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| Changes and Clinical Significance of Serum IMA and H-FABP Levels in Patients with ACS |
| NI Ting, LIU Min, WANG Ming-liang |
| Shanghai Putuo District People's Hospital, Shanghai 200060, China |
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Abstract 【Objective】 To investigate the changes and significance of ischemia-modified albumin (IMA) and cardiac fatty acid binding protein (H-FABP) in patients with acute coronary syndrome (ACS). 【Methods】 From January 2017 to November 2018, 120 patients with ACS (ACS group), 60 patients with stable angina pectoris (SAP group) and 60 healthy volunteers (control group) were selected as the research objects. The levels of serum IMA and H-FABP were detected in the three groups. According to grace risk stratification score, the ACS group was divided into low-risk group, medium risk group and high-risk group for hierarchical analysis. Receiver operating curve (ROC) was drawn to analyze the clinical value of IMA and H-FABP in the diagnosis of ACS patients.【Results】 The levels of serum IMA and H-FABP in the ACS group were significantly higher than those in the SAP group and the control group, while only H-FABP level in the SAP group was significantly higher than that in the control group (P<0.05). The levels of serum IMA and H-FABP in the high-risk group were significantly higher than those in the medium risk group and the low-risk group, while those in the medium risk group were significantly higher than those in the low-risk group (P<0.05). The sensitivity, specificity and AUC value of area under ROC curve of IMA and H-FABP were 55.91%, 72.09% and 0.668, respectively; the sensitivity, specificity and AUC value of area under ROC curve were 89.41%, 83.32% and 0.867 respectively; the sensitivity, specificity and AUC value of area under ROC curve of IMA combined with H-FABP were 96.84%, 86.59% and 0.937 respectively. 【Conclusion】 The levels of serum IMA and H-FABP in patients with ACS are significantly higher than those in healthy people, and have important clinical value in risk stratification and diagnosis of ACS.
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Received: 21 November 2018
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2020, Vol. 37 
