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Quick Search     Adv Search 2019 Vol. 36, No. 9 Published: 2019-09-30   1665 Imaging Vascular Networks on the Whole brain Scale Using High Resolution Synchrotron Radiation Technique SHI Shu-peng, HU Xin-hang, FU Dong-ni,et al DOI: 10.3969/j.issn.1671-7171.2019.09.001 【Objective】To explore the application of synchrotron radiation phase contrast imaging in the study of rat brain microvascular network.【Methods】Five SD rats were perfused without contrast medium to obtain brain, and then scanned and imaged based on synchrotron radiation phase contrast imaging technology. Multidimensional multi-plane reconstruction was performed using filtering algorithm and imaging software.【Results】A complete visualization system from projection map, two-dimensional slice to 3D image of whole cerebrovascular network was established. The skeleton of whole cerebrovascular network was further extracted and the rendered images of different color levels were obtained. 【Conclusion】The establishment of brain microvascular visualization system provides a new imaging basis for multi-plane and multi-angle analysis of 3D blood supply distribution in the whole brain and local target areas, and provides a powerful technical support for the study of cerebrovascular diseases. 2019 Vol. 36 (9): 1665-1667 [Abstract] ( 68 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 1668 Effect of Local Continuous Chemotherapy and Postural Drainage in Stage I Posterior Debridement, Bone Grafting and Instrumentation for the Treatment of Lumbar Spinal Tuberculosis XIAO Pei-fen, LUO Jing DOI: 10.3969/j.issn.1671-7171.2019.09.002 【Objective】 To investigate the effect of local continuous irrigation and chemotherapy on lumbar tuberculosis in stage I posterior debridement, bone graft fusion and internal fixation. 【Methods】From January 2010 to January 2014, 55 consecutive patients with lumbar tuberculosis were treated in our hospital. Among them, 30 patients underwent stage I posterior debridement, bone graft fusion and internal fixation (group A), and 25 patients underwent stage I posterior debridement, bone graft fusion and internal fixation combined with local continuous irrigation and chemotherapy (group B). The clinical efficacy and imaging results of the two groups were compared. 【Results】All patients were followed up for 23 (12~36) months. The intervertebral bone graft fusion time in the group B was 6.5 (5~10) months, which was significantly shorter than that in the group A [8.5 (6~12) months] (P<0.05). Erythrocyte sedimentation rate (ESR) in the group B was significantly lower than that in the group A at 6 weeks after operation (P<0.05), but ESR returned to normal at the last follow-up. The neurological symptoms of the two groups recovered to varying degrees. The wounds healed in the first stage. No chronic sinus formation, internal fixation rupture, loosening and other phenomena occurred in either group. 【Conclusion】The treatment of lumbar tuberculosis by posterior debridement, bone graft fusion and internal fixation combined with local continuous irrigation and chemotherapy can significantly accelerate the fusion of bone graft and the regression of inflammation, which is worthy of clinical application. 2019 Vol. 36 (9): 1668-1671 [Abstract] ( 55 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 1671 Expression and Significance of GDF-15 microRNAs in Serum of Patients with Cervical Cancer HUANG Jiang-mei, XIAO Fang, ZHAO Min, et al DOI: 10.3969/j.issn.1671-7171.2019.09.003 【Objective】 To investigate the expression and significance of growth differentiation factor 15 (GDF-15) miRNA in serum of patients with cervical cancer.【Methods】 Sixty-four patients with cervical cancer (cervical cancer group) and 54 patients with cervical intraepithelial neoplasia (CIN) (CIN group) were enrolled in our hospital from May 2012 to March 2016. Forty-six healthy subjects in the hospital were used as a control group.The expression of GDF-15 miRNA in serum of three groups was detected by RT-PCR, and the relationship between GDF-15 miRNA expression and clinical pathology and prognosis of cervical cancer patients was analyzed.