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Quick Search     Adv Search 2025 Vol. 42, No. 12 Published: 2025-12-26 Original Articles          Original Articles 2017 Correlation Analysis of Imaging Manifestations and Pathological Features of Pancreatoblastoma in Children PENG Yaozong, YIN Yiwei, LI Chunwang, et al DOI: 10.3969/j.issn.1671-7171.2025.12.001 【Objective】 To explore the correlation between imaging manifestations and pathological features of pancreatoblastoma in children, and to improve the diagnostic accuracy of this disease.【Methods】 The clinical data of 9 children pathologically confirmed as pancreatoblastoma after surgery were retrospectively analyzed. The CT and MRI imaging data of the children were detailedly analyzed and compared with the pathological results. 【Results】 The tumors occurred in the pancreatic head region in 3 cases, in the pancreatic body region in 5 cases, and in both the pancreatic body and tail regions in 1 case. CT showed mixed-density masses with lobulated shapes; necrosis and calcification were observed in all 9 cases. The masses showed heterogeneous mild enhancement in the arterial phase of enhanced scan, and progressive enhancement in 6 cases. On MRI, the masses presented low signal or intermediate signal intensity on T1WI and isointense or hyperintense signal intensity on T2WI, with heterogeneous enhancement after contrast administration; main pancreatic duct dilatation was found in 1 case. Tumors with clear boundaries on imaging usually had relatively complete fibrous capsules on histopathological sections, while those with blurred boundaries often indicated that tumor cells infiltrated into the surrounding tissues with incomplete or absent capsules. The enhancement pattern of tumors on imaging was closely related to the vascular distribution of tumors on histopathological sections. 【Conclusion】 Pancreatoblastoma has certain characteristic manifestations on different imaging examinations and is closely correlated with pathological changes. Imaging examinations play an important role in the diagnosis, differential diagnosis and preoperative evaluation of pancreatoblastoma in children. Combining with pathological features can further improve the accuracy and reliability of diagnosis, providing a strong basis for formulating clinical treatment plans. 2025 Vol. 42 (12): 2017-2020 [Abstract] ( 12 ) HTML (1 KB)  PDF (2801 KB)  ( 3 ) 2021 Expression Level and Significance of circ_0000847 in Lung Cancer Tissues DING Lingyan, TANG Zhaohui, LI Lizhi DOI: 10.3969/j.issn.1671-7171.2025.12.002 【Objective】 To investigate the expression level and significance of circ_0000847 in lung cancer tissues. 【Methods】 Lung cancer tissues and adjacent normal tissues were collected from 29 patients with lung cancer who underwent surgical treatment in our hospital from June 2017 to June 2022. Normal bronchial epithelial cell line HBE and lung cancer cell lines H1299 and A549 were selected. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression level of circ_0000847 in each tissue and cell line. H1299 and A549 cells in logarithmic growth phase were transfected with si-NC (si-NC group) and si-circ_0000847 (si-circ_0000847 group), respectively. At 48 hours after transfection, methyl thiazolyl tetrazolium (MTT) colorimetry, flow cytometry and Transwell assay were used to detect and compare cell viability, apoptosis and invasion ability. 【Results】 The relative expression level of circ_0000847 in lung cancer tissues was significantly higher than that in adjacent tissues (P<0.05). Before transfection, the relative expression levels of circ_0000847 in H1299 and A549 cells were significantly higher than those in HBE cells (P<0.05). After transfection, compared with the si-NC group, the relative expression level of circ_0000847 in H1299 and A549 cells in the si-circ_0000847 group was significantly decreased (P<0.05). Compared with the si-NC group, the cell viability of H1299 and A549 cells in the si-circ_0000847 group was decreased (P<0.05), the apoptosis rate was increased (P<0.05), and the number of invasive cells was decreased (P<0.05). 【Conclusion】 circ_0000847 is highly expressed in lung cancer tissues and is involved in the proliferation and invasion of lung cancer cells. Interference with circ_0000847 expression reduces the proliferation and invasion of lung cancer cells and increases their apoptosis. 2025 Vol. 42 (12): 2021-2024 [Abstract] ( 13 ) HTML (1 KB)  PDF (1880 KB)  ( 1 ) 2025 Correlation Study Between Body Composition and Vitamin D Levels in School-Age Children LI Songting, ZHAO Sha, JIANG Yaohui, et al DOI: 10.3969/j.issn.1671-7171.2025.12.003 【Objective】 To investigate the correlation between body composition indices and vitamin D levels in school-age children. 【Methods】 A total of 440 school-age children aged 7-12 years who visited the outpatient department of Child Health Care in Hunan Children's Hospital from March to September 2020 were enrolled. According to their vitamin D levels, the children with vitamin D deficiency or insufficiency were assigned to the abnormal vitamin D group (n=171), and those with sufficient vitamin D were assigned to the normal vitamin D group (n=269). Bioelectrical impedance analysis was used to measure body composition indices including body fat mass (BF), protein, mineral salts, total body water, skeletal muscle mass (SMM), visceral fat area (VFA), waist-to-hip ratio (WHR), and body fat percentage (BFP). Pearson correlation coefficient was used to analyze the correlation between body composition indices and serum 25-hydroxyvitamin D [25-(OH)D] levels, and logistic regression analysis was performed to evaluate the effects of different body composition indices on vitamin D nutritional status. 【Results】 The levels of BF, protein, mineral salts, total body water, SMM and VFA in the normal vitamin D group were significantly lower than those in the abnormal vitamin D group (P<0.05). Pearson correlation analysis showed that BF, protein, mineral salts, total body water, SMM, VFA, WHR and BFP were all negatively correlated with vitamin D levels, with statistically significant differences (P<0.05). Multivariate logistic regression analysis revealed that the regression coefficient of BF was 0.172, with an odds ratio (OR) of 1.187 [95% confidence interval(CI):1.004, 1.404] (P<0.05); the regression coefficient of WHR was 6.365, with an OR of 581.434 (95%CI: 12.150, 27 824.271) (P<0.05). 【Conclusion】 Body composition indices are correlated with vitamin D levels in school-age children. Among these indices, body fat mass and waist-to-hip ratio are predictive variables for abnormal vitamin D status. 