a surgical method with minimal trauma,short opera-tion time,less blood loss,good efficacy and safe operation. 2014 Vol. 31 (6): 1044-1046 [Abstract] ( 27 ) HTML (1 KB)  PDF  (0 KB)  ( 30 ) 1047 Dosiology Study of Three-dimensional Conformal and Intensity-modulated Radiotherapy in Ra-diation Therapy of Liver Cancer [Objective]To explore the difference of dosiology of three-dimensional conformal(3DCRT)and static intensity-modulated radiology(sIMRT)in radiation therapy for liver cancer.[Methods]Totally 38 pa-tients with primary right lobe cancer of liver were chosen.All patients received 3DCRT and sIMRT.The dose was 50Gy for 25 fractions of radiation.The dosiology parameters of different radiotherapy target area and dan-gerous organ,accelerator hops(MU)and effective treatment time parameters were compared.[Results]The Dmax/Gy,Dmin/Gy and V95% target region dosiology in sIMRT were (52.9±0.3),(49.0±0.2)and (99.5±0.2)respectively which were lower than those in 3DCRT[(53.1±0.4),(46.2±0.6)and (97.4± 1.5),respectively],and there were significant differences(P<0.05).There was no significant difference in mean liver dose between sIMRT and sDCRT[(20.1± 4.3)Gy vs.(21.3±3.4)Gy](P>0.05).There was no significant difference in MU between 3DCRT and sIMRT[(403 ± 97)vs.(391±82)](P>0.05).The effective treatment time of 3DCRT was (2.0±0.1)min which was less than that in sIMRT[(4.9± 0.6)min] (P<0.05).[Conclusion]Both sIMRT and 3DCRT can markedly increase the curative effect and improve liv-er target dose coverage.Therefore,sIMRT technology is more effective means of treating liver cancer. 2014 Vol. 31 (6): 1047-1049 [Abstract] ( 41 ) HTML (1 KB)  PDF  (0 KB)  ( 28 ) 1049 Analysis of Comparative Proteomics of Eosinophilic Bronchitis Mouse Model and Asthma Mouse Model [Obj ective]To explore the differential expression of proteomics of eosinophilic bronchitis mouse model and asthma mouse model.[Methods]Four rats in each group including eosinophilic bronchitis model(EB model)(experimental group),asthma model(asthma group)and control group.Total protein was extracted from lung tissue.Matrix-assisted laser desorption/ionization time of flight mass spectrometry was used for sequence a-nalysis of proteins.[Results]Two dimensional electrophoresis image showed that there was difference in the ex-pression of protein among 3 groups(P<0.05).Twenty proteins such as glutathione-S-transferase M1(GSTM1) and heat shock protein B1(HSPB1)were identified through the analysis of peptide mass fingerprint spectrum of mass spectrometry contrasted with standard molecular weight and isoelectric point.GSTM1 was down-regulated in asthma group,while HSPB1 was up-regulated in asthma group.[Conclusion]GSTM1 and HSPB1 may involve in the occurrence of airway hyperresponsiveness. 2014 Vol. 31 (6): 1049-1052 [Abstract] ( 66 ) HTML (1 KB)  PDF  (0 KB)  ( 27 ) 1053 Analysis of the Relationship Between Serum Monocyte Chemoattractant Protein-1 Level and the Stability of Carotid Atherosclerotic Plaque in Elderly Patients with Acute Cerebral Infarction HE Dan%CHEN Chan-juan%LIU Si-Xin [Objective]To analyze the association between serum monocyte chemoattractant protein-1 (MCP-1)concentration and the stability of carotid atherosclerotic plaque in elderly patients with acute cerebral infarction among Han people of Hunan province.[Methods]Totally 154 elderly patients with acute cerebral infarction and 80 healthy volunteers were recruited in our hospital from Dec.2010 to May 2013.Enzyme-linked immunosorbent assay(ELISA)was used to measure serum MCP-1 level in all subj ects.Carotid intima-media thickness(IMT)were measured color Doppler ultrasonography.According to IMT,all patients were di-vided into non-plaque group(n=32),stable plaque group(n=49)and unstable plaque group(n=73).The difference in serum MCP-1 level among groups was analyzed.The relationship between serum MCP-1 level and the stability of carotid atherosclerotic plaque was also analyzed.[Results]Serum MCP-1 level in unstable plaque group(113.64±48.04 pg/mL)was higher than that in stable plaque group(61.78±22.34pg/mL),and that in stable plaque group was higher than that in non-plaque group(44.84±25.26pg/mL),and there was significant difference between two groups(F=80.06,P<0.01).There was no significant difference in ser-um MCP-1 level between non-plaque group and control group.Serum MCP-1 level was correlated with the sta-bility of carotid atherosclerotic plaque(P >0.05).[Conclusion]Serum MCP-1 level may be associated with the stability of carotid atherosclerotic plaque in elderly patients with acute cerebral infarction among Han peo- #br# ple of Hunan province. 2014 Vol. 31 (6): 1053-1058 [Abstract] ( 29 ) HTML (1 KB)  PDF  (0 KB)  ( 43 ) 1056 Effect of Silencing SOX2 Gene on Cell Proliferation and Invasion of Human Cervical Cancer Cells and Its Mechanism [Obj ective]To explore the effect of the up-regulation of transcription factor SOX2 on cell prolif-eration and invasion of cervical cancer cells.[Methods]The specific short hairpin(shRNA)SOX2 interference vector was transfected into cervical squamous cell SiHa in order to obtain stable transfection cell line(SOX2 in-terference group).MTT assay was used to detect the change of cell proliferation.The difference of cell inva-sion was detected by using Transwell invasion cabin.Western Blot was used to detect the expressions of SOX2,MMP2,MMP9 and epithelial-mesenchymal transition associated factors,which were compared with those in negative transfection control group and blank control group.[Results]MTT result showed that cell proliferation in SOX2 interference group was significantly reduced in comparison with negative transfection control group and blank control group.Transwell result showed that cell-penetrating number was significantly reduced and cell invasion was decreased(P<0.05).Western Blot result showed that SOX2 was up regulated markedly,and the expressions of MMP2,MMP9 were decreased,but the protein level of E-cadherin was in-creased and the expression of Vimentin was decreased(P<0.05).There was no significant difference in all indicators between negative transfection control and blank control group.[Conclusion]Suppression of SOX2 expression can effectively inhibit proliferation and invasion of cervical cancer cell in vitro,which may be related to the inhibition of epithelial-mesenchymal transition processes. 2014 Vol. 31 (6): 1056-1058 [Abstract] ( 30 ) HTML (1 KB)  PDF  (0 KB)  ( 28 ) 1059 Clinical Characteristics of Patients with Primary Sjgren's Syndrome and Interstitial Lung Disease and the Detection of Serum Levels of Galectin-3 [Obj ective]To explore the role of galectin-3 (GAL-3 )in pathogenesis of primary Sjgren's syn-drome(pSS)patients with interstitial lung disease(ILD).[Methods]Clinical indexes of 73 pSS patients with and without ILD were compared.Enzyme linked immunosorbent assay(ELISA)was used to detect serum levels of GAL-3 in 73 pSS patients and 20 normal controls.[Results]Serum GAL-3 levels in pSS patients were obviously higher than those in normal controls,and there was significant difference(795.1±79.3pg/mL vs.458.0±97.4 pg/mL,P<0.05).Serum GAL-3 levels in pSS-ILD patients were markedly higher than those in simple pSS pa-tients(1047±110.7 pg/ml vs.628.6±72.62 pg/ml,P<0.01).Furthermore,the levels of IgG,C3,fibrinogen (FiB),acute phase reactive protein(CRP)and blood sedimentation in pSS-ILD patients were obviously higher than those in simple pSS patients,and there was significant difference(P<0.05 or P<0.01).Serum albumin(ALB) levels in pSS-ILD patients were obviously lower than those in simple pSS patients(P<0.01).Serum GAL-3 lev-els in pSS patients were positively correlated with CRP,IgG and FiB(r=0.487,P <0.001,r= 0.334,P =0.004,r=0.482,P<0.001).[Conclusion]GAL-3 may participate in immune inflammatory injury of pSS and the occurrence and development of ILD. 2014 Vol. 31 (6): 1059-1064 [Abstract] ( 29 ) HTML (1 KB)  PDF  (0 KB)  ( 35 ) 1062 Relationship Between Epidermal Growth Factor Receptor Tyrosine Kinase Domain Mutation and Radiosensitivity in Patients with Lung Adenocarcinoma SU Jia-li%ZHU Dao-qi%YANGYu [Obj ective]To explore the relationship between epidermal growth factor receptor tyrosine kinase domain (EGFR-TKD)mutation and radiosensitivity in patients with lung adenocarcinoma.[Methods]A total of 3 6 lung adeno-carcinoma patients with EGFR-TKD mutation were selected as the observation group.A total of 24 patients without EG-FR-TKD mutation were selected as the control group.Three-dimensional conformal radiotherapy was performed in prima-ry lung lesions of patients in 2 groups.Chest CT reexamination was performed 1 month after radiotherapy and used to e-valuate the short-term efficacy.[Results]All patients completed the treatment smoothly.In the observation group,1 0 patients were complete remission(CR),and 24 patients were partial remission(PR),and 2 patients were stable,and no one was developed,and the short-term total effective rate(CR+PR)was 94.4%.In the control group,7 patients were complete remission(CR),and 1 0 patients were partial remission(PR),and 6 patients were stable,and 1 patient was de-veloped,and the total short-term effective rate was 70.8%.There was significant difference in the short-term efficacy be-tween two groups(P<0.05).