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Quick Search     Adv Search 2018 Vol. 35, No. 4 Published: 2018-04-30 Article          Article 625 Correlation Analysis between Early Post-stroke Depression and Cerebral Infarct Locations CHEN Yu, WU Ming-xiang, CHEN Wen-jiao, et al DOI: 10.3969/j.issn.1671-7171.2018.04.001 【Objective】To investigate the distribution of infarct location in patients with early PSDs after early cerebral infarction and its correlation.【Methods】From March 2008 to August 2017, 78 patients with cerebral infarction were selected and divided into PSD group (n=40) and non-depression group (n=38, PSND). All patients were scanned with MRI, and the distribution of cerebral infarction in both groups was analyzed, and the correlation between the location of cerebral infarction and the occurrence of PSD was analyzed.【Results】The proportion of infarction in the frontotemporal and parietal cortex, occipital cortex, brainstem and cerebellum in the PSD group was significantly higher than that in the PSND group, the difference was statistically significant (P<0.05). The distance between the infarct site and the left frontal pole and the right frontal pole in the PSD group were (2.47±1.33) cm and (2.94 ±1.55)cm, respectively, which were lower than that in the PSND group (3.28 ±1.46) and (3.14 ±1.41) cm, respectively. The distance between the infarct site and the left frontal pole in the PSD group was significantly smaller than that in the PSND group; the difference was statistically significant (P<0.05). From the analysis of the correlation coefficient, the order of correlation between each indicator and PSD from big to small was: brain stem and cerebellum>frontotemporal parietal cortex>occipital cortex>left frontal polar distance>multiple infarction>hippocampal amygdala>left frontal lobe>posterior part>right frontal lobe>right frontal polar distance>coronal area>anterior part of brain>basal nucleus area.【Conclusion】When the cerebral infarction is located in the brain stem and cerebellum and the frontotemporal parietal and occipital cortex with smaller left frontal pole distance, it is easy to appear early PSD, and the early PSD is related to the location of the infarct. 2018 Vol. 35 (4): 625-627,631 [Abstract] ( 243 ) HTML (1 KB)  PDF  (0 KB)  ( 7 ) 628 A Study on the Prognostic Factors of Patients of Hypertrophic Cardiomyopathy with Atrial Fibrillation of Different Risk of Sudden Death DENG Sheng-rong, SHU Mao-qin, CHAI Hong, et al DOI: 10.3969/j.issn.1671-7171.2018.04.002 【Objective】To study the prognostic factors of patients with hypertrophic cardiomyopathy with atrial fibrillation of different risk of sudden death, so as to provide a reference for the treatment of HCM with atrial fibrillation with different risk of sudden death by radiofrequency ablation.【Methods】A total of 90 patients with HCM underwent AF catheter radiofrequency ablation from 2012 to 2015 were collected and analyzed. According to the 5-year risk assessment of sudden death, 27 cases were assigned into high risk group and 43 cases in low risk group (20 cases were excluded due to the same type of AF). All of them were followed up for (3.14 ±1.53) years, and the risk factors of prognosis between the two groups were compared.【Results】In 70 patients, 6 patients died, accounting for the total number of 8.5%, 4 of whom died of sudden cardiac death, 2 were non cardiogenic, and 12 had cardiogenic rehospitalization. In the COX scale risk model, the survival rate of the low risk group was significantly higher than that of the high risk group, and the results also showed that hs-CRP and left ventricular ejection fraction (LVEF) were the main risk factors for postoperative survival in the high risk group, while age was the main risk factor in the low risk group.【Conclusion】During clinical treatment, the hs-CRP value of patients with high risk of sudden death should be closely monitored and the postoperative nursing care should be strengthened according to the value of left ventricular ejection fraction (LVEF). 2018 Vol. 35 (4): 628-631 [Abstract] ( 122 ) HTML (1 KB)  PDF  (0 KB)  ( 7 ) 632 Relationship between High and Low Blood Pressure Targets and Mortality in Elderly Patients with Septic Shock at 28d and 90d LU Li-wen, TANG Yu-tao, PAN Chun-xi, et al DOI: 10.3969/j.issn.1671-7171.2018.04.003 【Objective】To investigate the relationship between high and low blood pressure (BP) targets and mortality in elderly patients with septic shock at 28 days and 90 days.【Methods】A total of 80 elderly patients with septic shock were randomly divided into the high target BP group (A) and low target BP group (B), with 40 cases in each group. All patients were treated with cluster therapy of septic shock. The MAP of A group and B group were controlled in 80~85mmHg and 65~70 mmHg, respectively. The survival status and related factors of the two groups at 28d and 90d were statistically analyzed.【Results】There was no significant difference in the relevant indicators between the two groups on admission (P>0.05). At 5 days after admission, the levels of MAP, SVRI, ScvO2of A group patients were significantly higher than those of B group patients. However, the level of ELWI, MODS and SOFA score were significantly lower in A group patients than in B group patients (P<0.05). The mortality rates in the A group at 28d and 90d were 32.50% and 45.00% respectively; they were not significantly different from those in the B group (42.50% and 60.00%, respectively, P>0.05). Univariate analysis showed that age, 5-day MAP, SVRI, ELWI, ScvO2, MODS, and SOFA scores after admission were independent risk factors affecting patients 28-day survival (P<0.05). It also showed that age, 5-day MAP, ScvO2, MODS, and SOFA scores after admission were independent risk factors that affected the 90-day survival of patients (P<0.05).【Conclusion】Setting high blood pressure targets is a promising idea in cluster therapy to improve hemodynamics, tissue perfusion and oxygen metabolism in elderly patients with septic shock. It can reduce the MODS and SOFA scores which may in turn lead to decreased mortality rates. 2018 Vol. 35 (4): 632-634 [Abstract] ( 103 ) HTML (1 KB)  PDF  (0 KB)  ( 7 ) 635 A Survey of Amblyopia of Preschool Children in Guilin City WU Xue-yun, QIAN Jin-fang, LI Dong-mei DOI: 10.3969/j.issn.1671-7171.2018.04.004 【Objective】To investigate and analyze the incidence of amblyopia in preschool children in Guilin City, and provide local epidemiological data for the prevention and treatment of children's amblyopia.【Methods】A total of 3014 preschool children from 22 kindergartens in Guilin city were examined for eyesight, refraction and eye position. Through statistical analysis, the prevalence rate of low vision and amblyopia in different age of groups and the distribution proportion of different types of amblyopia were investigated.【Results】Among the 3014 children, 362 (12.01%) were found to have low visual acuity; the incidence of amblyopia was 2.39%. There was no significant difference in the incidence of low visual acuity and amblyopia between the different genders (P>0.05). The type of amblyopia with ametropia accounted for 86.11%, the degree of amblyopia with moderate amblyopia accounted for 72.22%, and the main types of distal optic refractive errors accounted for 62.90%. The degree of amblyopia in children with different amblyopia and the degree of amblyopia in children with different types of ametropia were not statistically significant (P>0.05). The incidence of poor eyesight in children aged 3~4 years old, and 6~7 years old were higher than the other age groups. The difference is statistically significant (P<0.05). There is no significant difference in incidence of amblyopia among children of different ages (P>0.05). There is a statistically significant difference in the incidence of amblyopia between children of different ages (P<0.05).