2025 Vol. 42 (12): 2025-2027 [Abstract] ( 12 ) HTML (1 KB)  PDF (1238 KB)  ( 1 ) 2028 Risk Factors and Nomogram Prediction Model for Intracranial Infection after Artificial Dura Mater Patch Implantation FENG Jixiang, ZENG Lei, JIANG Xiaolong, et al DOI: 10.3969/j.issn.1671-7171.2025.12.004 【Objective】 To investigate the risk factors for intracranial infection following artificial dura mater patch implantation (ADMP) and to establish a risk prediction model.【Methods】 The clinical data of 231 patients who underwent ADMP were retrospectively analyzed. Multivariate logistic regression analysis was used to identify independent risk factors for postoperative intracranial infection, and a nomogram prediction model was constructed based on the results. The model's performance was evaluated using the receiver operating characteristic (ROC) curve, calibration curve, and decision curve analysis (DCA).【Results】 Among the 231 patients, 23 cases (9.96%) developed intracranial infection. Multivariate logistic regression analysis revealed that prolonged operative time, graft type, preoperative infection history, and cerebrospinal fluid (CSF) leakage were independent risk factors for postoperative intracranial infection (P<0.05). The nomogram model demonstrated an area under the curve (AUC) of 0.933. The calibration curve indicated good agreement between predicted and observed risks of intracranial infection. Decision curve analysis showed that the model could effectively improve the accuracy of clinical decision-making.【Conclusion】 Prolonged operative time, graft type, preoperative infection history, and CSF leakage significantly increase the risk of intracranial infection after ADMP. The prediction model based on these factors exhibits good discrimination and calibration, providing valuable reference for early identification of high-risk patients and optimization of clinical management strategies. 2025 Vol. 42 (12): 2028-2031 [Abstract] ( 10 ) HTML (1 KB)  PDF (1262 KB)  ( 3 ) 2032 Diagnostic Value of Cranial MRI Combined with Transcranial Sonography of the Substantia Nigra in Differentiating Parkinson's Disease from Vascular Parkinsonism ZHENG Shiru, REN Yafang, WANG Chunhui, et al DOI: 10.3969/j.issn.1671-7171.2025.12.005 【Objective】 To investigate the diagnostic value of cranial magnetic resonance imaging (MRI) combined with transcranial sonography (TCS) of the substantia nigra in differentiating Parkinson's disease (PD) from vascular parkinsonism (VPS).【Methods】 Thirty-eight PD patients (the PD group), 30 VPS patients (the VPS group), and 37 healthy volunteers (the control group) were enrolled. Cranial MRI and TCS findings were compared among the three groups. Receiver operating characteristic (ROC) curves were used to analyze the diagnostic value of MRI and TCS for PD and VPS.【Results】 The width of the pars compacta of the substantia nigra (WPCSN) and the WPCSN/midbrain diameter ratio were significantly lower in both the PD and VPS groups compared to the control group, with the PD group showing lower values than the VPS group (all P<0.05). The bilateral hyperechogenic areas of the substantia nigra, the total hyperechogenic area, and the ratio of hyperechogenic area to total midbrain area (S/M) in the PD and VPS groups were significantly higher than those in the control group, and they were higher in the PD group than in the VPS group (all P<0.05). Among the individual MRI and TCS parameters, the bilateral S/M showed the highest diagnostic value for differentiating PD from VPS. Combined MRI and TCS assessment demonstrated higher diagnostic performance than any single MRI or TCS parameter.【Conclusion】 The combined application of both cranial MRI and TCS can significantly improve the diagnostic efficiency in distinguishing PD from VPS, providing a valuable and noninvasive imaging basis for accurate clinical differentiation. 2025 Vol. 42 (12): 2032-2034 [Abstract] ( 12 ) HTML (1 KB)  PDF (1262 KB)  ( 2 ) 2035 Predictive Value of Dynamic Monitoring of Minimal Residual Disease Levels after Induction Chemotherapy for Short-Term Prognosis in Children with Acute Myeloid Leukemia SUN Jia, LIU Junshan, XIE Xin DOI: 10.3969/j.issn.1671-7171.2025.12.006 【Objective】 To investigate the predictive value of dynamic monitoring of minimal residual disease (MRD) levels after induction chemotherapy for short-term prognosis in children with acute myeloid leukemia (AML).【Methods】 Ninety-six children with AML were enrolled and divided into a poor prognosis group (n=35) and a good prognosis group (n=61) according to disease progression within 12 months after completion of chemotherapy. Clinical parameters and MRD levels after the first and second courses of induction chemotherapy were compared between the two groups. The dynamic MRD evolution patterns and their predictive value for prognosis were analyzed based on MRD results.【Results】 There were no significant differences in age, sex, or French-American-British(FAB) classification between the two groups (P>0.05). Compared with the good prognosis group, the poor prognosis group had higher initial white blood cell (WBC) counts, higher Charlson Comorbidity Index (CCI) scores, a greater proportion of bone marrow blasts ≥50%, and a higher incidence of high-risk chromosome karyotypes, while platelet counts (PLT) were lower (P<0.05). The MRD-positive rates after the first and second induction chemotherapy cycles in the poor prognosis group were significantly higher than those in the good prognosis group (P<0.05). The distribution of dynamic MRD evolution patterns differed significantly between the two groups (P<0.05), with the persistent positive pattern predominating in the poor prognosis group. Receiver operating characteristic (ROC) curve analysis showed that MRD positivity after the first and second induction chemotherapy cycles, as well as dynamic MRD evolution patterns, could effectively predict relapse risk in children with AML. The dynamic MRD evolution demonstrated superior predictive performance (P<0.05).【Conclusion】 The dynamic evolution pattern of MRD provides better predictive value for relapse risk in children with AML than single-point MRD detection after the first or second induction chemotherapy, and can serve as an important reference indicator for prognosis assessment. 