[Conclusion]Lung adenocarcinoma patients with EGFR-TKD mutation have better short-term efficacy.It suggests that EGFR-TKD mutation is an important indicator of predicting radiosensitivity. 2014 Vol. 31 (6): 1062-1064 [Abstract] ( 40 ) HTML (1 KB)  PDF  (0 KB)  ( 39 ) 1065 Alfacalcidol Capsule Pulse Therapy Combined with Hemoperfusion for the Treatment of Contin-uous Ambulatory Peritoneal Dialysis Patients with Severe Secondary Hyperparathyroidism [Objective]To evaluate the efficacy and safety of alfacalcidol[1a-(OH)-D3 ]capsule pulse ther-apy combined with hemoperfusion(HP)for the treatment of continuous ambulatory peritoneal dialysis(CAPD) patients with severe secondary hyperparathyroidism(SHPT).[Methods]Totally 37 CAPD patients with severe SHPT were collected and randomly divided into alfacalcidol pulse therapy combined with HP treatment group (group A,n=19)and alfacalcidol pulse therapy group(group B,n=18).The drug initial dose of two groups was 2~4μg twice a week.Group A simultaneously received HP treatment once a week for 3 weeks.All pa-tients were followed up for 6 months.Immunoreactive parathyroid hormone(iPTH)level,clinical symptoms and cardiac valve calcification before and after treatment were compared.[Results]After treatment,the stand-ard reaching rate of iPTH and symptomatic relief rate in combination group were obviously higher than those in single pulse therapy group,and there was significant difference(P<0.05).After 6 month of follow up,car-diac valve calcification rate in group A was lower than that in group B(73.6% vs.83.3%,P<0.05),while the standard reaching rate of iPTH in group A was higher than that in group B(94.7% vs.77.8%,P <0.05).In group A,the tolerance was good and none had severe side reaction.In group B,3 patients discon-tinued alfacalcidol therapy due to hypercalcemia and hyperphosphatemia.[Conclusion]Alfacalcidol pulse ther-apy combined with HP for the treatment of CAPD patients with severe SHPT has better efficacy and tolerance than single alfacalcidol pulse therapy. 2014 Vol. 31 (6): 1065-1067 [Abstract] ( 40 ) HTML (1 KB)  PDF  (0 KB)  ( 34 ) 1068 Comparative Study of Contrast-enhanced Ultrasound vs.Conventional Ultrasound in Preoperative Diagnosis and Clinical Stage of Cervical Cancer YANG Bi-yun%LI Hu-yi%YIN Hui [Obj ective]To compare the value of contrast-enhanced ultrasound vs.conventional ultrasound in preoperative diagnosis and clinical stage of cervical cancer.[Methods]Totally 50 patients with cervical cancer con-firmed by pathology were analyzed retrospectively.The diagnostic results of contrast-enhanced ultrasound and con-ventional ultrasound were analyzed and compared.[Results]The detection rate of contrast-enhanced ultrasound was 84.0% which was markedly higher than that of conventional ultrasound(50.0%),and there was significant difference(P<0.05).There was significant difference in the detection rate between grade Ⅰ and grade Ⅱ cervi-cal cancer(P<0.05),but there was no significant difference between gradeⅢ and gradeⅣ(P>0.05).The le-sion size and invasive range of cervical cancer measured by contrast-enhanced ultrasound was obviously larger than those measured by conventional ultrasound,and there was significant difference(P <0.05).[Conclusion]Con-trast-enhanced ultrasound can improve clinical diagnostic rate of cervical cancer,and is superior to conventional ul-trasound in preoperative diagnosis and clinical stage of cervical cancer,so it is worthy of clinical promotion. 2014 Vol. 31 (6): 1068-1070 [Abstract] ( 64 ) HTML (1 KB)  PDF  (0 KB)  ( 29 ) 1070 Discussion on the Value of Traditional Functional Nursing Mode for Preventing Postpartum Depres-sion [Obj ective]To observe the effect of the responsibility holistic nursing care on the prevention of postpartum depression in order to provide the reference for reducing the incidence of postpartum depression.[Methods]Clinical data of 100 pregnant women and parturients with postpartum depression tendency in obstetric department of our hospital from 2007 to 2019 were retrospectively collected as control group(traditional functional nursing mode).Clinical data of 100 pregnant women and parturients with postpartum depression tendency from Aug.2011 to Feb.2013 were collected as observation group(responsibility holistic nursing care).Self-rating anxi-ety scale(SAS)and self-rating depression scale(SDS)were used for the assessment of patients.The incidence of postpartum anxiety and depression in two groups was observed and compared.The data was analyzed by using SPSS13.0 analysis.[Results]There was no significant difference in prepartum SAS and SDS on admission be-tween observation group and control group(P>0.05).There was significant difference in postpartum SAS and SDS at discharging from the hospital between two groups(P <0.05).The incidence of postpartum anxiety and depression in observation group was lower than that in control group,and there was significant difference(P <0.05).[Conclusion]The responsibility holistic nursing care can effectively reduce the incidence of postpartum anx-iety and depression and alleviate the degree of depression,so it has certain clinical significance. 2014 Vol. 31 (6): 1070-1072 [Abstract] ( 53 ) HTML (1 KB)  PDF  (0 KB)  ( 26 ) 1073 Effect ofα-lipoic Acid on Islet Beta Cell Function and Oxidative Stress in Patients with New Di-agnosed Type 2 Diabetes Mellitus [Obj ective]To evaluate the effect ofα-lipoic acid on islet beta cell function and oxidative stress in patients with new diagnosed type 2 diabetes mellitus(T2DM).[Methods]Totally 80 patients with new di-agnosed T2DM in first hospital of Qinhuangdao city from March 2013 to Sept.2013 were randomly divided in-to group A and group B.All patients were given insulin pump intensification therapy for 2 weeks.Group A was simultaneously treated with intravenous infusion ofα-lipoic acid.Blood glucose and lipids of two groups were measured before and 2 weeks after treatment.Islet beta cell function index(HOMA-β)was calculated by using steady state model(HOMA).Enzyme linked immunosorbent assay was used to detect urine 8-isoprostan-es F2α(8-isoPGE).Oxidative stress was assessed.[Results]After treatment,HOMA-βin group A was higher than that in group B(P<0.05),while urine F2α(8-isoPGE)/Cr in group A was lower than that in group B(P<0.05).F2α(8-isoPGE)/Cr was positively correlated with 2h-postprandial glucose(2hPG)(r=0.432,P<0.01),total cholesterol(TC)(r=0.315,P<0.01)and body mass index(BMI)(r=0.256,P<0.05),but negatively correlated with HOMA-β(r=-0.217,P<0.05).The 2hPG was the independent risk factor of secretory rate of F2α(8-isoPGE)/Cr.[Conclusion]Theα-lipoic acid can improve islet beta cell function and re-duce oxidative stress level of patients with new diagnosed T2DM. 2014 Vol. 31 (6): 1073-1075 [Abstract] ( 44 ) HTML (1 KB)  PDF  (0 KB)  ( 35 ) 1076 Analysis of the Results of Patch Test for 430 Patients with Dermatitis and Eczema CHEN Hai-yan%TANG Yan-xiao%LIAO Xiao-yu [Objective]To explore the distribution of common allergens in pitch test for 430 patients with dermatitis and eczema.[Methods]A total of 430 patients wit dermatitis and eczema were chosen.Ruimin patch test reagent was used for allergen test.The result of allergens was analyzed.[Results]The most common aller-gens of patients with dermatitis and eczema were cobalt chloride,nickel sulfate,potassium dichromate,Kappa mixtures and aromatic mixture.[Conclusion]At present,heavy metal compound such as cobalt chloride and aromatic organic compound are the main allergens of dermatitis and eczema. 2014 Vol. 31 (6): 1076-1078 [Abstract] ( 29 ) HTML (1 KB)  PDF  (0 KB)  ( 35 ) 1078 Value of Clinical Pathway in Peritoneal Dialysis-related Peritonitis JIANG Li-ping%LIANG Jian-bo%WANG Ze-bin [Obj ective]To explore the efficacy of clinical pathway in the treatment of patients with perito-neal dialysis-related peritonitis.[Methods]Totally 49 patients with peritoneal dialysis-related peritonitis who were enrolled into clinical pathway in our department from July 2012 to July 2013 and 49 patients with perito-neal dialysis-related peritonitis patients who were not enrolled into clinical pathway from June 2011 to June 2012 were investigated.The positive rate of dialysate culture,the time of dialysate into clear liquid,hospital day,hospitalization expensens and recurrence in two groups were observed and compared.[Results]There was no significant difference in clinical indexes between two groups before treatment.The positive rate of dialysate culture in the experiment group was slightly higher than that in control group,but there was no significant difference between two groups(P>0.05).The time of dialysate turning better or normal in experiment group was lower than that in control group.Compared with the control group,the hospital day,per capita hospitali-zation expenses and the recurrence of peritonitis in experiment group were markedly decreased,and there were significant differences between two groups(P<0.05).