【Conclusion】The incidence and misdiagnosis rate of amblyopia in preschool children in the urban area of Guilin are relatively high. Strengthening children's eye care and emphasizing regular visual screening are the key to early prevention, early detection and early treatment of amblyopia. 2018 Vol. 35 (4): 635-637,641 [Abstract] ( 95 ) HTML (1 KB)  PDF  (0 KB)  ( 7 ) 639 Therapeutic Effect of arthroscopic Patellar Medial Patellofemoral Ligament Reconstruction Method Combined with Lateral Retinacular Release in the Treatment of Recurrent Patellar Dislocation GUO Zheng-zhong, WANG Meng-fei, ZHANG Ning, et al DOI: 10.3969/j.issn.1671-7171.2018.04.005 【Objective】To investigate the clinical effect of patellar medial patellofemoral ligament reconstruction method combined with lateral retinacular release in the treatment of recurrent patellar dislocation.【Methods】From August 2014 to August 2016, 16 cases of recurrent patellar dislocation were treated by arthroscopic medial patellar ligament reconstruction and lateral retinaculum release. Autologous free semitendinosus tendon was used as graft, the tendon was minimally invasive through the patellar bone canal, and the tension was dynamically adjusted under the arthroscope. The facial screws were fixed to the femoral canal. The follow-up subjects included the patellar extrapolation experiment and the fear experiment, the VAS score, and the evaluation of the congruence angle (CA), patella tilt angle (PTA) and patellar displacement rate (LPD) through the imaging examination. The knee joint function was evaluated by the Lysholmr score of the knee joint.【Results】Follow-up was achieved in 16 patients with a follow-up rate of 100 %. The post-operative pain score was significantly better than before surgery, and the location of the patient ' s patella was assessed by radiographic examination : the postoperative congruence angle (CA), patella tilt angle (PTA) and patellar displacement rate (LPD) were significantly improved compared to preoperative, and the anatomical location of the patella was reconstructed. 3 months after operation: all the patients were satisfied with the treatment, no redislocation cases, the patella extrapolation and fear test were all negative, only 3 patients had the knee joint pain and discomfort after the knee joint hyperactivity. At the last follow-up, the range of knee joint motion was satisfactory, but the extra patellar extrapolation and fear test were negative.【Conclusion】Arthroscopic medial patellofemoral ligament reconstruction and lateral retinaculum release can effectively treat recurrent patellar dislocation, reconstruct patella stability and improve clinical symptoms. 2018 Vol. 35 (4): 639-642 [Abstract] ( 115 ) HTML (1 KB)  PDF  (0 KB)  ( 7 ) 642 Laparoscopic Assisted Inguinal Surgery for the Treatment of High Refractory Iatrogenic Cryptorchidism DUAN Yi-xing, GUO Xi, ZHOU Qiang, et al DOI: 10.3969/j.issn.1671-7171.2018.04.006 【Objective】To investigate the clinical effect of laparoscopic assisted inguinal surgery in the treatment of high refractory cryptorchidism.【Methods】From January 2014 to April 2017, 21 children with unilateral high and refractory iatrogenic cryptorchidism were treated with laparoscopic assisted inguinal incision. The patients were followed up for 3 months to 1 year to record the recovery of the affected testis, postoperative complications and the phenomenon of retraction.【Results】All the 21 children underwent the operation successfully, and the operation time was 58～125 (78.6 ±15.3)min. No postoperative complications such as scrotal hematoma, abdominal pain, etc. The patients started eating at 6 hours after operation and was discharged from hospital 3～5 days later. The results of follow up showed that there was no atrophy of testis and normal blood flow in all of them, 9 of them were larger than those before operation, but smaller than those of normal side, all of them were fixed at the bottom of scrotum and had no retraction. There were 5 cases of inguinal incision scar formation due to re-operation. After applied scar and laser treatment of the plastic surgery department, the symptoms basically subsided.【Conclusion】Laparoscopically assisted inguinal surgery with high refractory cryptorchidism is safe and effective in the treatment of testicular blood flow. 2018 Vol. 35 (4): 642-643 [Abstract] ( 80 ) HTML (1 KB)  PDF  (0 KB)  ( 5 ) 644 Effects of Metformin Combined with Ethinylestradiol Cyproterone and Ovulation Induction on Glycolipid Metabolism,Endocrine and Pregnancy Rate in Patients with Polycystic Ovary Syndrome HUANG Liu-hai, FAN Chan, XIAO Guang-jun, et al DOI: 10.3969/j.issn.1671-7171.2018.04.007 【Objective】To investigate the effects of insulin sensitizer (metformin) combined with anti-androgens (Ethinyl estradiol cyproterone, Danein-35) and ovulation induction therapy on glycolipid metabolism, endocrine and pregnancy rate in patients with polycystic ovary syndrome (PCOS).【Methods】Ninety patients with PCOS were randomly divided into the treatment group (n=45) and the control group (n=45). All patients were treated with ethinylestradiol cyproterone acetate tablets, and the treatment group were additionally treated with metformin tablets. After 3 months of treatment, clomiphene (CC)-stimulated ovulation induction was used for promoting pregnancy. Before and after treatment, the physical indexes (BMI and WHR) of the two groups were measured. The levels of glucose and lipid metabolism, insulin resistance (IR) and endocrine indexes (HOMA-IR) were detected, and the status of ovulation and pregnancy was statistically analyzed.【Results】There were no significant differences in physical indicators, glucose and lipid metabolism, IR index and endocrine indexes between the two groups before the treatment (P>0.05). After treatment, BMI, waist hip ratio (WHR), fasting plasma glucose (FPG), triglyceride (TG), total cholesterol (TC), fasting insulin (FINS), insulin resistance index (HOMA-IR), estradiol (E2), testosterone (T), luteinizing hormone (LH) and LH/ follicle stimulating hormone (FSH) in the two groups were significantly lower than those before treatment (P<0.05). After treatment, the above indices in the treatment group were significantly lower than those in the control group (P<0.05). On the other hand, after treatment, the dominant follicles and endometrial thickness of the treatment group were significantly higher than those of the control group (P<0.01), and the ovulation rate and pregnancy rate (73.33%, 57.78%, respectively) were significantly higher than those in the control group (53.33%, 35.56%, respectively) (P<0.05).【Conclusion】Insulin sensitizer combined with anti-androgens can help to relieve the IR and endocrine disorders, and significantly improve the ovulation rate and pregnancy rate in patients with PCOS. 2018 Vol. 35 (4): 644-646,650 [Abstract] ( 111 ) HTML (1 KB)  PDF  (0 KB)  ( 5 ) 647 Research on the Effect and Mechanism of Cofilin-1 on Invasion, Migration and Adhesion in Human Glioma Cells ZHAO Yun-dong, SUN Dong-tao, CHEN Zhen-jun DOI: 10.3969/j.issn.1671-7171.2018.04.008 【Objective】To investigate the effects and possible molecular mechanisms of interfering Cofilin-1 gene expression on the invasion, migration and cell adhesion in human glioma cells.