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Abstract [Obj ective]To explore whether esmolol affects erythrocyte oxygen carrying capacity in patients with acute myocardial infarction.[Methods]Erythrocytes from patients with acute myocardial infarction were collected and suspended in isotonic PBS buffer solution with different pH value(pH7.4 and pH5.0).Erythro-cytes were pretreated with adrenaline,esmolol and adrenaline plus esmolol,respectively.The characteristic spectral changes of hemoglobin in single living erythrocytes were detected by using Raman spectroscopy analy-sis.[Results]Characteristic peak of oxyhemoglobin treated with PBS and esmolol at pH5.0 was decreased obvi-ously,but that treated with adrenaline was increased significantly. After pretreatment with esmolol plus adrenaline,the effect of adrenaline was not obvious.[Conclusion]Esmolol can reduce the effect of adrenaline for enhancing erythrocyte oxygen carrying capacity of hemoglobin in acid environment,and increase the disso-ciation of oxygen from hemoglobin,and is helpful for oxygen supply of anoxia tissue.
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2014, Vol. 31 
