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| Clinical Study of Radiofrequency Hyperthermia Combined with Radioactive Iodine Implantation in the Treatment of Advanced Non - small Cell Lung Cancer |
| GAO Ying-jun, LI Mei-shu |
| Department of General Surgery, the People's Hospital of Gu-an County, Langfang, Hebei 065500 China |
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Abstract 【Objective】To investigate the clinical efficacy of radiofrequency hyperthermia combined with radioactive iodine implantation in the treatment of advanced non-small cell lung cancer (NSCLC).【Methods】A total of 82 patients with advanced non-small cell lung cancer (NSCLC) were collected from July 2013 to July 2016, which were randomly divided into control group (n=41) and treatment group (n=41). Iodine seeds were implanted into the tumor under the guidance of CT localization. The radioactive iodine 125 seeds (particle activity 0.8 mCi) were permanently implanted into the tumor according to the particle implantation treatment plan system. The prescription dose was about 90 Gy. In the treatment group, high frequency hyperthermia was performed about 3 days after seed implantation, once every other day for about 60 minutes, and the temperature was controlled at about 42℃ for 3 consecutive times.【Results】The total effective rate of the treatment group was 70.73% (29/41), which was higher than that of the control group 48.78% (20/41). The difference was statistically significant (χ2= 4.018, P=0.043＜0.05). In the treatment group, the number of sleep improvement, weight gain, appetite increase and pain relief were higher than those in the control group, the differences were statistically significant (P<0.05). The improvement rate of quality of life was 46.34% in the control group and 68.29% in the treatment group, and the improvement rate of the quality of life in the treatment group was higher than that in the control group, the difference was statistically significant (χ2=4.038, P=0.044＜0.05).【Conclusion】High frequency hyperthermia combined with radioactive iodine seed implantation is an effective method for the treatment of advanced non-small cell lung cancer, which is better than single iodine implantation and has less side effects and easy to implement. It can be further applied in clinical practice.
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Received: 18 April 2017
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[1] 刘洪明,马瑞忠,杨晏慧.三维适形放疗联合内生场热疗治疗腹部肿瘤的临床观察[J].癌症进展,2012,10(5):502-507.
[2] Qian J,Bao Z,Zou J,et al.Effect of pedicle fixation combined with (125)I seed implantation for metastatic thoracolumbar tumors[J].J Pain Res.2016,10(9):271-278.
[3] 冷玲,佟仲生.WHO标准和RECIST标准对晚期乳腺癌疗效评价的比较[J].中华肿瘤防治杂志,2008,15(22):1746-1751.
[4] 高万露,汪小海.患者疼痛评分法的术前选择及术后疼痛评估的效果分析[J].实用医学杂志,2013,29(23):3892-3897.
[5] 李敬国,张明军,李娜,等.两种生活质量评分对甲磺酸伊马替尼治疗胃肠间质瘤患者生活质量评价的可行性[J].山东医药,2011,51(13):33-37.
[6] Li W,Dan G,Jiang J,et al.Repeated iodine-125 seed implantations combined with external beam radiotherapy for the treatment of locally recurrent or metastatic stage Ⅲ/Ⅳ non-small cell lung cancer:a retrospective study[J].Radiat Oncol.2016,11(1):119.
[7] 胡建林,杨和平,李前伟,等.经皮穿刺瘤体内植入125 I粒子治疗肺癌的初步评价[J].重庆医学,2002,31(9):774-779.
[8] Makino Y,Itoda N,Ikegaya H,et al.Search and removal of radioactive seeds:another application of postmortem computed tomography prior to autopsy[J].Int J Legal Med.2016 ,130(5):1329-1332.
[9] 刘建国 钟龙 郑飞,等.经直肠超声引导下125碘粒子植入治疗前列腺癌的疗效[J].医学临床研究,2015,32(9):1843-1849.
[10] 王婧 赵磊 李卉惠,等.体外高频热疗联合化疗治疗晚期胰腺癌的随机对照临床研究[J].中华胰腺病杂志,2016,16(3):149-153.
[11] Finkel P,Frey B,Mayer F,et al.The dual role of NK cells in antitumor reactions triggered by ionizing radiation in combination with hyperthermia[J].Oncoimmunology.2016,5(6):e1101206.
[12] Christie C,Molina S,Gonzales J,et al.Synergistic chemotherapy by combined moderate hyperthermia and photochemical internalization[J].Biomed Opt Express.2016,7(4):1240-1250. |
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. [J]. JOURNAL OF CLINICAL RESEARCH, 2018, 35(5): 1025-1026. |
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2018, Vol. 35 
