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Abstract [Obj ective]To explore the relationship between P-selectin(Ps)level and the severity of coronary ar-tery lesions in patients with coronary heart disease(CHD).[Methods]The levels of Ps in 42 patients with acute coronary syndrome(ACS group),27 patients with stable angina pectoris(SAP group)and 29 healthy controls were measured.The relationship of the number of the diseased coronary artery and Gensini score of coronary artery with the Ps level was analyzed.[Results]The levels of Ps in ACS group and SAP group were higher than those in con-trol group(P<0.05),and those in ACS group were higher than those in SAP group(P<0.05).Compared with single-vessel coronary lesion group,the levels of Ps in multiple-vessel coronary lesion group lesions were markedly increased,and there was significant difference between two groups(P<0.05).The levels of Ps in the subgroup with Gensini score≥20 were obviously higher than those in the subgroup with total score<20,and there was sig-nificant difference between two groups(P<0.05).[Conclusion]The level of Ps in patients with CHD is increased and correlated with the severity of coronary lesion,and can predict the severity of CHD.
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2014, Vol. 31 
