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Quick Search     Adv Search 2020 Vol. 37, No. 9 Published: 2020-09-30   1287 Analysis and Identification of Protein and Proteomics of Mawangdui Ancient Corpse HUANG Hua-lin, ZHOU Peng, LI Zhi-yuan DOI: 10.3969/j.issn.1671-7171.2020.09.003 【Objective】 To analyze the remaining proteins and proteomics in some tissues of Mawangdui ancient corpse .【Methods】 The remaining proteins in skin, muscle and subcutaneous tissues of Mawangdui corpse were detected by immunohistochemistry, and the remaining proteins in muscle tissues were analyzed and identified by mass spectrometry. 【Results】 No cell structure was observed in the skin, muscle and subcutaneous tissue of the corpse. Histone and actin were not detected by immunohistochemistry. The results of mass spectrometry showed that 216 proteins were identified in muscle tissue.【Conclusion】 It may play a unique role in the overall preservation of Mawangdui female corpse and the maintenance of organ morphology by mass spectrometry. 2020 Vol. 37 (9): 1287-1289 [Abstract] ( 50 ) HTML (0 KB)  PDF  (0 KB)  ( 8 ) 1290 Study on Sexual Function and Social Psychological Status after Partial Penectomy in Penile Cancer Patients TIAN Qi-wei, HU Xi-heng, LI Yang-le DOI: 10.3969/j.issn.1671-7171.2020.09.004 【Objective】 To evaluate the sexual function and social psychological status after partial penectomy due to penile cancer, and explore the relationship of sexual dysfunction with anxiety and depression in penile cancer patients after partial penectomy.【Methods】 Between December 2015 and January 2020, a total of 96 patients treated with partial penectomy due to penile cancer in our hospital were prospectively analyzed in the study. Sexual function (International Erectile Function Index Questionnaire, IIEF-15), age, body mass index (BMI) , penile length(PL)in the flaccid state after partial penectomy, surgical method (partial penectomy or partial penectomy combined with bilateral inguinal lymph node dissection) and psychological factors (Self-rating Anxiety Scale/SAS and Self-Rating Depression Scale/ SDS scores) were assessed. The IIEF-15, SAS and SDS scores of preoperative and postoperative were compared. Univariate and multivariate linear regression analyses were performed.【Results】 Ninety-six patients were included in our study. The median age was 58 years old, and the median penis length (PL) was 4.3 cm. The preoperative IIEF-15, SAS and SDS scores were significantly different from the postoperative scores. Postoperative erectile function, orgasm ability, sexual desire, satisfaction with sexual life and overall satisfaction were significantly lower than those before surgery, and SAS and SDS scores were significantly higher than those before surgery. There was no statistically significant difference in the IIEF-15 scores of patients treated with partial penectomy and partial penectomy + bilateralinguinal lymph node dissection. Erectile function, orgasmic ability, sexual desire, and intercourse satisfaction were negatively associated with SAS/SDS score. Results also showed that erectile function, sexual desire, and overall satisfaction were negatively associated with age, while intercourse satisfaction was positively associated with PL.【Conclusion】 The sexual function of patients with penile cancer decreases after partial penectomy, and the degree of anxiety and depression increase in patients after surgery. The sexual function of penile cancer patients after partial penectomy was negatively correlated with anxiety and depression. In addition, the sexual function was negatively affected by age but positively correlated with postoperative penis length. 2020 Vol. 37 (9): 1290-1293 [Abstract] ( 54 ) HTML (1 KB)  PDF  (0 KB)  ( 7 ) 1294 Clinical Characteristics of Drug Hypersensitivity Syndrome in Children LUO Yang-yang, SHU Ye, TANG Jian-ping, et al DOI: 10.3969/j.issn.1671-7171.2020.09.005 【Objective】 To investigate the clinical characteristics and prognosis of childhood patients with drug-induced hypersensitivity syndrome(DIHS). 【Methods】 The clinical data of 9 children with DIHS were retrospectively analyzed, including allergic drugs, clinical manifestations, laboratory examination, imaging examination, treatment and prognosis.【Results】 There were 4 males and 5 females, aged from 8 months to 10 years. Allergic antibiotics accounted for 44.4%, including 2 cases of mezlocillin sulbactam, 1 case of cefathiamidine and 1 case of fosfomycin; anticonvulsant drugs accounted for 33.4%, including carbamazepine in 3 cases; antipyretic drugs accounted for 22.2%, including ibuprofen in 2 cases; the incubation period was 20 (10~40) d. Course of disease from was 21 ds to 4 months, 6 cases showed exfoliative dermatitis, 5 cases with hepatomegaly, 8 cases with abnormal transaminase, 6 cases with myocardial injury, 5 cases with pneumonia, 2 cases with Epstein Barr virus infection and 1 case with cytomegalovirus infection. Among them, 8 cases were cured after symptomatic support treatment with intravenous hormone, gamma globulin, anti infection and fluid infusion, and 2 cases had two peaks in the treatment process One patient died of multiple organ failure and suspected hemophagocytic syndrome. 【Conclusion】 Antibiotics and anticonvulsant drugs are common in children with DIHS. Exfoliative dermatitis is the main manifestation of skin rash. Liver and myocardial damage often occur. For patients with chronic viral infection, we should be alert to the phenomenon of two peaks. Patients with rapid progress of disease can be complicated with Hemophilus syndrome. 2020 Vol. 37 (9): 1294-1296 [Abstract] ( 45 ) HTML (0 KB)  PDF  (0 KB)  ( 9 ) 1297 Relationship of Clinical Stage in Patients with Type 2 Diabetic Nephropathy with Osteoporosis and Growth Factors HAN Dong-mei, MAO Wei-wei, GONG Wei-wei, et al DOI: 10.3969/j.issn.1671-7171.2020.09.006 【Objective】 To investigate the relationship of clinical stage with osteoporosis and growth factors in patients with type 2 diabetic nephropathy (DN). 【Methods】 A total of 200 patients with type 2 diabetic nephropathy, who received treatment in our hospital, were selected as the observation group. According to the value of albumin excretion rate (UAE), patients were divided into group A (normal albuminuria, UAE<20 μg/min) , group B (microalbuminuria, UAE 20-200 μg/min), group C (large amount of albuminuria, UAE>200 μg/min) and group D (end-stage renal failure, GFR <10 mL/min). In the same time period, 50 healthy volunteers were enrolled as the control group. The levels of osteoporosis and growth factor-related indicators were evaluated. 【Results】 The bone mineral density and mineral content of both cancellous and cortical bones in the observation group were lower than those in the control group (P<0.05). The T value of the cancellous bone and the cortical bone were higher than those of the control group (P<0.05). There were significant differences in bone mineral density and growth factor indicators among the subgroups of the observation group (P<0.05). The cancellous and cortical bone mineral density and mineral content in group D were lower than those in group A, B and C, while the T value of the cancellous bone and the cortical bone were higher than those in group A, B and C (P<0.05). The levels of FGF-23 and IL-6 in the observation group were higher than those in the control group, and IGF-Ⅱ, EGF and TGF-βlevels were lower than those in the control group (P<0.05). The levels of FGF-23 and IL-6 in group D were higher than those in group A, B and C, and IGF-Ⅱ, EGF and TGF-βwere lower than those in group A, B and C (P<0.05). The levels of FGF-23 and IL-6 in group C were higher than those in group A and B, and IGF-Ⅱ, EGF and TGF-βwere lower than those in group A and B (P<0.05). 