2025 Vol. 42 (12): 2035-2038 [Abstract] ( 11 ) HTML (1 KB)  PDF (1234 KB)  ( 1 ) 2039 Relationship of the Expression of Long Non-Coding RNAs SNHG16 and SNHG19 in Breast Cancer Tissues with Pathological Features and Prognosis LIU Sujuan, ZHOU Xiaofen, WANG Dapeng DOI: 10.3969/j.issn.1671-7171.2025.12.007 【Objective】 To investigate the correlation between the expression levels of long non-coding RNA(LncRNA) SNHG16 and SNHG19 in breast cancer tissues and the pathological characteristics as well as prognosis of patients.【Methods】 The expression levels of LncRNA SNHG16 and SNHG19 were detected in breast cancer tissues and adjacent normal tissues from 98 patients with breast cancer. Their associations with pathological features and prognosis were analyzed.【Results】 The expression levels of LncRNA SNHG16 and SNHG19 in breast cancer tissues were significantly higher than those in adjacent normal tissues (both P<0.05). Patients with high expression levels of LncRNA SNHG16 and SNHG19 had significantly lower 3-year survival rates than those with low expression (both P<0.05). The expression levels of LncRNA SNHG16 and SNHG19 were significantly correlated with patient age, estrogen receptor (ER) status, progesterone receptor (PR) status, and lymph node metastasis (all P<0.05). Additionally,LncRNA SNHG19 expression was significantly associated with TNM staging (P<0.05). Advanced age, ER negativity, PR negativity, TNM stage Ⅲ-Ⅳ, lymph node metastasis, high LncRNA SNHG16 expression, and high LncRNA SNHG19 expression were all risk factors affecting patient prognosis (all P<0.05).【Conclusion】 LncRNA SNHG16 and SNHG19 may act as important biomarkers for poor prognosis in breast cancer. They can provide references for diagnosis, prognostic evaluation, and treatment of breast cancer. 2025 Vol. 42 (12): 2039-2041 [Abstract] ( 11 ) HTML (1 KB)  PDF (1232 KB)  ( 3 ) 2042 Clinical Application Effect of Endoscopic Retrograde Cholangiopancreatography without Nasobiliary Drainage in the Treatment of Common Bile Duct Stones HE Ju, HUANG Xin, QIU Xuejiao DOI: 10.3969/j.issn.1671-7171.2025.12.008 【Objective】 To investigate the clinical application effect of endoscopic retrograde cholangiopancreatography (ERCP) without nasobiliary drainage in the treatment of common bile duct stones. 【Methods】 The clinical data of 94 patients with common bile duct stones who underwent ERCP in our hospital from January 2021 to December 2023 were retrospectively analyzed. According to whether nasobiliary drainage was placed or not, the patients were divided into the observation group (without nasobiliary drainage, n=50) and the control group (with nasobiliary drainage, n=44). The perioperative indicators, incidence of complications, residual stone rate and recurrence rate were compared between the two groups. The serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBIL) before and after surgery, as well as the serum amylase (AMY) level 3 hours before and after surgery were compared between the two groups. 【Results】 The operation time, total hospitalization time and postoperative hospitalization time in the observation group were shorter than those in the control group, with statistically significant differences (P<0.05). There were no statistically significant differences in the intraoperative blood loss and Numerical Rating Scale (NRS) scores between the two groups (P>0.05). After surgery, the serum levels of ALT, AST and TBIL in both groups were lower than those before surgery, with statistically significant differences (P<0.05). There were no statistically significant differences in the serum levels of AMY, ALT, AST and TBIL between the two groups (P>0.05). There were no statistically significant differences in the incidences of postoperative abdominal infection or cholangitis, pancreatitis, gastrointestinal bleeding, hyperamylasemia and intestinal perforation between the two groups (P>0.05). There were no statistically significant differences in the postoperative residual bile duct stones and stone recurrence within half a year after surgery between the two groups (χ2=0.013, 0.033, all P>0.05). 【Conclusion】 ERCP has a good clinical effect in the treatment of common bile duct stones. On the premise of mastering the indications, the treatment scheme without nasobiliary drainage is safe and feasible. 2025 Vol. 42 (12): 2042-2045 [Abstract] ( 12 ) HTML (1 KB)  PDF (1204 KB)  ( 1 ) 2046 Effect of Phase Ⅰ Cardiac Rehabilitation on Cardiac Function and Serum STIM1 Level in STEMI Patients after Emergency PCI QIAN Yijun, ZHANG Yueyue, NI Ye, et al DOI: 10.3969/j.issn.1671-7171.2025.12.009 【Objective】 To investigate the effect of Phase Ⅰ cardiac rehabilitation on cardiac function and serum stromal interaction molecule 1 (STIM1) level in patients with ST-segment elevation myocardial infarction (STEMI) after emergency percutaneous coronary intervention (PCI). 【Methods】 A total of 100 STEMI patients who underwent emergency PCI in the Changhai Hospital and the Kongjiang Hospital from January to December 2024 were selected and randomly divided into a control group and a rehabilitation group, with 50 cases in each group. The control group received routine treatment after emergency PCI, while the rehabilitation group received Phase Ⅰ cardiac rehabilitation on the basis of routine treatment. Left ventricular ejection fraction (LVEF), N-terminal pro-brain natriuretic peptide (NT-proBNP) level, STIM1 level, physical component summary (PCS) score, mental component summary (MCS) score, peak oxygen uptake (VO2/kg), metabolic equivalent (MET), oxygen pulse (VO2/HR), ventilation-to-carbon dioxide production ratio (VE/VCO2 slope) and the occurrence of major adverse cardiovascular events (MACE) were compared between the two groups before treatment and 1 month after treatment. 【Results】 One month after treatment, the LVEF, PCS score and MCS score in the rehabilitation group were significantly higher than those in the control group (P<0.05), while the serum levels of NT-proBNP and STIM1 were significantly lower than those in the control group (P<0.05). The peak VO2/kg, MET and VO2/HR in the rehabilitation group were higher than those in the control group (P<0.05), and the VE/VCO2 slope was lower than that in the control group (P<0.05). There was no significant difference in the incidence of MACE between the two groups (P>0.05). 【Conclusion】 Phase Ⅰcardiac rehabilitation has a significant improvement effect on STEMI patients after emergency PCI. It can not only effectively improve cardiac function, reduce the risk of heart failure, but also enhance the quality of life and alleviate psychological burden of the patients. It may also promote patient recovery by reducing serum STIM1 level, which has good clinical promotion value. 