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Quick Search     Adv Search 2018 Vol. 35, No. 5 Published: 2018-05-31   833 Clinical Application Effect of Different Methods of ERCP in the Treatment of Elderly Patients with Common Bile Duct Stones XIA Yan, HUANG Ming-zhe, FAN Xiao,et al DOI: 10.3969/j.issn.1671-7171.2018.05.001 【Objective】 To explore clinical application effect of different methods of ERCP in the treatment of elderly patients with common bile duct stones. 【Methods】The clinical data of 158 elderly patients (≥ 60 years old) with choledocholithiasis treated with ERCP from June 2013 to May 2016 were analyzed retrospectively. According to the treatment method of ERCP, the patients were divided into two groups: endoscopic sphincterotomy group (EST group,n=68) and LEST+EPBD group (n=90). The operation time, hospitalization time, success rate of lithotomy and the occurrence of short-and long-term complications were observed and recorded in the two groups.【Results】There was no significant difference between the two groups in hospitalization time, success rate, the number of stones, the diameter of stones and the incidence of postoperative complications (mean P>0.05), but the rate of mechanical lithotripsy and operative time in the EST group were significantly higher than those in the LEST+ EPBD group, The lonh-term recurrence rate of stone in the EST group was significantly higher than that in LEST+ EPBD group (P<0.05).【Conclusion】ERCP is a safe and effective method for the treatment of elderly patients with choledocholithiasis. Both EST and LEST+ EPBD can achieve satisfactory results. But compared with EST, LEST+EPBD can preserve the normal anatomical structure and function of sphincter of duodenal papilla and effectively reduce the risk of postoperative complications and reduce the operation time, which is worthy of clinical application. 2018 Vol. 35 (5): 833-835 [Abstract] ( 73 ) HTML (1 KB)  PDF  (0 KB)  ( 5 ) 836 Effect of Lead Exposure on Genomic DNA Methylation in Children's Peripheral Blood and its Relationship with Behavioral Problems in Children XU Ning-an, ZHONG Yan, ZHAO Sha, et al DOI: 10.3969/j.issn.1671-7171.2018.05.002 【Objective】To investigate the effect of lead exposure on genomic DNA methylation in children's peripheral blood and the relationship between hyperleadinemia and behavioral problems in children.【Methods】From January to June 2016, 80 children with blood lead level ≥ 100 μg/L were selected as observation group and 80 healthy children in health examination of the same age, same sex and blood lead level < 100 μg/L as control group. The total methylation level of genomic DNA in peripheral blood mononuclear cells was detected by the MethyflashTM Total DNA Methylation Kit. Children's behavioral problems were screened by Conner's Children behavior questionnaire (parent scale), and the correlation between DNA methylation level and behavioral factor scores was analyzed.【Results】The detection rate of behavioral problems in the observation group was significantly higher than that in the control group (P<0.05). The scores of learning problems, impulsive hyperactivity and hyperactivity index in Conner's scale were significantly higher than those in control group (P<0.05). The total methylation level of genomic DNA in peripheral blood mononuclear cells was significantly decreased, the difference was statistically significant (P=0.0261). There was a negative correlation between total methylation level and blood lead level (P<0.001), and a negative correlation between total methylation level and impulse hyperactivity score (P<0.0436).【Conclusion】Hyperleadinemia can increase the incidence of behavioral problems in children, especially learning problems and impulses, hyperactivity behavior. The total methylation level of genomic DNA in children's peripheral blood is affected by blood lead, and it is negatively correlated with children's hyperactivity behavior problems. 2018 Vol. 35 (5): 836-838 [Abstract] ( 57 ) HTML (1 KB)  PDF  (0 KB)  ( 5 ) 839 Effects of Suspension Laparoscopic Surgery on Sex Hormone Levels and Pregnancy in Patients with Ovarian Cysts LIANG Xiao-hong DOI: 10.3969/j.issn.1671-7171.2018.05.003 【Objective】To analyze the effect of suspension laparoscopic surgery on postoperative sex hormone levels and pregnancy in patients with ovarian cysts. 【Methods】Ninety patients with ovarian cysts who underwent surgery in our hospital from August 2015 to June 2016 were selected as the subjects. All patients were divided into two groups according to the random number table method. The patients in the control group were treated with traditional laparotomy. The observation group was treated by suspension laparoscopic surgery. The changes of sex hormones were compared between the two groups before and 1 month, 3 months and 6 months after surgery. The outcome of 12-month pregnancy was compared as well. 【Results】The operation time, intraoperative blood loss, postoperative activity time for getting out of bed and length of hospital stay were longer in the control group than in the observation group, the difference was statistically significant (P<0.05).There were no significant differences in sex hormone levels between the two groups before and 6 months after operation (P>0.05);The levels of luteinizing hormone (LH), serum follicle stimulating hormone (FSH) and estradiol (E2) in the control group were higher than those in the observation group at 1 month and 3 months after operation; the differences were statistically significant (P<0.05);The natural pregnancy rate of the control group was significantly lower than that of the observation group (P<0.05).;There was no significant difference in spontaneous abortion rate, live birth rate and preterm birth rate between the two groups (P>0.05). 【Conclusion】For patients with ovarian cysts, the use of suspended laparoscopic surgery can effectively stabilize the postoperative sex hormone levels, ensure the normal ovulation function of ovaries, and contribute to the natural pregnancy after surgery. 2018 Vol. 35 (5): 839-841 [Abstract] ( 85 ) HTML (1 KB)  PDF  (0 KB)  ( 7 ) 842 Comparison of Intra-coronary Injection of Different Drugs on Slow Blood Flow in Patients with Myocardial Infarction ZHANG Zhe, HE Jian-xin, QIU Jian DOI: 10.3969/j.issn.1671-7171.2018.05.004 【Objective】To compare the effects of intracoronary injection of adrenalin or verapamil on slow blood flow during percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI).【Methods】The clinical data of 98 AMI patients treated with PCI from June 2016 to June 2017 were analyzed retrospectively. All patients were treated with PCI. The patients were divided into two groups: group A (intracoronary injection of epinephrine) and group B (intracoronary injection of verapamil). The coronary blood flow, serum inflammatory factor level and cardiovascular adverse events were compared between the two groups.