盐酸曲美他嗪联合不同他汀类药物对伴有高血压的心衰患者心功能的影响

doi:10.3969/j.issn.1671-7171.2018.04.011

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Abstract 【Objective】To observe the effects of tricetaxine hydrochloride combined with different statins on cardiac function of heart failure with hypertension patients.【Methods】A total of 120 patients with heart failure who were treated with hypertension from August 2015 to March 2017 were randomly divided into the group A, the group B and the group C, with 40 patients of each group. The three groups were given conventional basic treatment, and oral tricamalt hydrochloride tablets 20mg, 3 times one day, and the A group, the B group and the C group were respectively given oral fluvastatin, simvastatin, and atorvastatin 20mg, 1 time one day. After 6 months of treatment, the efficacy of the three groups were compared; the left ventricular ejection fraction (LVEF), the left ventricular end diastolic diameter (LVEDD), and the left ventricular end-diastolic diameter (LVESD), and the left ventricular end-diastolic diameter (LVEDD) were detected by ultrasonic diagnostic apparatus; the systolic blood pressure (SBP) and the diastolic blood pressure (DBP) were measured by a standard pool mercury sphygmomanometer; the total cholesterol (TC), the triglyceride (TG), the low density lipoprotein cholesterol (LDL-C) and the high density lipoprotein cholesterol (HDL-C) were measured by automatic biochemical analyzer; and drug safety analyze.【Results】The results of rank sum test showed that there was significant difference between the three groups (P<0.05). Total effective rate of the group C was significantly higher than that of the group A (P<0.05);the LVEF and HDL-C of the three groups were significantly higher than those before treatment (P<0.05), the LVESD, LVEDD, SBP, DBP, TG, TC, and LDL-C were significantly lower than those before treatment (P<0.05);the levels of LVEF and HDL-C of the group C were significantly higher than those of the group A and B (P<0.05), the LVESD, LVEDD, TG, TC and LDL-C were significantly lower than those of the group A and B (P<0.05);the LVEF and HDL-C of the group B were significantly higher than those of the group A (P<0.05), the LVESD, LVEDD, TG, TC and LDL-C were significantly lower than those of the group A (P<0.05);there was no significant difference in SBP and DBP between the group A, B and C (P>0.05);there was no significant difference in the incidence of adverse reactions of the three groups (P>0.05).【Conclusion】Trimetazidine hydrochloride combined with statins is effective in the treatment of hypertensive heart failure. However, its combination with atorvastatin can significantly improve cardiac function and blood lipid level, and has the highest efficacy and safety.

Key words： Heart Failure/CO Hypertension/CO Trimetazidine/PD Simvastatin/PD Heart Function Tests

Received: 26 October 2017

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R541.61

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2018.04.011 OR http://www.jcr.net.cn/EN/Y2018/V35/I4/657

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