CT和MRI图像融合下行HA-WBRT或HA-SRT对脑转移瘤患者的疗效及认知功能的影响

doi:10.3969/j.issn.1671-7171.2025.12.012

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Abstract 【Objective】 To investigate the efficacy and impact on neurocognitive function of hippocampal-avoidance whole-brain radiotherapy (HA-WBRT) or Hippocampal-Avoidance stereotactic radiotherapy(HA-SRT) guided by CT and MRI image fusion in patients with brain metastases.【Methods】 Forty patients with brain metastases who underwent HA-WBRT were evaluated for clinical efficacy and safety six months after treatment. Neurocognitive function and quality of life (QoL) were compared before treatment and at 1, 3, and 6 months after treatment.【Results】 At 6 months post-treatment, the overall response rate was 75.00% (30/40), the overall survival rate was 90.00% (36/40), and the intracranial progression-free rate was 87.50% (35/40). There were no statistically significant differences in the proportion of patients with normal cognitive function before and at 1, 3, and 6 months after treatment (P>0.05). One month after treatment, there was no statistically significant difference in the patients' Mini-Mental State Examination (MMSE) scores compared with those before treatment (P>0.05). At 3 and 6 months after treatment, the patients' MMSE scores were higher than those before treatment (P<0.05). There were no statistically significant differences in MMSE scores at different time points after treatment (P>0.05). The QoL scores decreased progressively at 1, 3, and 6 months after treatment; And all QoL scores were significantly lower than before treatment (P<0.05), with significant differences among those post-treatment time points (P<0.05).【Conclusion】 CT/MRI image fusion-guided HA-WBRT or HA-SRT demonstrates favorable therapeutic efficacy in patients with brain metastases, effectively reducing the risk of neurocognitive impairment and improving quality of life.

Key words： Neoplasm Metastasis Brain Neoplasms Tomography, Spiral Computed Magnetic Resonance Imaging Radiotherapy, Image-Guided

Received: 29 May 2025

PACS:

R739.41

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	WU Yali
	CAI Lihong

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WU Yali,CAI Lihong. Effect of Hippocampal-Avoidance Radiotherapy or Hippocampal-Avoidance Stereotactic Radiotherapy under CT and MRI Image Fusion on the Efficacy and Cognitive Function in Patients with Brain Metastases[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(12): 2057-2060.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.12.012 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I12/2057

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