2025 Vol. 42 (12): 2046-2049 [Abstract] ( 9 ) HTML (1 KB)  PDF (1252 KB)  ( 1 ) 2050 Distribution Characteristics and Antibiotic Resistance Analysis of Pathogens Causing Urinary Tract Infections in Patients with Chronic Kidney Disease WANG Xia, YU Xia, WANG Ping, et al DOI: 10.3969/j.issn.1671-7171.2025.12.010 【Objective】 To investigate the distribution characteristics and antibiotic resistance of pathogens causing urinary tract infections (UTIs) in patients with chronic kidney disease (CKD). 【Methods】 A retrospective analysis was conducted on 1413 CKD patients. Urine culture specimens were subjected to microbial identification and antibiotic susceptibility testing. The infection characteristics and drug resistance patterns of the pathogens were analyzed. 【Results】 Among the 1413 specimens, 223 were urine culture-positive, with a positive rate of 15.78%. The positive rate in male patients was 15.37% (95/618) and the positive rate in female patients was 16.10% (128/795), with no statistically significant difference between the two groups (P>0.05). Among the Gram-negative bacteria (G-) isolated from CKD patients, Escherichia coli was the most common (23.39%), followed by Klebsiella pneumoniae (14.92%) and Enterobacter faecalis (13.71%). The resistance rates of E. coli to ceftriaxone and levofloxacin both exceeded 80.00%, while K. pneumoniae showed the highest resistance to levofloxacin (81.08%). Both pathogens remained highly sensitive to imipenem and amikacin, with resistance rates below 10.00%. Among the main Gram-positive bacteria (G+), Enterococcus faecalis exhibited 100.00% resistance to ceftriaxone, and Enterococcus faecium showed 100.00% resistance to ceftazidime. These two major G+ isolates were fully susceptible to vancomycin and linezolid. 【Conclusion】 The pathogens causing urinary tract infections in CKD patients are diverse, with Escherichia coli being the most common. The isolated pathogens exhibit varying resistance patterns, highlighting the importance of selecting antibiotics based on pathogen-specific resistance profiles in clinical practice. 2025 Vol. 42 (12): 2050-2053 [Abstract] ( 8 ) HTML (1 KB)  PDF (1198 KB)  ( 1 ) 2054 Clinical Efficacy of Warm Acupuncture Combined with Hanbi Decoction in the Treatment of Patients with Lumbar Disc Herniation of Cold-Dampness Obstruction Type YU Xiaoyue, XU Hongliang, WANG Huifang, et al DOI: 10.3969/j.issn.1671-7171.2025.12.011 【Objective】 To explore the clinical efficacy of warm acupuncture combined with Hanbi Decoction in the treatment of patients with lumbar disc herniation of cold-dampness obstruction type. 【Methods】 A total of 100 patients with lumbar disc herniation of cold-dampness obstruction type diagnosed and treated in our hospital from January 2023 to January 2025 were selected and divided into a control group and an observation group according to the random number table method, with 50 cases in each group. The control group was treated with warm acupuncture alone, while the observation group was treated with warm acupuncture combined with Hanbi Decoction on the basis of the control group. The clinical efficacy, Oswestry Disability Index (ODI) score, Visual Analogue Scale (VAS) score, Japanese Orthopaedic Association (JOA) score and lumbar mobility were compared between the two groups before treatment and 5 weeks after treatment. 【Results】 The total effective rate of treatment in the observation group was significantly higher than that in the control group (P<0.05). Five weeks after treatment, the ODI score and VAS score of the observation group were lower than those of the control group, while the JOA score and lumbar mobility were higher than those of the control group, with statistically significant differences (all P<0.05).【Conclusion】 Warm acupuncture combined with Hanbi Decoction has a significant clinical efficacy in the treatment of lumbar disc herniation of cold-dampness obstruction type, which can effectively relieve pain and improve lumbar function and mobility. 2025 Vol. 42 (12): 2054-2056 [Abstract] ( 10 ) HTML (1 KB)  PDF (1233 KB)  ( 2 ) 2057 Effect of Hippocampal-Avoidance Radiotherapy or Hippocampal-Avoidance Stereotactic Radiotherapy under CT and MRI Image Fusion on the Efficacy and Cognitive Function in Patients with Brain Metastases WU Yali, CAI Lihong DOI: 10.3969/j.issn.1671-7171.2025.12.012 【Objective】 To investigate the efficacy and impact on neurocognitive function of hippocampal-avoidance whole-brain radiotherapy (HA-WBRT) or Hippocampal-Avoidance stereotactic radiotherapy(HA-SRT) guided by CT and MRI image fusion in patients with brain metastases.【Methods】 Forty patients with brain metastases who underwent HA-WBRT were evaluated for clinical efficacy and safety six months after treatment. Neurocognitive function and quality of life (QoL) were compared before treatment and at 1, 3, and 6 months after treatment.【Results】 At 6 months post-treatment, the overall response rate was 75.00% (30/40), the overall survival rate was 90.00% (36/40), and the intracranial progression-free rate was 87.50% (35/40). There were no statistically significant differences in the proportion of patients with normal cognitive function before and at 1, 3, and 6 months after treatment (P>0.05). One month after treatment, there was no statistically significant difference in the patients' Mini-Mental State Examination (MMSE) scores compared with those before treatment (P>0.05). At 3 and 6 months after treatment, the patients' MMSE scores were higher than those before treatment (P<0.05). There were no statistically significant differences in MMSE scores at different time points after treatment (P>0.05). The QoL scores decreased progressively at 1, 3, and 6 months after treatment; And all QoL scores were significantly lower than before treatment (P<0.05), with significant differences among those post-treatment time points (P<0.05).【Conclusion】 CT/MRI image fusion-guided HA-WBRT or HA-SRT demonstrates favorable therapeutic efficacy in patients with brain metastases, effectively reducing the risk of neurocognitive impairment and improving quality of life. 2025 Vol. 42 (12): 2057-2060 [Abstract] ( 11 ) HTML (1 KB)  PDF (1202 KB)  ( 1 ) 2061 Predictive Value of Combined Detection of Sex Hormone levels, Uterine Ultrasound Parameters and Bone Age Index in Girls with Rapidly Progressive Central Precocious Puberty WEN Huan, LIU Lingping, LIU Jinqiao DOI: 10.3969/j.issn.1671-7171.2025.12.013 【Objective】 To explore the predictive value of combined detection of sex hormone levels, uterine ultrasound parameters and bone age index in girls with rapidly progressive central precocious puberty (RP-CPP). 