童年时期虐待对精神分裂症患者血清瘦素的影响

doi:10.3969/j.issn.1671-7171.2018.04.015

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Abstract 【Objective】To investigate the effect of childhood abuse on serum leptin in schizophrenic patients.【Methods】A total of 112 patients with schizophrenia were enrolled in our hospital from January 2016 to June 2017. The Childhood Trauma Questionnaire (CTQ) was used to assess the extent and type of child abuse. According to CTQ scores, 112 patients were divided into abused group (n=40) and non-abused group (n=72). The psychiatric symptoms were assessed using the Positive and Negative Symptom Scale (PANSS). Serum levels of leptin, serotonin (5-HT) and brain-derived neurotrophic factor (BDNF) were measured by ELISA.【Results】There were statistically significant differences in the starting age of abuse, and the proportion of male and female victims between the abused and non-abused groups (P<0.05), but there was no significant difference in the number of years of education (P>0.05). The total score of CTQ and scores of emotional abuse, affective neglect, sexual abuse, physical abuse and physical neglect were significantly higher in the abused group than those of non-abused group (P<0.05). The total score of PANSS and scores of general pathology, positive symptoms and negative symptoms were significantly higher in the abused group than those of non-abused group (P<0.05). The levels of serum LP and 5-HT in the abused group were significantly lower than those in the non-abused group (P<0.05). There was no significant difference in serum BDNF levels between the two groups (P>0.05). Spearman correlation analysis showed that there was a significant positive correlation between CTQ score and PANSS score (r=0.536, P=0.032<0.05). There was a significant negative correlation between CTQ total score and LP (r=-0.511, P=0.039<0.05).【Conclusion】There are more female schizophrenia than male schizophrenia cases caused by childhood abuse. The earlier age of receiving abuse, the more severe clinical symptoms exist. The difference of serum LP and 5-HT levels between the abuse and non-abuse groups reflects the occurrence of schizophrenia.

Key words： Adult Survivors of Child Abuse Schizophrenia Leptin/BL Serotonin

Received: 07 August 2017

PACS:

R749.3

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	HUANG Shi-bin

Cite this article:

HUANG Shi-bin. Effect of Childhood Abuse on Serum Leptin in Patients with Schizophrenia[J]. JOURNAL OF CLINICAL RESEARCH, 2018, 35(4): 669-671.

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2018.04.015 OR http://www.jcr.net.cn/EN/Y2018/V35/I4/669

[1] Andreassen OA,Harbo HF,Wang Y,et al.Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder:differential involvement of immune-related gene loci[J].Mol Psychiatry,2015,20(2):207.
[2] 曹世林,田国强,梁胜林,等.童年创伤与精神分裂症症状类型的相关性[J].中国慢性病预防与控制,2015,23(6):445-447.
[3] Green MJ,Chia TY,Cairns MJ,et al.Catechol-O-methyltransferase (COMT) genotype moderates the effects of childhood trauma on cognition and symptoms in schizophrenia[J].J Psychiatr Res,2014,49(16):43-50.
[4] 刘得乐,胡茂荣.探究精神分裂症患者童年创伤的发生率及相关影响[J].当代医学,2017,23(15):102-103.
[5] 李仁军.儿童青少年首发精神分裂症患者认知功能损害与童年创伤的关系[J].精神医学杂志,2017,30(1):20-22.
[6] 陈方彦.CCMD-3 中国精神障碍分类与诊断标准[M].济南:山东科学技术出版社,2001.
[7] 陈静,杜亚松.童年期逆境与精神分裂症机制研究进展[J].中国神经精神疾病杂志,2016,42(11):697-700.
[8] 陈领,孔晓明,张晓倩,等.精神分裂症患者童年创伤经历和共情能力的相关性研究[J].齐齐哈尔医学院学报,2016,37(28):3493-3496.
[9] 梁晓书.精神分裂症患者童年创伤经历与眼区情绪识别的相关性研究[J].中国卫生产业,2014,11(21):157-158.
[10] Larsson S,Andreassen OA,Aas M,et al.High prevalence of childhood trauma in patients with schizophrenia spectrum and affective disorder[J].Compr Psychiatry,2013,54(2):123-127.
[11] 汪卫华,隋云川,刘丽,等.童年受虐对成人抑郁症患者血浆瘦素水平的影响[J].中华行为医学与脑科学杂志,2016,25(3):244-247.
[12] 赵子丛.精神分裂症患者童年创伤经历与眼区情绪识别的相关性研究[D].安徽医科大学,2013.
[13] Stubbs B,Wang AK,Vancampfort D,et al.Are leptin levels increased among people with schizophrenia versus controls? A systematic review and comparative meta-analysis[J].Psychoneuroendocrinology,2016,63:144-154.
[14] Tsuneyama N,Suzuki Y,Sawamura K,et al.Effect of Serum Leptin on Weight Gain Induced by Olanzapine in Female Patients with Schizophrenia[J].PloS One,2016,11(3):e0149518.
[15] Klemettil J P,Kampman O,Seppl N,et al.Association study of the HTR2C,leptin and adiponectin genes and serum marker analyses in clozapine treated long-term patients with schizophrenia[J].Eur Psychiatry,2015,30(2):296-302.
[16] Takayanagi Y,Cascella N G,Santora D,et al.Relationships between serum leptin level and severity of positive symptoms in schizophrenia[J].Neurosci Res,2013,77(1):97-101.