【Results】There was no significant difference in the number of vessel branches between the two groups (P>0.05). The recovery rate of grade Ⅲ TIMI in the group A was significantly higher than that in the group B, and the blood flow time to grade Ⅲ TIMI was lower in the group A than in the group B. The difference was statistically significant (P<0.05). The levels of serum hypersensitive C-reactive protein (hs-CRP) and creatine kinase isoenzyme (CK-MB) were significantly lower in the group A than the in the group B after PCI. There was no significant difference in the levels of NT-proBNP and cTnT between the two groups(P＞0.05). The incidence of cardiovascular adverse events in the group A 6.12％(3/49) was significantly lower than that the in the group B 12.24%(6/49), and the difference was statistically significant (χ2=7.354,P=0.017＜0.05).【Conclusion】Both adrenalin and verapamil can improve the slow blood flow in patients with myocardial infarction (PCI), while adrenalin injection has better effect and safety. 2018 Vol. 35 (5): 842-844 [Abstract] ( 53 ) HTML (1 KB)  PDF  (0 KB)  ( 6 ) 845 Analysis of Recurrence Rate of Gestational Diabetes Mellitus, Risk Factors for Recurrence and Maternal and Infant Prognosis of Recurrent Gestational Diabetes Mellitus LIU Mei, WANG Xing-he, ZHANG Ming-cheng, et al DOI: 10.3969/j.issn.1671-7171.2018.05.005 【Objective】To study the recurrence rate, risk factors of recurrence of gestational diabetes mellitus(GDM) and the prognosis of mother and infant in recurrent GDM. 【Methods】A total of 142 pregnant women who had ever had GDM from January to December 2016, who had been examined in our hospital's obstetrical clinic were followed up. At the time of OGTT, 76 patients with recurrent GDM entered the observation group and 66 pregnant women without diabetes mellitus entered the negative control group. At the same time, 80 patients with primary GDM were randomly selected as the positive control group. The three groups were followed up to 6 months postpartum according to the clinical follow-up table to observe and calculate the prognosis of mother and infant and to screen the risk factors for recurrence of GDM. 【Results】The recurrence rate of GDM was 54.2%. Compared the observation group with the negative control group, there were significant differences between the two groups in fasting blood glucose(FBG), 2 hours postprandial blood glucose (2hPG), the pre-pregnancy body mass index(BMI) , the complications during pregnancy and delivery and neonatal complications. Compared with the positive control group, there were differences between the observation group and the positive control group in the number of births, the complications of some pregnant and delivery women, the complications of some newborns; the differences in the results of postpartum OGTT were significant. Risk factors for relapse included BMI before this pregnancy, the FGP and 2 hPG at last pregnancy.【Conclusion】The higher the FPG and 2hPG in the last pregnancy, the heavier the weight of the pregnancy, the more likely the GDM will recur.The higher the FPG and 2hPG in the last pregnancy, the heavier the weight of the pregnancy, the more likely the GDM will recur. Infants of patients with recurrent GDM are more likely to develop hypoglycemia and unobturated foramen ovale than those with primary GDM, and the risk of long term postpartum diabetes is increased. 2018 Vol. 35 (5): 845-848 [Abstract] ( 55 ) HTML (1 KB)  PDF  (0 KB)  ( 4 ) 849 Efficacy of Budesonide Combined with Nasal Endoscopic Surgery in the Treatment of Refractory Rhinosinusitis and the Effect on Mucosal Tissue Remodeling ZHANG Shu-long, TAN Li-fan, LIU Yi-jun, et al DOI: 10.3969/j.issn.1671-7171.2018.05.006 【Objective】To study the efficacy of budesonide combined with nasal endoscopic surgery in the treatment of refractory rhinosinusitis (RRS) and the effect on mucosal tissue remodeling. 【Methods】 Sixty-eight patients with RRS treated in our hospital during November 2013 - November 2016 were randomly divided into the control group and the observation group, 34 cases in each group. The control group was treated by corrective nasal endoscopic surgery while the observation group was additionally treated with budesonide. The efficacy and effect on mucosal tissue remodeling were compared between the two groups. 【Results】 The operation time, intraoperative blood loss and operative field bleeding score of the observation group were significantly shorter, less and lower than those of the control group (P<0.05). The total effective rate in the observation group was significantly higher than that in control group (94.12% vs 76.47%) (P<0.05). After treatment, the scores of nasal obstruction, runny nose, olfactory injury, head pain and visual simulated pain were significantly decreased in the two groups (P<0.05). Lund-Kennedy score decreased significantly (P<0.05). Nasal mucosal injury was significantly improved (P<0.05). The positive ratio of TGF- β1 and the proportion of collagen Ⅲ positive basement membrane thickness>20μm were significantly reduced (P<0.05 ), and the improvement amplitude of the observation group was greater than that of the control group (P<0.05 ) ; 6 months after operation, the total incidence of complications in the observation group was 11.76% and the recurrence rate was 5.88%, which was significantly lower than that in the control group (26.47% and 23.53%,P<0.05).【Conclusion】 Application of budesonide in corrective nasal endoscopic surgery for RRS can significantly shorten the operation time, reduce blood loss, inhibit the nasal mucosa remodeling, decrease postoperative complications and recurrence, and improve the prognosis. 2018 Vol. 35 (5): 849-852 [Abstract] ( 64 ) HTML (1 KB)  PDF  (0 KB)  ( 4 ) 853 Analysis of Survival and Prognostic Factors of Primary Gastric Diffuse Large B Cell Lymphoma HUANG Feng-xiang, LIU Chang, LV Gui-yang, et al DOI: 10.3969/j.issn.1671-7171.2018.05.007 【Objective 】To analyze the clinical characteristics, survival and prognostic factors of primary gastric diffuse large B-cell lymphoma (PG-DLBCL). 【Methods】The clinical data of 41 patients with PG-DLBCL were retrospectively analyzed. we applied Kaplan-Meier to estimate the survival time of all patients. 【Results】 Among the 41 patients, the OS (overall survival) rate at 1- , 3- , and 5 years were 77.3%, 62.8%, 55.0%, respectively. Patients with surgery alone had very poor diagnosis. In PG-DLBCL patient with over 6 cycles of chemotherapy, there was no significant difference in the survival rate between chemotherapy alone and surgery combined chemotherapy (P>0.05). Patients with more than 6 cycles of chemotherapy had a significantly higher survival rate than patients under chemotherapy for 6 cycles(P＜0.05). The prognosis of R-CHOP chemotherapy was better than CHOP. Univariate analysis showed that B-symptoms, Lugano stage ⅡE~Ⅳ, IPI (International Prognosis Index) score of 3-5 points, peripheral blood NLR ≥ 3.5, high CA125 , and LDH levels were predictors for poor prognosis in patients with PG-DLBCL(P＜0.05). 【Conclusion】B symptoms, Lugano staging of ⅡE~Ⅳ, IPI score of 3~5 points, peripheral blood NLR≥3.5, increased CA125, and elevated LDH level were important influencing factors for poor prognosis of PG-DLBCL(P＜0.05).Chemotherapy-based treatment program is recommended.Chemotherapy regimen of more than 6 cycles and chemotherapy with rituximab can improve the prognosis of patients. 