[Conclusion]Clinical pathway in the treatment of per-itoneal dialysis-related peritonitis can promote clinical improvement,reduce hospital day and hospitalization ex-penses and decrease the recurrence of peritonitis.Therefore,it is worthy of clinical promotion. 2014 Vol. 31 (6): 1078-1081 [Abstract] ( 18 ) HTML (1 KB)  PDF  (0 KB)  ( 35 ) 1082 Clinical Study of Early Parenteral Nutrition Through Peripheral Central Venous Catheter in Very Low Birth Weight Infants [Obj ective]To explore the tolerance and clinical efficacy of early parenteral nutrition through pe-ripheral central venous catheter in very low birth weight infants(VLBWIs).[Methods]Totally 98 VLBWIs who were not tolerant to full enteral nutrition in neonatology department of our hospital were randomly divided into two groups.The observation group(n=49)received parenteral nutrition through peripheral central venous catheter within 2h after birth,while the routine treatment group(n=49)received traditional venous nutrition scheme at 48h after birth.Calories and protein in two groups during hospitalization were calculated.Blood glucose,head circumference and body weight were monitored.Blood samples were collected to determine biochemical indexes. All the results were statistically analyzed.[Results]Calories and protein intake in observation group at 3 days after birth reached the intake standard of premature infant,and there was significant difference between observation group and routine treatment group(P<0.01).There was no significant difference in calories and protein intake at 9 days after birth between observation group and control group(P>0.05).The accumulation lose of calories and protein in observation group at 3,9 and 21 days after birth were obviously lower than those in routine treatment group,and there was significant difference(P<0.01).The time to regain birth weight in observation group was obviously shorter than that in routine treatment group,and there was significant difference(P <0.01).The growth of head circumference and body height in observation group were faster than those in routine treatment group,and there was significant difference(P <0.05).There was no significant difference in the incidence of complications between two groups.[Conclusion]VLBWIs have good tolerance to early parenteral nutrition.The weight gain is fast,and the time to reach full enteral feeding is shortened,and parenteral nutrition-related compli-cations are not increased. 2014 Vol. 31 (6): 1082-1085 [Abstract] ( 59 ) HTML (1 KB)  PDF  (0 KB)  ( 33 ) 1086 Clinical Observation of Nimotuzumab Combined with IMRT and GP Regimen in the Treatment of Locally Recurrent Nasopharyngeal Carcinoma [Obj ective]To explore the efficacy of nimotuzumab combined with intensity-modulated radiothera-py(IMRT)and GP regimen(gemcitabine plus cisplatin)in the treatment of locally recurrent nasopharyngeal carci-noma(NPC).[Methods]A total of 7 1 patients with locally recurrent NPC in our hospital were randomly divided into observation group(n=35)and control group(n=36).All patients received IMRT and GP regimen(gemcit-abine plus cisplatin).The observation group was intravenously administered nimotuzumab 100mg weekly for 6~7 weeks before radiotherapy.The efficacy of two groups was observed and compared.[Results]The complete re-sponse(CR)of primary lesion at 3 months after treatment and local control rate at 1 and 2 years after treatment in the observation group were 65.7%,91.4% and 82.9% respectively,while those in the control group were 41.7%,72.2% and 61.1% respectively,and there was significant difference between two groups(P <0.05). The distant metastasis-free survival rate in the observation group at 1 and 2 years after treatment were 88.6% and 77.1% respectively which were higher than those in the control group(75.0% and 66.6%,respectively),but there was no significant difference between two groups(P>0.05).There was no significant difference in the inci-dence of short-term and long-term toxic side effects between two groups.[Conclusion]Nimotuzumab combined with IMRT and GP regimen can improve the CR rate and local control rate of locally recurrent NPC. 2014 Vol. 31 (6): 1086-1091 [Abstract] ( 38 ) HTML (1 KB)  PDF  (0 KB)  ( 40 ) 1089 Observation of the Efficacy of Pericardial Fenestration by Thoracoscopy Combined with Intracavity Sa-pylin for the Treatment of Malignant Pericardial Effusion [Obj ective]To explore clinical efficacy of pericardial fenestration by thoracoscopy combined with intracavity sapylin for the treatment of malignant pericardial effusion.[Methods]Totally 38 patients with malignant pericardial effusion in our hospital from Jan.2009 to Jan.2013 were randomly divided into two groups.The control group was given conventional conservative treatment,while the observation group was given pericardial fenestration by thoracoscopy and perfused with Sapylin during the operation.The short-term efficacy,disease progression time,median survival time and Karnofsky score of two groups before and after treatment were compared.[Results]The short-term effective rate of observation group(94.7%)was higher than that of control group(55.6%),and there was significant difference(P<0.05).The disease progression time and mean survival time in observation group after operation were longer than those in control group,and there was significant difference(P<0.05).Karnofsky score of observation group after operation was higher than that of control group,and there was significant difference(P<0.05).[Conclusion]Pericardial fenestra-tion by thoracoscopy combined with intracavity Sapylin for the treatment of malignant pericardial effusion has good efficacy,and can obviously improve clinical symptoms,prolong the survival time and increase quality of life of patients.Therefore,it is worthy of further clinical promotion. 2014 Vol. 31 (6): 1089-1091 [Abstract] ( 52 ) HTML (1 KB)  PDF  (0 KB)  ( 35 ) 1092 Value of Doppler Ultrasound in the Evaluation of Kidney Structure and Hemodynamics Change in Elderly People NIU Yaling [Obj ective]To explore the value of Doppler ultrasound in the evaluation of kidney structure and hemodynamics in elderly people.[Methods]Totally 85 elderly patients with chronic kidney disease(observa-tion group)and 85 subjects with normal kidney function(control group)were randomly chosen.The size, shape and structure of two kidneys,renal parenchyma thickness and echo in two groups were observed and compared.Color flow mapping was used to measure renal interlobar artery peak systolic velocity(PSV),end diastolic velocity(EDV),mean blood flow velocity(Vm),resistance index(RI),pulsatility index(PI)and oth-er renal interlobar artery hemodynamic parameters.[Results]Renal long and short diameters in observation group were (72.1±8.1)mm and (33.5 ± 2.8)mm respectively,which were far shorter than those in control group.Compared with control group,renal parenchyma in observation group was thickened obviously and the echo was strengthened markedly,and there was significant difference(P<0.05).The PSV,EDV and Vm in observation group were (22.56±4.58 )mL/s,(6.78±1.59)mL/s and (14.70±3.05)mL/s respectively which were markedly lower than those in control group(P<0.05),while RI and PI in observation group were (0.69±0.28)and (1.07±0.65)respectively which were markedly higher than those in control group(P<0.05).[Conclusion]Color Doppler ultrasound in the measurement of renal structure and hemodynamics chan-ges in elderly people is of great clinical value. 2014 Vol. 31 (6): 1092-1096 [Abstract] ( 74 ) HTML (1 KB)  PDF  (0 KB)  ( 45 ) 1094 Analysis of Arthroscopy for the Treatment of 3 0 Cases of Mediopatellar Syndrome [Obj ective]To explore the selection of the indications,operation skills and clinical efficacy of ar-throscopy for the treatment of mediopatellar syndrome.[Methods]A total of 30 patients with mediopatellar syn-drome from Jan.2012 to June 2013 were treated by the complete excision of synovial fold under arthroscopy.Ly-sholm score system was used to evaluate knee joint function before operation and at the latest follow-up after oper-ation.[Results]All the 30 patients were followed up for 7 to 21months,and the average follow up time was 12 months.Compared with before operation,knee joint functions were improved obviously,and Lysholm scores were increased obviously(90.7 vs.63.2,P<0.05).Among them,29 patients were excellent and good,and 1 patient was fair.The excellent and good rate was 96.7%.[Conclusion]Mediopatellar resection under arthroscopy for the treatment of mediopatellar syndrome has advantages such as minimal invasion and rapid recovery of joint function, and can improve knee joint function effectively. 2014 Vol. 31 (6): 1094-1096 [Abstract] ( 51 ) HTML (1 KB)  PDF  (0 KB)  ( 38 ) 1097 Clinical Application of 3D Printing Technology in the Treatment of Acetabular Fracture [Objective]To explore the feasibility and clinical value of three-dimension(3D)printing tech-nology in the treatment of acetabular fracture.