【Methods】The RNAi technique was used to interfere with the expression of Cofilin-1 gene in human glioma cell line SHG-44. The interference effect of Cofilin-1 was verified by Real-time PCR and Western blot. Scratch assay was used to detect cell migration ability. Transwell chamber assay was used to detect cell invasion ability. Adhesion experiment was used to detect cell adhesion ability. The expression of ICAM-1 and NF-κB p65 protein in cytoplasm and nucleus were detected by Western blot.【Results】RNAi interference successfully inhibited the expression of Cofilin-1 in SHG-44 cells. Interference of Cofilin-1 expression inhibited the migration, invasion and adhesion in SHG-44 cells, decreased the expression of ICAM-1 and the expression of NF-κB p65 in nucleus.【Conclusion】Interference of Cofilin-1 expression can inhibit the migration, invasion and adhesion in glioma cells, and may play a role by regulating the activation of NF-κB pathway. Cofilin-1 may be a potential therapeutic target for gliomas. 2018 Vol. 35 (4): 647-650 [Abstract] ( 79 ) HTML (1 KB)  PDF  (0 KB)  ( 2 ) 651 Effect of Neoadjuvant Chemotherapy on Peripheral Blood Treg Cells, Serum Levels of TGF-β1 and VEGF, and Expression of VEGF and CD105 in Cervical Cancer Tissues GAO Xue-lian DOI: 10.3969/j.issn.1671-7171.2018.04.009 【Objective】To study the influence of neoadjuvant chemotherapy on the ratio of Treg / CD4 cells in the peripheral blood, serum levels of TGF-β1 and VEGF, and the expression of VEGF and CD105 in tumor tissues.【Methods】A total of 97 patients with uterine cervical cancer (UCC) who were treated in our department from Mar 2014 to Mar 2017 were enrolled in this study (UCC group); all patients received neoadjuvant therapy. Meanwhile, 70 healthy women were included in the control group (HC group). The ratio of Treg/ CD4+ cells was measured by the flow cytometry assay, ; serum levels of TGF-β1 and VEGF were detected by ELISA assay, and the expression of VEGF and CD105 in the tumor tissue was evaluated by the immunohistochemistry.【Results】Before the neoadjuvant therapy, the ratio of the peripheral Treg/CD4 cells and the serum levels of TGF-β1 and VEGF were significantly higher in the UCC group than in the HC group (P＜0.05). The ratio of Treg/CD4 cells and the serum levels of TGF-β1 and VEGF were significantly decreased after the neoadjuvant therapy (P＜0.05). The expression of VEGF and CD105 in the tumor tissue of the UCC group significantly decreased after neoadjuvant therapy (P＜0.05). A positive correlation between VEGF and CD105 expression in the UCC tissue was found by the Pearson correlation analysis (r=0.557, P=0.032).【Conclusion】Neoadjuvant therapy can decrease the ratio of the peripheral Treg/CD4+ cells, reduce the release of TGF-β1, and downregulate the expression of CD105 and VEGF in the UCC tissue, thereby inhibiting angiogenesis and improving remission. 2018 Vol. 35 (4): 651-653 [Abstract] ( 100 ) HTML (1 KB)  PDF  (0 KB)  ( 7 ) 654 Short-term Efficacy and Long-term Prognosis of Patients with Diffuse Proximal Advanced Gastric Cancer Treated with Different Surgical Methods JIANG Qiang DOI: 10.3969/j.issn.1671-7171.2018.04.010 【Objective】To investigate the short-term efficacy and long-term prognosis of different surgical methods for treating diffuse proximal advanced gastric cancer (AGC).【Methods】A total of 80 patients with diffuse proximal AGC treated in our hospital from February 2011 to April 2014 were enrolled in the study. They were randomly divided into two groups by random number table method, with 40 cases in each group. The observation group (A group) was treated with total gastrectomy, while the control group (B group) was treated with proximal gastrectomy (partial resection). All patients were followed up for 3 years after surgery. The general data, early recovery after surgery, hemoglobin (Hb), albumin (Alb), total protein (TP), 3-year survival rates, tumor-free survival rates and recurrence rates were compared between the two groups.【Results】The surgical time was shorter and intraoperative blood loss was less in the A group compared to those of the B group (P<0.05), while the number of dissected lymph nodes was significantly more than that in the B group (P<0.05). Levels of plasma Hb, Alb and TP one year after surgery in both groups were decreased (P<0.05), but there was no significant difference between the two groups (P>0.05). The 3-year survival rate (53.33%) and tumor-free survival rate (46.67%) of the A group were higher than those of the B group (31.11% and 22.22%, respectively;P<0.05), while there was no significant difference in recurrence rate between the two groups (P>0.05). The incidence of complications in the A group within 3 years after surgery was significantly lower than that in the B group (P<0.05).【Conclusion】The short-term efficacy of total gastrectomy is a good way to treat diffuse proximal AGC. It can shorten the surgical time, reduce intraoperative blood loss, increase the number of dissected lymph nodes, and significantly improve the 3-year survival rate and tumor-free survival rate of patients. 2018 Vol. 35 (4): 654-656 [Abstract] ( 93 ) HTML (1 KB)  PDF  (0 KB)  ( 9 ) 657 Effects of Tricetaxine Hydrochloride Combined with Different Statins on Cardiac Function of Heart Failure with hypertension CHI Shao-li, LIU Yan, WANG Hai-bing, et al DOI: 10.3969/j.issn.1671-7171.2018.04.011 【Objective】To observe the effects of tricetaxine hydrochloride combined with different statins on cardiac function of heart failure with hypertension patients.【Methods】A total of 120 patients with heart failure who were treated with hypertension from August 2015 to March 2017 were randomly divided into the group A, the group B and the group C, with 40 patients of each group. The three groups were given conventional basic treatment, and oral tricamalt hydrochloride tablets 20mg, 3 times one day, and the A group, the B group and the C group were respectively given oral fluvastatin, simvastatin, and atorvastatin 20mg, 1 time one day. After 6 months of treatment, the efficacy of the three groups were compared; the left ventricular ejection fraction (LVEF), the left ventricular end diastolic diameter (LVEDD), and the left ventricular end-diastolic diameter (LVESD), and the left ventricular end-diastolic diameter (LVEDD) were detected by ultrasonic diagnostic apparatus; the systolic blood pressure (SBP) and the diastolic blood pressure (DBP) were measured by a standard pool mercury sphygmomanometer; the total cholesterol (TC), the triglyceride (TG), the low density lipoprotein cholesterol (LDL-C) and the high density lipoprotein cholesterol (HDL-C) were measured by automatic biochemical analyzer; and drug safety analyze.【Results】The results of rank sum test showed that there was significant difference between the three groups (P<0.05). Total effective rate of the group C was significantly higher than that of the group A (P<0.05);the LVEF and HDL-C of the three groups were significantly higher than those before treatment (P<0.05), the LVESD, LVEDD, SBP, DBP, TG, TC, and LDL-C were significantly lower than those before treatment (P<0.05);the levels of LVEF and HDL-C of the group C were significantly higher than those of the group A and B (P<0.05), the LVESD, LVEDD, TG, TC and LDL-C were significantly lower than those of the group A and B (P<0.05);the LVEF and HDL-C of the group B were significantly higher than those of the group A (P<0.05), the LVESD, LVEDD, TG, TC and LDL-C were significantly lower than those of the group A (P<0.05);there was no significant difference in SBP and DBP between the group A, B and C (P>0.05);there was no significant difference in the incidence of adverse reactions of the three groups (P>0.05).