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| Correlation between Molecular Margin and Clinical Factors of Laryngeal Carcinoma and its Prognosis |
| ZHANG Hong-lei, LI Da-peng, LI Jia, et al |
| Department of ENT, Affiliated Hospital of Beijing Air Force Aviation Medical Research Institute, Beijing 100089 |
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Abstract 【Objective】 To investigate the relationship between molecular cutting edge and clinical factors of laryngeal carcinoma and its prognosis.【Methods】The clinical data of 129 patients with laryngeal cancer who underwent surgical treatment from January 2010 to December 2011 were collected. All patients were followed up until September 2016 or death at the end of the year, and were divided into two groups according to recurrent or not: recurrence group (47 cases) and non recurrence group (82 cases). The correlation between the molecular margin and clinical factors of the two groups of laryngocarcinoma and prognosis were discussed.【Results】The proportion of subglottic tumor in T3~T4 stage, middle and low differentiation carcinoma with cervical lymph node metastasis was significantly higher than that in the non-recurrence group (P<0.05). There was no significant difference in sex, age and postoperative radiotherapy between the two groups (P>0.05). The expression of cyclind1 and composition ratio in the recurrent group was significantly higher than that in the non-recurrence group (P<0.05). The positive expression rate of P27 in the recurrent group was lower than that in the non-recurrent group (P<0.05). The positive expression rate of P53 eIF4E was significantly higher than that of the non-recurrence group (P<0.05). The linear regression equation was established. The results of Spearman relation test showed that the expression of cyclind1 in the molecular cutting edge was positively correlated with the prognosis(r=0.716,P=0.002).P53 and eIF4E were positively correlated with the prognosis(r=0.616,0.928,P=0.014,0.000)and there was a negative correlation between the P27 and the prognosis(r=-0.741,P=0.012).【Conclusion】The molecular cut edge of laryngeal carcinoma is closely related to prognosis. At the same time, cervical lymph node metastasis accompanied, higher T stage and tumor located in the subglottic are the main factors affecting the prognosis of laryngeal carcinoma.
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Received: 18 May 2017
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2018, Vol. 35 
