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| Relationship between Peripheral Blood MicroRNA29, Chemokines and Cardiac Function and Left Ventricular Remodeling in Patients with CHF |
| YUAN Zi-hua, WU Xiu-zhen |
| CITIC Huizhou Hospital,Huizhou 516006, China |
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Abstract 【Objective】 To investigate the relationship between the levels of microRNA29 (miR-29a) and chemokines in peripheral blood of patients with chronic heart failure (CHF) and their cardiac function and cardiac remodeling. 【Methods】 Clinical data of 120 patients with CHF (observation group) treated in our hospital from March 2017 to March 2018 were selected, and 60 healthy volunteers (control group) who underwent physical examination in our hospital at the same time were selected. The levels of miR-29a and chemokines in peripheral blood were compared between the two groups. Left ventricular ejection fraction (LVEF), cardiac output (CO), left ventricular end diastolic diameter (LVEDD), left ventricular posterior wall thickness (LVPW), left ventricular mass index (LVMI), and left ventricular remodeling index (LVRI) were detected in the CHF group. The correlation between miR-29a, chemokines and cardiac function indexes was analyzed. 【Results】 The levels of serum miR-29a and chemokine in the observation group were higher than those in the control group (P<0.05). The levels of serum miR-29a and chemokine in patients with CHF of grade Ⅱ, grade Ⅲ and grade Ⅳ were gradually increased, and the differences between the two groups were statistically significant (P<0.05). LVEDD, LVPW and LVMI of patients with CHF of grade Ⅱ,Ⅲ and IV showed a trend of gradual increase, and the differences between groups were statistically significant (P<0.05); LVEF, CO and LVRI of patients with CHF of grade Ⅱ, Ⅲ and IV showed a trend of gradual decrease, and the differences between groups were statistically significant (P<0.05). The levels of serum miR-29a and chemokines were negatively correlated with LVEF and LVRI (P<0.05).【Conclusion】 The expression of miR-29a and chemokines in CHF patients are significantly increased. At the same time, the expression of miR-29a and chemokines are closely related to cardiac function and cardiac remodeling in CHF patients.
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Received: 03 October 2018
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[1] 刘英华,高晓丽,张小坤,等.血清 NT-proBNP、Cys-C 水平评估对老年慢性心衰患者合并急性肾损伤的预后价值[J].医学临床研究,2020,37(1):86-88.
[2] 王宁. 微小RNA对心肌梗死中心肌细胞活性的影响及治疗前景[J].第二军医大学学报,2016,37(8):996-1001.
[3] 熊玮.趋化素通过上调磷酸化JNK促进小鼠血管平滑肌细胞的增殖[J].中国病理生理杂志,2015,31(12):2282-2286.
[4] 张楚婕,程蕾蕾. 循环微小RNA诊断心肌病变的研究进展[J].复旦学报(医学版),2017,44(1):110-116.
[5] Tahhan AS, Vaduganathan M, Greene SJ, et al. Enrollment of older patients, women, and racial and ethnic minorities in contemporary heart failure clinical trials[J].JAMA Cardiol,2018,35(8):103-106.
[6] 陈峰,王华,杨杰孚. 微小RNA在心力衰竭中的功能研究及其应用前景[J].中华心血管病杂志,2015,43(9):833-836.
[7] 陈君. 微小RNA对心力衰竭患者早期诊断价值的Meta分析[J].中华卫生应急电子杂志,2017,3(6):369-371.
[8] 黄平,王科科. 血清趋化素在不同程度心力衰竭患者中的水平变化[J].中国药物经济学,2015,10(7):128-129.
[9] 王蒙琴. 血清趋化素水平与慢性心力衰竭患者左室重构的相关性研究[J].中国现代医学杂志,2018,28(14):76-79.
[10] 梅艳,郗爱旗,廖宝霞,等. 低氧环境下慢性充血性心力衰竭患者脂肪因子水平变化对心室构型的影响[J].第三军医大学学报,2017,39(23):2299-2302. |
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2020, Vol. 37 
