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| Analysis of the Relationship Between Serum Monocyte Chemoattractant Protein-1 Level and the Stability of Carotid Atherosclerotic Plaque in Elderly Patients with Acute Cerebral Infarction |
| HE Dan%CHEN Chan-juan%LIU Si-Xin |
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Abstract [Objective]To analyze the association between serum monocyte chemoattractant protein-1 (MCP-1)concentration and the stability of carotid atherosclerotic plaque in elderly patients with acute cerebral infarction among Han people of Hunan province.[Methods]Totally 154 elderly patients with acute cerebral infarction and 80 healthy volunteers were recruited in our hospital from Dec.2010 to May 2013.Enzyme-linked immunosorbent assay(ELISA)was used to measure serum MCP-1 level in all subj ects.Carotid intima-media thickness(IMT)were measured color Doppler ultrasonography.According to IMT,all patients were di-vided into non-plaque group(n=32),stable plaque group(n=49)and unstable plaque group(n=73).The difference in serum MCP-1 level among groups was analyzed.The relationship between serum MCP-1 level and the stability of carotid atherosclerotic plaque was also analyzed.[Results]Serum MCP-1 level in unstable plaque group(113.64±48.04 pg/mL)was higher than that in stable plaque group(61.78±22.34pg/mL),and that in stable plaque group was higher than that in non-plaque group(44.84±25.26pg/mL),and there was significant difference between two groups(F=80.06,P<0.01).There was no significant difference in ser-um MCP-1 level between non-plaque group and control group.Serum MCP-1 level was correlated with the sta-bility of carotid atherosclerotic plaque(P >0.05).[Conclusion]Serum MCP-1 level may be associated with the stability of carotid atherosclerotic plaque in elderly patients with acute cerebral infarction among Han peo- #br# ple of Hunan province.
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| Cite this article: |
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HE Dan%CHEN Chan-juan%LIU Si-Xin. Analysis of the Relationship Between Serum Monocyte Chemoattractant Protein-1 Level and the Stability of Carotid Atherosclerotic Plaque in Elderly Patients with Acute Cerebral Infarction[J]. 医学临床研究, 2014, 31(6): 1053-1058.
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| URL: |
| http://www.jcr.net.cn/EN/ OR http://www.jcr.net.cn/EN/Y2014/V31/I6/1053 |
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2014, Vol. 31 