【Results】 The expression of serum GDF-15 miRNA in cervical cancer patients was (3.12±1.11), which was higher than 1.97±0.53 in the CIN group and 1.07±0.37 in the healthy control group.The expression of serum GDF-15 miRNA in cervical cancer patients was not correlated with age, pathological type and tumor size (P>0.05), and was associated with FIGO stage, lymph node metastasis and differentiation (P<0.05).Sixty-four patients with cervical cancer were followed up for 3 years. 45 patients (70.31%) survived, 19 patients (9.69%) died, and the average survival time was (29.39±1.36) months.The total survival time of patients with GDF-15 miRNA>3.12 cervical cancer was 25.87(±2.27) months, which was significantly less than that of GDF-15 miRNA≤3.12 (32.50±1.39 months) , the difference was statistically significant (P<0.05). 【Conclusion】 The expression of serum GDF-15 microRNAs increases in cervical cancer patients, which is related to FIGO staging, lymph node metastasis and differentiation. Monitoring GDF-15 is helpful to evaluate the prognosis of cervical cancer patients. 2019 Vol. 36 (9): 1671-1673 [Abstract] ( 58 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 1674 Application of Multi-mode Comprehensive Analgesia in Patients Undergoing Interventional Surgery for Primary Hepatocellular Cancer ZHU Bo, LIU Shao-xing, CAO De-jun,et al DOI: 10.3969/j.issn.1671-7171.2019.09.004 【Objective】To investigate the effect of multi-modal analgesia on primary hepatocellular carcinoma (PHC) treated with hepatic arterial chemoembolization (TACE). 【Methods】A total of 68 cases of PHC patients received TACE treatment were randomly divided into two groups, with 34 cases in each group. The control group used traditional analgesia and the observation group used multimodal analgesia. Visual pain simulation score (VAS) was used to assess the degree of pain in the patient at 1 h before surgery, at the time of administration, immediately after surgery (T0), 2 h after surgery (T2), 4 h (T4), 6 h (T6), 12 h (T12), 24 h (T24) and 48 h (T48) after surgery. The levels of IL-6 and S100β protein were detected and compared at 1 day before surgery and d1,d3 after operation. The adverse reactions within 48 hours after surgery were recorded in both groups. 【Results】The VAS scores of the T0, T2, T4, T6, T12, and T24 in the observation group were significantly lower than those in the control group (P<0.05). There was no significant difference in the VAS scores of the two groups at T48 after surgery (P>0.05). There was no significant difference in the levels of serum IL-6 and S100β between the two groups at 1 day before operation (P>0.05). The levels of serum IL-6 and S100β in the observation group were significantly lower than those in the control group at 1d and 3d after operation (P<0.05). The incidence of total adverse reactions in two group was no significant difference (P>0.05). 【Conclusion】The use of multimodal analgesia in TACE can help reduce postoperative pain in PHC patients and reduce the level of inflammatory response without increasing adverse reactions. 2019 Vol. 36 (9): 1674-1676 [Abstract] ( 67 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 1677 Effect of Labellol Combined with Enoxaparin on Hypertensive Patients During Pregnancy FU Hong DOI: 10.3969/j.issn.1671-7171.2019.09.005 【Objective】To investigate the effects of labelore combined with enoxaparin on blood pressure level and its safety in patients with hypertensive diseases in pregnancy. 【Methods】 One hundred and two patients with gestational hypertension admitted to our hospital from June 2017 to June 2018 were randomly divided into two groups. The control group was treated with oral labetalol tablets, and the study group was treated with labetalol combined with enoxaparin. The clinical therapeutic effect, blood pressure level, 24 h urinary protein level, blood lipid level before and after treatment, and the incidence of adverse reactions and severe adverse pregnancy outcomes were compared between the two groups. 