【Methods】 A total of 168 girls initially diagnosed with central precocious puberty (CPP) in our hospital from January to December 2023 were selected as the research subjects. According to the progression rate of puberty, they were divided into the RP-CPP group (n=88) and the slowly progressive central precocious puberty (SP-CPP) group (n=80). The clinical data of the two groups were compared. Multivariate Logistic regression analysis was used to identify the influencing factors for the progression of CPP to RP-CPP in girls. Receiver operating characteristic (ROC) curve was adopted to analyze the predictive value of uterine volume and bone age index for the progression of CPP to RP-CPP in girls. 【Results】 There were significant differences in height, weight, body mass index (BMI), luteinizing hormone, follicle-stimulating hormone, bone age index, uterine volume and mean ovarian volume between the RP-CPP group and the SP-CPP group at the initial diagnosis (P<0.05). Logistic regression analysis showed that bone age index and uterine volume were the influencing factors for the progression of CPP to RP-CPP in girls. ROC curve analysis indicated that when the bone age index was 1.20, the area under the curve (AUC) of bone age index for predicting the progression of CPP to RP-CPP in girls was 0.686; when the uterine volume was 1.664 mL, the AUC of uterine volume for predicting the progression of CPP to RP-CPP in girls was 0.805. 【Conclusion】 Bone age index and uterine volume have certain predictive value for the progression of CPP to RP-CPP in girls. When the bone age index is 1.20 and the uterine volume is 1.664 mL, it suggests a high possibility of CPP progressing to RP-CPP in girls, and these indicators can be used as auxiliary indexes for the diagnosis of RP-CPP. 2025 Vol. 42 (12): 2061-2063 [Abstract] ( 8 ) HTML (1 KB)  PDF (1251 KB)  ( 2 ) 2064 Application of DSA-Based 3D Technology in Neurointerventional Thrombectomy for Patients with Ischemic Stroke XU Longwei, XIANG Guangyu, HE Zhigang DOI: 10.3969/j.issn.1671-7171.2025.12.014 【Objective】 To investigate the application of three-dimensional (3D) technology based on digital subtraction angiography (DSA) in neurointerventional thrombectomy for patients with acute ischemic stroke (AIS).【Methods】 A total of 72 AIS patients were randomly divided into an observation group and a control group, with 36 patients in each group. The control group received intravenous thrombolytic therapy, while the observation group underwent neurointerventional thrombectomy assisted by DSA-based 3D technology in addition to intravenous thrombolysis. The vascular recanalization rate and cerebral hemodynamic parameters[middle cerebral arterial mean velocity (MV), cerebrovascular resistance (RV), and pulsatility index (PI)] were compared between the two groups at 1 week after treatment. Neurological function including modified Rankin Scale (mRS) score and National Institutes of Health Stroke Scale (NIHSS) score was assessed before treatment, at 1 week, and at 3 months after treatment.【Results】 At 1 week after treatment, the vascular recanalization rate in the observation group was higher than that in the control group. The observation group had a higher MV and lower RV and PI than the control group (P< 0.05). The mRS and NIHSS scores of the observation group were significantly lower than those of the control group at both 1 week and 3 months (P< 0.05). The overall incidence of adverse reactions in the observation group was also lower than that in the control group (P< 0.05).【Conclusion】 DSA-based 3D technology-assisted neurointerventional thrombectomy can significantly improve vascular recanalization, enhance cerebral perfusion, promote neurological recovery in AIS patients, and has good safety. 2025 Vol. 42 (12): 2064-2067 [Abstract] ( 13 ) HTML (1 KB)  PDF (1205 KB)  ( 2 ) 2068 Application Effect of Modified Prone Position in Patients with Acute Respiratory Distress Syndrome YANG Li, HAN Xueying, YANG Yang DOI: 10.3969/j.issn.1671-7171.2025.12.015 【Objective】 To explore the application effect of modified prone position in patients with acute respiratory distress syndrome (ARDS).【Methods】 A total of 82 ARDS patients admitted to our hospital from June 2022 to January 2024 were selected and divided into a control group (given traditional prone position intervention) and an observation group (given modified prone position intervention) according to the time of admission, with 41 cases in each group. The respiratory mechanics indexes [chest wall compliance (Ccw), airway resistance (R)], hemodynamic indexes [mean arterial pressure (MAP), central venous pressure (CVP), heart rate (HR)], Murray Lung Injury Score, Marshall Multiple Organ Dysfunction Score, incidence of pressure injury, psychological status [Hamilton Anxiety Scale (HAMA) score and Hamilton Depression Scale (HAMD) score], and nursing quality score were compared between the two groups. 【Results】 After intervention, there were no significant differences in R, MAP, CVP and HR between the two groups (P>0.05); the Ccw of the observation group was higher than that of the control group (P<0.05); the Murray score, Marshall score, HAMA score, HAMD score and incidence of pressure injury in the observation group were lower than those in the control group (P<0.05); all nursing quality scores in the observation group were higher than those in the control group (P<0.05). 【Conclusion】 The application of modified prone position intervention in ARDS patients can improve the Ccw of patients, alleviate lung injury and multiple organ dysfunction, relieve anxiety and depression, reduce the incidence of pressure injury, and improve the overall intervention quality. 2025 Vol. 42 (12): 2068-2071 [Abstract] ( 10 ) HTML (1 KB)  PDF (1195 KB)  ( 1 ) 2072 Application of Bundled Operating Room Intervention in Hysteroscopic Resection of Endometrial Lesions LI Yaping, LI Wen, WANG Yajuan DOI: 10.3969/j.issn.1671-7171.2025.12.016 【Objective】 To explore the application effect of the bundled surgical room intervention in patients undergoing hysteroscopic endometrial lesion resection. 【Methods】 From February 2023 to February 2025, 100 patients who underwent hysteroscopic endometrial lesion resection in our hospital were selected and divided into the observation group (conventional surgical room intervention combined with bundled surgical room intervention) and the control group (conventional surgical room intervention) according to the random number table method, with 50 cases in each group. The heart rate, diastolic blood pressure, systolic blood pressure, coagulation function indicators [coagulation regulatory protein (TM), tissue-type plasminogen activator-inhibitor complex (t-PAIC)], stress response indicators [adrenocorticotropic hormone (ACTH), corticotropin-releasing hormone (CRH)] and patient satisfaction were compared between the two groups. 