【Conclusion】 The severity of DN in patients with type 2 diabetes is closely related to osteoporosis and growth factors. The occurrence of osteoporosis in DN patients may be related to growth factors. 2020 Vol. 37 (9): 1297-1299 [Abstract] ( 52 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 1300 Effect of Calcium Carbonate Combined with Compound Alpha-ketoacid Tablets on Calcium and Phosphorus Metabolism and Nutritional Status in MHD Patients with Chronic Kidney Disease SONG Chun-yan DOI: 10.3969/j.issn.1671-7171.2020.09.007 【Objective】 To investigate the effect of calcium carbonate combined with compound alpha-ketoacid tablets on improving calcium and phosphorus metabolism and nutritional status in maintenance hemodialysis(MHD) patients with chronic kidney disease. 【Methods】 A total of 126 patients with chronic kidney disease undergoing MHD were randomly divided into two groups. The control group was treated with calcium carbonate, while the observation group was treated with calcium carbonate combined with compound alpha-ketoacid tablets. Patients received treatment for six months. The blood calcium, blood phosphorus, calcium-phosphorus product, serum parathyroid hormone (iPTH), PA, ALB, HGB, SGA score, IL-6, TNF-α, CRP and adverse reactions were compared between the two groups before treatment, 3 months and 6 months after treatment. 【Results】 After 3 and 6 months of treatment, the levels of blood phosphorus, calcium-phosphorus product and iPTH in the two groups were lower than those before treatment, and the levels in the observation group were significantly lower than those in the control group (P<0.05). The scores of PA, ALB, HGB and SGA in the two groups after treatment were higher than those before treatment, and those in the observation group were significantly higher than in the control group (P<0.05). The levels of IL-6, CRP and TNF-α in the two groups after treatment were lower than those before treatment, and those indicators in the observation group were significantly lower than in the control group (P<0.05). The incidence of adverse reactions in two group was not shown significant difference (P>0.05). 【Conclusion】 Calcium carbonate combined with compound alpha-ketoacid tablets can effectively improve calcium and phosphorus metabolism, improve nutritional status and inhibit inflammatory reaction in patients with chronic kidney disease undergoing MHD. 2020 Vol. 37 (9): 1300-1302 [Abstract] ( 49 ) HTML (0 KB)  PDF  (0 KB)  ( 11 ) 1303 Clinical Characteristics and Survival Status of Patients with Hypopharyngeal Carcinoma HU Ke-bo, HE Heng-sheng, YU Ting-ting DOI: 10.3969/j.issn.1671-7171.2020.09.008 【Objective】 To investigate the clinical characteristics and survival status of patients with hypopharyngeal carcinoma. 【Methods】 A retrospective analysis of the clinical data of 148 patients with hypopharyngeal carcinoma admitted to our hospital was analyzed. According to the patient's 5-year survival rate, patients were divided into the survival group of 55 cases and the death group of 93 cases. The age, gender, smoking status, T grade, N grade, lesion location, clinical grade, functional status (PS) score, and treatment methods were compared between the two groups. The factors affecting the survival status of patients with hypopharyngeal carcinoma were determined by univariate analysis. Independent factors influencing the survival of patients with hypopharyngeal carcinoma were determined by multivariate analysis. 【Results】 Univariate analysis showed that the factors influencing the survival of patients with hypopharyngeal carcinoma included smoking, T grade, N grade, clinical grade, PS score, and treatment. Multivariate analysis also showed that smoking, T grade, N grade,PS score, and treatment were independent factors influencing the survival of patients with hypopharyngeal cancer. Among the 148 patients, the total number of complications in 5 years was 26, with an incidence of 17.6%.【Conclusion】 The factors influencing the survival status of patients with hypopharyngeal carcinoma include smoking, TNM staging and surgical treatment. In order to improve the survival rate of patients, the combined therapy should be the main treatment. 2020 Vol. 37 (9): 1303-1305 [Abstract] ( 67 ) HTML (0 KB)  PDF  (0 KB)  ( 9 ) 1306 Effect of Mucin 5AC Protein on the Occurrence and Development of Malignant Gastric Polyps YU Zhi-tao, ZHANG Lei, LIN Song-rong, et al DOI: 10.3969/j.issn.1671-7171.2020.09.009 【Objective】 To investigate the expression of Mucin 5AC protein in gastric polyps and its clinical significance. 【Methods】 A total of 160 patients with gastric polyps treated in our hospital from January 2017 to January 2018 were selected, meanwhile 87 normal gastric mucosa tissues and 90 gastric cancer tissues were enrolled as controls.Mucin 5AC protein expression was detected by immunohistochemical staining. 【Results】 The positive expression rate of Mucin 5AC protein in gastric polyps was 64.38% (103/160), which was significantly higher than that in gastric cancer (41.11%, P<0.05), but lower than that in normal gastric tissues (87%, P<0.05). The positive expression rate of Mucin 5AC protein in proliferative polyps was 71.43%, which was significantly higher than that in adenomatous polyps (53.23%, P<0.05); There were no significant difference in terms of the positive expression rate of Mucin 5AC protein in different age, gender, size and location of gastric polyps (P>0.05). 【Conclusion】 Mucin 5AC protein may be down-regulated during malignant transformation of gastric polyps, which deserves further study. 2020 Vol. 37 (9): 1306-1308 [Abstract] ( 46 ) HTML (0 KB)  PDF  (0 KB)  ( 8 ) 1309 Effect of Dexmedetomidine Combined with Dizocine on Analgesia of Laparoscopic Cholecystectomy WEN Bang-jiang, JIANG Tai-gong, YANG Yu DOI: 10.3969/j.issn.1671-7171.2020.09.010 【Objective】 To investigate the analgesic effect of dexmedetomidine (Dex) combined with dextrozine in laparoscopic cholecystectomy(LC). 【Methods】 A total of 90 patients undergoing LC in our hospital from June 30, 2017 to June 30, 2019 were randomly divided into the Dex group, the combination group (Dex combined with dextrozine) and the control group, with 30 cases in each group. The operation time, propofol dosage, recovery time and postoperative adverse reactions were recorded in the three groups. The heart rate (HR) and mean arterial pressure (MAP) at different times during operations (before surgery, after pneumoperitoneum, the moment of gallbladder excision, and the moment of laryngeal mask removal) were measured and recorded. The postoperative pain (VAS score) and sedation (Ramsay score) were compared among the 3 groups. Blood glucose, cortisol, and blood norepinephrine (NE) levels were compared as well before and after surgery. 