【Conclusion】Trimetazidine hydrochloride combined with statins is effective in the treatment of hypertensive heart failure. However, its combination with atorvastatin can significantly improve cardiac function and blood lipid level, and has the highest efficacy and safety. 2018 Vol. 35 (4): 657-660,663 [Abstract] ( 113 ) HTML (1 KB)  PDF  (0 KB)  ( 7 ) 661 Clinical Observations of Cook Cervical Dilatation Balloon in Promoting Cervical Ripening in Women with Advanced Pregnancy LIU Ying-ju, RUAN He-yun, XU Li-hu, et al DOI: 10.3969/j.issn.1671-7171.2018.04.012 【Objective】To analyze the clinical effects of Cook cervical dilatation balloon in promoting the cervical ripening in women with late-stage pregnancy.【Methods】A total of 189 cases of induced abortion syndrome patients from January 2014 to January 2017 in our hospital were included in the study. According to the different processing methods, patients were divided into Cook cervical dilatation balloon group (COOK group), dinoprostone group and oxytocin group, with 63 cases in each group. The effects of cervical ripening and the rate of vaginal delivery among those groups were compared.【Results】There were no significant differences in cervical Bishop scores among the three groups before induction of labor (P>0.05). In the COOK group, the cervical Bishop score was (4.3±1.9) after Cook cervical dilatation balloon treatment, which was significantly higher than that before induction of labor (P<0.05). No statistical difference was shown in cervical Bishop score between the dinoprostone group and oxytocin group before and after treatment (P>0.05). In the Cook group, 51 cases of natural childbirth, and 12 cases of cesarean section; the vaginal delivery rate was 80.95%.The rate of natural childbirth in the dinoprostone group was 76.19%, which was not significant different compared to the COOK group (P>0.05), however, they both were significantly higher than that in the oxytocin group (58.73% P<0.05).【Conclusion】Cook cervical dilatation balloon is used as a mechanical method to promote cervical ripening, which can increase vaginal delivery rate significantly with high safety levels and fewer complications. It is an ideal method for promoting cervical ripening in late-stage pregnancy. 2018 Vol. 35 (4): 661-663 [Abstract] ( 78 ) HTML (1 KB)  PDF  (0 KB)  ( 2 ) 664 Correlation of D-dimer and C-reactive protein protein Levels with the Incidence of Deep Venous Thrombosis after Internal Fixation of Tibial Fractures JIANG Hui, TIAN Jia-lin, TAN Hai-ying DOI: 10.3969/j.issn.1671-7171.2018.04.013 【Objective】To investigate the correlation between the levels of D-dimer (D-D) and C-reactive protein (CRP) and the incidence of deep venous thrombosis (DVT) after tibial internal fixation.【Methods】A retrospective study was conducted. A total of 122 patients of tibial fracture treated by internal fixation in our hospital were selected as the experimental group. In addition, 122 healthy adults in the same period were selected as the control group. The D-D and CRP levels in the two groups were compared, and the incidence of thrombosis in D-D and CRP patients at different levels were analyzed to reveal the relationship between D-D and CRP levels and the occurrence of DVT.【Results】The postoperative D-D and CRP levels in the experimental group were significantly higher than those before surgery, and were significantly higher than those in the control group. The differences were statistically significant (P<0.05). The incidence of postoperative thrombosis in the experimental group was positively correlated with D-D and CRP levels. When D-D>600 ug/L and CRP>50 mg/L, the incidence of DVT reached about 15%.【Conclusion】The incidence of deep venous thrombosis after the internal fixation of tibial fracture is positively correlated with D-D and CRP levels, which can be a clinical predictor for DVT incidence. 2018 Vol. 35 (4): 664-666 [Abstract] ( 68 ) HTML (1 KB)  PDF  (0 KB)  ( 7 ) 666 Effect of Mindfulness Meditation Training on Anxiety-depression and Coping Style of Patients Undergone Colorectal Cancer Operation CHENG Yan, TANG Hua-jun DOI: 10.3969/j.issn.1671-7171.2018.04.014 【Objective】To investigate the effect of mindfulness meditation training on anxiety-depression and coping style of patients undergone colorectal cancer operation.【Methods】A total of 116 cases of patients undergone colorectal cancer operation and admitted to hospital from October 2015 to December 2016 were selected as the research objects, and divided into observation group and control group using the random number table method, with 58 cases in each group. Patients in the control group were performed routine nursing intervention including health education, psychological nursing, rehabilitation training and prevention of complications. Based on this, patients in the observation group were also performed mindfulness meditation training. The degree of anxiety and depression, coping style and other indexes between the two groups were compared.【Results】The scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) in the observation group were significantly lower than those in the control group (P<0.05); the scores of palliative, escape, foreordination and self-reliance were significantly lower than those in the control group, and the scores of optimism, confrontation, support seeking and emotional catharsis were significantly higher than those in the control group ( P<0.05).【Conclusion】Mindfulness meditation training can help to relieve the anxiety-depression degree of patients with colorectal cancer, avoid their negative coping behaviors and promote the development of active coping style. 2018 Vol. 35 (4): 666-668 [Abstract] ( 53 ) HTML (1 KB)  PDF  (0 KB)  ( 4 ) 669 Effect of Childhood Abuse on Serum Leptin in Patients with Schizophrenia HUANG Shi-bin DOI: 10.3969/j.issn.1671-7171.2018.04.015 【Objective】To investigate the effect of childhood abuse on serum leptin in schizophrenic patients.【Methods】A total of 112 patients with schizophrenia were enrolled in our hospital from January 2016 to June 2017. The Childhood Trauma Questionnaire (CTQ) was used to assess the extent and type of child abuse. According to CTQ scores, 112 patients were divided into abused group (n=40) and non-abused group (n=72). The psychiatric symptoms were assessed using the Positive and Negative Symptom Scale (PANSS). Serum levels of leptin, serotonin (5-HT) and brain-derived neurotrophic factor (BDNF) were measured by ELISA.