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| Effect of Mucin 5AC Protein on the Occurrence and Development of Malignant Gastric Polyps |
| YU Zhi-tao, ZHANG Lei, LIN Song-rong, et al |
| Guangdong Second People's Hospital 510317 |
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Abstract 【Objective】 To investigate the expression of Mucin 5AC protein in gastric polyps and its clinical significance. 【Methods】 A total of 160 patients with gastric polyps treated in our hospital from January 2017 to January 2018 were selected, meanwhile 87 normal gastric mucosa tissues and 90 gastric cancer tissues were enrolled as controls.Mucin 5AC protein expression was detected by immunohistochemical staining. 【Results】 The positive expression rate of Mucin 5AC protein in gastric polyps was 64.38% (103/160), which was significantly higher than that in gastric cancer (41.11%, P<0.05), but lower than that in normal gastric tissues (87%, P<0.05). The positive expression rate of Mucin 5AC protein in proliferative polyps was 71.43%, which was significantly higher than that in adenomatous polyps (53.23%, P<0.05); There were no significant difference in terms of the positive expression rate of Mucin 5AC protein in different age, gender, size and location of gastric polyps (P>0.05). 【Conclusion】 Mucin 5AC protein may be down-regulated during malignant transformation of gastric polyps, which deserves further study.
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Received: 28 July 2019
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[1] 何金龙, 陈磊, 代剑华,等. 10137例胃息肉的临床及病理特征分析[J].第三军医大学学报, 2018, 40(3):248-254.
[2] 胃息肉合并幽门螺杆菌感染患者的临床特点[J].中国老年学杂志, 2018, 38(21):104-105.
[3] 绳荣湍, 平倩, 陈良荣,等. 336例胃息肉中医证型与病理类型分布规律相关性研究[J].辽宁中医杂志, 2018,11(3):554-556.
[4] Houssem H, Triki H, Ahmedi M. Gastroduodenojejunal Intussusception: A Very Rare Complication of a Pedunculated Gastric Harmatomatous Giant Polyp[J].Am J Gas,2017, 112(1):14.
[5] 施绍瑞, 张林琳, 刘英. 免疫试纸半定量法与放射免疫法检测尿微量白蛋白的比较研究[J].实用检验医师杂志, 2017, 9(3):150-152.
[6] Zhang H, Liu Y, Xie H, et al. High mucin 5AC expression predicts adverse postoperative recurrence and survival of patients with clear-cell renal cell carcinoma.[J].Oncotarget,2017, 8(35):59777-59790.
[7] Pabalan N, Sukcharoensin S, Butthongkomvong K, et al. Expression and Serum Levels of Mucin 5AC (MUC5AC) as a Biomarker for Cholangiocarcinoma: a Meta-analysis[J].J Gas Cancer,2017,11(1):1-8.
[8] 血清胃泌素、胃蛋白酶原及Mucin 5AC蛋白表达与胃息肉恶变关系的研究[D].川北医学院, 2016,11(1):88-93.
[9] Ermund A, Meiss L N, Rodriguez-Pineiro A M, et al. The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC mucin[J].Biochemical & Bio Res Communications,2017, 492(3):331-337.
[10] Xu Q, Chen L X, Ran D H, et al. Bombesin receptor-activated protein regulates neutrophil elastase-induced mucin 5AC hypersecretion in human bronchial epithelial cells.[J].Experimental Cell Res,2017, 357(2):145-149.
[11] Yang D, Jin M, Bai C, et al. Peroxiredoxin 6 Suppresses Muc5ac Overproduction in LPS-Induced Airway Inflammation Through H2O2-EGFR-MAPK Signaling Pathway.[J].Respiratory Physiology & Neurobiology,2017, 236(Complete):84-85.
[12] 血清胃泌素、胃蛋白酶原及Mucin 5AC蛋白表达与胃息肉恶变关系的研究[D].川北医学院, 2016,11(3):77-83. |
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2020, Vol. 37 