2018 Vol. 35 (5): 853-855 [Abstract] ( 101 ) HTML (1 KB)  PDF  (0 KB)  ( 6 ) 856 Effect of Xingnaojing Injection Combined with Sodium Valproate and Levetiracetam on the Electroencephalogram Result and Prognosis of Elderly Patients with Post-stroke Epilepsy YU Qi DOI: 10.3969/j.issn.1671-7171.2018.05.008 【Objective】To explore the effect of Xingnaojing injection combined with sodium valproate and levetiracetam on the electroencephalogram result and prognosis of elderly patients with post-stroke epilepsy (PSE). 【Methods】A total of 72 elderly patients with PSE from January 2016 to June 2017 in our hospital were enrolled for the study and randomly divided into observation group (n=36) and control group (n=36). Patients in the control group were given sodium valproate combined with levetiracetam therapy for 8 weeks. Based on that, cases in the observation group were combined with Xingnaojing injection. Electroencephalogram result, serum levels of neuron specific enolase (NSE), matrix metalloproteinase-9 (MMP-9) and tumor necrosis factor-α(TNF-α) were compared between the two groups before and after treatment. The clinical efficacy and incidence of adverse reactions were compared between the two groups. 【Results】①There were no significant differences in electroencephalogram result including epileptiform discharges and involved lead number between the two groups before treatment (P>0.05), and epileptiform discharges and involved lead number after treatment in the two groups were significantly lower than those before treatment, and the epileptic discharge and the number of leads involved in the observation group was significantly lower than those in the control group (P<0.05). ②The clinical efficacy and the total effective rate (97.2% vs. 77.8%) in the observation group were significantly better than those in the control group (P<0.05).③There were no significant differences in serum levels of NSE, MMP-9 and TNF-α between the two groups before treatment (P>0.05), and serum levels of NSE, MMP-9 and TNF-α after treatment in the two groups were significantly lower than those before treatment, and serum levels of NSE, MMP-9 and TNF-αin the observation group were significantly lower than those in the control group (P<0.05).④All patients had no serious adverse reactions. These adverse reactions were improved after symptomatic treatment and they did not affect the treatment process. There were no significant differences in the incidences of adverse reactions including nausea and vomiting, mild insomnia, abnormal sensation, abnormal liver function, drug rash between the two groups (P>0.05). 【Conclusion】Xingnaojing injection combined with sodium valproate and levetiracetam could significantly improve electroencephalogram discharges in patients with PSE, reduced serum levels of NSE, MMP-9 and TNF-α, whose clinical effect is better than sodium valproate combined with levetiracetam therapy, and it dose not increase the risk of adverse reactions. 2018 Vol. 35 (5): 856-859 [Abstract] ( 60 ) HTML (1 KB)  PDF  (0 KB)  ( 5 ) 860 Effects of 3+1 Holistic Rehabilitation Nursing on Cognitive Function Recovery and Quality of Life in Elderly Patients with POCD after General Anesthesia Hip Replacement TU Chan, ZHANG Li-bin, XING Hang,et al DOI: 10.3969/j.issn.1671-7171.2018.05.009 【Objective】To observe the effects of 3+1 holistic rehabilitation nursing on cognitive function recovery and quality of life in elderly patients with Postoperative cognitive dysfunction (POCD) after general anesthesia hip replacement. 【Methods】A total of 92 elderly patients with POCD after general anesthesia hip replacement treated in our hospital from September 2015 to September 2017 were randomly divided into the control group and the study group, with 46 cases in each group. Both groups were given basic treatment. Routine nursing care was applied to patients in the control group, while 3+1 holistic rehabilitation nursing was applied to patients in the study group, with the intervention continuing until patient discharge. The mini mental state examination (MMSE) score, activity of daily living scale (ADL) score and the world health organization quality of life- brief scale (WHO QOL-BREF) score were compared between the two groups before and after intervention. 【Results】After intervention, the scores of MMSE (orientation, memory, attention, calculation, recall ability and language ability) in the two groups were significantly higher than those before the intervention (P<0.05), and were significantly higher in the study group compared tothe control group (P<0.05).The ADL scores in the two groups after intervention were significantly lower than those before intervention (P<0.05), and the ADL score in the study group was significantly lower than that in the control group (P<0.05). After intervention, the scores of the two groups in the physiology, psychology, social relations and environment were significantly higher than those before the intervention (P<0.05) and those in the study group were significantly higher than those in the control group (P<0.05). 【Conclusion】3+1 holistic rehabilitation nursing can effectively promote the recovery of cognitive function and improve the quality of life for the elderly POCD patients with general anesthesia hip replacement. 2018 Vol. 35 (5): 860-863 [Abstract] ( 43 ) HTML (1 KB)  PDF  (0 KB)  ( 6 ) 864 Evaluation of Efficacy and Prognosis of Laparoscopic Surgery on Ectopic Pregnant Patients ZHAO Yin-ling, QAIN Hua, YUAN Dong-lan, et al DOI: 10.3969/j.issn.1671-7171.2018.05.010 【Objective】To evaluate the clinical efficacy and prognosis of laparoscopic surgery for ectopic pregnancy patients. 【Methods】A total of 62 patients with ectopic pregnancy who were treated in our hospital from January 2011 to December 2015 were divided into two groups according to the operation methods: the laparotomy group (21 cases, laparotomy) and the laparoscopic group (41 cases). The operative parameters, hemorheology indexes and serum chorionic gonadotropin (HCG) levels were compared between the two groups. The fallopian tube recanalization and postoperative fertility of the two groups were recorded and compared as well.【Results】Compared to the laparotomy group, the intraoperative blood loss was reduced in the laparoscopic group, and the operation time, ambulation and anal exhaust, duration of postoperative abdominal pain, and catheter indwelling time were all shortened; the differences were statistically significant (P<0.05). After laparoscopic surgery, high-cutting whole blood viscosity, low-cutting whole blood viscosity, plasma viscosity, hematocrit, and serum β-HCG levels were lower than before surgery, and were lower in the laparoscopic group than those in the laparotomy group; the difference was statistically significant (P<0.05). In the laparoscopic group, fallopian tubal patency rate was 90.24% (37/41) and the postoperative intrauterine pregnancy rate was 73.17% (30/41), which were higher than those in the laparotomy group [61.90% (13/21), 47.62% (10/21), respectively] .The differences were statistically significant (P<0.05).