【Results】 After intervention, the heart rate, diastolic blood pressure, systolic blood pressure, ACTH and CRH levels in the observation group were lower than those in the control group (P<0.05), and the levels of TM, t-PAIC and patient satisfaction were higher than those in the control group (P<0.05). 【Conclusion】 The bundled surgical room intervention can effectively stabilize the vital signs of patients undergoing hysteroscopic endometrial lesion resection, reduce stress response, improve coagulation function, and increase patient satisfaction. 2025 Vol. 42 (12): 2072-2074 [Abstract] ( 13 ) HTML (1 KB)  PDF (1228 KB)  ( 2 ) 2075 Construction of a Predictive Model for Post-Stroke Epilepsy Cognitive Impairment Based on Neurotrophic Factors and Quantitative Electroencephalography Indicators LIU Xiao, LU Zhe DOI: 10.3969/j.issn.1671-7171.2025.12.017 【Objective】 To investigate the development of a predictive model for post-stroke epilepsy cognitive impairment (PSCI) in elderly patients, based on neurotrophic factors and quantitative electroencephalography (QEEG) indicators.【Methods】 A total of 106 elderly patients with post-stroke epilepsy were enrolled. According to the Montreal Cognitive Assessment-Basic (MoCA-B) scores, patients were divided into the PSCI (post-stroke epilepsy cognitive impairment) group (79 cases) and the PSCN (post-stroke epilepsy cognitive normal) group (27 cases). Serum levels of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and QEEG indicators [α wave, β wave, θ wave, δ wave ratio,θ/α(TAR), and (θ+δ)/(α+β)(DTABR) ratio] were compared between the two groups. Binary logistic regression analysis was used to identify influencing factors of PSCI in elderly patients with post-stroke epilepsy. A nomogram prediction model was then constructed, and its predictive performance and accuracy were evaluated.【Results】 The PSCI group showed lower BDNF and α-wave ratio, and higher NGF, θ wave ratio, TAR, and DTABR compared with the PSCN group (all P<0.05). There were no statistically significant differences in β wave or δ wave between the two groups (P>0.05). Logistic regression analysis indicated that BDNF and α wave ratio were protective factors for PSCI, while NGF, θ wave, TAR, and DTABR were risk factors. Model validation demonstrated a concordance index of 0.932, with the calibration curve closely aligned with the ideal curve, indicating good accuracy and consistency.【Conclusion】 A predictive model based on neurotrophic factors and QEEG indicators can effectively assess the risk of cognitive impairment in elderly patients with post-stroke epilepsy, providing a valuable reference for clinical practice. 2025 Vol. 42 (12): 2075-2078 [Abstract] ( 11 ) HTML (1 KB)  PDF (1256 KB)  ( 2 ) 2079 Ultrasound Features of Juvenile Xanthogranuloma in Children HUANG Ting, HU yuan, LIU Jinqiao DOI: 10.3969/j.issn.1671-7171.2025.12.018 【Objective】 To explore the ultrasonic features of juvenile xanthogranuloma (JXG). 【Methods】 The ultrasonic image data of 25 children with JXG, who underwent surgical resection and were pathologically confirmed in our hospital from January 2018 to December 2025, were collected, and the ultrasonic features of JXG in children were analyzed. 【Results】 Among the 25 children with JXG, 22 cases were cutaneous juvenile xanthogranuloma (CJXG), and the main ultrasonic manifestations were single or multiple hypoechoic nodules in the subcutaneous soft tissue with clear boundaries and regular shapes. Some nodules had linear hyperechoic bands inside, and the blood flow signals inside the nodules were mainly punctate or no blood flow signals. Three cases were systemic juvenile xanthogranuloma (SJXG), involving in the liver 3 cases, in the kidney 1 case, and in the pancreas 1 case. The main manifestations were single or multiple homogeneous or heterogeneous hypoechoic nodules in different organs, with some nodules having linear hyperechoic bands inside and punctate blood flow signals inside. 【Conclusion】 The ultrasonic features of JXG have certain specificity and have clinical value for the auxiliary diagnosis of JXG. 2025 Vol. 42 (12): 2079-2081 [Abstract] ( 11 ) HTML (1 KB)  PDF (1313 KB)  ( 1 ) 2082 Application Effect of Percutaneous Minimally Invasive Pedicle Screw Internal Fixation Combined with Posterior Decompression and Bone Grafting in Elderly Patients with Spinal Fractures SHAO Xinwei, XU Songshan, ZHOU Jinge DOI: 10.3969/j.issn.1671-7171.2025.12.019 【Objective】 To explore the application effect of percutaneous minimally invasive pedicle screw internal fixation combined with posterior decompression and bone grafting in elderly patients with spinal fractures. 【Methods】 A total of 108 elderly patients with spinal fractures admitted to our hospital from January 2021 to December 2024 were selected and divided into the control group (treated with percutaneous minimally invasive pedicle screw internal fixation) and the observation group (treated with percutaneous minimally invasive pedicle screw internal fixation combined with posterior decompression and bone grafting), with 54 cases in each group. The surgical-related indicators, spinal function [Oswestry Disability Index (ODI) score], pain degree [Visual Analogue Scale (VAS) score], and vertebral body recovery were compared between the two groups. 【Results】 The intraoperative blood loss in the observation group was greater than that in the control group, and the operation time and incision healing time were longer than those in the control group (P<0.05). At 3 months after surgery, there was no statistically significant difference in the VAS score between the two groups (P>0.05). The ODI score in the observation group was lower than that in the control group (P<0.05), the posterior convex Cobb angle of the vertebral body in the observation group was smaller than that in the control group (P<0.05), and the anterior and middle height of the vertebral body were higher than those in the control group (P<0.05). 【Conclusion】 Although percutaneous minimally invasive pedicle screw internal fixation combined with posterior decompression and bone grafting prolongs the operation time and incision healing time and increases blood loss, it can more effectively improve the spinal function of patients with spinal fractures, correct vertebral body deformity, and maintain vertebral body height. 