【Results】 The dosage of propofol and sufentanil in the combination group was lower than that in the Dex group and the control group (P<0.05), but there were no significant differences in the operation time and recovery time among the three groups (P>0.05). There was no statistically significant difference in the incidence of adverse reactions between the three groups (P>0.05). The VAS scores at 1, 6, 12, and 24 h after operation were lower in the combination group than in the control group and the Dex group (P<0.05). The Ramsay scores at 1, 6 h after operation of the combination group were higher than those of the control group and the Dex group (P<0.05). There were no significant differences in HR and MAP among the three groups before operation, after pneumoperitoneum, and at the moment of the gallbladder excision (P>0.05). When the laryngeal mask was pulled, the HR and MAP in the combined group were lower than those in the control group and the Dex group (P<0.05). At the end of the operation, the blood glucose, cortisol and NE in the combined group were lower than those in the control group and the Dex group (P<0.05). 【Conclusion】 Dexmedetomidine combined with dextrozine has significant analgesic and sedative effects during laparoscopic cholecystectomy, which can also reduce the stress response. It is pretty safe for LC. 2020 Vol. 37 (9): 1309-1311 [Abstract] ( 47 ) HTML (1 KB)  PDF  (0 KB)  ( 9 ) 1312 Comparison of the Clinical Efficacy of PLIF with PACS in the treatment of OVCF with LSS KE Chang-wu DOI: 10.3969/j.issn.1671-7171.2020.09.011 【Objective】 To investigate the efficacy and safety of posterior lumbar interbody fusion (PLIF) and posterior-anterior combined surgery (PACS) in the treatment of osteoporotic vertebral compression fracture (OVCF) with lumbar spinal stenosis (LSS).【Methods】 The clinical data of 37 elderly patients with OVCF complicated with LSS who were treated in our hospital from January 2013 to January 2018 were retrospectively analyzed. Among them, 14 cases were treated with PLIF (PLIF group), and 23 cases were treated with PACS (PACS group). The operation time, blood loss, postoperative hospital stay, postoperative complications and other clinical data were compared between the two groups. The American Spinal Injury Association Injury Scale (AIS) rating, lumbar lordosis angle (LLA) and bone fusion results of the two groups were observed before and after operation.【Results】 The AIS grading of the PLIF group and the PACS group was significantly improved compared with that before operation (P<0.05), but there was no significant difference in AIS grading between the two groups before and after operation (P>0.05). The ADLs scores of the PLIF group and the PACS group were significantly improved compared with those before operation (P<0.05). There was no significant difference in ADLs between the two groups before and after operation (P>0.05). The operation time, intraoperative blood loss and postoperative hospital stay in the PLIF group were significantly less than those in the PACS group (P<0.05).There was no significant difference between the PLIF group and the PACS group in LLA, LLA correction degree, correction loss and spinal fusion rate before, after and at the last follow-up (P>0.05). There was no significant difference in the incidence of pulmonary infection, dural tear, knife edge infection, pedicle screw loosening, adjacent vertebral fracture and reoperation between the PLIF group and the PACS group (P>0.05).【Conclusion】 For the elderly patients of OVCF combined with LSS, PLIF can fully decompress the spinal canal through a single posterior approach, and achieve posterior fixation through pedicle screw and hook screw system. Its surgical trauma is lower than that of PACS, and the clinical effect is satisfactory, which is worthy of clinical application. 2020 Vol. 37 (9): 1312-1315 [Abstract] ( 44 ) HTML (0 KB)  PDF  (0 KB)  ( 11 ) 1316 Study on Characteristics of EGFR Gene Mutation in Patients with Different Pathological Types of Lung Adenocarcinoma ZHOU Rui-qing, YANG Rui-qing, LIU Bin, et al DOI: 10.3969/j.issn.1671-7171.2020.09.012 【Objective】 To investigate the characteristics of epidermal growth factor receptor (EGFR) gene mutation in patients with different pathological types of lung adenocarcinoma. 【Methods】 A total of 286 patients with lung adenocarcinoma were retrospectively analyzed. Basic information of patients (gender, age, nationality, smoking history, drinking history, family history, blood type, tumor location, clinical stage, degree of differentiation, lymph node metastasis) were counted and compared. The mutants of EGFR gene were detected to show the characteristics of EGFR gene mutation in patients with different pathological types.【Results】 Test results showed that among 286 cases of lung adenocarcinoma, 152 patients had EGFR gene mutation mainly with E19 and E21 mutations, accounting for 40.79% and 39.47%, respectively. The proportion of EGFR gene-positive women, Han nationality, no smoking history, clinical stage Ⅲ or Ⅳ, and well-differentiated patients was significantly higher than that of men, ethnic minorities, smoking history, clinical stage Ⅰ or Ⅱ, and poorly differentiated patients (P<0.05) .There were significant differences in EGFR gene positivity among patients with different pathological types in the new classification (P<0.05).In semi-quantitative comprehensive classification, the positive pathological types of EGFR gene were not mainly adherent and acinar-based, instead nipple and variant-containing types were significantly more than EGFR negative patients (P<0.05).There was no significant difference in the proportion of positive and negative EGFR in WHO pathological types (P>0.05). 【Conclusion】 The mutation of EGFR gene in lung adenocarcinoma is more common in women, Han nationality, non-smoking history, clinical stage Ⅲ or Ⅳ, highly differentiated patients, and there are differences in the incidence of EGFR gene mutations in patients with different pathological types in the new classification criteria of lung adenocarcinoma. 2020 Vol. 37 (9): 1316-1318 [Abstract] ( 90 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 1319 Comparison of the Efficacy of Transvaginal and Hysteroscopic CSP Lesion Resection in the Treatment of Incomplete Abortion of Uterine Scar Pregnancy after Cesarean Section HUANG Wei, MAN Na DOI: 10.3969/j.issn.1671-7171.2020.09.013 【Objective】 To compare the efficacy of transvaginal and hysteroscopic resection of uterine scar pregnancy (CSP) for incomplete abortion after cesarean section.【Methods】 The clinical data of 80 patients with CSP incomplete abortion after cesarean section in our hospital from January 2014 to January 2019 were retrospectively analyzed. All patients received uterine artery embolization before operation, including 36 cases of transvaginal CSP lesion resection and repair (observation group), 44 cases of hysteroscopic CSP lesion resection (control group). The conversion rate, complications, intraoperative and postoperative indexes were compared between the two groups. 【Results】 No serious complications such as bladder injury, TURP syndrome and hysterectomy occurred in both groups. The conversion rate of the control group (22.7%) was higher than that of the observation group (5.6%), and the difference was statistically significant (P<0.05); there was no significant difference in the rate of intrauterine infection and abdominal pain between the two groups (P>0.05); the average intraoperative blood loss in the observation group (105 mL) was lower than that in the control group (325 ml), and the difference was statistically significant (P<0.05). The success rate of the first operation in the observation group was higher than that in the control group, the difference was statistically significant (P<0.05); the amount of postoperative vaginal bleeding was lower than that of the control group, and the duration of postoperative vaginal bleeding was shorter than that of the control group, the difference was statistically significant (P<0.05). The average decrease rate of HCG level in the observation group was higher than that in the control group (P<0.05). There was no significant difference in operation time and hospitalization time between the two groups (P<0.05). 