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| Expression of VEGF, VEGFR-2 and TSP-1 in Elderly Patients with T2DM |
| SANG Dan, LUO Cai-xian, YE Yi-yi, et al |
| Department of Endocrinology, The eighth affiliated Hospital with Sun Yat-sen University, Shenzhen Futian 518033 |
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Abstract 【Objective】To investigate the expression level and clinical significance of vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor-2 (VEGFR-2) and platelet reactive protein-1 (TSP-1) in elderly patients with type 2 diabetes mellitus (T2DM).【Methods】The elderly patients with type 2 diabetes mellitus treated in our hospital from June 2015 to February 2017 were selected as the subjects, and the non-diabetic elderly patients who were examined in our hospital during the same period were selected as the controls. The differences of serum VEGF, VEGFR-2, TSP-1, blood glucose and cytokine levels between the two groups were compared, and the correlation of VEGF, VEGFR-2 and TSP-1 levels with blood glucose and cytokine levels in elderly patients with type 2 diabetes mellitus was analyzed.【Results】The levels of serum VEGF, VEGFR-2, TSP-1, interleukin-18 (IL-18), interleukin-6 (IL-6) and hypersensitivity C reaction protein (hs-CRP) in the diabetic group were higher than those in the control group. The average blood glucose (MBG), average blood glucose standard deviation (SDBG) and effective fluctuation times (NEGE) were higher in the diabetic group than those in the control group. The level of VEGF, VEGFR-2 and TSP-1 in elderly patients with type 2 diabetes mellitus were positively related to the levels of MBG, SDBG, NEGE, IL-18, IL-6 and hs-CRP.【Conclusion】The levels of VEGF, VEGFR-2 and TSP-1 in elderly patients with type 2 diabetes mellitus are higher, and are closely related to the cytokines and blood glucose levels.
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Received: 03 November 2017
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2018, Vol. 35 
