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| Correlation Analysis between Early Post-stroke Depression and Cerebral Infarct Locations |
| CHEN Yu, WU Ming-xiang, CHEN Wen-jiao, et al |
| CT/MRI Room, Shenzhen People's Hospital, Shenzhen, Guangdong 518020 |
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Abstract 【Objective】To investigate the distribution of infarct location in patients with early PSDs after early cerebral infarction and its correlation.【Methods】From March 2008 to August 2017, 78 patients with cerebral infarction were selected and divided into PSD group (n=40) and non-depression group (n=38, PSND). All patients were scanned with MRI, and the distribution of cerebral infarction in both groups was analyzed, and the correlation between the location of cerebral infarction and the occurrence of PSD was analyzed.【Results】The proportion of infarction in the frontotemporal and parietal cortex, occipital cortex, brainstem and cerebellum in the PSD group was significantly higher than that in the PSND group, the difference was statistically significant (P<0.05). The distance between the infarct site and the left frontal pole and the right frontal pole in the PSD group were (2.47±1.33) cm and (2.94 ±1.55)cm, respectively, which were lower than that in the PSND group (3.28 ±1.46) and (3.14 ±1.41) cm, respectively. The distance between the infarct site and the left frontal pole in the PSD group was significantly smaller than that in the PSND group; the difference was statistically significant (P<0.05). From the analysis of the correlation coefficient, the order of correlation between each indicator and PSD from big to small was: brain stem and cerebellum>frontotemporal parietal cortex>occipital cortex>left frontal polar distance>multiple infarction>hippocampal amygdala>left frontal lobe>posterior part>right frontal lobe>right frontal polar distance>coronal area>anterior part of brain>basal nucleus area.【Conclusion】When the cerebral infarction is located in the brain stem and cerebellum and the frontotemporal parietal and occipital cortex with smaller left frontal pole distance, it is easy to appear early PSD, and the early PSD is related to the location of the infarct.
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Received: 22 January 2018
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[1] Starkstein SE,Robinson RG,Berthier M,et al.Depression disorders following posterior circulationas compared with middle cerebral artery infarects[J].Brain,1998,111(pt 2):375-387.[2] Whyte EM,Mulsnt BH.Poststroke depression:epideemiology,pathophysiology,and biological treatment[J].Biol Psychiatry,2002,52(3):253-264.
[3] Robinson RG,Bloom FE.Pharmacological treatment following experimental cerebral infarction:Implications for understanding psychological symptoms of human stroke[J].Biol Psychiatry,1977,12(5):669-680.
[4] Alexopoulos GS,Meyers BS,Young RC,et al.'Vascular depression' hypothesis[J].Arch Gen Psychiatry,1997,54(10):915-922.
[5] Robinson RG.Neuropsychiatric consequences of stroke[J].Annu Rev Med,1997,48(3):217-229.
[6] Hama S,Yamashita H,Shigenobu M,et al.Post-stroke affective or apathetic depression and lesion location:left frontal lobe and bilateral basal ganglia[J].Eur Arch Psychiatry Clin Neurosci,2007,257(3):149-152.
[7] Wongwandee M,Tangwongchai S,Phanthumchinda K.Relationship between poststroke depression and ischemic lesion location[J].J Med Assoc Thai,2012,95(3):330-336.
[8] Zhang T,Jing X,zhao X,et al.A prospective cohort study of lesion location and its relation to post-stroke depression among Chinese patients[J].J Affect Disord,2012,136(1-2):e83-e87.
[9] Terroni L,Amaro E,Iosifeseu DV,et al.Stroke lesion in cortical neural circuits and post-stroke incidence of major depressive episode:a 4 month prospective study[J].World J Biol Psychiatry,2011,12(7):539-548.
[10] Strakowski SM,Delbello MP,Adler CM.The functional neuroanatomy of bipolar disorder:a review of neuroimaging findings[J].Mol Psychiatry,2005,10(1):105-116.
[11] Smith KA,Ploghaus A,Cowen PJ,et al.Cerebellar responses during anticipation of noxious stimuli in subjects recovered from depression Functional magnetic resonance imaging study[J].Br J Psychiatry,2002,181(11):411-415.
[12] Fu CH,Williams SC,Cleare AJ,et al.Attenuation of the neural response to sad faces in major depression by antidepressant treatment:a prospective,event-related functional magnetic resonance imaging study[J].Arch Gen Psychiatry,2004,61(9):877-889. |
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2018, Vol. 35 