[Methods]Spiral CT scan was performed in 6 patients with ace-tabular fracture.DICOM data were imported into Mimics software.The 3D printing technology was used to print the fracture models.Operative planning was worked out,and the surgical process was simulated before internal fixation,and then the operation was implemented.The aspects including operation approach,plate length,screw count and length were compared.Meanwhile,the actual operation time was recorded.[Results]The planned fixation method was completely used in 6 patients.The number and length of fixation plate and screw in 5 patients were concurrent with those before operation.The follow-up CT showed that 4 patients (66.7%)achieved anatomic reduction of articular surface,and 2 patients achieved satisfactory results without screw penetration into articular cavity.[Conclusion]The 3D printing technology for the treatment of acetabular fracture is feasible and of clinical significance.It is useful for surgeons to learn about acetabular facture and may be a powerful tool to work out preoperative planning. 2014 Vol. 31 (6): 1097-1103 [Abstract] ( 56 ) HTML (1 KB)  PDF  (0 KB)  ( 40 ) 1101 Influence of Different Pacing Modes on Left Heart Function and NT-proBNP [Objective]To explore the influence of physiological pacing(DDD)and non-physiological pa-cing(VVI)on cardiac structure and N-terminal pro-brain nitric peptide(NT-proBNP)in order to accumulate the experience for the coping strategies after cardiac pacemaker implantation.[Methods]A total of 6 5 patients treated with pacemaker in cardiology department of our hospital from Jan.2012 to Dec.2012 were chosen. According to different pacing mode,all patients were divided into two groups.The control group was treated with VVI,while the study group was treated with DDD.Left ventricular structure and NT-proBNP in two groups before and after pacemaker implantation were recorded and compared.[Results]There was no signifi-cant difference in LAD,LVD,IVST,PWT and EF before pacemaker implantation between two groups(P>0.05).After pacemaker implantation,LAD in the study group was lower than that in the control group(P<0.05),while EF in the study group was higher than that in the control group(P<0.05).There was no sig-nificant difference in NT-proBNP before pacemaker implantation between two groups(P>0.05).After pace-maker implantation,NT-proBNP in the study group was lower than that in the control group (P <0.05).[Conclusion]Patients with the indications of pacemaker should be treated with atrial-ventricular sequential pa-cing in order to reduce the effect of pacing on cardiac structure and function. 2014 Vol. 31 (6): 1101-1103 [Abstract] ( 32 ) HTML (1 KB)  PDF  (0 KB)  ( 36 ) 1104 Relationship Between Plasma Free Fatty Acids and Ischemic Stroke Subtype FAN Bing-qian%GAO Xiao-ping [Obj ective]To explore the relationship between free fatty acids(FFA)and subtypes of ischemic stroke.[Methods]General clinical date of 715 patients with acute ischemic stroke on admission in Hunan pro-vincial people's hospital from July 2010 to Dec.2013 were collected.The relationship between FFA concentra-tion and subtypes of ischemic stroke was analyzed retrospectively.[Results]Of 7 1 5 patients,there was signif-icant difference in serum FFA concentration between cardioembolic(CE)stroke and non-CE stroke(1194.68± 806.45Eq/L vs.793.73±611.87Eq/L)(P<0.001).FFA concentration in stroke patients with atrial fibrilla-tion(AF)was obviously higher than that in stroke patients without AF(1297.48±818.48Eq/L vs.776.50± 596.00Eq/L),and there was significant difference between two groups(P <0.001).FFA concentration in CE stroke patients with AF was obviously higher than that in non-CE stroke patients with AF(1311.53 ± 830.61Eq/L vs.894.77±663.20Eq/L),and there was also significant difference between two groups(P<0.001).[Conclusion]Fasting FFA concentration in patients with acute ischemic stroke is associated with CE stroke.The increasing of FFA concentration and combination with AF can be used as predictive indicators of CE stroke . 2014 Vol. 31 (6): 1104-1106 [Abstract] ( 33 ) HTML (1 KB)  PDF  (0 KB)  ( 43 ) 1107 Transurethral Electro-vaporization Separate Resection of Prostate for the Treatment of High-risk Benign Prostatic Hyperplasia [Obj ective]To explore the safety and efficacy of transurethral electro-vaporization separate re-section of prostate for the treatment of high-risk benign prostatic hyperplasia(BPH).[Methods]Transurethral electro-vaporization separate resection of prostate was performed in 90 patients with high-risk BPH.[Results]The procedures were operated in 90 patients for one time.Of all patients,86 patients were followed up for 1~3 months.Hematuria and irritation symptoms of bladder were reduced or disappeared,and micturition was good.Five patients with urinary incontinence recovered 2 months after anal raising exercise.Three patients with urethral stricture were cured by urethral expansion.[Conclusion]Transurethral electro-vaporization sep-arate resection of prostate is safe and effective,so it is an effective method of treating high-risk BPH. 2014 Vol. 31 (6): 1107-1108 [Abstract] ( 28 ) HTML (1 KB)  PDF  (0 KB)  ( 35 ) 1109 Analysis of the Correlation Between Lactic Acid Level and Prognosis in Children with Sepsis [Obj ective]To explore the correlation between serum lactate level and the prognosis in children with sep-sis.[Methods]According to serum lactate level in pediatric intensive care unit(PICU)within 24h,365 children with sep-sis in PICU of our hospital were divided into severely elevated group (≥4mmol/L,n=47 ),mildly elevated group (2mmol/L≤lactate<4mmol/L,n=108)and normal group(<2mmol/L,n=210).The correlation of serum lactate level and 6h-lactate clearance rate with disease severity and prognosis of pediatric patients with sepsis was analyzed.[Re-sults]The incidence of severe sepsis or septic shock in severe lactate elevation group,mild lactate elevation group and nor-mal group was 48.54%,37.23% and 14.25%(P<0.05)respectively.The incidence multiple organ dysfunction syn-drome in 3 groups was 45.34%,32.15% and 13.67%(p<0.05)respectively.The lactate levels in septic shock group, severe sepsis group and general sepsis group were 4.00±3.851mmol/L,2.98±2.537mmol/L and 1.85±1.523mmol/L respectively,and there was significant difference(H=38.551,P=0.000).The 6h-lactate clearance rate of 3 groups was (8.01±0.703)%,(12.34±15.89)% and (22.28 ± 14.46)% respectively,and there was significant difference(H=15.008,P=0.000).Lactic acid was gadually decreased at admission,admission 24 hours and 48 hours of admission,but the difference was no statistically significant (P>0.05).Lactate level in survival group and death group on admission were 2.085±1.669mmol/L and 4.27±4.135mmol/L respectively,and there was significant difference(u=4424.00,P=0.002).Serum lactate levels of survival children at 1,2 and 3 days had the decreasing trend,while those of death or a-bandoned children had the increasing trend(P<0.05).The mortality in low lactate clearance rate group was obviously higher than that in high lactate clearance rate group,and there was significant difference(P<0.05).[Conclusion]The dynamic monitoring of the changes of lactate and lactate clearance rate is conducive to grasp the condition and prognosis of patients. 2014 Vol. 31 (6): 1109-1112 [Abstract] ( 41 ) HTML (1 KB)  PDF  (0 KB)  ( 41 ) 1112 Influence of Full High-quality Nursing Mode on Negative Emotion of Patients with Esophageal Cancer YANG Lingjuan%ZOU Jinmei%CAOMei [Obj ective]To explore the influence of full high-quality nursing mode on negative emotion of pa-tients with esophageal cancer.[Methods]Totally 80 inpatients with esophageal cancer in oncology department of our hospital were randomly divided into observation group and control group.The control group received conven-tional nursing,while the observation group received full high-quality nursing mode.The negative emotion status, quality of life and compliance in two groups were evaluated by self-rating anxiety scale(SAS),self-rating depres-sion scale(SDS)and 3 6-item short-form health survey (SF-3 6 ).[Results]After 2 weeks of admission,the SAS and SDS scores of control group[(53.3±7.8)and (52.4±5.5),respectively]were higher than those of observa-tion group[(48.9.±7.2)and (48.7±5.3),respectively],and there was significant difference(P<0.05).The scores of quality of life including physiological,social and affective function in observation group were better than the control group(P<0.05).The compliance of observation group was better than control group,and there was significant difference(P<0.05).[Conclusion]The full high-quality nursing mode can obviously alleviate the neg-ative emotion of patients with esophageal cancer,increase the compliance and improve the quality of life and treat-ment efficacy. 2014 Vol. 31 (6): 1112-1114 [Abstract] ( 23 ) HTML (1 KB)  PDF  (0 KB)  ( 36 ) 1115 Design and Clinical Application of the Aiming Device for Free-hand Distal Locking Screw Place-ment of Femoral Intramedullary Nail [Obj ective]To design a simple and accurate X-ray aiming device for free-hand distal locking screw placement of femoral intramedullary nail and to verify clinical efficacy.