【Conclusion】Laparoscopic surgery for ectopic pregnancy has the advantages of small surgical trauma, low risk and quick recovery. It helps to maximize fertility, improve hemorheology, reduce HCG level and benefit patients. 2018 Vol. 35 (5): 864-866 [Abstract] ( 62 ) HTML (1 KB)  PDF  (0 KB)  ( 6 ) 867 Analysis of the Predictive Value of NT-proBNP in Patients with Acute Coronary Syndrome (ACS) LIU Rong, QIAO Shu-bin DOI: 10.3969/j.issn.1671-7171.2018.05.011 【Objective】To analyze the predictive value of NT-proBNP in patients with acute coronary syndrome (ACS). 【Methods】From October 2014 to August 2015, the clinical data of 364 patients with ACS were collected from our hospital. The venous blood was taken from them 1~3 days after admission, and the levels of NT-proBNP and troponin cTnT or cTnI were examined. Left ventricular end-diastolic diameter(LVEDD)and left ventricular ejection fraction (LVEF) were examined by echocardiography. Patients were followed up for 24 months by outpatient or telephone to record cardiac death.【Results】Among the 343 patients, there were 148 cases of ST-segment elevation myocardial infarction(STEMI), 54 cases of acute non-ST-segment elevation myocardial infarction(NSTEMI) and 141 cases of unstable angina pectoris(UA). There were significant differences in the positive rate of age, hypertension,hypercholesterolemia,LVEF,InNT-proBNP,cTnT or cTnI between the STEMI group ,the NSTEMI group and the UA group (P<0.05). According to whether they died of cardiogenic disease, they were divided into two groups: the death group (n=20) and the survival group (n=321). The positive rate of cTnT or cTnI in the death group was significantly higher than that in the survival group (P<0.05). The age, positive rate of cTnT or cTnI , LVEF and InNT-proBNP in the dead group were significantly higher than those in the survival group (P<0.05). NT-proBNP was an independent predictor of cardiac death (P<0.05 ) , the area under ROC curve was 0.773 (P=0.000 ) . When the optimum threshold point of NT-proBNP was set at 1269 fmol/mL according to the ROC curve, the highest accuracy was 82.5%.【Conclusion】NT-proBNP is a good predictor of mid-term cardiac death in patients with acute coronary syndrome. 2018 Vol. 35 (5): 867-869 [Abstract] ( 51 ) HTML (1 KB)  PDF  (0 KB)  ( 6 ) 870 Analysis of Epstein-Barr Virus Infection in Breast Cancer Patients in Shenzhen HU Hong, ZHONG Cai-neng, ZHANG Ya-yuan, et al DOI: 10.3969/j.issn.1671-7171.2018.05.012 【Objective】 To study the Epstein-Barr virus infection in Breast Cancer Patients in Shenzhen. 【Methods】Twenty-five patients with breast cancer admitted to Shenzhen people's Hospital from June 2015 to January 2016 were selected as study objects (observation group) and 36 patients with benign breast diseases (control group). EBV early antigen IgM, core antigen IgG and capsid antigen IgG were detected in their serum, and the results were analyzed statistically. 【Results】In the observation group, the positive rate of EBV core antigen (IgG) was 76.0% (19 / 25), the positive rate of capsid antigen (IgG) was 92. 0% (23/ 25), and the positive rate of capsid antigen (IgA) was 100% ( 25 / 25). In the control group, the positive rate of EBV core antigen (IgG) was 86.1%(31/36), and the positive rate of capsid antigen (IgG) was 97.22 % (35 / 36). The weak positive rate of capsid antigen (IgA) was only 19.4%. Capsid antigen IgA and core antigen IgG had statistical significance between the two groups (P<0.01). In addition, no Epstein-Barr capsid antigen IgM was detected in the observation group and the control group.【Conclusion】The infection rate of EBV in patients with breast cancer and benign diseases is higher, and the positive rate of capsid antigen IgA in breast cancer patients was significantly higher than that in patients with benign breast diseases. There may be some correlation between EBV infection and breast cancer, which needs further study. 2018 Vol. 35 (5): 870-872 [Abstract] ( 59 ) HTML (1 KB)  PDF  (0 KB)  ( 4 ) 873 Effect of Shenshuai Enema (Renal Failure Enema) on Quality of Life in Patients with Decompensated Chronic Renal Failure WANG Nan, LAN Pei-ming, FAN Li-feng, et al DOI: 10.3969/j.issn.1671-7171.2018.05.013 【Objective】To explore the effect of Shenshuai enema (renal failure enema) on anemia, toxin removal and quality of life in patients with chronic renal failure (CRF) in decompensated stage. 【Methods】A total of 94 patients with CRF in the decompensated stage were randomly divided into two groups, with 47 cases in each group. The control group was given conventional therapy, and the enema group received Shenshuai enema treatment for two weeks on the basis of conventional therapy. The therapeutic effect, anemia, toxin clearance and quality of life were compared between the two groups. 【Results】The total effective rate in the enema group was significantly higher than that in the control group (91.19% vs 74.47%); the difference was statistically significant (P<0.05). After treatment, the levels of hemoglobin, red blood cell count and white blood cell count increased significantly in the two groups, the values in the enema group increased more significantly than those in the control group (P<0.05). The anemia improvement rate in enema group was 93.02% (40/43), which was significantly higher than that in the control group 76.19% (32/42) (P<0.05). After treatment, the levels of serum creatinine, blood uric acid, blood urea nitrogen, serum phosphorus and serum cystatin decreased significantly. The quality of life scores also increased significantly (P<0.05). The changes in the enema group were more significant than those in the control group (P<0.05). 【Conclusion】Renal failure enema can significantly relieve the symptoms and anemia, improve renal toxin clearance rate and the quality of life in patients with CRF. 2018 Vol. 35 (5): 873-875 [Abstract] ( 50 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 876 Effect of Levodopa Combined with Rivastigmine on Myotonia and Dopa Transporter in Patients with Parkinson's Disease ZHU Dong-mei, XIONG Xue-zhi DOI: 10.3969/j.issn.1671-7171.2018.05.014 【Objective】To study the effect of levodopa combined with rivastigmine on myotonia and dopa transporter in patients with Parkinson's disease (PD). 【Methods】 A total of 101 patients with early Parkinson disease treated in our hospital were randomly divided into control group (n=50) and observation group (n=51). Patients in the control group were treated with levodopa, and patients in the control group were treated with levodopa plus rivastigmine in continuous treatment for 6 months. Parkinson's severity, balance function, Parkinson's grade, clinical symptom improvement time, dopamine transporter radiation count and adverse reactions were compared between the two groups. 【Results】After treatment, UP-DRS (UP-DRS) in the observation group was lower than that in the control group (P<0.05); Berg balance score higher than that of the control group (P<0.05); Parkinson's Hoehn-Yahr classification was lower than that of the control group (P<0.05); Myotonic stiffness, resting tremor and bradykinesia were shorter than those in the control group (P<0.05). The ratio of basal ganglia (BG) to occipital lobe (OC) tended to increase, but the incidence of contralateral control group was higher than that before treatment (P<0.05). The incidence of adverse reactions in the observation group was lower than that in the control group (P<0.05). 