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| Comparison of Intra-coronary Injection of Different Drugs on Slow Blood Flow in Patients with Myocardial Infarction |
| ZHANG Zhe, HE Jian-xin, QIU Jian |
| Department of Cardiovascular Disease, the Guangzhou General Hospital, Guangzhou military region, Guangzhou, Guangdong 510001 |
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Abstract 【Objective】To compare the effects of intracoronary injection of adrenalin or verapamil on slow blood flow during percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI).【Methods】The clinical data of 98 AMI patients treated with PCI from June 2016 to June 2017 were analyzed retrospectively. All patients were treated with PCI. The patients were divided into two groups: group A (intracoronary injection of epinephrine) and group B (intracoronary injection of verapamil). The coronary blood flow, serum inflammatory factor level and cardiovascular adverse events were compared between the two groups.【Results】There was no significant difference in the number of vessel branches between the two groups (P>0.05). The recovery rate of grade Ⅲ TIMI in the group A was significantly higher than that in the group B, and the blood flow time to grade Ⅲ TIMI was lower in the group A than in the group B. The difference was statistically significant (P<0.05). The levels of serum hypersensitive C-reactive protein (hs-CRP) and creatine kinase isoenzyme (CK-MB) were significantly lower in the group A than the in the group B after PCI. There was no significant difference in the levels of NT-proBNP and cTnT between the two groups(P＞0.05). The incidence of cardiovascular adverse events in the group A 6.12％(3/49) was significantly lower than that the in the group B 12.24%(6/49), and the difference was statistically significant (χ2=7.354,P=0.017＜0.05).【Conclusion】Both adrenalin and verapamil can improve the slow blood flow in patients with myocardial infarction (PCI), while adrenalin injection has better effect and safety.
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Received: 18 July 2017
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[1] Teraguchi I,Imanishi T,Ozaki Y, et al.Acute-phase glucose fluctuation is negatively correlated with myocardial salvage after acute myocardial infarction - Involvement of monocyte subsets[J].Circulation,2014,78(1):170-179.
[2] Altiok E,Tiemann S,Becker M, et al. Myocardial deformation imaging by two-dimensional speckle-tracking echocardiography for prediction of global and segmental functional changes after acute myocardial infarction: A comparison with late gadolinium enhancement cardiac magnetic resonance[J].J Am Soc Echocardiogr,2014,27(3):249-257.
[3] Widimsky P,Coram R,Abou-Chebl A, et al.Reperfusion therapy of acute ischaemic stroke and acute myocardial infarction: Similarities and differences[J].Eur Heart J,2014,35(3):147-155.
[4] Sambola A,Francisco J,García-DelBlanco B, et al.Tissue factor pathway inhibitor is an early biomarker of myocardial injury in patients with ST-segment elevation acute myocardial infarction[J].Int J Cardiol,2014,172(1):279-281.
[5] 武国东,邹颖刚,及志勇,等.血栓抽吸术在急性ST段抬高心肌梗死介入治疗中的疗效[J].中国老年学杂志,2014,11(16):4448-4450.
[6] Usami M,Sakata Y,Nakatani D, et al.Clinical impact of acute hyperglycemia on development of diabetes mellitus in non-diabetic patients with acute myocardial infarction[J].J Cardiol,2014,63(3/4):274-280.
[7] 周勇,黄松群,徐飞,等.术前与术中使用替罗非班对急性ST段抬高心肌梗死急诊介入治疗慢血流的比较及安全性[J].中国临床药理学与治疗学,2014,19(11):1268-1271.
[8] 张东伟,康艳霞,刘丽媛,等.替格瑞洛对急性 ST 段抬高型心肌梗死患者急诊经皮冠状动脉介入治疗术中慢血流的影响研究[J].实用心脑肺血管病杂志,2015,23(9):7-9,10.
[9] 郑卫峰,王晓阳,张守彦,等.H型高血压与急性心肌梗死患者急诊经皮冠状动脉介入治疗术后发生慢血流的相关性[J].中国动脉硬化杂志,2015,23(10):1035-1038.
[10] 吴永辉,吴立华,任凤学,等.冠状动脉慢血流现象相关危险因素的分析[J].北京医学,2014,36(5):347-349.
[11] 刘文民,陈国藩,菅颖,等.长期应用他汀类药物对急性心肌梗死PCI术中慢血流或无复流现象的影响[J].医学研究杂志,2014,43(6):104-107.
[12] 郭金成,李静,李东宝,等.经灌注球囊冠状动脉注射维拉帕米处理介入术中慢血流与无复流的疗效[J].中华老年心脑血管病杂志,2015,17(10):1025-1027.
[13] 孙保中,杨希营,隽兆东等.脂肪乳剂联合肾上腺素对布比卡因中毒羊血流动力学的影响[J].医学综述,2015,21(14):2620-2622.
[14] 王洋,徐烨华,熊爱琴,等.氧化苦参碱抑制异丙肾上腺素诱导大鼠慢性心力衰竭及对ADMA代谢通路的影响[J].中国中药杂志,2014,39(3):471-477. |
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2018, Vol. 35 