[Methods]The aiming device for free-hand distal locking screw placement was self designed,made and applied in clinical practice.Totally 28 patients with femoral shaft fracture who failed to distal locking screw with traditional aiming device in orthopedic department of our hospital from Oct.2012 to Oct.2013 were randomly divided into two groups.Group A underwent free-hand nail placement by self-made aiming device,while group B underwent nail placement without the aiming device for fluoroscopy.The locking operation time,blood loss and fluoroscopy times were compared between two groups.[Results]The locking operation time,blood loss and fluoroscopy times of group A were markedly less than those of group B,and there was significant difference(P<0.05).[Conclusion]This aiming device is simple in struc-ture,accurate in positioning and convenient in application.Therefore,it is a good choice as an effective remedy method of nail placement after the failure of traditional distal locking screw placement of femoral intramedullary nail. 2014 Vol. 31 (6): 1115-1120 [Abstract] ( 60 ) HTML (1 KB)  PDF  (0 KB)  ( 30 ) 1118 Effect of Hospital-community Continuous Nursing Model on Overall Quality of Life in Elderly Patients with COPD LIUYan-hua%ZHU Dao-ping [Obj ective]To explore the effect of hospital-community continuous nursing model on overall function of elderly patients with COPD.[Methods]Totally 93 elderly patients diagnosed in our hospital were divided into two groups.The control group received routine nursing care,while continuous nursing group re-ceived community continuous nursing model based on conventional care.Self-rating anxiety scale(SAS)and self-rating depression scale(SDS)were used to observe the negative emotions of patients in two groups before and after treatment and the overall quality of life in continuous nursing group after treatment.[Results]The score of quality of life in continuous nursing group was (81.3± 6.4),which was markedly better than that in control group(65.8±10.3)(P <0.05).The SAS score in continuous nursing group after nursing care was (27.7±7.1),which was markedly lower than that in control group(49.6±8.4)(P<0.05).The total scores of functional scale and symptom scale in continuous nursing group were (76.8±13.4)and (23.7±8.5)% re-spectively,and those after nursing care were better than those before nursing care,and there was significant difference(P<0.05).[Conclusion]Hospital-community continuous nursing model can improve the overall life function in elderly patients with COPD and raise the quality of life of patients,so it is conducive to the cure of the disease. 2014 Vol. 31 (6): 1118-1120 [Abstract] ( 89 ) HTML (1 KB)  PDF  (0 KB)  ( 36 ) 1121 Expression of NOD1 in Adipocytes of Obese Patients with Diabetes Mellitus and Its Effect on Insu-lin Resistance [Obj ective]To explore the expression of immunologic receptor nucleotide-binding oligomerization domain-containing protein 1(NOD1)in adipocytes of obese patients with diabetes mellitus(DM)and its relation with insulin re-sistance(IR).[Methods]Abdominal subcutaneous adipocytes were drawn from 10 obese patients with DM(DM group) and 1 0 obese patients without DM(NDM group).Real-time PCR was used to detect the expression of NOD1 in adipocytes of two groups.NOD1 receptor agonist iE-DAP was administered.Enzyme linked immunosorbent assay(ELISA)was used to detect the levels of inflammatory cytokines such as interleukin-6(IL-6),interleukin-8(IL-8)and monocyte chemotactic factor-1(MCP-1)in two groups.The baseline state and iE-DAP-stimulated glucose uptake were observed by 2-deoxy-D-3 H glucose uptake assay.[Results]NOD1 mRNA expression in adipocytes of DM group was markedly higher than that of NDM group(P <0.05).The levels pf IL-6,IL-8 and MCP-1 in DM group with iE-DAP stimulation were markedly higher than those in NDM group(P<0.05).Adipocyte glucose transport rate in DM group with iE-DAP stim-ulation was significantly lower than that in NDM group(P<0.05).[Conclusion]NOD1-mediated inflammatory response may involve in the occurrence of IR in obese DM. 2014 Vol. 31 (6): 1121-1124 [Abstract] ( 32 ) HTML (1 KB)  PDF  (0 KB)  ( 37 ) 1124 Study of the Correlation of Cervical Infection with IVF-ET and Natural Pregnancy Threatened A-bortion [Obj ective]To explore the correlation of cervical infection with in vitro fertilization-embryo transfer (IVF-ET)and natural pregnancy threatened abortion.[Methods]A total of 3 7 patients with threatened abortion after IVF-ET in our hospital from July 2012 to July 2013 were chosen as the study group.Concurrent 40 patients with natural pregnancy threatened abortion were randomly chosen as the control group.Cervical secretion culture (anaerobic bacteria,mycoplasma and bacteria)was performed in all patients.Cervical infection was compared be-tween them.[Results]The positive rate of cervical secretions in the study group and control group was 67.57%and 27.50% respectively,and that in the study group was obviously higher than that in control group,and there was significant difference in the positive rate between two groups(χ2=17.839,P<0.05).There was significant difference in the level of TNF-αbetween patients with positive and negative cervical infection of two groups(t=23.678,27.340,P<0.05).But there was no significant difference between two groups(t=1.241,1.352,P>0.05).[Conclusion]There is correlation between patients with threatened abortion and cervical infection,but pa-tients with IVF-ET is more easy to be infected.Routine cervical secretion culture in the treatment of threatened a-bortion should be taken so as to increase the success rate of pregnancy. 2014 Vol. 31 (6): 1124-1126 [Abstract] ( 91 ) HTML (1 KB)  PDF  (0 KB)  ( 36 ) 1127 Expression and Clinical Significance of MiR-20b in Gastric Cancer XIE Xue-Fei%LIU Zhan [Objective]To explore clinical significance of miR-20b expression in pathogenesis of gastric cancer among Chinese population.[Methods]Totally 75 fresh tissues of gastric adenocarcinoma and 20 para-cancerous tissues were collected.Total RNA of these tissues was extracted by routine Trizol method.After reverse transcription of total RNAs into miRNA cDNA,the expression of miR-20b was examined in these tis-sues by using qPCR method.The correlation between miR-20b expression and clinical parameters of gastric cancer was analyzed by using SPSS1 5 .0 software.[Results]Compared with para-cancerous gastric tissue,the expression of miR-20b in gastric cancer tissue was obviously increased.Furthermore,the increased expression of miR-20b was positively associated with tumor size,lymph node metastasis and clinical stage obviously.[Conclusion]The expression of miR-20b in gastric cancer tissue is increased,and can promote the progression of gastric cancer. 2014 Vol. 31 (6): 1127-1129 [Abstract] ( 48 ) HTML (1 KB)  PDF  (0 KB)  ( 34 ) 1130 Clinical Analysis of 224 Twin Premature Infants with Different Gestational Age and Birth Weight LIAOZhen-yu%HUANGRui-wen%XIAOAi-qing [Obj ective]To analyze the incidence of the complications and mortality rate of twin premature infants with different gestational age and birth weight.[Methods]According to gestational age,224 twin premature infants hos-pitalized in neonate department of our hospital from July 2010 to July 2012 were divided into less than 32-week group,32~34-week group and 34~37 week group.According to birth weight,all patients were divided into less than 1500g group,1500-2500g group and more than 2500g group.The incidence of complications and mortality rate were compared among different groups.[Results]There were significant differences in the incidence of anemia,respiratory failure,reti-nopathy of prematurity(ROP),neonatal respiratory distress syndrome(NRDS)and bronchopulmonary dysplasia(BPD)a-mong twin premature infant groups with different gestational age and birth weight(P<0.05),and the smaller the gesta-tion age and the lighter birth weight,the higher the incidence rate.There was significant difference in the incidence of hy-poglycemia among twin premature infant groups with different gestation age and birth weight(P<0.05),and the lighter birth weight,the higher the incidence rate.There was significant difference in the incidence of apnea among twin prema-ture infant groups with different gestation age and birth weight(P<0.05).Among 224 patients,15 patients died and the mortality rate was 6 .7%.The smaller gestation age and the lighter birth weight,the higher the mortality rate,and there was significant difference among groups(P<0.05).[Conclusion]Health service for pregnant women of twin pre-mature infants should be strengthened in order to decrease the occurrence of premature and low birth weight infants.The prevention and treatment of common complications of twin premature infants should be strengthened so as to decrease the mortality rate. 2014 Vol. 31 (6): 1130-1132 [Abstract] ( 56 ) HTML (1 KB)  PDF  (0 KB)  ( 38 ) 1133 Clinical Observation of Long-term Efficacy and Complication ofSurgical Treatment of Cataract in Children LIUXing-hong%XIANGXiao-fang [Obj ective]To explore the efficacy and complications of phacoemulsification for the treatment of children with cataract.