【Conclusion】 Levodopa combined with rivastigmine can alleviate the symptoms of PD, improve the balance ability of patients and reduce the adverse reactions in patients with Parkinson's disease. 2018 Vol. 35 (5): 876-878 [Abstract] ( 56 ) HTML (1 KB)  PDF  (0 KB)  ( 5 ) 879 Effects of Tamoxifen and Metformin on Lipid Metabolism and Prognosis in Women with Polycystic Ovary Syndrome Complicated with Infertility ZHANG Qin DOI: 10.3969/j.issn.1671-7171.2018.05.015 【Objective】To investigate the effect of tamoxifen and metformin on lipid metabolism and prognosis in women with polycystic ovary syndrome (PCOS) complicated with infertility. 【Methods】A total of 108 cases of PCOS complicated with infertility were selected from January 2014 to June 2016 in our hospital. According to the random number method, patients were divided into the study group (54 cases) and the control group (54 cases). Patients in the control group received tamoxifen and patients in the study group were treated with tamoxifen and metformin. All patients started administration at d5 after menstrual period, and 21 days of continuous treatment was a cycle. The patient received the same procedure again at d5 of the next menstruation, and a total of 3 cycles were given. At the fourth menstrual period d5, ovulation induction therapy was used and follicular clinical monitoring was performed at d10. To evaluate the clinical effect of patients, luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol (E2), prolactin (PRL), and testosterone (T) were detected before and after treatment in the two groups. Meanwhile lipid metabolism indicators like total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A (apo A) and apolipoprotein B (apo B) were also detected. All patients were followed for one year, and the ovulation and pregnancy status of the two groups were compared.【Results】The total effective rate of patients in the study group after treatment was significantly higher than that in the control group, the difference was statistically significant (P<0.05). After treatment, the levels of LH, E2, and T in the two groups of patients decreased significantly, and the study group had a more significant decrease, with a statistically significant difference (P<0.05).While the levels of TC, TG, HDL-C, LDL-C, apo A and apo B were significantly increased in the two groups after treatment.TG and HDL-C levels were significantly higher than those in the control group, while the LDL-C and apo B levels were significantly lower than those in the control group; the differences were statistically significant (P<0.05). After follow-up, the normal ovulation rate and pregnancy rate in the study group were significantly higher than those in the control group, the differences were statistically significant (P<0.05). 【Conclusion】Tamoxifen combined with metformin can effectively improve the clinical symptoms of polycystic ovary syndrome with infertility patients, regulate the body's sex hormone levels and balance of lipid metabolism, promote normal ovulation to increase the ovulation rate and pregnancy rate of patients. It is worthy of clinical promotion. 2018 Vol. 35 (5): 879-882 [Abstract] ( 52 ) HTML (1 KB)  PDF  (0 KB)  ( 7 ) 883 Application of crown lengthening to the patients with tooth splitting to deeper parts of subgingival YANG Qing, YUAN Rong DOI: 10.3969/j.issn.1671-7171.2018.05.016 【Objective】 To explore the application of crown lengthening in the treatment of dental repair in patients with teeth splitting to the deeper parts to subgingival. 【Methods】Selected January 2014 to 2016 January in the dental clinic of our hospital for diagnosis and treatment of 120 cases (120 teeth due to dental splitting to gingival deep patients were studied by randomly divided into study group and control group, 60 cases (60 teeth), the study group with crown lengthening surgery exposed section, the group take gingival resection exposed section, postoperative again conventional post crown repair, compared two groups of patients before surgery and after 6 weeks of plaque index (PLI), probing depth (PD), bleeding index (SBI) and aesthetic effect. 【Results】Before the operation, the study group and the control group PLI, PD, SBI in gingival difference were not statistically significant (P>0.05); after 6 weeks, the two groups of patients with PLI, PD, gingival SBI values were significantly decreased compared with preoperative, the difference was statistically significant (P<0.05), the study group of teeth PLI, PD, SBI gum was lower than the control group, the difference was statistically significant (P<0.05); 6 months after operation, the study group of patients with gingival color, with adjacent teeth and facial coordination restoration, color and shape are consistent with adjacent teeth satisfaction rates were 85%, 81.67%, 88.33% were higher than the control group 80%, 78.33%, 80%, but the difference was not statistically significant (P>0.05). 【Conclusion】Crown lengthening surgery used to treat tooth splitting reach deeper parts of subgingival restorative treatment of patients with better clinical results. 2018 Vol. 35 (5): 883-885 [Abstract] ( 56 ) HTML (1 KB)  PDF  (0 KB)  ( 4 ) 886 Correlation between Molecular Margin and Clinical Factors of Laryngeal Carcinoma and its Prognosis ZHANG Hong-lei, LI Da-peng, LI Jia, et al DOI: 10.3969/j.issn.1671-7171.2018.05.017 【Objective】 To investigate the relationship between molecular cutting edge and clinical factors of laryngeal carcinoma and its prognosis.【Methods】The clinical data of 129 patients with laryngeal cancer who underwent surgical treatment from January 2010 to December 2011 were collected. All patients were followed up until September 2016 or death at the end of the year, and were divided into two groups according to recurrent or not: recurrence group (47 cases) and non recurrence group (82 cases). The correlation between the molecular margin and clinical factors of the two groups of laryngocarcinoma and prognosis were discussed.【Results】The proportion of subglottic tumor in T3~T4 stage, middle and low differentiation carcinoma with cervical lymph node metastasis was significantly higher than that in the non-recurrence group (P<0.05). There was no significant difference in sex, age and postoperative radiotherapy between the two groups (P>0.05). The expression of cyclind1 and composition ratio in the recurrent group was significantly higher than that in the non-recurrence group (P<0.05). The positive expression rate of P27 in the recurrent group was lower than that in the non-recurrent group (P<0.05). The positive expression rate of P53 eIF4E was significantly higher than that of the non-recurrence group (P<0.05). The linear regression equation was established. The results of Spearman relation test showed that the expression of cyclind1 in the molecular cutting edge was positively correlated with the prognosis(r=0.716,P=0.002).P53 and eIF4E were positively correlated with the prognosis(r=0.616,0.928,P=0.014,0.000)and there was a negative correlation between the P27 and the prognosis(r=-0.741,P=0.012).