性激素水平、子宫超声参数及骨龄指数联合检测对女童快进展型中枢性性早熟的预测价值

doi:10.3969/j.issn.1671-7171.2025.12.013

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Abstract 【Objective】 To explore the predictive value of combined detection of sex hormone levels, uterine ultrasound parameters and bone age index in girls with rapidly progressive central precocious puberty (RP-CPP). 【Methods】 A total of 168 girls initially diagnosed with central precocious puberty (CPP) in our hospital from January to December 2023 were selected as the research subjects. According to the progression rate of puberty, they were divided into the RP-CPP group (n=88) and the slowly progressive central precocious puberty (SP-CPP) group (n=80). The clinical data of the two groups were compared. Multivariate Logistic regression analysis was used to identify the influencing factors for the progression of CPP to RP-CPP in girls. Receiver operating characteristic (ROC) curve was adopted to analyze the predictive value of uterine volume and bone age index for the progression of CPP to RP-CPP in girls. 【Results】 There were significant differences in height, weight, body mass index (BMI), luteinizing hormone, follicle-stimulating hormone, bone age index, uterine volume and mean ovarian volume between the RP-CPP group and the SP-CPP group at the initial diagnosis (P<0.05). Logistic regression analysis showed that bone age index and uterine volume were the influencing factors for the progression of CPP to RP-CPP in girls. ROC curve analysis indicated that when the bone age index was 1.20, the area under the curve (AUC) of bone age index for predicting the progression of CPP to RP-CPP in girls was 0.686; when the uterine volume was 1.664 mL, the AUC of uterine volume for predicting the progression of CPP to RP-CPP in girls was 0.805. 【Conclusion】 Bone age index and uterine volume have certain predictive value for the progression of CPP to RP-CPP in girls. When the bone age index is 1.20 and the uterine volume is 1.664 mL, it suggests a high possibility of CPP progressing to RP-CPP in girls, and these indicators can be used as auxiliary indexes for the diagnosis of RP-CPP.

Key words： Puberty, Precocious Gonadal Steroid Hormones Ultrasonography Age Determination by Skeleton Child

Received: 05 March 2025

PACS:

R725.85

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	WEN Huan
	LIU Lingping
	LIU Jinqiao

Cite this article:

WEN Huan,LIU Lingping,LIU Jinqiao. Predictive Value of Combined Detection of Sex Hormone levels, Uterine Ultrasound Parameters and Bone Age Index in Girls with Rapidly Progressive Central Precocious Puberty[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(12): 2061-2063.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.12.013 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I12/2061

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