【Conclusion】 Compared with hysteroscopy, transvaginal resection of CSP focus has the advantages of less bleeding, higher success rate, faster postoperative recovery, and repair of uterine scar diverticulum, which is an ideal method for the treatment of incomplete abortion of CSP. 2020 Vol. 37 (9): 1319-1322 [Abstract] ( 43 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 1323 Efficacy of Continuous Renal Replacement Therapy in Patients with Severe Acute Kidney Injury CHEN-Rui DOI: 10.3969/j.issn.1671-7171.2020.09.014 【Objective】 To investigate the efficacy of continuous renal replacement therapy (CRRT) in patients with severe acute kidney injury (AKI).【Methods】 A total of 92 patients with severe AKI underwent CRRT in our hospital between March 2016 and August 2017 were retrospectively reviewed. Patients were divided into the survival group (n=42 cases) and the death group (n=50 cases) according to the outcomes. The mortality was the main endpoint at 28 days after ICU admission. The The efficacy and related index changes were observed and compared. 【Results】 The hospital stay and ICU stay in the survival group were significantly longer than those in the death group (P<0.05). The unrecovered rate in the survival group was significantly lower than that in the death group (26.19% vs. 76.00%), while the partial recovery rate in the survival group was 57.62% (20/42),which was significantly higher than that in the control group (12.00%, 6/50). The difference was statistically significant (P<0.05). Before the start of CRRT, the MAP and urine volume of the survival group were significantly higher than those of the death group, while the MPV and RDW were significantly lower than those of the death group (P<0.05). After the CRRT, the MPV, PCT and Cys-C of the survival group were significantly lower than those of the death group, and PLT and urine volume were significantly higher than those of death group (P<0.05). Before and after CRRT treatment, the MPV and urine volume in the survival group were significantly higher than those in the death group, while its Cys-C was significantly lower than that in the death group (P<0.05). The multivariate regression analysis showed that preoperative MAP, MPV and postoperative Cys-C were independent factors influencing the prognosis of patients with severe AKI.【Conclusion】 High MAP level is beneficial to the prognosis of severe AKI patients during CRRT.The elevated MPV and Cys-C can be used as independent risk factors for severe AKI mortality. 2020 Vol. 37 (9): 1323-1325 [Abstract] ( 41 ) HTML (0 KB)  PDF  (0 KB)  ( 11 ) 1326 Effect of Craniotomy Hematoma Evacuation Combined with Extraventricular Drainage in the Treatment of Hypertensive Cerebral Hemorrhage into Ventricle GAO Yi-kai, YUAN Yue, YIN Chang-jiang DOI: 10.3969/j.issn.1671-7171.2020.09.015 【Objective】 To investigate the clinical effect of craniotomy hematoma removal combined with extraventricular drainage in the treatment of hypertensive intracerebral hemorrhage into ventricle . 【Methods】 A retrospective analysis was performed on 100 patients with hypertensive cerebral hemorrhage who underwent surgery in our hospital from January 2016 to May 2018. Among them, 50 patients in the observation group were treated with craniotomy hematoma evacuation and extraventricular drainage, while 50 patients in the control group were treated with simple craniotomy hematoma clearance only. Glasgow coma score (GCS) and intracranial pressure (ICP) were compared between the two groups at different time points before and after surgery. The serum N-terminal pro-brain natriuretic peptide (NT-proBNP) and high mobility group box 1 protein (HMGB-1) levels of the two groups were analyzed before and 2 weeks after surgery. Prognosis and surgical complications were evaluated by the modified Rankin scale questionnaire (MRS) at 6 months postoperatively. 【Results】 There were no significant differences in GCS scores and ICP measurements between the two groups before and 1 day after surgery (P>0.05). The GCS scores of the observation group at 3 days and 7 days after surgery were higher than those of the control group, while the ICP values of the observation group were lower than those of the control group (P<0.05). There was no significant difference between the two groups in the determination of NT-proBNP and HMGB1 before operation (P>0.05). At 2 weeks after surgery, the levels of NT-proBNP and HMGB1 in the observation group were lower than those in the control group (P<0.05). At 3 months after operation, the prognosis rate of the observation group was 58.00% (29/50), which was higher than that of group B (38.00%, 19/50). The difference was statistically significant (χ2=4.006, P=0.045<0.05). The complication rate in the observation group was 14.00% (7/50) , which was lower than 22.00% (11/50) in the control group, however, the difference was not statistically significant (χ2=4.006,P=0.298>0.05). 【Conclusion】 In patients with hypertensive cerebral hemorrhage breaking into the ventricle, the effect of treatment with craniotomy hematoma evacuation combined with extraventricular drainage is superior to the treatment with extraventricular drainage alone. It is beneficial to the recovery of blood-brain barrier and the prognosis of patients. 2020 Vol. 37 (9): 1326-1329 [Abstract] ( 46 ) HTML (0 KB)  PDF  (0 KB)  ( 9 ) 1330 Analysis of the Proportion and Apoptosis of Peripheral Blood CD8+ T Lymphocytes in Patients with Primary Liver Cancer YU Kuai, LI Qiu DOI: 10.3969/j.issn.1671-7171.2020.09.016 【Objective】 To explore the mechanism of CD8+ T lymphocyte apoptosis in peripheral blood of patients with primary liver cancer. 【Methods】 Sixty four patients with primary liver cancer who were treated in our hospital from July 2016 to July 2018 were selected as the observation group, and 62 healthy volunteers who received physical examination in our hospital during the same period were selected as the control group. The proportion of peripheral blood CD8+ T lymphocyte and the apoptosis ratio of peripheral blood CD8+ T lymphocyte were compared.【Results】 The proportion of peripheral blood CD8+ T lymphocytes in the observation group was lower than that in the control group, and the apoptosis rate of peripheral blood CD8+ T lymphocytes in the observation group was significantly higher than that in the control group (P<0.05). The proportion of CD8+ T lymphocytes in peripheral blood of TNM stageⅠ-Ⅱ group was significantly higher than that of stageⅢ-Ⅳ group, and the apoptosis rate of peripheral blood CD8+ T lymphocyte was significantly lower than that of stage Ⅲ-Ⅳ (P<0.05). The proportion of peripheral blood CD8+ T lymphocytes in the observation group was lower than that in the control group, and the apoptosis rate of peripheral blood CD8+T cells in the observation group was higher than that in the control group (P<0.05).【Conclusion】 The proportion of CD8+ T lymphocytes in peripheral blood of patients with primary liver cancer is lower than that of healthy people, and the apoptosis of CD8+ T lymphocytes in patients with TNM stage Ⅲ-Ⅳ is more serious. 