【Conclusion】The molecular cut edge of laryngeal carcinoma is closely related to prognosis. At the same time, cervical lymph node metastasis accompanied, higher T stage and tumor located in the subglottic are the main factors affecting the prognosis of laryngeal carcinoma. 2018 Vol. 35 (5): 886-888 [Abstract] ( 65 ) HTML (1 KB)  PDF  (0 KB)  ( 5 ) 889 Clinical Effect of Endovascular Interventional Therapy on Patients with Intra - cerebral Artery Bifurcation Aneurysms HUANG Wei-jia, XIE Jian-guo DOI: 10.3969/j.issn.1671-7171.2018.05.018 【Objective】To investigate the clinical effect of intravascular interventional therapy on patients with intra - cerebral artery bifurcation aneurysms .【Methods】From January 2014 to December 2016, 72 patients with aneurysm of middle cerebral artery bifurcation in our hospital were divided into observation group and control group according to the different treatment methods, 36 cases in each group. The patients in the observation group were treated with endovascular treatment. The control group was treated with craniotomy. The clinical efficacy and complications of the two groups were observed. The operative time, hospital stay, and the recurrence and neurological deficit of the two groups were compared after 6 months. 【Results】The proportion of patients with good prognosis in the observation group was significantly higher than that in the control group, and the proportion of the poor prognosis in the observation group was lower than that in the control group (P<0.05), but there was no significant difference in the mortality between the two groups (P>0.05). The operation time and hospitalization time in the observation group were all smaller than those in the control group, and the difference was statistically significant (P<0.05). The incidence of postoperative complications in the observation group (11.11%(4/36) was significantly lower than that in the control group 32.35%(11/36) (P<0.05), and there was no significant difference between the two groups in terms of postoperative recurrence after 6 months follow-up(5.56% vs 2.78%,χ2=0.411,P=0.522>0.05). 【Conclusion】Endovascular interventional therapy has the advantages of short operation time, less complications, quick postoperative recovery, significant curative effect and low recurrence rate. It is a safe and feasible method for the treatment of middle cerebral artery bifurcation aneurysms. 2018 Vol. 35 (5): 889-892 [Abstract] ( 61 ) HTML (1 KB)  PDF  (0 KB)  ( 6 ) 893 Influence of Different Internal Fixations on the Activities of Daily Living and Motor Function in Elderly Patients with Intertrochanteric Fractures GAI Wei, GONG Zi-shun, ZHU Dong-bo, et al DOI: 10.3969/j.issn.1671-7171.2018.05.019 【Objective】To compare the effects of different internal fixation schemes on the activities of daily living and motor function in elderly patients with intertrochanteric fractures to provide references for the selection of internal fixations. 【Methods】 A total of 195 cases of elderly intertrochanteric femoral fractures in our hospital from March 2014 ~2017 February were collected for the study. Patients were divided into three groups: Proximal Femoral Nail Anti-rotation, (PFNA) group, Dynamic Hip Screw (DHS) group, and Locking Proximal Femoral Plate (LPFP), with 65 cases in each group. The operation, recovery, complications, Barthel index (activities of daily living) and motor function of three groups were compared. The advantages and disadvantages of the three internal fixation schemes were summarized, and the clinical treatment ideas were discussed. 【Results】 In group PFNA, intraoperative blood loss and fracture healing time were lower than those in group DHS and group LPFP. The amount of bleeding and operative time in the LPFP group were lower than those in the DHS group, and the fracture healing time in the PFNA group was higher than that in the DHS.group. All these differences between groups were statistically significant (P<0.05). The incidence of postoperative complications in the PFNA group was 4.62%, which was lower than that in the DHS group (7.69%) and the LPFP group (15.38%); the differences between groups were statistically significant (P<0.05).All patients were followed up with for one year. Barthel index at 6 to 12 months after surgery in three groups were higher than that before operation. The Barthel index at 6 to 12 months after surgery was higher in the PFNA group than in the DHS group and LPFP group. The clinical excellent rate of the PFNA group was higher than that of the DHS group at 1 year after surgery. The clinical and excellent rate of the DHS group was higher than that of the LPFP group. The difference between groups was statistically significant (P<0.05).【Conclusion】The efficacy and safety of PFNA in the treatment of elderly patients with femoral intertrochanteric fractures are the most ideal, and PFNA can also effectively improve the activities of daily living and promote the recovery of motor function. It is worthy of clinical promotion. 2018 Vol. 35 (5): 893-896 [Abstract] ( 37 ) HTML (1 KB)  PDF  (0 KB)  ( 5 ) 897 Expression of MiR-34b and Target Gene CDK6 in Osteosarcoma HUANG Cheng-xiao, YU Hua-long, GAO Chao, et al DOI: 10.3969/j.issn.1671-7171.2018.05.020 【Objective】The aim of this study was to investigate the expression and clinical significance of miR-34b and target gene cyclin-dependent kinase 6 (CDK6) in osteosarcoma, and to provide a new therapeutic approach for gene therapy of osteosarcoma. 【Methods】A total of 51 cases of osteosarcoma patients who underwent surgical resection in our hospital from March 12, 2016 to March 12, 2017 were selected as the subject of study. There were 51 cases of osteosarcoma and corresponding 51 cases of normal bone tissue (At least 2 cm from the edge of the cancer tissue) were collected. The levels of miR-34b and CDK6 mRNA in osteosarcoma and adjacent normal tissues were detected by qRT-PCR. The expression of CDK6 protein in osteosarcoma and adjacent normal tissues was detected by immunohistochecmistry (S-P method). The relationship between the expression of miR-34b and CDK6 was analyzed, and the correlation between the expression of the two genes and their clinicopathological features of osteosarcom was analyzed as well. 【Results】 The expression level of miR-34b mRNA in osteosarcoma tissue was 0.34±0.16, which was significantly lower than that in adjacent tissues (1.06±0.13); the difference was statistically significant (Z=24.942,P=0.000). The expression level of CDK6 mRNA in osteosarcoma tissue was 4.37±0.46, which was significantly higher than that in adjacent tissue (1.03±0.12, Z=50.174, P=0.000). The positive expression rate of CDK6 protein in osteosarcoma tissue was 78.43%, which was significantly higher than that in adjacent tissue 17.65%(χ2=37.744,P=0.000). The expression of miR-34b and CDK6 was negatively correlated (r=-0.483, P=0.000). The expression of miR-34b and CDK6 were not significantly correlated with age, sex, tumor size and tumor location of osteosarcoma patients (Z=0.203、0.384、0.230、0.135;P=0.840、0.703、0.819、0.894.