2025 Vol. 42 (12): 2082-2084 [Abstract] ( 10 ) HTML (1 KB)  PDF (1229 KB)  ( 1 ) 2085 Effect of Seamless Integrated Emergency Nursing on the Coma Degree of Patients with Severe Craniocerebral Trauma WEI Hailong, WANG Lei DOI: 10.3969/j.issn.1671-7171.2025.12.020 【Objective】 To investigate the effect of seamless integrated emergency nursing on coma in patients with severe craniocerebral trauma.【Methods】 A total of 96 patients with severe craniocerebral trauma were randomly divided into an observation group and a control group, with 48 cases in each group. The control group received routine emergency nursing, while the observation group received seamless integrated emergency nursing. Emergency outcomes, vital signs before and after intervention, coma degree [Glasgow Coma Scale (GCS) score], neurological function [National Institutes of Health Stroke Scale (NIHSS) score], and the incidence of complications were compared between the two groups.【Results】 After the intervention, the pre-hospital emergency response time, time from admission to surgical resuscitation, and operation time in the observation group were all shorter than those in the control group. The observation group had lower heart rate, systolic blood pressure, and diastolic blood pressure compared to the control group. The GCS score was higher and the NIHSS score was lower in the observation group than in the control group (P<0.05). The overall incidence of complications in the observation group was also lower than that in the control group (P<0.05).【Conclusion】 Seamless integrated emergency nursing can significantly shorten the emergency response and surgical resuscitation time for patients with severe craniocerebral trauma, reduce heart rate and blood pressure, improve GCS scores, lower NIHSS scores, and reduce the incidence of complications, thereby effectively improving patient prognosis. 2025 Vol. 42 (12): 2085-2088 [Abstract] ( 10 ) HTML (1 KB)  PDF (1197 KB)  ( 1 ) 2089 Intervention Effect of MAKS Combined with Reminiscence Therapy on Patients with Dementia SONG Kun, ZHANG Jihong DOI: 10.3969/j.issn.1671-7171.2025.12.021 【Objective】 To investigate the intervention effect of MAKS combined with reminiscence therapy on patients with dementia.【Methods】 Eighty patients with dementia were randomly divided into a control group and an observation group, with 40 patients in each group. The control group received routine interventions, while the observation group was treated with MAKS combined with reminiscence therapy. Differences in cognitive function [Montreal Cognitive Assessment (MoCA) score], agitated emotional and behavioral symptoms [Chinese version of the Cohen-Mansfield Agitation Inventory (CMAI) score], activities of daily living [Alzheimer's Disease Cooperative Study-Activities of Daily Living (ADCS-ADL) score], neuropsychiatric symptoms [Neuropsychiatric Inventory-Nursing Home Version (NPI-NH) score], and quality of life [Quality of Life in Alzheimer's Disease (QOL-AD) score] were compared between the two groups before and after the intervention.【Results】 After the intervention, the observation group had higher MoCA scores (P<0.05), lower CMAI scores in all items (P<0.05), higher ADCS-ADL scores (P<0.05), lower NPI-NH scores (P<0.05), and higher QOL-AD scores in all items (P<0.05)than those the control group.【Conclusion】 The application of MAKS combined with reminiscence therapy in the intervention for patients with dementia can effectively improve cognitive function, alleviate agitated emotional and behavioral symptoms, enhance activities of daily living, improve neuropsychiatric status, and enhance quality of life. 2025 Vol. 42 (12): 2089-2092 [Abstract] ( 10 ) HTML (1 KB)  PDF (1193 KB)  ( 2 ) 2093 Application Effect of Interactive Intervention Based on Mindfulness-Acceptance-Action Theory in Children with Mycoplasma Pneumonia WANG Lingling, LU Ping, ZHANG Jing DOI: 10.3969/j.issn.1671-7171.2025.12.022 【Objective】 To explore the application effect of interactive intervention based on the Mindfulness-Acceptance-Action Theory in children with mycoplasma pneumonia. 【Methods】 A total of 92 children with mycoplasma pneumonia admitted to our hospital from January 2023 to December 2024 were selected and divided into a control group (given routine intervention) and an observation group (given interactive intervention based on the Mindfulness-Acceptance-Action Theory) according to the random number table method, with 46 cases in each group. The treatment compliance, emotional state [Screen for Child Anxiety Related Emotional Disorders (SCARED) score], coping style [Coping Orientations to Problems Experienced (CODI) score], and quality of life [Pediatric Quality of Life Inventory score] were compared between the two groups. 【Results】 The treatment compliance rate of the observation group was higher than that of the control group (P<0.05). After intervention, the scores of generalized anxiety, school fear, social fear, separation anxiety and somatization in the observation group were lower than those in the control group (P<0.05); the scores of acceptance, self-comfort and fantasy in positive coping of the observation group were higher than those in the control group, while the scores of negative emotional response and avoidance in negative coping were lower than those in the control group (P<0.05); the scores of physical and mental health, social and psychological function, living environment and life satisfaction in the observation group were higher than those in the control group (P<0.05). 【Conclusion】 The interactive intervention based on the Mindfulness-Acceptance-Action Theory can effectively improve the treatment compliance of children with mycoplasma pneumonia, alleviate anxiety, optimize coping styles and enhance quality of life. 2025 Vol. 42 (12): 2093-2096 [Abstract] ( 10 ) HTML (1 KB)  PDF (1194 KB)  ( 2 ) 2097 Efficacy of Bronchial Artery Chemoembolization Combined with 125I Seed Implantation in the Treatment of Non-Small Cell Lung Cancer WANG Tong, ZHANG Yanchao, WEI Lequn, et al DOI: 10.3969/j.issn.1671-7171.2025.12.023 【Objective】 To investigate the efficacy of bronchial artery chemoembolization (BACE) combined with 125I seed implantation in the treatment of non-small cell lung cancer (NSCLC). 【Methods】 A total of 82 NSCLC patients were randomly divided into a control group (gemcitabine plus cisplatin chemotherapy) and an observation group (BACE combined with 125I seed implantation), with 41 cases in each group. Clinical efficacy, tumor diameter, pulmonary function indices, cancer pain scores, frailty scores, and adverse reactions were compared between the two groups before and after treatment. 