2020 Vol. 37 (9): 1330-1332 [Abstract] ( 43 ) HTML (0 KB)  PDF  (0 KB)  ( 9 ) 1333 Effect of Old Lacunar Infarction on Prognosis of Patients with Primary Cerebral Infarction CAI Rui-yu, WAHG Hai-ping, BAI Bei-bei DOI: 10.3969/j.issn.1671-7171.2020.09.017 【Objective】 To investigate the effect of old lacunar infarction (LI) on the prognosis of patients with primary cerebral infarction. 【Methods】 The clinical data of 145 patients with primary cerebral infarction with old LI history were retrospectively analyzed. According to the number of old Li, the patients were divided into group A (lesions≤4) and group B (lesions > 4). The grade of cerebral microbleeds, white matter lesions and intracranial artery calcification were compared between the two groups. The factors influencing the prognosis were analyzed by regression analysis.【Results】 Compared with the group A, the proportion of grade 3 cerebral microbleeds in the group B was significantly increased (P<0.05), the proportion of grade 2 and 3 white matter lesions was significantly increased (P<0.05), and the proportion of intracranial artery calcification score above 3 points was significantly increased (P<0.05). Spearman analysis showed that the number of old LI lesions was positively correlated with the grade of cerebral microbleeds, the degree of white matter lesions and the score of intracranial artery calcification (Rs=0.735,0.774,0.695,P<0.05). Multivariate COX regression analysis showed that the number of old LI lesions, grade of cerebral microbleeds, grade of white matter lesions, intracranial artery calcification score, no use of antiplatelet drugs after discharge and no use of statins were independent risk factors for the prognosis of patients with primary cerebral infarction (P<0.05).【Conclusion】 The number of old LI lesions is closely related to cerebral microvascular lesions, white matter lesions and intracranial artery calcification score, and are independent risk factors for the prognosis of patients with initial cerebral infarction 2020 Vol. 37 (9): 1333-1335 [Abstract] ( 49 ) HTML (0 KB)  PDF  (0 KB)  ( 10 ) 1336 Changes and Clinical Significance of Serum IMA and H-FABP Levels in Patients with ACS NI Ting, LIU Min, WANG Ming-liang DOI: 10.3969/j.issn.1671-7171.2020.09.018 【Objective】 To investigate the changes and significance of ischemia-modified albumin (IMA) and cardiac fatty acid binding protein (H-FABP) in patients with acute coronary syndrome (ACS). 【Methods】 From January 2017 to November 2018, 120 patients with ACS (ACS group), 60 patients with stable angina pectoris (SAP group) and 60 healthy volunteers (control group) were selected as the research objects. The levels of serum IMA and H-FABP were detected in the three groups. According to grace risk stratification score, the ACS group was divided into low-risk group, medium risk group and high-risk group for hierarchical analysis. Receiver operating curve (ROC) was drawn to analyze the clinical value of IMA and H-FABP in the diagnosis of ACS patients.【Results】 The levels of serum IMA and H-FABP in the ACS group were significantly higher than those in the SAP group and the control group, while only H-FABP level in the SAP group was significantly higher than that in the control group (P<0.05). The levels of serum IMA and H-FABP in the high-risk group were significantly higher than those in the medium risk group and the low-risk group, while those in the medium risk group were significantly higher than those in the low-risk group (P<0.05). The sensitivity, specificity and AUC value of area under ROC curve of IMA and H-FABP were 55.91%, 72.09% and 0.668, respectively; the sensitivity, specificity and AUC value of area under ROC curve were 89.41%, 83.32% and 0.867 respectively; the sensitivity, specificity and AUC value of area under ROC curve of IMA combined with H-FABP were 96.84%, 86.59% and 0.937 respectively. 【Conclusion】 The levels of serum IMA and H-FABP in patients with ACS are significantly higher than those in healthy people, and have important clinical value in risk stratification and diagnosis of ACS. 2020 Vol. 37 (9): 1336-1339 [Abstract] ( 51 ) HTML (0 KB)  PDF  (0 KB)  ( 8 ) 1340 Effects of Olanzapine and Risperidone on Serum Levels of BDNF, NGF and IL-6 in Patients with Schizophrenia ZHU Miao, YIN An-min, ZHANG Dong-liang DOI: 10.3969/j.issn.1671-7171.2020.09.019 【Objective】 To compare the effect of olanzapine and risperidone on serum brain derived neurotrophic factor (BDNF), nerve growth factor (NGF), interleukin-6 (IL-6) levels and clinical application effect in patients with schizophrenia. 【Methods】 Seventy-two patients with schizophrenics admitted to our hospital from March 2016 to September 2018 were enrolled for the study and randomly divided into risperidone group (n=36) and olanzapine group (n=36), and they were treated with risperidone and olanzapine respectively for 6 months. The serum levels of BDNF, NGF, IL-6, the score of positive and negative symptom scale (PANSS) and the incidence of adverse reactions were compared before and after intervention between two groups. 【Results】 There were no significant differences in baseline data, total score of PANSS, serum levels of BDNF, NGF and IL-6 between two groups (P>0.05). For intra-comparison, the PANSS total score and serum level of IL-6 at 1, 3, 6 months after intervention in two groups were significantly lower than that before intervention, and serum levels of BDNF and NGF at 1, 3, 6 months after intervention were significantly higher than that before intervention (P<0.05). For inter-comparison, the PANSS total score and serum level of NGF at 6 months after intervention in olanzapine group were significantly higher than that in the risperidone group at the same time, the serum level of BDNF at 3 and 6 months after intervention in the olanzapine group was significantly higher than that of the risperidone group at the same time, and the serum level of IL-6 at 6 months after intervention in the olanzapine group was significantly lower than that in the risperidone group at the same time (P<0.05). The incidence of extrapyramidal system in the olanzapine group was significantly lower than that in the risperidone group (P<0.05), and there were no significant differences in other adverse reactions including headache, dizziness, abnormal sleep, increased body mass and dry mouth between two groups (P>0.05). 【Conclusion】 Olanzapine can significantly reduce the serum levels of BDNF, NGF and L-6 in schizophrenic patients. Olanzapine can better alleviate the symptoms of schizophrenia. The long-term effect of olanzapine is better than risperidone, and the safety is higher. 2020 Vol. 37 (9): 1340-1342 [Abstract] ( 39 ) HTML (0 KB)  PDF  (0 KB)  ( 10 ) 1343 Expression and Significance of Cdc42 in the Hippocampus Rat Tissue Caused by Sevoflurane Neurotoxicity HAN Tao, CHEN Qin DOI: 10.3969/j.issn.1671-7171.2020.09.020 【Objective】 The aim of this study is to explore the expression and significance of Cdc42 (cell division cyclin42) in the hippocampus tissue of rats with neurotoxicity of sevoflurane. 【Methods】 Forty-two Sprague Dawley (SD) rats of 7 days old were randomly divided into three groups (n=14): group A, group B and group C. Rats in group A were exposed to 2% sevoflurane and 80% oxygen inhalation once for 2 hours. Rats in group B were exposed to 2% sevoflurane and 80% oxygen inhalation 2 hours/day for three consecutive days. Rats in group C received only 80% oxygen inhalation for 2 hours. Rats were sacrificed at 3 hours after experimental models completed and the hippocampus tissues were collected to measure the expression of Cdc42 and cleaved caspase3 (cysteine proteolytic enzyme 3, CI-Csp3) by western blot. Spatial learning and memory ability of adult rats were detected by Morris water maze (MWM) test at 45-49 days after birth. 