【Results】There were statistically significant differences in the starting age of abuse, and the proportion of male and female victims between the abused and non-abused groups (P<0.05), but there was no significant difference in the number of years of education (P>0.05). The total score of CTQ and scores of emotional abuse, affective neglect, sexual abuse, physical abuse and physical neglect were significantly higher in the abused group than those of non-abused group (P<0.05). The total score of PANSS and scores of general pathology, positive symptoms and negative symptoms were significantly higher in the abused group than those of non-abused group (P<0.05). The levels of serum LP and 5-HT in the abused group were significantly lower than those in the non-abused group (P<0.05). There was no significant difference in serum BDNF levels between the two groups (P>0.05). Spearman correlation analysis showed that there was a significant positive correlation between CTQ score and PANSS score (r=0.536, P=0.032<0.05). There was a significant negative correlation between CTQ total score and LP (r=-0.511, P=0.039<0.05).【Conclusion】There are more female schizophrenia than male schizophrenia cases caused by childhood abuse. The earlier age of receiving abuse, the more severe clinical symptoms exist. The difference of serum LP and 5-HT levels between the abuse and non-abuse groups reflects the occurrence of schizophrenia. 2018 Vol. 35 (4): 669-671 [Abstract] ( 72 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 672 A 2-Year Follow-up Analysis of the Use of Ticagrelor Double Antiplatelet Therapy after PCI in Patients with NSTE-ACS ZHANG Gui-xia, LI Da-peng, WANG Huan-yu, et al DOI: 10.3969/j.issn.1671-7171.2018.04.016 【Objective】To investigate the long-term effect of tigrilol dual antiplatelet therapy after percutaneous coronary stenting (PCI) in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACSC).【Methods】The clinical data of 500 patients diagnosed by coronary angiography and treated with PCI from May 2013 to January 2016 were retrospectively analyzed. The patients were divided into two groups: the observation group (n=256) and the control group (n=244). The patients in the observation group were treated with tigrello double antiplatelet therapy, and the control group were treated with routine double antiplatelet therapy. The biochemical indexes and left ventricular ejection fraction (LVEF) were observed and compared before and after treatment in the two groups. Adverse reactions and major adverse cardiovascular events within 2 years (MACEE) and bleeding events.【Results】After treatment, the levels of serum creatinine and LVEF in the two groups were significantly higher than those in the control group. The indexes of Cr and LVEF in the observation group was significantly higher than those in the control group (P<0.05). The serum creatine kinase isoenzyme (CK-MB), troponin I (cTnI) and platelet maximum aggregation rate (MPAR) in the two groups were significantly lower than those before treatment, and the decrease in the observation group was significantly higher than that in the control group (P<0.05). After 12 and 24 months follow-up, the incidence of total MACE and total haemorrhage events in the observation group was significantly lower than that in the control group, After 12 and 24 months follow-up, the incidence of total MACE and total haemorrhage events in the observation group was significantly lower than that in the control group, the difference was statistically significant (P<0.05). The incidence of adverse reactions in the observation group was 11.33% (29/256) and in the control group was 14.75% (36/244).There was no significant difference in the incidence of adverse reactions between the two groups (χ2=1.296, P>0.05).【Conclusion】Tigrilol has a good inhibitory effect on platelet aggregation after PCI in patients with NSTE-ACS, and has a rapid effect. Stable drug effect does not increase the adverse reactions of patients. It can reduce the incidence of long-term MACE and is worthy of clinical application. 2018 Vol. 35 (4): 672-674,678 [Abstract] ( 61 ) HTML (1 KB)  PDF  (0 KB)  ( 4 ) 675 A Comparative Study of Therapeutic Effects and Safety Among Small Bone Flap Craniotomy, Traditional Craniotomy, Repanation and Drainage in Patients with Hypertensive Cerebral Hemorrhage ZHU Xing-quan, WU Qing DOI: 10.3969/j.issn.1671-7171.2018.04.017 【Objective】To compare and analyze the therapeutic effects and safety of small bone flap craniotomy, traditional craniotomy, repanation and drainage in patients with hypertensive cerebral hemorrhage.【Methods】The clinical data of 150 patients with hypertensive intracerebral hemorrhage treated in our hospital from June 2012 to August 2017 were retrospectively analyzed and patients were divided into group A (63 cases), group B (30 cases), group C (57 cases), according to the different treatment methods. Patients in the group A were treated with small bone flap craniotomy, patients in the group B were treated with traditional craniotomy, and patients in the group C were treated with trepanation and drainage. Then the curative effect, operative time, intraoperative blood loss, hospitalization time, postoperative complications, GSS, ADL score and prognosis of the three groups were compared and analyzed.【Results】The operation time, intraoperative blood loss and hospital stay in the group B were higher than those in the groups A and C (P<0.05); The operation time in the group A was longer than that in the group C (P<0.05), but the intraoperative blood loss and the hospitalization time of the group A and the group C had no significant difference (P>0.05). GSS scores of the three groups at 3 months post-operation decreased, while ADL scores increased (P<0.05); The GSS scores in the group A were higher than those in the group B and C at 3 months after operation, and the ADL scores in the group A were lower than those in the group B and C (P<0.05), moreover no significant difference was found in the GSS and ADL scores between the group B and the group C at 3 months post-operation (P>0.05); The total incidence of postoperative complications in the group B was significantly higher than that in the group A and the group C (P<0.05), while no significant difference was found in the incidence of postoperative complications between the group A and the group C (P>0.05); The good prognosis rate of the group B was significantly lower than that of the group A and C (P<0.05), with no significant difference between the group A and the group C (P>0.05); The total effective treatment of the group B and C was slightly higher than that of the group A, but there was no statistical difference between the three groups (P>0.05).【Conclusion】The comparison among small bone flap craniotomy, traditional craniotomy, repanation and drainage shows that each treatment has its own advantages and disadvantages, the application should combined with patient's condition. 2018 Vol. 35 (4): 675-678 [Abstract] ( 61 ) HTML (1 KB)  PDF  (0 KB)  ( 9 ) 679 Expression of VEGF, VEGFR-2 and TSP-1 in Elderly Patients with T2DM SANG Dan, LUO Cai-xian, YE Yi-yi, et al DOI: 10.3969/j.issn.1671-7171.2018.04.018 【Objective】To investigate the expression level and clinical significance of vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor-2 (VEGFR-2) and platelet reactive protein-1 (TSP-1) in elderly patients with type 2 diabetes mellitus (T2DM).【Methods】The elderly patients with type 2 diabetes mellitus treated in our hospital from June 2015 to February 2017 were selected as the subjects, and the non-diabetic elderly patients who were examined in our hospital during the same period were selected as the controls. The differences of serum VEGF, VEGFR-2, TSP-1, blood glucose and cytokine levels between the two groups were compared, and the correlation of VEGF, VEGFR-2 and TSP-1 levels with blood glucose and cytokine levels in elderly patients with type 2 diabetes mellitus was analyzed.