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| Efficacy of Sodium Nitroprusside Combined with Dopamine on the Routine Laboratory Indicators and Renal Function in Patients with Refractory Heart Failure |
| ZUO Hong-yan, XIAONG Lu, ZHANG Bo-li |
| Mianyang Orthopedic Hospital, Mianyang, Sichuan Province 621000 |
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Abstract 【Objective】To investigate the protective effects of sodium nitroprusside combined with dopamine on the routine laboratory indexes and renal function in patients with refractory heart failure.【Methods】A total of 92 patients with refractory heart failure were randomly divided into two groups, with 46 cases in each group. Patients in the control group received conventional treatment, while patients in the observation group were treated with sodium nitroprusside and dopamine in addition to routine treatment. The total effective rate was compared between the two groups. The heart rate (HR), mean arterial pressure (MAP), respiratory rate (RR), left ventricular ejection fraction (LVEF), cardiothoracic ratio (CTR), N-terminal pro-brain natriuretic peptide (NT-proBNP), and 6min walk test (6MWT) were used to evaluate the cardiac function. Serum creatinine (SCr), blood urea nitrogen (BUN) and blood uric acid (UA) were renal function indicators. Adverse reactions were also recorded and compared between the two groups.【Results】The effective rate in the observation group, 95.65% (44/46), was significantly higher than that in the control group, 80.43% (37/46) (P<0.05). After treatment, HR, MAP, and respiratory rate in the observation group were lower than those in the control group (P<0.05). Meanwhile CTR and NT-proBNP levels in the observation group were lower than those in control group (P<0.05). On the other hand, LVEF and 6MWT in the observation group were superior to those in the control group (P<0.05), while SCr, BUN and UA levels were significantly lower (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (10.87% vs 8.70%) (P>0.05).【Conclusion】Sodium nitroprusside combined with dopamine can effectively improve the routine laboratory indexes and protect the renal function in the treatment of patients with refractory heart failure and is worthy of clinical application.
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Received: 08 December 2016
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2018, Vol. 35 