χ2=0.644、0.051、2.403、0.746;P=0.422、0.821、0.121、0.689), while itwas closely related to Enneking staging and tumor metastasis (Z=2.509、3.962, P=0.016、0.000;χ2=6.451、4.217,P=0.040、0.040). 【Conclusion】miR-34b may be involved in the development of osteosarcoma through regulating the expression of target gene CDK6 gene. 2018 Vol. 35 (5): 897-899 [Abstract] ( 56 ) HTML (1 KB)  PDF  (0 KB)  ( 3 ) 900 Ulinastatin Combined with Continuous Renal Replacement Therapy in the Treatment of Type I Acute Cardiorenal Syndrome WANG Jing, FENG Li-rong DOI: 10.3969/j.issn.1671-7171.2018.05.021 【Objective】 To investigate the clinical curative effect of ulinastatin combined with continuous renal replacement therapy (CRRT) in the treatment of type I acute cardiorenal syndrome (ACRS). 【Methods】 A total of 120 patients with ACRS were divided into two groups by the random method, with 60 cases in each group. Patients in the control group were given CRRT while patients in the observation group were treated with ulinastatin for 3 consecutive days in addition to CRRT. The renal and cardiac function were evaluated between the two groups after 14 days of treatment. The levels of plasma creatinine (Scr) and NT-proBNP were detected. The Ccr and GFR were calculated. The LVEF was diagnosed. 【Results】 The survival rate of the observation group was 83.33% (50/60), which was slightly higher than that of the control group 71.66% (43/60). The recovery rate of renal function and the rate of grade Ⅱ to Ⅲ of the heart function after treatment in the observation group were 45.0% (27/60) and 25.0% (15/60), respectively, which were slightly higher than those in the control group, which were 31.67% (19/60), and 15.0% (9/60), respectively. However, those differences were not statistically significant (P>0.05). After treatment, LVEF (left ventricular ejection fraction), Ccr (endogenous creatinine clearance) and GFR (glomerular filtration rate) were higher in the observation group than those in the control group, while levels of NT-proBNP (plasma N-terminal B-type natriuretic peptide precursor) and Scr (creatinine) were lower than in the control group, and the difference was statistically significant (P<0.05). 【Conclusion】 The application of ulinastatin combined with CRRT in the treatment of ACRS can protect cardiac and renal function, but the improvement of short-term prognosis is not obvious. 2018 Vol. 35 (5): 900-902 [Abstract] ( 44 ) HTML (1 KB)  PDF  (0 KB)  ( 3 ) 903 Multi-slice CT Imaging Features of Thin-walled Cavity Lung Cancer LIU Jiang-yong, LI Guo-xiong, AI Guo-ping DOI: 10.3969/j.issn.1671-7171.2018.05.022 【Objective】 To analyze the features of multi-slice CT images in patients with thin-wall cavity lung cancer during clinical follow-up.【Methods】Nine patients (male/ female, 6 /3; age range, 53 ~ 77 years) who were confirmed as thin-wall-cavity typed lung cancer by post-operative pathology were collected into this study. Their CT images in the course of clinical follow-up were reviewed retrospectively. 【Results】 At first CT examination , the maximum diameter of lesions in 9 cases of cavity type lung cancer was 1.5~4.5(2.9±0.96)mm , and the wall thickness was 1.5～4.5 ( 2.9 ± 0.96 ) mm. Mural nodules were found in 9 cases, and the mean diameter of the mural nodules was 1.59 ±24.2mm(11.4 ±6.75)mm. Typical CT features of 9 cases of cavity lung cancer include: there were 6 cases with irregular contour(66.7%), 4 cases with burr on the edge of the lesion(44.4%), 4 cases with pleural line sign(44.4%), 9 cases with luminal wall nodule(100%), 5 cases with intraluminal septum(55.6%). In 4 cases of cavity lung cancer, lesions and wall nodules gradually increased and irregular thickening was found during clinical follow-up.【Conclusion】 Cavity type lung cancer is characterized by irregular thin-walled cavity with wall nodule or / and intraluminal stripe separation. The clinical follow-up of cavity type lung cancer showed progressive thickening of cavity wall and enlargement of wall nodule. 2018 Vol. 35 (5): 903-906 [Abstract] ( 45 ) HTML (1 KB)  PDF  (0 KB)  ( 4 ) 907 Investigation of the Composition and Characteristics of Stones in 276 Cases with Urinary Calculi in Meishan City QIU Jian-qiang, DUAN Tao, WANG Zuo, et al DOI: 10.3969/j.issn.1671-7171.2018.05.023 【Objective】To study the composition and characteristics of urinary stones in 276 cases with urinary calculi in Meishan. 【Methods】A total of 276 cases with urinary calculi in Meishan were enrolled in the study and the composition and characteristics of the stones were investigated. 【Results】The incidence rate of urinary calculi in male (68.47%, 189/276) was higher than that in female (31.53%, 87/276); the difference was statistically significant (P < 0.05). The incidence rate was 25.72% in the age group of 50~59 years old, which was significantly higher than those in other age groups[≤19 years old (2.54%), 20 ~ 29 years old (9.42%), 30 ~ 39 years old (18.48%), 60 to 69 years old (14.13%) and ≥ 70 years old (6.88%); P < 0.05], except for the age group of 40~49 years old (P＞0.05). Most simple stones were composed of calcium oxalate and calcium urate, accounting for 44.93% and 1.51% of the stones, respectively. In mixed stones, calcium oxalate combined with carbonate apatite and calcium oxalate combined with uric acid were the most common, accounting for 35.14% and 10.51%, respectively. The detection rate of calcium oxalate was the highest in stones at different sites of urinary system. The distribution rates of calcium oxalate in kidney, ureter, bladder and urethra were 67.03%, 22.10%, 4.71% and 0.36%, respectively. 【Conclusion】The main compositions of urinary calculi in patients in Meishan are calcium oxalate and calcium urate. The major site of calculi is the upper urinary tract. Our results indicate that appropriate treatment and preventive measures can be applied to improve the therapeutic effect and reduce the recurrence of urinary stones. 2018 Vol. 35 (5): 907-908 [Abstract] ( 40 ) HTML (1 KB)  PDF  (0 KB)  ( 4 ) 909 Effects of Different Blood Purification Methods on Inflammatory Factors and Related Indicators in Patients with End-stage Renal Disease Tan Hui-feng, CAO Pei-lian DOI: 10.3969/j.issn.1671-7171.2018.05.024 【Objective】To investigate the effects of two different blood purification methods on the levels of inflammatory factors, blood urea nitrogen (BUN), parathyroid hormone (PTH) and β2-microglobulin (β2-MG) in patients with end-stage renal disease (ESRD). 【Methods】A total of 80 cases of patients undergoing maintenance hemodialysis (MHD) were divided into two groups: group A with routine hemodialysis and group B with routine hemodialysis combined with hemoperfusion (HP), with 40 cases in each group. After 6 months of treatment, the residual renal function (RRF) was calculated. The levels of BUN, C reactive protein (CRP), interleukin -6 (IL-6), plasma homocysteine (Hcy), PTH and β2-MG were determined. 