氨基末端B型脑钠肽前体对急性冠脉综合征患者中期心源性病死的预测价值

doi:10.3969/j.issn.1671-7171.2018.05.011

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Abstract 【Objective】To analyze the predictive value of NT-proBNP in patients with acute coronary syndrome (ACS). 【Methods】From October 2014 to August 2015, the clinical data of 364 patients with ACS were collected from our hospital. The venous blood was taken from them 1~3 days after admission, and the levels of NT-proBNP and troponin cTnT or cTnI were examined. Left ventricular end-diastolic diameter(LVEDD)and left ventricular ejection fraction (LVEF) were examined by echocardiography. Patients were followed up for 24 months by outpatient or telephone to record cardiac death.【Results】Among the 343 patients, there were 148 cases of ST-segment elevation myocardial infarction(STEMI), 54 cases of acute non-ST-segment elevation myocardial infarction(NSTEMI) and 141 cases of unstable angina pectoris(UA). There were significant differences in the positive rate of age, hypertension,hypercholesterolemia,LVEF,InNT-proBNP,cTnT or cTnI between the STEMI group ,the NSTEMI group and the UA group (P<0.05). According to whether they died of cardiogenic disease, they were divided into two groups: the death group (n=20) and the survival group (n=321). The positive rate of cTnT or cTnI in the death group was significantly higher than that in the survival group (P<0.05). The age, positive rate of cTnT or cTnI , LVEF and InNT-proBNP in the dead group were significantly higher than those in the survival group (P<0.05). NT-proBNP was an independent predictor of cardiac death (P<0.05 ) , the area under ROC curve was 0.773 (P=0.000 ) . When the optimum threshold point of NT-proBNP was set at 1269 fmol/mL according to the ROC curve, the highest accuracy was 82.5%.【Conclusion】NT-proBNP is a good predictor of mid-term cardiac death in patients with acute coronary syndrome.

Key words： NatriureticPeptide,Brain CoronaryArteryDisease AcuteDisease Syndrome

Received: 22 December 2017

PACS:

R543.31

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	LIU Rong
	QIAO Shu-bin

Cite this article:

LIU Rong,QIAO Shu-bin. Analysis of the Predictive Value of NT-proBNP in Patients with Acute Coronary Syndrome (ACS)[J]. JOURNAL OF CLINICAL RESEARCH, 2018, 35(5): 867-869.

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2018.05.011 OR http://www.jcr.net.cn/EN/Y2018/V35/I5/867

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