【Results】 Compared to the group C, the expression of Cdc42 and Cl-Csp3 in the hippocampus of the group A had no significant difference (P>0.05), whereas the expression of Cdc42 and Cl-Csp3 in the hippocampus of group B increased significantly (P<0.05). In place navigation test, there was no significant difference of the escape latency between group C and group A (P>0.05). The escape latency of rats in the group B were significantly longer than that of C group (P<0.05). In probe trial test, the percent time in target quadrant in group A was not different from that of group C (P>0.05), While the percent time in target quadrant in group B decreased (P<0.05). 【Conclusion】 Multiple inhalation of sevoflurane can induce neurotoxicity and memory dysfunction, which may be related to the increase in the expression of Cdc42. 2020 Vol. 37 (9): 1343-1346 [Abstract] ( 45 ) HTML (0 KB)  PDF  (0 KB)  ( 11 ) 1347 Relationship between Peripheral Blood MicroRNA29, Chemokines and Cardiac Function and Left Ventricular Remodeling in Patients with CHF YUAN Zi-hua, WU Xiu-zhen DOI: 10.3969/j.issn.1671-7171.2020.09.021 【Objective】 To investigate the relationship between the levels of microRNA29 (miR-29a) and chemokines in peripheral blood of patients with chronic heart failure (CHF) and their cardiac function and cardiac remodeling. 【Methods】 Clinical data of 120 patients with CHF (observation group) treated in our hospital from March 2017 to March 2018 were selected, and 60 healthy volunteers (control group) who underwent physical examination in our hospital at the same time were selected. The levels of miR-29a and chemokines in peripheral blood were compared between the two groups. Left ventricular ejection fraction (LVEF), cardiac output (CO), left ventricular end diastolic diameter (LVEDD), left ventricular posterior wall thickness (LVPW), left ventricular mass index (LVMI), and left ventricular remodeling index (LVRI) were detected in the CHF group. The correlation between miR-29a, chemokines and cardiac function indexes was analyzed. 【Results】 The levels of serum miR-29a and chemokine in the observation group were higher than those in the control group (P<0.05). The levels of serum miR-29a and chemokine in patients with CHF of grade Ⅱ, grade Ⅲ and grade Ⅳ were gradually increased, and the differences between the two groups were statistically significant (P<0.05). LVEDD, LVPW and LVMI of patients with CHF of grade Ⅱ,Ⅲ and IV showed a trend of gradual increase, and the differences between groups were statistically significant (P<0.05); LVEF, CO and LVRI of patients with CHF of grade Ⅱ, Ⅲ and IV showed a trend of gradual decrease, and the differences between groups were statistically significant (P<0.05). The levels of serum miR-29a and chemokines were negatively correlated with LVEF and LVRI (P<0.05).【Conclusion】 The expression of miR-29a and chemokines in CHF patients are significantly increased. At the same time, the expression of miR-29a and chemokines are closely related to cardiac function and cardiac remodeling in CHF patients. 2020 Vol. 37 (9): 1347-1349 [Abstract] ( 45 ) HTML (0 KB)  PDF  (0 KB)  ( 11 ) 1350 Effects of Phoroglucinol Combined with Oxytocin on Labor process, NRS Score, and Maternal and Infant Outcomes in Full-term Parturients WANG Ya-nan, SHI Jun, SONG Feng-li DOI: 10.3969/j.issn.1671-7171.2020.09.022 【Objective】 To explore the effects of phloroglucinol combined with oxytocin on the labor process, numerical rating scale (NRS) score, and maternal and infant outcomes in full-term parturients. 【Methods】 A total of 128 full-term parturients in our hospital from September 2017 to February 2019 were selected and divided into the observation group and the control group by single and double numbering according to the order of admission. The control group was given oxytocin, while the observation group was given phloroglucinol on the basis of the control group. Labor process, NRS score, and maternal and infant outcomes of the two groups were compared. 【Results】 The first stage of labor, the second stage of labor and the total stage of labor in the observation group were significantly shorter than those in the control group (P<0.05), while there was no significant difference in the third stage of labor between the two groups (P>0.05). The NRS score and the delivery time of placenta in the observation group were significantly lower and shorter than those in the control group (P<0.05), and the Bishop score of cervix was significantly higher than that in the control group (P<0.05). There was no significant difference in the amount of bleeding in 24 hours between the two groups (P>0.05). The rate of vaginal delivery in the observation group was 76.56%, which was higher than 54.69% in the control group; and the rate of cervical edema was 4.69%, which was lower than 15.63% in the control group (P<0.05). There was no significant difference in the incidence of intrauterine distress, neonatal asphyxia, Apgar score and maternal adverse reactions between the two groups (P>0.05). 【Conclusion】 Phloroglucinol combined with oxytocin can effectively shorten the labor process of full-term parturients, relieve pain during delivery, improve the rate of vaginal delivery, reduce complications and promote placental delivery. 2020 Vol. 37 (9): 1350-1352 [Abstract] ( 39 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 1353 Effect of Preoperative Paravertebral Block Combined with Intravenous Analgesia on Perioperative Analgesia in Patients Undergoing Thoracoscopic Lobectomy WANG Zhao-jun, SHANG You DOI: 10.3969/j.issn.1671-7171.2020.09.023 【Objective】 To investigate the effect of preoperative paravertebral block (TPVB) combined with intravenous analgesia on perioperative analgesia in patients undergoing thoracoscopic lobectomy.【Methods】 From September 2019 to April 2020, 99 patients with elective thoracoscopic lobectomy in our hospital were selected and randomly divided into group A (n=33), group B (n=33) and group C (n=33). The group A was given patient-controlled intravenous analgesia; group B was given single and double-point TPVB before induction; group C was placed with ultrasound-guided paravertebral catheter before induction, and continuous TPVB was used for postoperative analgesia. The VAS and sedation scores at 1 h (T0), 4 h (T1), 24 h (T2) and 48 h (T3) of the three groups were recorded; the dosage of propofol, sevoflurane and sufentanil during the operation was recorded; the times of pressing, the times of pain relief, recovery time, extubation time and adverse reactions were recorded. 【Results】 The VAS score of the group B and the group C was lower than that of the group A at T0, T1, T2 and T3, and that of the group C was lower than that of the group B (all P<0.05). The sedation score of the group B and the group C was higher than that of the group A (P<0.05); there was no significant difference between the group B and the group C (P>0.05). The times of pressing and the times of pain relief in the group B and the group C were lower than those in the group A (P<0.05); there was no significant difference between the group B and the group C (P>0.05). The intraoperative dosage of propofol, sevoflurane and sufentanil in the group B and C was lower than that in the group A (P<0.05), and the recovery time and extubation time in the group B and C were shorter than those in the group A (P<0.05), but there was no significant difference between groups B and C (P>0.05). The incidence of adverse reactions was 30.30% (10 / 33) in the group A, 21.21% (7 / 33) in the group B and 15.15% (5 / 33) in the group C. There was no significant difference among the three groups (P>0.05).