【Results】After hemodialysis, the value of RRF and BUN decreased in both groups; however, RRF and BUN in group B were higher than those in group A (P<0.05). After hemodialysis, levels of CRP, IL-6, Hcy, PTH and β2-MG in group B were lower than those before hemodial4ysis (P<0.05), but these indices did not undergo much change after hemodialysis compared to before in group A. So, there were significant differences between the two groups after hemodialysis (P<0.05). 【Conclusion】Compared to routine hemodialysis, hemodialysis combined with hemoperfusion can clear inflammatory factors as well as PTH and β2-MG in patients with ESRD, and reduce the damage to RRF. 2018 Vol. 35 (5): 909-911 [Abstract] ( 55 ) HTML (1 KB)  PDF  (0 KB)  ( 4 ) 912 Study of Cognitive Function Impairment of Patients with First-diagnosed Schizophrenia QING Jian-ming, LI Jian-guo, ZHANG Hong-yan, et al DOI: 10.3969/j.issn.1671-7171.2018.05.025 【Objective】To analyze the cognitive function impairment of first-diagnosed schizophrenics. 【Methods】From March 2013 to March 2017, 92 untreated schizophrenic patients were selected as the study subjects, and 80 healthy volunteers were selected as the control group. Cognitive function was assessed by a complete set of cognitive function assessment tools (CANTAB) and an improved Wisconsin card sorting test (M-WCST). According to the cognitive impairment, the patients in the study group were divided into two groups: normal cognitive group and cognitive impairment group. The positive and negative symptom scale (PANSS) was used to analyze the mental symptoms in the normal cognitive group and the cognitive disorder group, and the serum folic acid and homocysteine (Hcy) levels were compared.【Results】The assessment level of cognitive function in the observation group was better than that of the control group (P<0.05), and the symptoms and total scores of PANSS in the cognitive impairment group were significantly higher than those in the cognitive normal group, and the difference was statistically significant (P<0.05); the level of serum folic acid in the cognitive impairment group was (4.21 ± 1.53) ng/mL lower than that of the cognitive normal group (7.62 ± 1.94) ng/mL(P<0.05), the Hcy level was (26.45 ± 2.79) mol/L higher than that of the normal cognitive group (19.28 ± 2.17) mol/L, the difference was statistically significant (P<0.05).【Conclusion】The cognitive function of the first diagnosed schizophrenic patients is lower than that of the normal subjects, and their psychopathological symptoms, serum folic acid and Hcy levels are correlated with the degree of cognitive impairment. 2018 Vol. 35 (5): 912-914 [Abstract] ( 54 ) HTML (1 KB)  PDF  (0 KB)  ( 6 ) 915 Effect of Kinesio Taping Combined with Continuous Cold Therapy on Detumescence after Anterior Cruciate Ligament Reconstruction WU Ling, PAN Wei-yi, CHEN Jun-qi, et al DOI: 10.3969/j.issn.1671-7171.2018.05.026 【Objective】 To investigate the effect of Kinesio taping in combination of continuous cold therapy on detumescence after anterior cruciate ligament reconstruction . 【Methods】A total of 84 patients who underwent arthroscopic anterior cruciate ligament reconstruction in our department from January 2015 to December -2017 were selected as the subjects. According to the random number table method, they were divided into the observation group and the control group, with 42 cases in each group. Kinesio Taping treatment was given to patients in the control group immediately after surgery..The Kinesio taping was administrated once every two days for one week and sustained for 48h. While patients in the observation group, in addition to treatment of the control group, received continuous cold therapy starting within 6h after operation for 3 consecutive days . The pain degree (VAS score), the degree of swelling, the function of the knee joint (Lysholm score) and the effect of detumescence (swelling reduction) were compared between the two groups. 【Results】The rate of detumescence in the observation group was 69.05%, which was higher than that in the control group (38.10%). The difference was statistically significant(P<0.05). After treatment, the VAS scores in both groups decreased, and the VAS score in the observation group was lower than that in the control group at the same time period; the difference was statistically significant(P<0.05). The swelling value of the observation group at each time after treatment was less than that of the control group at the same time(P<0.05). At 4 weeks after treatment, the Lysholm score of the observation group was higher than that of the control group; the difference was statistically significant(P<0.05). 【Conclusion】Kinesio taping combined with continuous cold therapy can effectively relieve swelling and pain after anterior cruciate ligament reconstruction, and promote early rehabilitation of knee joint function.It is worthy of clinical promotion. 2018 Vol. 35 (5): 915-917 [Abstract] ( 64 ) HTML (1 KB)  PDF  (0 KB)  ( 5 ) 918 Comparison of Effects of Docetaxel Alone and Its Combination with Thiotepa in the Treatment of Metastatic Breast cancer LI Ai-feng DOI: 10.3969/j.issn.1671-7171.2018.05.027 【Objective】To study the effects and prognosis of docetaxel alone and its combination with thiotepa in the treatment of metastatic breast cancer(MBC). 【Methods】A total of 86 patients with MBC were divided into the docetaxel treatment group (group A,n=42) and docetaxel combined with thiotepa group (group B,n=44). The short-term curative effect, adverse reactions and survival rate were compared between the two groups. 【Results】The effective rate of treatment and clinical control rate in group A were 50% and 80.95%, respectively, while those in group B were 56.82% and 90.91%, respectively; the differences were not statistically significant (P>0.05). The neutropenia, anemia, thrombocytopenia and adverse reactions in group B were more serious than those in group A; and the differences were statistically significant (P<0.05). The progression-free survival time was 12.64 months in group A and 14.26 months in group B. There was no significant difference between the two groups (P>0.05). The 1-year, 2-year and 3-year local control rates of tumor and survival rates were 42.8%, 19.05%, 2.38% and 47.62%, 21.43%, 4.76% in group A, while those in group B were 50%, 22.73%, 11.36% and 54.55%, 31.82%, 15.91%. The 3-year survival rate showed significant difference (P<0.05). There was no significant difference in the rate of tumor control and survival between the two groups at 1 year and 2 years (P>0.05), but the 3-year survival rate in group A was lower than that in group B, and the difference was significant (P<0.05). 【Conclusion】The short-term and long-term effects of docetaxel alone and its combination with thiotepa are similar in the treatment of metastatic breast cancer. Although the toxicity of docetaxel alone is smaller, its 3-year survival rate is lower than that of the combination group. The specific chemotherapy should be chosen according to the actual condition of patients. 2018 Vol. 35 (5): 918-920 [Abstract] ( 58 ) HTML (1 KB)  PDF  (0 KB)  ( 6 )

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