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| Effects of Different Blood Purification Methods on Inflammatory Factors and Related Indicators in Patients with End-stage Renal Disease |
| Tan Hui-feng, CAO Pei-lian |
| Zhangjiagang Hospital of Traditional Chinese Medicine, Medical School of Nanjing University, Jiangsu Zhangjiagang 215600 |
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Abstract 【Objective】To investigate the effects of two different blood purification methods on the levels of inflammatory factors, blood urea nitrogen (BUN), parathyroid hormone (PTH) and β2-microglobulin (β2-MG) in patients with end-stage renal disease (ESRD). 【Methods】A total of 80 cases of patients undergoing maintenance hemodialysis (MHD) were divided into two groups: group A with routine hemodialysis and group B with routine hemodialysis combined with hemoperfusion (HP), with 40 cases in each group. After 6 months of treatment, the residual renal function (RRF) was calculated. The levels of BUN, C reactive protein (CRP), interleukin -6 (IL-6), plasma homocysteine (Hcy), PTH and β2-MG were determined. 【Results】After hemodialysis, the value of RRF and BUN decreased in both groups; however, RRF and BUN in group B were higher than those in group A (P<0.05). After hemodialysis, levels of CRP, IL-6, Hcy, PTH and β2-MG in group B were lower than those before hemodial4ysis (P<0.05), but these indices did not undergo much change after hemodialysis compared to before in group A. So, there were significant differences between the two groups after hemodialysis (P<0.05). 【Conclusion】Compared to routine hemodialysis, hemodialysis combined with hemoperfusion can clear inflammatory factors as well as PTH and β2-MG in patients with ESRD, and reduce the damage to RRF.
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Received: 31 March 2017
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2018, Vol. 35 