【Conclusion】 The effect of continuous TPVB combined with intravenous analgesia by paravertebral catheterization and ultrasound-guided single and double point TPVB in patients undergoing thoracoscopic lobectomy is superior to patient-controlled intravenous analgesia in reducing the dosage of propofol, sevoflurane and sufentanil, but the effect of TPVB combined with intravenous analgesia is better than that of single and double point TPVB, and TPVB combined with intravenous analgesia does not increase the incidence of postoperative adverse reactions. 2020 Vol. 37 (9): 1353-1356 [Abstract] ( 43 ) HTML (0 KB)  PDF  (0 KB)  ( 11 ) 1357 Effect of Cartoon Gaming-Health Education on Auditory Function and Quality of Life in Children with Cochlear Implantation WU Li-ping, LI Gang, LIU Dong, et al DOI: 10.3969/j.issn.1671-7171.2020.09.024 【Objective】 To investigate the effect of cartoon gaming-health education on auditory function and quality of life in children with cochlear implant. 【Methods】 A total of 142 children with cochlear implantation in our hospital from January 2016 to June 2017 was selected as the research objects, and they were divided into observation group and control group according to different health education methods, with 71 cases in each group. The control group was given routine health education including cognitive education, psychological intervention, behavior guidance and follow-up, while the observation group was given cartoon game health education. After 6 months of follow-up, the compliance, hearing function and quality of life of the two groups were compared.【Results】 The compliance rate of treatment and nursing in the observation group was 90.14% (64 / 71), which was significantly higher than 74.65% (53 / 71) of the control group (χ2=6.282,P=0.008<0.05). After 6 months of follow-up, the confidence score, alertness score and significance score of the two groups were significantly higher than those before treatment, and the observation group was better than the control group, the difference was statistically significant (P<0.05). The scores of physiological function, psychological function and social function of the two groups were significantly higher than before treatment, and the observation group was higher than the control group, the differences were statistically significant (P<0.05).【Conclusion】 Cartoon game health education can improve the compliance of the patients receiving treatment and nursing, improve the hearing function and improve the quality of life. 2020 Vol. 37 (9): 1357-1359 [Abstract] ( 47 ) HTML (0 KB)  PDF  (0 KB)  ( 11 ) 1360 Imaging Features of Diabetic Pulmonary Tuberculosis and Nontuberculous Pneumonia ZENG Ming, ZHENG Xin-jie, LEI Yi-fan DOI: 10.3969/j.issn.1671-7171.2020.09.025 【Objective】 To investigate the imaging features of diabetic pulmonary tuberculosis and non tuberculous pneumonia. 【Methods】 The clinical data of 50 cases of diabetic pulmonary tuberculosis and 50 cases of nontuberculous pneumonia were analyzed retrospectively. The imaging features of the two groups were compared.【Results】 The lesions of non tuberculous pneumonia patients mainly distributed in the right upper lobe, right lower lobe and right middle lobe; the lesions of diabetic pulmonary tuberculosis patients mainly distributed in the right upper lobe, left upper lobe and right lower lobe. The main CT signs of non tuberculous pneumonia patients were bronchiectasis, bronchitis and cavity; the main CT signs of diabetic pulmonary tuberculosis patients were bronchiectasis and cavity. In the diabetic pulmonary tuberculosis group, the cavity position was mostly in the internal zone, while in the non tuberculous pneumonia group, the cavity position was mostly in the outer zone; the CT signs of bronchiectasis in the diabetic pulmonary tuberculosis group were mostly columnar, cystic and mixed type, while the CT signs of bronchiectasis in the non tuberculous pneumonia group were mostly columnar.【Conclusion】 There are differences in the location of lesion distribution, cavity location and bronchiectasis morphology between patients with diabetic pulmonary tuberculosis and non tuberculous pneumonia, which can be used as the basis for differential diagnosis. 2020 Vol. 37 (9): 1360-1362 [Abstract] ( 46 ) HTML (1 KB)  PDF  (0 KB)  ( 9 ) 1363 Expression and Clinical Significance of mir-125 in Cervical Cancer TAN Xiao-lang, CHEN Wen, WANG DI DOI: 10.3969/j.issn.1671-7171.2020.09.026 【Objective】 To study the expression of miR-125 and its clinical significance in cervical cancer tissues. 【Methods】 The expression of mir-125 was detected by RT-PCR in 110 cases of cervical cancer and its corresponding normal tissues. The correlation between the expression of mir-125 and the pathological characteristics and prognosis of patients with cervical cancer was analyzed. The expression of TRAF6 protein in cancer tissues and adjacent tissues was detected by immunohistochemistry.【Results】 The expression of mir-125 in cervical cancer was significantly lower than that in adjacent normal tissues (P<0.05); the expression level of mir-125 was correlated with tumor differentiation, clinical stage and lymph node metastasis (P<0.05); the median survival time of high expression of mir-125 was higher than that of low expression patients(P<0.05). 【Conclusion】 The low expression of mir-125 in cervical cancer is related to the degree of differentiation, clinical stage, lymph node metastasis, parauterine invasion and prognosis of cervical cancer, suggesting that mir-125 can be used as a new target for clinical diagnosis and treatment of cervical cancer and an indicator for prognosis evaluation. 2020 Vol. 37 (9): 1363-1365 [Abstract] ( 38 ) HTML (0 KB)  PDF  (0 KB)  ( 15 ) 1366 Effect and Mechanism of Ciprofloxacin (CIP) on Apoptosis of Lung Cancer Cells Induced by TRAIL WANG Bing-chi, WANG Yong-sheng, Gao Pei-hui DOI: 10.3969/j.issn.1671-7171.2020.09.027 【Objective】 To investigate the effect and mechanism of ciprofloxacin (CIP) on apoptosis of lung cancer cells induced by (tumor necrosis factor-associated apoptosis inducing ligand,TRAIL).【Methods】 Human adenocarcinoma A549 cells were divided into blank control group (untreated), CIP group (CIP 100μg/mL in medium), trail group (trail 50 ng/mL in medium) and combination group (CIP 100 μg/mL and trail 50 ng/mL in medium);Trypan blue staining was used to calculate cell viability;The expression of death receptor 4 (DR4), death receptor 5 (DR5) and CCAAT / enhancer binding protein homologous protein (CHOP) were detected by Western blot.【Results】 There was no significant difference between the blank control group and the CIP group in A549 cell viability (P>0.05). The cell viability of the TRAIL group and the CIP group was lower than that of blank the control group and the CIP group (P<0.05), and the A549 cell viability of the combined group was significantly lower than that of the trail group (P<0.05). At 24 h and 48 h, the relative expression levels of CHOP, DR4 and DR5 in the TRAIL group were significantly higher than those in the blank control group and the CIP group (P<0.05), and the relative expression levels of CHOP, DR4 and DR5 in the combined group were significantly higher than those in the TRAIL group (P<0.05). 