[Methods]A total of 56 children with cataract(68 eyes)underwent phacoemulsification combined with or without intraocular lens implantation.All patients were followed up for 3~5 years.The recov-ery of visual function and complications were observed.[Results]The visual acuity of 99.8% of patients was im-proved.Patients with visual acuity≥0.5 accounted for 57%.The main complications were uveitis,corneal edema, after-cataract,secondary glaucoma and intraocular lens shift.[Conclusion]Phacoemulsification for the treatment of children with cataract has reliable long-term efficacy,but the incidence of postoperative glaucoma and iritis is higher and should be paid more attention. 2014 Vol. 31 (6): 1133-1135 [Abstract] ( 25 ) HTML (1 KB)  PDF  (0 KB)  ( 34 ) 1135 Study on the Change of Time Domain Index of Heart Rate Variability in Patients with Peripartum Cardio-myopathy and Pregnancy Induced Hypertension and ItsMechanism LIJing%LIXiao-ji [Objective]To explore the change of time domain index of heart rate variability(HRV)in patients with peripartum cardiomyopathy(PPCM)and pregnancy induced hypertension(PIH)and its mechanism.[Meth-ods]Totally 30 patients with PPCM(PPCM group),30 patients with PIH(PIH group)and 30 normal healthy peo-ple(control group)were collected.The indexes of time domain of HRV and echocardiography among 3 groups were compared.[Results]SDNN,SDANN,RMSSD and PNN50 in PPCM group and PIH group were markedly lower than those in control group,and those in PPCM group were markedly lower than those in PIH group,and there was significant difference(P <0.05).There was no significant difference in ventricular wall thickness a-mong 3 groups(P >0.05).There were significant differences in ventricular antero-posterior diameter,motion amplitude and EF between PPCM group and PIH group or control group(P<0.05),but there was no significant difference between PIH group and control group(P >0.05).[Conclusion]PPCM patients at third trimester of pregnancy have the change of cardiac structure and function due to autonomic nerve function damage induced by cardiac remodeling and the decreasing of time domain index of HRV.Patients with PIH have the disorder of the balance between sympathetic and parasympathetic nerve and the decreasing of time domain index of HRV. 2014 Vol. 31 (6): 1135-1137 [Abstract] ( 49 ) HTML (1 KB)  PDF  (0 KB)  ( 44 ) 1138 Analysis of the Feasibility of Laparoscopic Super Low Rectal Cancer Radical Resection [Obj ective]To explore the efficacy of laparoscopic super low rectal cancer radical resection with anal preservation.[Methods]Clinical data of 5 9 patients with super low rectal cancer undergoing anterior rectal cancer resection by laparoscopy in our department from Jan.2010 to Dec.2012 were analyzed retrospectively.[Results]All patients completed laparoscopic surgery successfully.No one converted to open surgery.The success rate of anal preservation was 100%.No intraoperative death was found.The average operation time was (147 ± 38)min.Lymph nodes(5~12)were removed.The average bleeding volume was (123±47)mL. The time of intestinal function recovery after operation was 2~4 days.The hospitalization time was 8~1 7 days.[Conclusion]Laparoscopic super low rectal cancer radical resection with anal preservation is safe and fea-sible. 2014 Vol. 31 (6): 1138-1139 [Abstract] ( 47 ) HTML (1 KB)  PDF  (0 KB)  ( 41 ) 1140 Study on the Relationship Between Esmolol and Erythrocyte Oxygen Carrying Capacity in Pa-tients with Acute Myocardial Infarction [Obj ective]To explore whether esmolol affects erythrocyte oxygen carrying capacity in patients with acute myocardial infarction.[Methods]Erythrocytes from patients with acute myocardial infarction were collected and suspended in isotonic PBS buffer solution with different pH value(pH7.4 and pH5.0).Erythro-cytes were pretreated with adrenaline,esmolol and adrenaline plus esmolol,respectively.The characteristic spectral changes of hemoglobin in single living erythrocytes were detected by using Raman spectroscopy analy-sis.[Results]Characteristic peak of oxyhemoglobin treated with PBS and esmolol at pH5.0 was decreased obvi-ously,but that treated with adrenaline was increased significantly. After pretreatment with esmolol plus adrenaline,the effect of adrenaline was not obvious.[Conclusion]Esmolol can reduce the effect of adrenaline for enhancing erythrocyte oxygen carrying capacity of hemoglobin in acid environment,and increase the disso-ciation of oxygen from hemoglobin,and is helpful for oxygen supply of anoxia tissue. 2014 Vol. 31 (6): 1140-1142 [Abstract] ( 39 ) HTML (1 KB)  PDF  (0 KB)  ( 48 ) 1142 Clinical Observation of Alprostadil Combined with Ginkgo Damole Injection for the Treatment of 2 6 Patients with Chronic Renal Insufficiency YIN Wei%LIANGYu-mei [Obj ective]To observe clinical efficacy of alprostadil combined with Ginkgo Damole inj ection for the treatment of chronic renal insufficiency(CRI).[Methods]A total of 5 3 CRI patients in our hospital were randomly divided into alprostadil combined with Ginkgo Damole inj ection treatment group(observation group) and conventional treatment group(control group).The changes of plasma urea nitrogen(BUN),serum creati-nine(SCr)and estimated glomerular filtration rate(eGFR)in 2 group were observed and compared.[Results]Compared with before treatment,BUN,SCr and eGFR in observation group after treatment were improved obviously,and there was significant difference(P<0.05).There was no significant difference in BUN,SCr and eGFR of control group between before and after treatment(P >0.05).After treatment,there was also significant difference between observation group and control group(P<0.05).[Conclusion]Alprostadil com-bined with Ginkgo Damole inj ection can improve renal function of patients with CRF and delay the progression of renal function. 2014 Vol. 31 (6): 1142-1144 [Abstract] ( 59 ) HTML (1 KB)  PDF  (0 KB)  ( 39 ) 1145 Application of Microanatomy of Petrosal Vein in Microsurgical Decompression for Trigeminal Neuralgia [Obj ective]To explore the application of microanatomy of petrosal vein in microsurgical decom-pression for trigeminal neuralgia.[Methods]Clinical data of 547 patients with trigeminal neuralgia undergoing microsurgical decompression in our hospital were analyzed retrospectively.[Results]Of 127 patients undergo-ing surgical management of petrosal vein,5 patients died and 1 patient suffered cerebellum and brainstem in-farction.Of 420 patients who did not undergo surgical management of petrosal vein,no one died.[Conclusion]Petrosal vein compressing trigeminal nerve is one of the causes of trigeminal neuralgia.During microsurgical decompression for the treatment of trigeminal neuralgia,the protection and rational management of petroal vein are the important factors of decreasing the mortality.The management of petroal vein should be careful. 2014 Vol. 31 (6): 1145-1147 [Abstract] ( 48 ) HTML (1 KB)  PDF  (0 KB)  ( 31 ) 1147 Comparison of the Efficacy of Three Kinds of Lithotripsy for the Treatment of Complicated Bladder Calculi RANGuang-shun%LUOJiang-yan%ZHAOZe-ju [Obj ective]To explore the value of three kinds of lithotripsy in the treatment of complicated bladder calculi.[Methods]Clinical data of 1 2 6 patients with complicated bladder calculus undergoing surgical treatment in our hospital were analyzed.Among 126 patients,55 patients were single stones with diameter 2.5~4.7cm,and 71 patients were multiple stones with minimum diameter≥1.0cm.Of all patients,33 patients underwent pneumatic lithotripsy,and 5 1 patients underwent ultrasonic lithotripsy by using Swiss EMS sys-tem,and 42 patients underwent holmium laser.Iintraoperative flushing water volume,blood loss,operative time,postoperative hospital stay,bladder mucosal inj ury and postoperative cystospasm ratio were analyzed and compared among 3 groups.[Results]Transurethral bladder calculi of 126 patients were removed for one time. None turned to the operation.Except long operative time in holmium laser group,the other indicators were better than the other groups(P<0.05).Except flushing water volume in EMS group,there was no signifi-cant difference in other indicators between EMS group and pneumatic lithotripsy group(P>0.05).[Conclu-sion]Holmium laser for the treatment of complicated bladder calculi can effectively prevent intraoperative stone drift and too more flushing water,and reduce bladder inj ury,postoperative bladder spasms and postoperative hospital stay. 2014 Vol. 31 (6): 1147-1149 [Abstract] ( 31 ) HTML (1 KB)  PDF  (0 KB)  ( 42 ) 1150 Changes of DD,FIB,APTT and PLT of Patients with DIC in Obstetric Department Before and after Treatment XUJing%GUOXi-xi [Obj ective]To explore the changes of D-dimer(DD),fibrinogen(FIB),activated partial throm-boplastin time(APTT)and platelet(PLT)of patients with disseminated intravascular coagulation(DIC)in ob-stetric department before and after treatment and the significance.[Methods]A total of 28 DIC parturients in our hospital from Jan.2009 to Aug.2012 were selected as the observation subjects.Dynamic DD,FIB, APTT and PLT before and after the occurrence of DIC and until successful treatment were measured(once per 6h and 1~2 times every day after stable condition).The measurement result before and after treatment was observed.