【Results】 The clinical response rate in the observation group (80.49%) was higher than that in the control group (51.22%) (P<0.05). After treatment, tumor diameter, cancer pain scores, and frailty scores in the observation group were lower than those in the control group (P<0.05). Forced vital capacity, forced expiratory volume in 1 second, and maximal voluntary ventilation were all higher in the observation group than in the control group (P<0.05). The incidences of nausea, vomiting, alopecia, and grade Ⅰ-Ⅳ myelosuppression in the observation group were lower those in the group group (P<0.05). 【Conclusion】 BACE combined with 125I seed implantation can significantly improve the clinical efficacy in NSCLC patients, reduce tumor size, improve pulmonary function, alleviate cancer pain and frailty, and reduce adverse reactions. 2025 Vol. 42 (12): 2097-2099 [Abstract] ( 10 ) HTML (1 KB)  PDF (1230 KB)  ( 3 ) 2100 The Effect of a Structured Comprehensive Protection Protocol on Neonatal Skin Scratches and Indwelling Catheter Dislodgement LI Lingyu, ZHANG Meigui, ZHUANG Meihong, et al DOI: 10.3969/j.issn.1671-7171.2025.12.024 【Objective】 To explore the effect of a structured comprehensive protection protocol on neonatal skin scratches and indwelling catheter dislodgement. 【Methods】 A total of 80 full-term or near-term neonates admitted to the Department of Pediatrics of our hospital from January 2022 to March 2024 were selected and divided into the control group (given routine nursing care) and the observation group (given the structured comprehensive protection protocol) according to propensity score matching, with 40 cases in each group. The incidence of skin complications, indwelling catheter dislodgement and neonatal growth and development were compared between the two groups. 【Results】 The total incidence of skin complications such as contact dermatitis, folliculitis, epidermal exfoliation, skin laceration and skin infiltration in the observation group was lower than that in the control group (P<0.05). The incidence of indwelling catheter dislodgement in the observation group was lower than that in the control group (P<0.05). The height, weight, chest circumference and head circumference of neonates in the observation group at discharge were better than those in the control group (P<0.05). 【Conclusion】 The application of a structured comprehensive protection protocol in neonates can reduce the incidence of skin-related complications and indwelling catheter dislodgement, improve the quality of nursing care, and promote the growth and development of neonates. 2025 Vol. 42 (12): 2100-2103 [Abstract] ( 8 ) HTML (1 KB)  PDF (1194 KB)  ( 2 ) 2104 Effect of Programmatic Management on Disease Self-Management Ability and Quality of Life in Patients with Rheumatic and Immune Diseases LI Ruili, JIAO Yating, LAI Yanan DOI: 10.3969/j.issn.1671-7171.2025.12.025 【Objective】 To explore the effect of programmatic management on disease self-management ability and quality of life in patients with rheumatic and immune diseases.【Methods】 A total of 72 patients with rheumatic and immune diseases were randomly divided into an observation group (receiving programmatic management based on routine management,n=36) and a control group (receiving routine management alone,n=36). Disease self-management ability, pain level, quality of life, and medication adherence were compared between the two groups before and after the intervention.【Results】 After 3 months of intervention, scores for exercise, cognitive symptom management, and communication with physicians in the disease self-management ability scale were significantly higher in the observation group than in the control group (P<0.05). Pain scores in the observation group were lower than those in the control group (P<0.05). Scores for physical, psychological, social, and material functions in the quality-of-life scale were all higher in the observation group compared to the control group (P<0.05). Medication adherence in the observation group was also higher than that in the control group(P<0.05).【Conclusion】 Programmatic management can significantly enhance disease self-management ability, effectively relieve pain symptoms, comprehensively improve quality of life, and increase medication adherence in patients with rheumatic and immune diseases, demonstrating clinical value in optimizing comprehensive disease management. 2025 Vol. 42 (12): 2104-2106 [Abstract] ( 8 ) HTML (1 KB)  PDF (1221 KB)  ( 2 ) 2107 Efficacy of Xiaochaihu Decoction Combined with Liuwei Dihuang Pills in the Treatment of Children with Attention Deficit Hyperactivity Disorder PANG Zhongliang, LIU Xijun, SUN Pan, et al DOI: 10.3969/j.issn.1671-7171.2025.12.026 【Objective】 To investigate the clinical efficacy of Xiaochaihu Decoction combined with Liuwei Dihuang Pills in the treatment of children with attention-deficit/hyperactivity disorder (ADHD).【Methods】 A total of 90 children with ADHD were randomly assigned to either a control group or an observation group, with 45 cases in each group. The control group received relaxation training combined with psychological intervention, while the observation group received Xiaochaihu Decoction plus Liuwei Dihuang Pills in addition to the same interventions as the control group. Changes in traditional Chinese medicine (TCM) syndrome scores, serum indicators [cortisol (CORT), adrenocorticotropic hormone (ACTH), and plasma ghrelin(GHRP)], cognitive function [Wechsler Intelligence Scale for Children-Chinese Revision (WISC-CR) score], and behavioral performance [Swanson Nolan and Pelham Rating Scale-Ⅳ (SNAP-Ⅳ) score] were compared before and after treatment in the two groups.【Results】 After treatment, the observation group showed significantly lower TCM syndrome scores than the control group (P<0.05). Levels of CORT and ACTH in the observation group were lower than that in the control group, while GHRP level in the observation group were higher than that in the control group (P<0.05). WISC-CR scores were higher, and SNAP-Ⅳ scores across all dimensions were lower in the observation group compared with the control group (P<0.05).【Conclusion】 Xiaochaihu Decoction combined with Liuwei Dihuang Pills can effectively improve TCM syndrome manifestations, regulate related serum hormone levels, enhance cognitive function, and alleviate behavioral abnormalities in children with ADHD. 2025 Vol. 42 (12): 2107-2110 [Abstract] ( 10 ) HTML (1 KB)  PDF (1198 KB)  ( 2 )

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