酮咯酸氨丁三醇复合小剂量芬太尼与咪唑安定混合舒芬太尼在LC术后PCIA中的应用效果比较

doi:10.3969/j.issn.1671-7171.2018.04.026

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Abstract 【Objective】To compare the effects of ketorolac tromethamine combined with low dose fentanyl and midazolam in combination with sufentanil in patient-controlled intravenous analgesia (PCIA) after laparoscopic cholecystectomy (LC).【Methods】A total of 86 patients with LC who admitted to our hospital from November 2014 to November 2016 were randomly divided into two groups, with 43 cases in each group. Patients in group A were treated with midazolam combined with sufentanil, while patients in group B received ketorolac tromethamine combined with a lower dose of fentanyl. The PRINCE-ENRY score, RAM-SAY sedation score, analgesic effect, overall PCIA analgesia and the incidence of adverse reactions at 4h, 8h, 12h and 24h after surgery were observed in the two groups.【Results】The PRINCE-ENRY score and RAM-SAY sedation score at 4h, 8h, 12h, 24h after surgery in group B were lower than those in group A; the difference between groups was significant statistically (P<0.05). The overall postoperative analgesic effect of group B in terms of the proportion of level Ⅰ was significantly higher than that of group A, while the proportion of level Ⅳ in group B was significant lower than that in the group A; the difference between groups was statistically significant (P<0.05). The total number of PCIA in group B was less than that in group A (P<0.05). The incidence of adverse reactions in group B was significantly lower than that in group A, and the difference was statistically significant (P<0.05).【Conclusion】The use of ketorolac tromethamine combined with fentanyl as well as midazolam combined with sufentanil can achieve certain effect after laparoscopic cholecystectomy. The combination of ketorolac tromethamine and low-dose fentanyl has relatively better postoperative analgesic effect and can also inhibit the opioid receptor induced adverse reactions.

Key words： Cholecystectomy, Laparoscopic Ketorolac Tromethamine/TU Fentanyl/AD Midazolam/AD Sufentanil/AD Analgesia,Patient-Controlled

Received: 24 July 2017

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R657.4

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DU Yan-ru. Effects of Ketorolac Tromethamine Combined with Low-dose Fentanyl and Midazolam in Combination with Sufentanil in Laparoscopic Cholecystectomy Patients after Patient-Controlled Intravenous Analgesia (PCIA)[J]. JOURNAL OF CLINICAL RESEARCH, 2018, 35(4): 703-705,709.

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2018.04.026 OR http://www.jcr.net.cn/EN/Y2018/V35/I4/703

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