他莫昔芬联合二甲双胍对多囊卵巢综合征合并不孕症患者脂代谢及预后的影响

doi:10.3969/j.issn.1671-7171.2018.05.015

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Abstract 【Objective】To investigate the effect of tamoxifen and metformin on lipid metabolism and prognosis in women with polycystic ovary syndrome (PCOS) complicated with infertility. 【Methods】A total of 108 cases of PCOS complicated with infertility were selected from January 2014 to June 2016 in our hospital. According to the random number method, patients were divided into the study group (54 cases) and the control group (54 cases). Patients in the control group received tamoxifen and patients in the study group were treated with tamoxifen and metformin. All patients started administration at d5 after menstrual period, and 21 days of continuous treatment was a cycle. The patient received the same procedure again at d5 of the next menstruation, and a total of 3 cycles were given. At the fourth menstrual period d5, ovulation induction therapy was used and follicular clinical monitoring was performed at d10. To evaluate the clinical effect of patients, luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol (E₂), prolactin (PRL), and testosterone (T) were detected before and after treatment in the two groups. Meanwhile lipid metabolism indicators like total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A (apo A) and apolipoprotein B (apo B) were also detected. All patients were followed for one year, and the ovulation and pregnancy status of the two groups were compared.【Results】The total effective rate of patients in the study group after treatment was significantly higher than that in the control group, the difference was statistically significant (P<0.05). After treatment, the levels of LH, E₂, and T in the two groups of patients decreased significantly, and the study group had a more significant decrease, with a statistically significant difference (P<0.05).While the levels of TC, TG, HDL-C, LDL-C, apo A and apo B were significantly increased in the two groups after treatment.TG and HDL-C levels were significantly higher than those in the control group, while the LDL-C and apo B levels were significantly lower than those in the control group; the differences were statistically significant (P<0.05). After follow-up, the normal ovulation rate and pregnancy rate in the study group were significantly higher than those in the control group, the differences were statistically significant (P<0.05). 【Conclusion】Tamoxifen combined with metformin can effectively improve the clinical symptoms of polycystic ovary syndrome with infertility patients, regulate the body's sex hormone levels and balance of lipid metabolism, promote normal ovulation to increase the ovulation rate and pregnancy rate of patients. It is worthy of clinical promotion.

Key words： Tamoxifen/PD Metformin/PD PolycysticOvarySyndrome/CO Infertility,Female/ET Fats/ME

Received: 18 September 2017

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R711.75

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	ZHANG Qin

Cite this article:

ZHANG Qin. Effects of Tamoxifen and Metformin on Lipid Metabolism and Prognosis in Women with Polycystic Ovary Syndrome Complicated with Infertility[J]. JOURNAL OF CLINICAL RESEARCH, 2018, 35(5): 879-882.

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2018.05.015 OR http://www.jcr.net.cn/EN/Y2018/V35/I5/879

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