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Abstract [Obj ective]To observe the effect of sevoflurane low-flow maintenance anesthesia on the hemodynamics,hepat-ic and renal function and blood gas index of children undergoing elective surgery,and to assess the safety and feasibility.[Methods]A total of 40 ASAⅡorⅢchildren undergoing elective surgery with tracheal intubation under general anesthesia (operation time of 2~4h)were chosen and randomly divided into group A(low-flow group,n=20)and group B(middle-flow group,n=20).Both two groups were given rapid venous induction with oxygen flow at 2L/min,and then oxygen supply by face mask compression.After tracheal intubation,sevoflurane volatilizing j ar was regulated to 3%.Oxygen flow in group A and group B was 0.5L/min and 2.5L/min respectively.Heart rate(HR),blood pressure(MAP),PET CO2 and SpO2 of all pa-tients were monitored.HR,MAP,PET CO2 and SpO2 at 10min after intubation(T0 ),1h after intubation(T1 ),2h after intu-bation(T2 )and the end of operation(T3 )were recorded.Radial arterial blood at each time points was drawn to gas analysis. Venous blood before and 24h after operation were drawn to monitor hepatic and renal function.[Results]There was no sig-nificant difference in HR,MAP,PET CO2 ,SpO2 and arterial gas analysis index at each checking point between group A and group B(P>0.05).There was no significant difference in hepatic and renal function indicators before and after operation between two groups(P>0.05).No hypoxemia and hypercarbia occurred during the whole procedure in both groups.[Con-clusion]Sevoflurane low-flow fresh gas with oxygen flow at 0.5L/min for maintenance anesthesia has no obvious influence on hepatic and renal function in children undergoing elective surgery,and the hemodynamics and arterial gas indexes are in nor-mal range.Therefore,it is safe in elective surgical anesthesia of children.
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2014, Vol. 31 