【Results】The levels of serum VEGF, VEGFR-2, TSP-1, interleukin-18 (IL-18), interleukin-6 (IL-6) and hypersensitivity C reaction protein (hs-CRP) in the diabetic group were higher than those in the control group. The average blood glucose (MBG), average blood glucose standard deviation (SDBG) and effective fluctuation times (NEGE) were higher in the diabetic group than those in the control group. The level of VEGF, VEGFR-2 and TSP-1 in elderly patients with type 2 diabetes mellitus were positively related to the levels of MBG, SDBG, NEGE, IL-18, IL-6 and hs-CRP.【Conclusion】The levels of VEGF, VEGFR-2 and TSP-1 in elderly patients with type 2 diabetes mellitus are higher, and are closely related to the cytokines and blood glucose levels. 2018 Vol. 35 (4): 679-681 [Abstract] ( 76 ) HTML (1 KB)  PDF  (0 KB)  ( 8 ) 682 Study of the Correlation Between the Distribution of the Peripheral Red Blood Cell Width and Clinical Prognosis in Elderly Patients with Severe Pneumonia XU Chuan-qin, CHEN Jian-hui, ZHENG Yu-long, et al DOI: 10.3969/j.issn.1671-7171.2018.04.019 【Objective】To investigate the correlation between the distribution of red cell distribution width and the prognosis of the severe pneumonia of the elderly patients.【Methods】We performed a retrospective analysis of 74 elderly patients with severe pneumonia in our hospital from June 2013 to December 2015. According to the survival of discharge, the patients were divided into the survival group and death group. The records included gender, age, acute physiology and chronic heath evaluationⅡ (APACHE Ⅱ) score, WBC, HCT, MCV, Hb, PLT and PDW. RDW on day 1, 3, and 7 were collected as well. Multivariate regression analysis of clinical prognostic factors was conducted.【Results】The mean RDW of d1, d3and d7in the death group increased gradually, however, the mean value of RDW of d1, d3and d7did not show a linear trend in the survival group. Multivariate regression analysis showed that age, APACHE II score, RDW and progressive elevation of RDW were the independent risk factors of severe pneumonia in the elderly patients (P＜0.05).【Conclusion】RDW was the independent risk factors for the mortality of severe pneumonia in the elderly patients, and the progressive increase of RDW suggests a poor prognosis. 2018 Vol. 35 (4): 682-683,686 [Abstract] ( 69 ) HTML (1 KB)  PDF  (0 KB)  ( 7 ) 684 Expression Levels of Serum Adiponectin, Insulin and High-Sensitivity C-reactive Protein in Patients with Pregnancy-Induced Hypertension SUN Sha, YUAN Ke-fang, GAO Zhi-min, et al DOI: 10.3969/j.issn.1671-7171.2018.04.020 【Objective】To investigate the levels of serum adiponectin (APN), fasting insulin (FINS) and high sensitive C reactive protein (hs-CRP) in patients with pregnancy induced hypertension and to analyze the correlation of APN with FINS, hs-CRP and insulin resistance (IRI).【Methods】A total of 128 pregnant women with hypertension during treatment from March 2014 to March 2017 in our hospital were selected as the observation group, including 89 cases of mild preeclampsia (mild group) and 39 cases of severe preeclampsia (severe group). Another 68 normal pregnant women at the same period were selected as the control group. FINS APN, hs-CRP. and fasting blood glucose (FBG) of all pregnant women were detected, and the IRI was calculated. The correlation of APN with FINS, hs-CRP and IRI were analyzed.【Results】Compared with the control group, the serum APN level in the mild and severe hypertension groups was significantly lower, and the levels of hs-CRP, FINS, and IRI were higher (F=8.712, 12.314, 10.698, 7.383, P=0.045, 0.023, 0.039, 0.049). Compared to the mild hypertension group, serum APN level in the severe hypertension group was significantly lower, and hs-CRP, FINS levels, and IRI were significantly higher (t=6.938, 8.856, 10.318, 5.964, P=0.045, 0.029, 0.014, 0.047). Pearson correlation analysis showed that there was a significant negative correlation of APN with FINS, hs-CRP and IRI (r=-0.289,-0.472,-0.675, P=0.034, 0.029, 0.013).【Conclusion】The expression level of APN in serum of hypertensive patients with pregnancy is decreased, and it is significantly negatively related with FINS, hs-CRP and IRI. 2018 Vol. 35 (4): 684-686 [Abstract] ( 76 ) HTML (1 KB)  PDF  (0 KB)  ( 8 ) 687 Efficacy of Sodium Nitroprusside Combined with Dopamine on the Routine Laboratory Indicators and Renal Function in Patients with Refractory Heart Failure ZUO Hong-yan, XIAONG Lu, ZHANG Bo-li DOI: 10.3969/j.issn.1671-7171.2018.04.021 【Objective】To investigate the protective effects of sodium nitroprusside combined with dopamine on the routine laboratory indexes and renal function in patients with refractory heart failure.【Methods】A total of 92 patients with refractory heart failure were randomly divided into two groups, with 46 cases in each group. Patients in the control group received conventional treatment, while patients in the observation group were treated with sodium nitroprusside and dopamine in addition to routine treatment. The total effective rate was compared between the two groups. The heart rate (HR), mean arterial pressure (MAP), respiratory rate (RR), left ventricular ejection fraction (LVEF), cardiothoracic ratio (CTR), N-terminal pro-brain natriuretic peptide (NT-proBNP), and 6min walk test (6MWT) were used to evaluate the cardiac function. Serum creatinine (SCr), blood urea nitrogen (BUN) and blood uric acid (UA) were renal function indicators. Adverse reactions were also recorded and compared between the two groups.【Results】The effective rate in the observation group, 95.65% (44/46), was significantly higher than that in the control group, 80.43% (37/46) (P<0.05). After treatment, HR, MAP, and respiratory rate in the observation group were lower than those in the control group (P<0.05). Meanwhile CTR and NT-proBNP levels in the observation group were lower than those in control group (P<0.05). On the other hand, LVEF and 6MWT in the observation group were superior to those in the control group (P<0.05), while SCr, BUN and UA levels were significantly lower (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (10.87% vs 8.70%) (P>0.05).【Conclusion】Sodium nitroprusside combined with dopamine can effectively improve the routine laboratory indexes and protect the renal function in the treatment of patients with refractory heart failure and is worthy of clinical application. 2018 Vol. 35 (4): 687-689 [Abstract] ( 68 ) HTML (1 KB)  PDF  (0 KB)  ( 7 ) 690 Clinical Study of Radiofrequency Hyperthermia Combined with Radioactive Iodine Implantation in the Treatment of Advanced Non - small Cell Lung Cancer GAO Ying-jun, LI Mei-shu DOI: 10.3969/j.issn.1671-7171.2018.04.022 【Objective】To investigate the clinical efficacy of radiofrequency hyperthermia combined with radioactive iodine implantation in the treatment of advanced non-small cell lung cancer (NSCLC).【Methods】A total of 82 patients with advanced non-small cell lung cancer (NSCLC) were collected from July 2013 to July 2016, which were randomly divided into control group (n=41) and treatment group (n=41). Iodine seeds were implanted into the tumor under the guidance of CT localization. The radioactive iodine 125 seeds (particle activity 0.8 mCi) were permanently implanted into the tumor according to the particle implantation treatment plan system. The prescription dose was about 90 Gy. In the treatment group, high frequency hyperthermia was performed about 3 days after seed implantation, once every other day for about 60 minutes, and the temperature was controlled at about 42℃ for 3 consecutive times.