深圳市乳腺癌患者Epstein-Barr病毒感染情况分析

doi:10.3969/j.issn.1671-7171.2018.05.012

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Abstract 【Objective】 To study the Epstein-Barr virus infection in Breast Cancer Patients in Shenzhen. 【Methods】Twenty-five patients with breast cancer admitted to Shenzhen people's Hospital from June 2015 to January 2016 were selected as study objects (observation group) and 36 patients with benign breast diseases (control group). EBV early antigen IgM, core antigen IgG and capsid antigen IgG were detected in their serum, and the results were analyzed statistically. 【Results】In the observation group, the positive rate of EBV core antigen (IgG) was 76.0% (19 / 25), the positive rate of capsid antigen (IgG) was 92. 0% (23/ 25), and the positive rate of capsid antigen (IgA) was 100% ( 25 / 25). In the control group, the positive rate of EBV core antigen (IgG) was 86.1%(31/36), and the positive rate of capsid antigen (IgG) was 97.22 % (35 / 36). The weak positive rate of capsid antigen (IgA) was only 19.4%. Capsid antigen IgA and core antigen IgG had statistical significance between the two groups (P<0.01). In addition, no Epstein-Barr capsid antigen IgM was detected in the observation group and the control group.【Conclusion】The infection rate of EBV in patients with breast cancer and benign diseases is higher, and the positive rate of capsid antigen IgA in breast cancer patients was significantly higher than that in patients with benign breast diseases. There may be some correlation between EBV infection and breast cancer, which needs further study.

Key words： BreastNeoplasms Herpesvirus4,Human Infection

Received: 19 July 2017

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R737.9

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2018.05.012 OR http://www.jcr.net.cn/EN/Y2018/V35/I5/870

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