|
Abstract [Obj ective]To explore the role of galectin-3 (GAL-3 )in pathogenesis of primary Sjgren's syn-drome(pSS)patients with interstitial lung disease(ILD).[Methods]Clinical indexes of 73 pSS patients with and without ILD were compared.Enzyme linked immunosorbent assay(ELISA)was used to detect serum levels of GAL-3 in 73 pSS patients and 20 normal controls.[Results]Serum GAL-3 levels in pSS patients were obviously higher than those in normal controls,and there was significant difference(795.1±79.3pg/mL vs.458.0±97.4 pg/mL,P<0.05).Serum GAL-3 levels in pSS-ILD patients were markedly higher than those in simple pSS pa-tients(1047±110.7 pg/ml vs.628.6±72.62 pg/ml,P<0.01).Furthermore,the levels of IgG,C3,fibrinogen (FiB),acute phase reactive protein(CRP)and blood sedimentation in pSS-ILD patients were obviously higher than those in simple pSS patients,and there was significant difference(P<0.05 or P<0.01).Serum albumin(ALB) levels in pSS-ILD patients were obviously lower than those in simple pSS patients(P<0.01).Serum GAL-3 lev-els in pSS patients were positively correlated with CRP,IgG and FiB(r=0.487,P <0.001,r= 0.334,P =0.004,r=0.482,P<0.001).[Conclusion]GAL-3 may participate in immune inflammatory injury of pSS and the occurrence and development of ILD.
|
|
|
|
|
|
2014, Vol. 31 