【Results】The total effective rate of the treatment group was 70.73% (29/41), which was higher than that of the control group 48.78% (20/41). The difference was statistically significant (χ2= 4.018, P=0.043＜0.05). In the treatment group, the number of sleep improvement, weight gain, appetite increase and pain relief were higher than those in the control group, the differences were statistically significant (P<0.05). The improvement rate of quality of life was 46.34% in the control group and 68.29% in the treatment group, and the improvement rate of the quality of life in the treatment group was higher than that in the control group, the difference was statistically significant (χ2=4.038, P=0.044＜0.05).【Conclusion】High frequency hyperthermia combined with radioactive iodine seed implantation is an effective method for the treatment of advanced non-small cell lung cancer, which is better than single iodine implantation and has less side effects and easy to implement. It can be further applied in clinical practice. 2018 Vol. 35 (4): 690-692 [Abstract] ( 59 ) HTML (1 KB)  PDF  (0 KB)  ( 7 ) 693 Efficacy Comparison of Four Schemes for Treatment of Cesarean Scar Pregnancy LV Yan, HAN Qian DOI: 10.3969/j.issn.1671-7171.2018.04.023 【Objective】To compare the effects of four schemes for treating cesarean scar pregnancy (CSP) and the time after treatment for human chorionic gonadotropin β (β-HCG) to drop to normal level in each scheme.【Methods】A total of 130 patients with CSP were enrolled in the study. The patients were randomly divided into group A (n=32), group B (n=30), group C (n=35) and group D (n=33) by random number table method, according to patient's own will. Patients in group A were treated with methotrexate alone, patients in group B were treated with methotrexate combined with uterus curettage, patients in group C were treated with uterine artery embolization combined with methotrexate and uterus curettage, and patients in group D were treated with hysteroscopic operation. The state of operation was compared among group B, group C and group D. The recovery indexes were compared among the four groups.【Results】The vaginal bleeding time, blood β-HCG dropping to normal time, and the time of lesion disappearing in group A were [ (29.55±5.20) d, (44.01±7.23) d, (50.21±6.34) d], respectively, which were significantly longer than those in group B, group C or group D (P<0.05). The intraoperative blood loss, length of hospitalization, vaginal bleeding time and time for blood β-HCG to drop to normal in group B were [ (152.74±58.59) ml, (12.33±3.72) d, (26.18±4.08) d, (31.14±6.14) d], respectively, which were significantly more or longer than those in group C or group D (P<0.05).【Conclusion】All four schemes are effective in the treatment of CSP. Uterine artery embolization combined with hysteroscopic surgery has advantages of a small amount of bleeding, complete debridement and quick recovery, however, it requires equipment and techniques. The most reasonable treatment plan should be chosen according to the actual condition of patients. 2018 Vol. 35 (4): 693-695,699 [Abstract] ( 65 ) HTML (1 KB)  PDF  (0 KB)  ( 4 ) 696 Pathological and In Situ Hybridization Study of HPV Infection in Papilloma of External Auditory Canal CHENG Mo-yu, WANG Xu DOI: 10.3969/j.issn.1671-7171.2018.04.024 【Objective】To investigate the etiology and pathogenesis of papilloma of external auditory canal (PEAC), and analyze the relationship between the PEAC and human papilloma virus (HPV) infection.【Methods】From January 2011 to December 2016, 130 PEAC surgical specimens were collected from our hospital. The infection of HPV6 / 11 DNA and HPV16/18 DNA infection were detected by HE staining and in situ hybridization.【Results】The low-risk HPV6/11 DNA infection rate of PEAC with koilocyte (79.52%) was significantly higher than that of PEAC without koilocyte (P<0.05), while the HPV16/18 DNA infection rate of PEAC with half koilocyte (17.54%) was higher than that of PEAC without koilocyte, but the difference was not statistically significant (0) (P>0.05). The HPV6/11DNA infection rate in men was significantly higher than that in women (80.21% vs 47.06%), but there was no statistically significant difference between men and women in the HPV16/18 DNA infection rate (21.87% vs 14.71%). HE staining showed that squamous epithelium was papillary hyperplasia, mild or severe hyperkeratosis of epidermis, parakeratosis cells scattered in epithallium, lymphocytes infiltration in central connective tissues, a large number of koilocytes in epidermal superficial or middle-level cells and dermal papilla hyperplasia and dilatation of capillaries. The results of in situ hybridization found that HPV6/11 positive cells showed positive nucleus, while HPV16/18 positive cells showed positive cytoplasm.【Conclusion】The etiology and pathogenesis of PEAC may due to HPV virus infection. 2018 Vol. 35 (4): 696-699 [Abstract] ( 56 ) HTML (1 KB)  PDF  (0 KB)  ( 9 ) 700 Analysis of Anticoagulant Therapy and Thrombotic Complications in Different Vascular Pathways in Patients Undergoing Maintenance Hemodialysis ZHANG Wen-qiang, SHI Zhu-mei DOI: 10.3969/j.issn.1671-7171.2018.04.025 【Objective】To explore the selection of vascular access and incidence of related complications in patients with maintenance hemodialysis (MHD) and analyze the conditions of anticoagulant therapy.【Methods】A total of 88 patients with MHD in our hospital were divided into long-term indwelling central venous catheter group (CVC, n=10) and autologous internal arteriovenous fistula group (AVF, n=78). The status of anticoagulant therapy and incidence of complications were compared between the two groups.【Results】①Most of the patients who chose AVF pathway were patients whose primary disease was glomerulonephritis, while most patients who chose CVC pathway were female and diabetic patients. The total duration of hemodialysis in the AVF group was longer than that in the CVC group (P<0.05). ②In the CVC group, the proportion of patients using low molecular weight heparin (LMWH) anticoagulant was higher than that in the AVF group (P<0.05), but there was no significant difference in the dose of anticoagulant between the two groups (P>0.05). ③The incidence of thrombotic complications in the CVC group was higher than that in the AVF group (P<0.05). There was no significant difference in the incidence of bleeding complications between the two groups (P>0.05). The incidence of thrombosis in AVF group was significantly lower than that in CVC group (P<0.05). ④The dosage of anticoagulants of patients with thrombotic complications in the two groups was higher than that of patients with bleeding complications (P<0.05).【Conclusion】The incidence of thrombotic complications is higher in MHD patients with CVC vascular access. Anticoagulant therapy is based on LMWH. However, the dose and standard of drug use are not so good and the anticoagulant therapy needs to be further standardized. 2018 Vol. 35 (4): 700-702 [Abstract] ( 52 ) HTML (1 KB)  PDF  (0 KB)  ( 6 ) 703 Effects of Ketorolac Tromethamine Combined with Low-dose Fentanyl and Midazolam in Combination with Sufentanil in Laparoscopic Cholecystectomy Patients after Patient-Controlled Intravenous Analgesia (PCIA) DU Yan-ru DOI: 10.3969/j.issn.1671-7171.2018.04.026 【Objective】To compare the effects of ketorolac tromethamine combined with low dose fentanyl and midazolam in combination with sufentanil in patient-controlled intravenous analgesia (PCIA) after laparoscopic cholecystectomy (LC).