[Results]The DD of 28 parturients with DIC was obviously increased,and FIB was decreased,and APTT was prolonged,and PLT was reduced progressively.All indexes after treatment were improved,and there was significant difference between two stages(P<0.05).All 28 patients were recovered and discharged after treatment.[Conclusion]Dynamic detection of DD,FIB,APTT and PLT is helpful for clinical diagnosis and the monitoring of the prognosis of patients. 2014 Vol. 31 (6): 1150-1151 [Abstract] ( 72 ) HTML (1 KB)  PDF  (0 KB)  ( 33 ) 1152 Study on the Relationship Between P-selectin and the Severity of Coronary Artery Lesions in Pa-tients with Coronary Heart Disease [Obj ective]To explore the relationship between P-selectin(Ps)level and the severity of coronary ar-tery lesions in patients with coronary heart disease(CHD).[Methods]The levels of Ps in 42 patients with acute coronary syndrome(ACS group),27 patients with stable angina pectoris(SAP group)and 29 healthy controls were measured.The relationship of the number of the diseased coronary artery and Gensini score of coronary artery with the Ps level was analyzed.[Results]The levels of Ps in ACS group and SAP group were higher than those in con-trol group(P<0.05),and those in ACS group were higher than those in SAP group(P<0.05).Compared with single-vessel coronary lesion group,the levels of Ps in multiple-vessel coronary lesion group lesions were markedly increased,and there was significant difference between two groups(P<0.05).The levels of Ps in the subgroup with Gensini score≥20 were obviously higher than those in the subgroup with total score<20,and there was sig-nificant difference between two groups(P<0.05).[Conclusion]The level of Ps in patients with CHD is increased and correlated with the severity of coronary lesion,and can predict the severity of CHD. 2014 Vol. 31 (6): 1152-1153 [Abstract] ( 47 ) HTML (1 KB)  PDF  (0 KB)  ( 33 ) 1154 Expression and Its Clinical Significance of MicroRNA-6 1 3 in Papillary Thyroid Carcinoma [Objective]To detect the difference of the expression of microRNA-613(miR-613)in papillary thyroid carcinoma(PTC),nodular goiter and normal thyroid tissues surrounding the cancer,and to explore the significance of miR-613 in PTC.[Methods]A total of 190 cases of PTC undergoing thyroid resection,44 cases of distal non-tumor normal thyroid tissue surrounding the cancer and 3 1 cases of nodular goiter in our hospital from March 2012 to Sept.2013 were collected.The expression level of miR-613 in PTC tissue,normal thyroid tissue surrounding the cancer and nodular goiter tissue were assayed by real-time polymerase chain reaction (PCR).The correlation between miR-6 1 3 expression and clinicopathologic features of PTC was analyzed.[Re-sults]The expression level of miR-6 1 3 in PTC tissue was obviously lower than that in non-tumor tissue(P<0.05),but there was no significant difference among non-tumor tissues(P>0.05).The expression level of miR-613 was correlated with extra-thyroid invasion of PTC(P<0.05).[Conclusion]The expression level of miR-6 1 3 in PTC is decreased and correlated with tumor invasiveness. 2014 Vol. 31 (6): 1154-1156 [Abstract] ( 30 ) HTML (1 KB)  PDF  (0 KB)  ( 34 ) 1156 Effect of the Incidence of Urinary Symptoms on Quality of Life of Patients with Adenomyosis XIEHong-min [Obj ective]To explore the incidence of urinary symptoms in patients with adenomyosis and the influence on the patients'quality of life(QOF).[Methods]Totally 90 patients with adenomyosis diagnosed by gynecological ultrasonography in our hospital from Dec.2012 to Dec.2011 were randomly selected as adeno-myosis group.Other 90 healthy subjects with showed by normal myometrial structure were selected as control group.All patients received pelvioscopy and filled two questionnaires such as urogenital distress inventory (UDI-6)and incontinence impact questionnaire(IIQ-7).The incidence of urinary symptoms was recorded.[Results]Compared with control group,the incidence of urinary symptoms such as stress urinary incontinence, urgency,daytime frequent micturition,urgent urinary incontinence and algopareunia in adenomyosis group was markedly increased,and there was significant difference between two groups(P<0.05).Total scores of UDI scores in adenomyosis group were significantly higher than those in control group(P<0.05).IIQ scores of questions regarding social relations in adenomyosis group were also significantly higher than those in control group(P<0.05).[Conclusion]The incidence of urinary tract dysfunction is high.Urinary symptoms may af-fect the QOF of patients. 2014 Vol. 31 (6): 1156-1158 [Abstract] ( 38 ) HTML (1 KB)  PDF  (0 KB)  ( 40 ) 1159 Application of Sevoflurane Low-flow Maintenance Anesthesia in the Elective Surgery of Children [Obj ective]To observe the effect of sevoflurane low-flow maintenance anesthesia on the hemodynamics,hepat-ic and renal function and blood gas index of children undergoing elective surgery,and to assess the safety and feasibility.[Methods]A total of 40 ASAⅡorⅢchildren undergoing elective surgery with tracheal intubation under general anesthesia (operation time of 2~4h)were chosen and randomly divided into group A(low-flow group,n=20)and group B(middle-flow group,n=20).Both two groups were given rapid venous induction with oxygen flow at 2L/min,and then oxygen supply by face mask compression.After tracheal intubation,sevoflurane volatilizing j ar was regulated to 3%.Oxygen flow in group A and group B was 0.5L/min and 2.5L/min respectively.Heart rate(HR),blood pressure(MAP),PET CO2 and SpO2 of all pa-tients were monitored.HR,MAP,PET CO2 and SpO2 at 10min after intubation(T0 ),1h after intubation(T1 ),2h after intu-bation(T2 )and the end of operation(T3 )were recorded.Radial arterial blood at each time points was drawn to gas analysis. Venous blood before and 24h after operation were drawn to monitor hepatic and renal function.[Results]There was no sig-nificant difference in HR,MAP,PET CO2 ,SpO2 and arterial gas analysis index at each checking point between group A and group B(P>0.05).There was no significant difference in hepatic and renal function indicators before and after operation between two groups(P>0.05).No hypoxemia and hypercarbia occurred during the whole procedure in both groups.[Con-clusion]Sevoflurane low-flow fresh gas with oxygen flow at 0.5L/min for maintenance anesthesia has no obvious influence on hepatic and renal function in children undergoing elective surgery,and the hemodynamics and arterial gas indexes are in nor-mal range.Therefore,it is safe in elective surgical anesthesia of children. 2014 Vol. 31 (6): 1159-1163 [Abstract] ( 59 ) HTML (1 KB)  PDF  (0 KB)  ( 40 ) 1161 Observation of the Efficacy of Arthroscopic Joint Debridement for the Treatment of Knee Osteoar-thritis [Objective]To explore the efficacy of arthroscopic joint debridement for the treatment of knee osteoar-thritis.[Methods]A total of 1 3 5 knees of inpatients diagnosed as knee osteoarthritis were collected.According the treat-ment methods,all patients were divided into two groups.The conservative treatment group(62 knees)included early and middle stage group(40 knees)and advanced stage group(22 knees).The surgical treatment group(64 knees)included ear-ly and middle stage group(46 knees)and advanced stage group(18 knees).The efficacy was compared between joint de-bridement and conservation therapy for the treatment of early,middle and advance stage knee osteoarthritis.[Results]Of 1 3 5 knees,1 2 6 knees were followed up,and the follow-up rate was 9 3 .3%,and the follow-up time was 6~1 2 months. All 98 patients with the follow-up were followed up by using Lysholm knee joint function assessment table.The patients in early and middle stage group receiving conservation treatment and the patients in surgical treatment group could obtain satisfactory efficacy,but there was no significant difference in the scores between two groups(P>0.05).The efficacy of conservative treatment of patients in advanced stage group was poor,and the efficacy was markedly decreased especially at 1 2 months of follow up.There was significant difference in the scores between patients in advanced stage group receiving conservation treatment and patients undergoing operation(P<0.05).The efficacy of surgical treatment in early and mid-dle stage group and advanced stage group was good,but the scores of the former were higher than those of the latter.[Conclusion]Arthroscopic joint debridement for the treatment of knee osteoarthritis can achieve satisfactory efficacy.The efficacy of patients in early and middle stage group is better. 2014 Vol. 31 (6): 1161-1163 [Abstract] ( 56 ) HTML (1 KB)  PDF  (0 KB)  ( 30 ) 1164 Comparison of Clinical Efficacy of Gastroscopy Combined with Laparoscopy vs.Traditional Laparotomy Surgery in the Treatment of Early Gastric Cancer [Obj ective]To compare the clinical effect of gastroscopy combined with laparoscopy vs.tradi-tional laparotomy surgery for the treatment of early gastric cancer.