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| Relationship of Clinical Stage in Patients with Type 2 Diabetic Nephropathy with Osteoporosis and Growth Factors |
| HAN Dong-mei, MAO Wei-wei, GONG Wei-wei, et al |
| Shanghai First Rehabilitation Hospital, Shanghai, 200090 |
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Abstract 【Objective】 To investigate the relationship of clinical stage with osteoporosis and growth factors in patients with type 2 diabetic nephropathy (DN). 【Methods】 A total of 200 patients with type 2 diabetic nephropathy, who received treatment in our hospital, were selected as the observation group. According to the value of albumin excretion rate (UAE), patients were divided into group A (normal albuminuria, UAE<20 μg/min) , group B (microalbuminuria, UAE 20-200 μg/min), group C (large amount of albuminuria, UAE>200 μg/min) and group D (end-stage renal failure, GFR <10 mL/min). In the same time period, 50 healthy volunteers were enrolled as the control group. The levels of osteoporosis and growth factor-related indicators were evaluated. 【Results】 The bone mineral density and mineral content of both cancellous and cortical bones in the observation group were lower than those in the control group (P<0.05). The T value of the cancellous bone and the cortical bone were higher than those of the control group (P<0.05). There were significant differences in bone mineral density and growth factor indicators among the subgroups of the observation group (P<0.05). The cancellous and cortical bone mineral density and mineral content in group D were lower than those in group A, B and C, while the T value of the cancellous bone and the cortical bone were higher than those in group A, B and C (P<0.05). The levels of FGF-23 and IL-6 in the observation group were higher than those in the control group, and IGF-Ⅱ, EGF and TGF-βlevels were lower than those in the control group (P<0.05). The levels of FGF-23 and IL-6 in group D were higher than those in group A, B and C, and IGF-Ⅱ, EGF and TGF-βwere lower than those in group A, B and C (P<0.05). The levels of FGF-23 and IL-6 in group C were higher than those in group A and B, and IGF-Ⅱ, EGF and TGF-βwere lower than those in group A and B (P<0.05). 【Conclusion】 The severity of DN in patients with type 2 diabetes is closely related to osteoporosis and growth factors. The occurrence of osteoporosis in DN patients may be related to growth factors.
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Received: 26 August 2019
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2020, Vol. 37 
