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Abstract [Obj ective]To evaluate the effect ofα-lipoic acid on islet beta cell function and oxidative stress in patients with new diagnosed type 2 diabetes mellitus(T2DM).[Methods]Totally 80 patients with new di-agnosed T2DM in first hospital of Qinhuangdao city from March 2013 to Sept.2013 were randomly divided in-to group A and group B.All patients were given insulin pump intensification therapy for 2 weeks.Group A was simultaneously treated with intravenous infusion ofα-lipoic acid.Blood glucose and lipids of two groups were measured before and 2 weeks after treatment.Islet beta cell function index(HOMA-β)was calculated by using steady state model(HOMA).Enzyme linked immunosorbent assay was used to detect urine 8-isoprostan-es F2α(8-isoPGE).Oxidative stress was assessed.[Results]After treatment,HOMA-βin group A was higher than that in group B(P<0.05),while urine F2α(8-isoPGE)/Cr in group A was lower than that in group B(P<0.05).F2α(8-isoPGE)/Cr was positively correlated with 2h-postprandial glucose(2hPG)(r=0.432,P<0.01),total cholesterol(TC)(r=0.315,P<0.01)and body mass index(BMI)(r=0.256,P<0.05),but negatively correlated with HOMA-β(r=-0.217,P<0.05).The 2hPG was the independent risk factor of secretory rate of F2α(8-isoPGE)/Cr.[Conclusion]Theα-lipoic acid can improve islet beta cell function and re-duce oxidative stress level of patients with new diagnosed T2DM.
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2014, Vol. 31 