【Methods】A total of 86 patients with LC who admitted to our hospital from November 2014 to November 2016 were randomly divided into two groups, with 43 cases in each group. Patients in group A were treated with midazolam combined with sufentanil, while patients in group B received ketorolac tromethamine combined with a lower dose of fentanyl. The PRINCE-ENRY score, RAM-SAY sedation score, analgesic effect, overall PCIA analgesia and the incidence of adverse reactions at 4h, 8h, 12h and 24h after surgery were observed in the two groups.【Results】The PRINCE-ENRY score and RAM-SAY sedation score at 4h, 8h, 12h, 24h after surgery in group B were lower than those in group A; the difference between groups was significant statistically (P<0.05). The overall postoperative analgesic effect of group B in terms of the proportion of level Ⅰ was significantly higher than that of group A, while the proportion of level Ⅳ in group B was significant lower than that in the group A; the difference between groups was statistically significant (P<0.05). The total number of PCIA in group B was less than that in group A (P<0.05). The incidence of adverse reactions in group B was significantly lower than that in group A, and the difference was statistically significant (P<0.05).【Conclusion】The use of ketorolac tromethamine combined with fentanyl as well as midazolam combined with sufentanil can achieve certain effect after laparoscopic cholecystectomy. The combination of ketorolac tromethamine and low-dose fentanyl has relatively better postoperative analgesic effect and can also inhibit the opioid receptor induced adverse reactions. 2018 Vol. 35 (4): 703-705,709 [Abstract] ( 73 ) HTML (1 KB)  PDF  (0 KB)  ( 3 ) 706 Clinical Efficacy and Bleeding Risk of Tigrilol Combined with Bivaludine in Patients with Acute Coronary Syndrome (ACS) Treated with Emergency PCI YOU San-li, WANG Zhao DOI: 10.3969/j.issn.1671-7171.2018.04.027 【Objective】To investigate the clinical efficacy and bleeding risk of tigrilol combined with bivaludine in patients with acute coronary syndrome (ACS) treated with emergency percutaneous coronary intervention (PCI).【Methods】The clinical data of 116 patients with ACS treated with emergency PCI from November 2016 to November 2017 in Hunan Brain Hospital were retrospectively analyzed and divided into observation group (n=52, administrated with tigrilol before operation and intraoperatively combined with bivaldine) and control group (n=64, administrated with tigrilol before operation intraoperatively combined with common heparin) according to their drug use. Both groups were given aspirin orally before operation. The blood flow grade of thrombolytic test in myocardial infarction was observed during operation, and the clinical effect was observed after operation. Left ventricular ejection fraction (LVEF) and left ventricular end-diastolic diameter (LVDED) were compared at 7 days after operation. The major cardiovascular events (MACEE) and the incidence of hemorrhage were recorded and compared between the two groups.【Results】There was no significant difference in the number of stents implanted by PCI, and the level of LVEDV and LVEF in both groups at 7 days and 1 month after operation (mean P>0.05), and there was no significant difference between the two groups in the proportion of TIMI blood flow grading and sucking thrombus before and after operation (P>0.05). There was no significant difference in the incidence of MACE, acquired thrombocytopenia and stent thrombosis between the two groups 1 month after operation (mean P>0.05), the total incidence of hemorrhage in the observation group after PCI was lower than that in the control group, and the two groups had slight hemorrhage. The difference was statistically significant (P<0.05).【Conclusion】Tigrilol combined with bivaludine for emergency PCI treatment in ACS patients dose not increase thrombotic events within 30 days and could effectively reduce the incidence of bleeding. 2018 Vol. 35 (4): 706-709 [Abstract] ( 80 ) HTML (1 KB)  PDF  (0 KB)  ( 4 ) 711 Clinical Study on Single-Hole Thoracoscopic Surgery and Postoperative Application of Negative Pressure Drainage for Benign Chest Disease FAN Jian-kun, CHENG Liang, FEGN Qi, et al DOI: 10.3969/j.issn.1671-7171.2018.04.028 【Objective】To explore the clinical application of single-hole thoracoscopic surgery and negative pressure drainage after surgery for benign chest diseases.【Methods】A total of 182 patients who underwent thoracoscopic surgery in our hospital from May 2014 to May 2017 were enrolled in this study. According to the different thoracoscopic procedures, patients were divided into the single-hole thoracoscopic surgery and postoperative application of negative pressure drainage ball drainage group (hereinafter referred to as single-hole thoracoscopic surgery group) with 102 cases and the conventional thoracoscopic surgery and postoperative application of ordinary drainage group (hereinafter referred to as traditional thoracoscopic surgery group) with 80 cases. Patients in the single-hole thoracoscopic surgery group underwent single-hole thoracoscopic surgery, while patients in the traditional thoracoscopic surgery group received three-hole thoracoscopic surgery. The intraoperative blood loss, operation time, length of hospitalization and drainage were compared between the two groups. Postoperative pain, postoperative complications, and quality of life for 3 months after surgery were evaluated as well.【Results】The intraoperative blood loss and drainage volume of patients with the single hole thoracoscopic surgery were less than those of the traditional thoracoscopic surgery group (P<0.05), but the operation time in the single-thoracic surgery group was longer than that of the conventional thoracoscopic surgery group (P<0.05). The hospitalization time of patients with single-hole thoracoscopic surgery was shorter than that in the conventional thoracoscopic surgery group; the difference was statistically significant (P<0.05). The maximum pain at 3 and 7 days postoperatively, and the lowest pain at 7 days after operation in the single-hole thoracoscopic surgery group were lower than those in the conventional thoracoscopic surgery group; the differences were statistically significant (P<0.05). However, there was no statistically significant difference in the incidence of postoperative complications between the two groups. After 3 months of surgery, the scores of physiological function, physical pain, social function, emotional function and mental health in patients who underwent single-hole thoracoscopic surgery were significantly higher than those in patients underwent traditional thoracoscopic surgery; the differences were statistically significant (P<0.05).【Conclusion】Compared to traditional thoracoscopic surgery with ordinary drainage tube, the use of single-hole thoracoscopic surgery with negative pressure thoracic drainage treatment of thoracic surgery can more effectively reduce the amount of intraoperative blood loss, shorten the length of hospital stay, reduce drainage volume, relieve pain, and improve the quality of life. It is worthy of clinical promotion. 2018 Vol. 35 (4): 711-713 [Abstract] ( 84 ) HTML (1 KB)  PDF  (0 KB)  ( 5 )

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