替格瑞洛联合比伐卢定对行急诊PCI术的急性冠脉综合征患者疗效观察

doi:10.3969/j.issn.1671-7171.2018.04.027

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Abstract 【Objective】To investigate the clinical efficacy and bleeding risk of tigrilol combined with bivaludine in patients with acute coronary syndrome (ACS) treated with emergency percutaneous coronary intervention (PCI).【Methods】The clinical data of 116 patients with ACS treated with emergency PCI from November 2016 to November 2017 in Hunan Brain Hospital were retrospectively analyzed and divided into observation group (n=52, administrated with tigrilol before operation and intraoperatively combined with bivaldine) and control group (n=64, administrated with tigrilol before operation intraoperatively combined with common heparin) according to their drug use. Both groups were given aspirin orally before operation. The blood flow grade of thrombolytic test in myocardial infarction was observed during operation, and the clinical effect was observed after operation. Left ventricular ejection fraction (LVEF) and left ventricular end-diastolic diameter (LVDED) were compared at 7 days after operation. The major cardiovascular events (MACEE) and the incidence of hemorrhage were recorded and compared between the two groups.【Results】There was no significant difference in the number of stents implanted by PCI, and the level of LVEDV and LVEF in both groups at 7 days and 1 month after operation (mean P>0.05), and there was no significant difference between the two groups in the proportion of TIMI blood flow grading and sucking thrombus before and after operation (P>0.05). There was no significant difference in the incidence of MACE, acquired thrombocytopenia and stent thrombosis between the two groups 1 month after operation (mean P>0.05), the total incidence of hemorrhage in the observation group after PCI was lower than that in the control group, and the two groups had slight hemorrhage. The difference was statistically significant (P<0.05).【Conclusion】Tigrilol combined with bivaludine for emergency PCI treatment in ACS patients dose not increase thrombotic events within 30 days and could effectively reduce the incidence of bleeding.

Key words： Acute Coronary Syndrome/TH Angioplasty, Transluminal, Percutaneous Coronary Platelet Aggregation Inhibitors/TU Hemorrhage

Received: 06 March 2018

PACS:

R543.31

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	YOU San-li
	WANG Zhao

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YOU San-li,WANG Zhao. Clinical Efficacy and Bleeding Risk of Tigrilol Combined with Bivaludine in Patients with Acute Coronary Syndrome (ACS) Treated with Emergency PCI[J]. JOURNAL OF CLINICAL RESEARCH, 2018, 35(4): 706-709.

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2018.04.027 OR http://www.jcr.net.cn/EN/Y2018/V35/I4/706

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