妊娠期高血压患者血清脂联素、胰岛素、高敏C反应蛋白的表达水平及其意义

doi:10.3969/j.issn.1671-7171.2018.04.020

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (0 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To investigate the levels of serum adiponectin (APN), fasting insulin (FINS) and high sensitive C reactive protein (hs-CRP) in patients with pregnancy induced hypertension and to analyze the correlation of APN with FINS, hs-CRP and insulin resistance (IRI).【Methods】A total of 128 pregnant women with hypertension during treatment from March 2014 to March 2017 in our hospital were selected as the observation group, including 89 cases of mild preeclampsia (mild group) and 39 cases of severe preeclampsia (severe group). Another 68 normal pregnant women at the same period were selected as the control group. FINS APN, hs-CRP. and fasting blood glucose (FBG) of all pregnant women were detected, and the IRI was calculated. The correlation of APN with FINS, hs-CRP and IRI were analyzed.【Results】Compared with the control group, the serum APN level in the mild and severe hypertension groups was significantly lower, and the levels of hs-CRP, FINS, and IRI were higher (F=8.712, 12.314, 10.698, 7.383, P=0.045, 0.023, 0.039, 0.049). Compared to the mild hypertension group, serum APN level in the severe hypertension group was significantly lower, and hs-CRP, FINS levels, and IRI were significantly higher (t=6.938, 8.856, 10.318, 5.964, P=0.045, 0.029, 0.014, 0.047). Pearson correlation analysis showed that there was a significant negative correlation of APN with FINS, hs-CRP and IRI (r=-0.289,-0.472,-0.675, P=0.034, 0.029, 0.013).【Conclusion】The expression level of APN in serum of hypertensive patients with pregnancy is decreased, and it is significantly negatively related with FINS, hs-CRP and IRI.

Key words： Hypertension, Pregnancy-Induced Adiponectin/BL Insulin/BL C-Reactive Protein/AN Insulin Resistance

Received: 28 August 2017

PACS:

R714.246

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

URL:

http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2018.04.020 OR http://www.jcr.net.cn/EN/Y2018/V35/I4/684

[1] 宋静,彭素芳.妊娠期糖尿病患者血清脂联素与炎症因子的关系及临床意义[J].现代检验医学杂志,2011,26(3):139-140.
[2] 孙慧,吴永全,严松彪.脂联素与血管内皮细胞功能障碍的相关性[J].中国动脉硬化杂志,2011,19(11):952-955.
[3] 高玉洁,李璐.妊娠期高血压胰岛素抵抗及胎盘生乳素、雌二醇、NO、NOS水平的检测意义[J].华南国防医学杂志,2014,(4):314-317.
[4] 李桂荣,张玮.胰岛素抵抗相关因子与妊娠期高血压疾病的关系[J].中国妇幼保健,2011,26(6):944-946.
[5] 乐杰主编.妇产科学[M].第6 版.北京:人民卫生出版社,2004:97-104.
[6] Mastorakos G,Valsamakis G,Dimitrios C,et al.The role of adipocytokines in insulin resistance in normal pregnancy:visfatin concentrations in early pregnancy predict insulin sensitivity [J].Clin Chem,2007,53(8):1477-1483.
[7] 李红,赵欣,黄彩梅,等.硝苯地平对妊娠期高血压病患者胰岛素抵抗的作用[J].中国临床医学,2012,19(5):514-515.
[8] 欧阳漪,程洁,王平芳,等.血清脂联素、同型半胱氨酸、超敏C反应蛋白、胰岛素抵抗与2型糖尿病大血管病变关系的研究[J].医学临床研究,2012,29(8):1478-1481.
[9] 颜建英,张东妹.子痫前期患者血清脂联素表达水平与血脂代谢及胰岛素抵抗的相关性[J].国际妇产科学杂志,2012,39(1):88-91,106.
[10] 孙亚惠,李云.妊娠糖尿病合并妊娠高血压患者血清同型半胱氨酸水平与胰岛素抵抗的变化[J].西部医学,2014,26(10):1304-1305.
[11] 庞天舒,王颖.胰岛素抵抗与妊娠期高血压疾病发病的关系[J].临床医学工程,2014,(8):1079-1080.
[12] 周晓飞,黄凌霄,林晓华,等.妊娠期高血压疾病患者脂联素与胰岛素抵抗的相关性[J].现代实用医学,2012,24(3):264-266.
[13] 曹慧芳,孙敬霞,吴春凤,等.子痫前期胰岛素抵抗相关因素研究进展[J].现代生物医学进展,2013,13(5):980-982.
[14] 吴晶晶,颜建英.子痫前期患者血清内脂素水平与血脂代谢及胰岛素抵抗的相关性[J].国际妇产科学杂志,2013,40(6):510-513.
[15] 王江玲,陈思思,唐杰,等.子痫前期患者血清内脂素、肿瘤坏死因子α水平与胰岛素抵抗的相关性[J].中国病理生理杂志,2016,32(9):1677-1682.