[Methods]Totally 5 6 patients with early gastric cancer in our hospital from April 2012 to April 2013 were chosen and randomly divided into conserva-tion group and control group with 28 patients in each group.The observation group underwent gastroscopy combined with laparoscopy,while the control group underwent traditional laparotomy surgery.The operation time,intraoperative blood loss,postoperative recovery time of intestinal function,hospitalization time and postoperative complications of two groups were observed and compared.[Results]Intraoperative blood loss, postoperative recovery time of intestinal function and hospitalization time in observation group were markedly better than the control group(P <0.05).The postoperative complications such as lung infection,urinary tract inflammation,pleural effusion and wound infection in observation group were obviously lower than those in the control group.[Conclusion]Compared with traditional laparotomy surgery,gastroscopy combined with laparoscopy for the treatment of early gastric cancer can shorten the treatment time and reduce the pain,and is safe and reliable,so it is safe and feasible method.It is worthy of clinical promotion. 2014 Vol. 31 (6): 1164-1168 [Abstract] ( 46 ) HTML (1 KB)  PDF  (0 KB)  ( 37 ) 1166 Significance of Central Vein-arterial Partial Pressure Difference of Carbon Dioxide in Fluid Resus-citation for Severe Acute Pancreatitis [Obj ective]To explore clinical significance of central vein-arterial partial pressure difference of carbon di-oxide(Pcv-aCO2 )in the assessment of further fluid resuscitation for severe acute pancreatitis(SAP)patients with central venous oxygen saturation(ScvO2 )>70% who receive fluid resuscitation at acute phase.[Methods]Totally 47 SAP pa-tients with ScvO2>70% who received early fluid resuscitation in ICU from Feb.2013 to Oct.2013 were chosen.Ac-cording to Pcv-aCO2 with the threshold of 6mmHg at grouping(T1 ),all patients were divided into low Pcv-aCO2 group (group A,n=24)and high Pcv-aCO2 group(group B,n=23).Pcv-aCO2 at 12h after resuscitation(T2 )was measured again.[Results]There was significant difference in lactic acid(LA)between group A and group B at T1 [(3.35±0.49 mmol/L)vs.(4.46±1.18)mmol/L](P<0.01),but there was no significant difference in ScvO2 between two groups [(72.92±2.21)% vs.(74.43±3.94)%](P>0.05).The clearance of lactate acid(LAC)in group A from T1 to T2 was higher than that in group B(P<0.01).Pcv-aCO2 at T1 and T2 had linear correlation with LA(r=0.523,0.537, all P<0.01),and good negative correlation with LAC(r=-0.49,0.54,all P<0.01).[Conclusion]Although the target value of ScvO2 70% is up to the standard,SAP patients receiving fluid resuscitation have insufficient tissue perfu-sion.Pcv-aCO2>6mmHg can be used as the index of further fluid resuscitation of SAP patients with standard ScvO2 after early resuscitation. 2014 Vol. 31 (6): 1166-1168 [Abstract] ( 48 ) HTML (1 KB)  PDF  (0 KB)  ( 41 ) 1169 Clinical Significance of Different Cytokines in the Diagnosis of Severe Pneumonia CHEN Chong [Obj ective]To explore the significance of different cytokines in clinical diagnosis of patients with severe pneumonia.[Methods]Totally 100 patients with pneumonia were collected.According to the pa-tient's condition,all patients were divided into severe pneumonia group(n=40)and common pneumonia group (n=60).Other 50 healthy subjects were selected as control group.The levels of interleukin-6(IL-6),inter-leukin-8(IL-8),tumor necrosis factor(TNF),C-reactive protein(CRP)and white blood cell(WBC)were measured and compared among 3 groups.[Results]The levels of serum cytokines TNF,IL-6,IL-8,CRP and WBC in severe pneumonia group were markedly higher than those in common pneumonia group and control group,and those in common pneumonia group were markedly higher than those in control group,and there were significant differences(P<0.05).[Conclusion]The increasing of serum cytokines TNF,IL-6,IL-8 is of certain significance in the diagnosis of patients with severe pneumonia. 2014 Vol. 31 (6): 1169-1171 [Abstract] ( 40 ) HTML (1 KB)  PDF  (0 KB)  ( 35 ) 1171 Percutaneous Vertebroplasty for the Treatment of Nonunion of Osteoporotic Vertebral Compression Fracture [Obj ective]To explore the feasibility and clinical efficacy of percutaneous vertebroplasty(PVP) in the diagnosis and treatment of nonunion of osteoporotic vertebral compression fracture(OVCF).[Methods]A total of 7 patients with nonunion of osteoporotic vertebral fractures undergoing PVP from May 2009 to May 2013 were analyzed retrospectively.There were 2 males and 5 females.The mean age was 72.5 years(61~88 years).The fracture vertebrae were 3 cases in T12 ,3 cases in L1 and 1 case in L2 .The disease duration was 15~23 months.All patients received X-rays,CT and MRI examination.The surgical result was evaluated by visual analogue scale(VAS),anterior vertebral height(AH)and wedge angle(WA).[Results]All patients were operated successfully without severe complications.All patients were followed up for 5~35 months (mean 1 5 .5 months).Postoperative pain was alleviated obviously.Pain VAS before and at d1 after operation was (8.10±1.50)and (1.25±1.04)respectively,and there was significant difference between them(P <0.05).The VAS at final follow up was (1.15±0.87),but there was no significant difference between the fi-nal follow up and post-operation(P>0.05).Compared with before operation,AH and WA after operation had no obvious improvement(P>0.05).There was no significant difference in AH and WA between the final follow up and post-operation(P>0.05).[Conclusion]PVP can obviously improve back pain caused by non-union of OVCF,but has no obvious effect on the recovery of the height of the diseased vertebra. 2014 Vol. 31 (6): 1171-1176 [Abstract] ( 25 ) HTML (1 KB)  PDF  (0 KB)  ( 40 ) 1174 Effect of Dexmedetomidine on Stress Response of Intubation with Double-lumen Endobronchial tube under Anesthesia Induction TANGLi [Obj ective]To observe the effect of pre-inj ection with dexmedetomidine before anesthesia in-duction on stress response of intubation with double-lumen endobronchial tube.[Methods]A total of 5 9 pa-tients undergoing lung or esophagus surgery under general anesthesia in our hospital were randomly divided in-to control group(group C,n=29)and observation group(group D,n=30).Group D was given an intrave-nous transfusion of dexmedetomidine 0.6μg/kg before anesthesia induction,while group C was given an intra-venous inj ection of isovolume normal saline.Then patients were given the target controlled infusion of propofol with plasma target level of 3μg/ml and an intravenous injection of sufentanil 0.3μg/kg and cisatracurium 0.2 mg/kg.Intubation with double-lumen endobronchial tube was performed 5min later.Blood samples were col-lected before anesthesia induction(T0 )and immediately after tracheal intubation(T2 ).High performance liquid chromatography(HPLC)was used to detect plasma epinephrine(E)and norepinephrine(NE).The changes of mean arterial pressure(MAP)and heart rate(HR)at T0,before tracheal intubation(T1 )and T2 were observed and recorded.[Results]There was no obvious change in MAP and HR at T0 and T1 between group D and group C(P>0.05).MAP and HR in group D at T2 were obviously lower than those in group C,and there was significant difference(P<0.05).Compared with before anesthesia induction,the levels of E and NE in two groups at T2 were increased obviously.The levels of E and NE in group D at T2 were obviously lower than those in group C,and there was significant difference(P<0.05).[Conclusion]Pre-injection with dexmedeto-midine before anesthesia induction can effectively reduce the stress response of intubation with double-lumen endobronchial tube and decrease the levels of E and NE after intubation with double-lumen endobronchial tube. Therefore it can be used as an adj uvant method of anesthesia induction. 2014 Vol. 31 (6): 1174-1176 [Abstract] ( 44 ) HTML (1 KB)  PDF  (0 KB)  ( 31 ) 1177 Analysis on Pathogen Distribution and Escherichia Coli Drug Resistance in Urinary System In-fection [Obj ective]To explore the pathogen distribution and drug resistance of patients with urinary system infection.[Methods]Urine specimens of 183 patients with urinary system infection were collected for pathogen iden-tification and Escherichia coli drug resistance in vitro.[Results]The infection rate of gram-negative bacilli,gram-posi-tive cocci and fungi in urinary system infection was 84.15%,14.21% and 1.64%,respectively.The top three pathogens were Escherichia coli(63.93%),klebsiella pneumonia(7.65%)and Enterococcus faecium(4.92%).There were 70 strains of Escherichia coli producing extended spectumβ-lactamases (ESBLs),which the positive rate was 59.83%.The drug resistance of Escherichia coli to penicillin and cephalosporins was higher,while the drug sensitivi-ty to carbapenem was higher,and the drug resistance to piperacillin/tazobactam,nitrofurantoin and amikacin was lower.[Conclusion]Escherichia coli is the most common pathogen in patients with urinary system infection of our hospital.The drug resistance of Escherichia coli to penicillin and cephalosporins is higher. 2014 Vol. 31 (6): 1177-1179 [Abstract] ( 46 ) HTML (1 KB)  PDF  (0 KB)  ( 26 )

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