【Conclusion】 TRAIL combined with CIP can up regulate the expression of DR4 and DR5 in A549 cells, reduce the viability of A549 cells, and increase the apoptosis level of A549 cells; CHOP may play an important role in CIP induced DR5 up regulation and lung adenocarcinoma A549 cell apoptosis, which is worthy of further clinical research 2020 Vol. 37 (9): 1366-1368 [Abstract] ( 44 ) HTML (0 KB)  PDF  (0 KB)  ( 9 ) 1369 Study on the Influencing Factors of Anemia in 387 Premature Infants ZHANG Li, SHEN Jian-jia, WANG Xiao-li DOI: 10.3969/j.issn.1671-7171.2020.09.028 【Objective】 To investigate the major risk factors in the development of anemia among premature infants (gestational age <37 weeks) in hospital. 【Methods】 The medical data of 571 premature infants admitted to our department of neonatology from Janurary 2016 to December 2017 were retrospectively reviewed. There were 387 premature infants included in the study after excluding 36 cases of congenital anemia and 148 cases of short hospitalization with only one blood collection. According to complication with anemia or not,all 387 infants were divided into two groups: anemia group and non-anemia group.At the same time, data on birth weight, gestational age at birth, comorbidities, basal hemoglobin (HB) level, blood volume collected during hospitalization, and maternal hemoglobin value at the end of pregnancy were collected to analyze the related high-risk factors associated with anemia of prematurity during hospitalization. 【Results】 There were statistically significant differences between the two groups of infants with gestational age, birth weight, length of hospitalization, gestational age, and the proportion of newborns' weight <2000 g (P<0.05). The blood sampling volume and the incidence of anemia in preterm infants less than 32 weeks gestational age were significantly higher than those of 33 weeks gestational age preterm infants and 36 weeks gestational age premature infants, the difference was statistically significant (P<0.05). The incidence of NRDS, Apnea, CPAP, FI in the anemia group were higher than those in the non-anemia group, and the difference was statistically significant(P<0.05).Multiple factor Logistic regression analysis revealed that anemia of prematurity was associated with blood loss from laboratory testing and the basal hemoglobin level. The lower basal HB level and the greater blood sampling volume were risk factors for anemia in preterm infants (P<0.05).【Conclusion】 Anemia of prematurity is associated with the gestation, birth weight,the basal hemoglobin level and the blood loss due to laboratory testing. We should pay attention to the basal hemoglobin level, and decrease the blood loss from laboratory blood collection. 2020 Vol. 37 (9): 1369-1371 [Abstract] ( 49 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 1372 Effect of Follow-up Management Based on Smart System of Disease Management (SSDM) on Self-management Ability and Quality of Life in Patients with Rheumatoid Arthritis (RA) GONG Zuo-ping, LI Jie, KANG Jing, et al DOI: 10.3969/j.issn.1671-7171.2020.09.029 【Objective】 To explore the effect of follow-up management based on Smart System of Disease Management (SSDM) on self-management ability and quality of life in patients with rheumatoid arthritis (RA). 【Methods】 A total of 112 RA patients discharged from hospital from July 2016 to June 2017 were selected,and divided into treatment group and control group with 56 cases by random number table. The control group was given routine follow-up management, and the treatment group was applied for follow-up management based on Smart System of Disease Management (SSDM) . Followed up for 6 months, the self-management ability, clinical efficacy indicators, and quality of life were compared between the two groups. 【Results】 After the intervention, for the treatment group, the scores of good habits in the treatment group were (8.12±1.02) points, the self-disposal drug behavior score was (8.25±1.14) points, the self-monitoring symptom behavior score was (6.35±0.82) points, the self-psychological adjustment behavior score was (7.68±1.21) points, the self-recovery training score was (7.52±1.21) points, and the ability to deal with new problems in a timely manner score was (7.26±1.06) points. The self-management ability scores of the treatment group were significantly higher than those before the intervention and the control groups (P<0.05). After intervention, the score of disease activity score in 28joints (DAS28) in the treatment group was (2.54±0.40) points, significantly lower than those before self intervention and the control group (P<0.05). After the intervention, the physical function score of the treatment group was (13.24±1.45) points, the psychological function score was (14.35±2.12) points, the social function score was (14.65±2.20) points, and the health self-recognition score was (13.45±1.52) points. The scores of quality of life in the treatment group were significantly lower than those before the intervention and the control group (P<0.05, P<0.01). 【Conclusion】 The follow-up management based on Smart System of Disease Management (SSDM) is helpful to promote the self-management ability of patients with rheumatoid arthritis, relieve their clinical symptoms and improve the quality of life. 2020 Vol. 37 (9): 1372-1375 [Abstract] ( 48 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 1376 Effect of Scenario Simulation Health Education on Disease Cognition and Self-management Ability of Patients with Chronic Obstructive Pulmonary Disease QI Dong-mei, XUE Yan-li, LI Li-feng DOI: 10.3969/j.issn.1671-7171.2020.09.030 【Objective】 To investigate the effect of scenario-simulated health education on disease cognition and self-management ability of patients with chronic obstructive pulmonary disease (COPD) in China. 【Methods】 A total of 94 COPD patients from January to December 2019 was selected and divided into observation group (July to December 2019) and control group (January to June 2019) according to the length of stay, 47 cases in each group. The control group was given routine health education, and the observation group was given scenario simulation health education. After 12 weeks of follow-up, the cognitive level of disease, self-management ability and lung function were compared between the two groups.【Results】 After 12 weeks of follow-up, the disease cognitive level scores of the two groups were higher than those before the intervention, and the observation group was significantly higher than the control group, the differences were statistically significant (P<0.05). In addition to emotional management, the scores of all dimensions of self-management ability in the two groups were higher than those before the intervention, and the scores of symptom management, daily life management, information management and self-efficacy in the observation group were higher than those in the control group (P<0.05). The ratio of FEV1 to FVC in the observation group was significantly higher than that in the control group (P<0.05).【Conclusion】 Scenario simulation health education can improve the cognitive level of COPD patients and enhance their self-management ability, which is of great significance to improve lung function. 2020 Vol. 37 (9): 1376-1378 [Abstract] ( 59 ) HTML (1 KB)  PDF  (0 KB)  ( 11 )

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