【Results】The total effective rate was 94.1% (48/51) in the observation group, which was significantly higher than 78.4% (40/51) in the control group. The difference was statistically significant (χ2=7.318,P<0.05). Before treatment, there was no significant difference in blood pressure and 24-hour urinary protein between the two groups (P>0.05); after treatment, the above indicators in both groups decreased significantly compared with before treatment (P<0.05), and the observation group decreased more significantly (P<0.05). Before treatment, there was no significant difference in blood lipid levels between the two groups (P>0.05); after treatment, the levels of LDL-C, TC and TG in the two groups were significantly lower than those before treatment, and the levels of HDL-C were significantly higher than those before treatment, and the observation group was significantly better than those before treatment. The control group (P<0.05). Compared with the control group, the incidence of adverse pregnancy outcomes such as premature delivery, postpartum hemorrhage, fetal distress and neonatal asphyxia in the observation group was significantly lower than that in the control group, and the difference was statistically significant (P<0.05). The total incidence of adverse reactions was 39.22% (20/51) in the observation group and 35.29% (18/51) in the control group. There was no significant difference between the two groups (P>0.05). The adverse reactions in the two groups were mild and improved by symptomatic treatment without affecting the follow-up treatment.【Conclusion】Labellol combined with enoxaparin in the treatment of pregnancy-induced hypertension can significantly reduce blood pressure and 24-hour urinary protein levels, reduce the incidence of adverse pregnancy outcomes, and has high safety, which is worthy of clinical application. 2019 Vol. 36 (9): 1677-1680 [Abstract] ( 60 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 1680 Effect of TUSC3 on Proliferation, Migration and Invasion of Human Hepatoma Cells KE Dong-ping, ZHU Jin-xiang, MAO Jun-qian,et al DOI: 10.3969/j.issn.1671-7171.2019.09.006 【Objective】To investigate the effect of tumor suppressor candidate 3 (TUSC3) on proliferation, migration and invasion of hepatoma cells(SMMC-7721). 【Methods】TUSC3 overexpression vector was transfected into SMMC-7721 cells, and TUSC3 mRNA and protein expression were detected by Real-time PCR and Western blot to verify the transfection efficiency of plasmid. MTT was used to detect cell proliferation at 24 h, 48 h, 72 h and 96 h after transfection. The cell migration ability was detected by wound healing and the invasion ability was detected by Transwell chamber. 【Results】TUSC3 was overexpressed in SMMC-7721 successfully. The results of MTT showed that the cell proliferation in TUSC3-overexpression group was significantly lower than that in empty vector group (P<0.01). The results of the wound healing showed that the cell migration in the TUSC3 overexpression transfection group was also significantly decreased (P<0.05). Similar to wound healing, the results of Transwell also showed that the invasive of hepatoma cells decreased after TUSC3 overexpression (P<0.01). 【Conclusion】 TUSC3 could inhibit proliferation, migration and invasion of hepatoma cells cells, and may play a tumor suppressing role in the development of hepatic carcinoma. 2019 Vol. 36 (9): 1680-1683 [Abstract] ( 61 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 1684 TImpact of Betel Quid、Tobacco and Alcohol on Early-onset Age for Oral Squamous Cell Carcinoma HU Yi-na, YANG Jia-cheng, LI Hong-yan,et al DOI: 10.3969/j.issn.1671-7171.2019.09.007 【Objective】To investigate the effects of betel nut chewing, smoking and drinking on the age of onset of oral squamous cell carcinoma (OSCC). 【Methods】A total of 488 patients with oral squamous cell carcinoma from August 2014 to September 2015 in a third-level hospital of Hunan Province were collected. The relationship between bad living habits and age of onset of oral squamous cell carcinoma was drawn by Kaplan-Meier method.COX risk model was used to assess the risk ratio and 95% CI confidence interval between bad living habits and age at onset.【Results】Betelnut chewing in earlier than 21 years of age has an effect on the age of onset of oral squamous cell carcinoma [aHR = 1.8, 95% CI (1.5~2.1),P<0.001]. The greater the amount of betel nut chewing, the longer the exposure time, the greater the risk of early onset (P<0.001). Smoking had an effect on the age of onset (P=0.039). The age of onset of oral squamous cell carcinoma was 3 years earlier in smokers than in non-smokers [aHR=1.6, 95% CI (1.2~2.2),P=0.001]. Compared with non-smokers and non-drinkers, those who chewed betel nut and smoked earlier than 21 years of age had 9 years earlier onset age [aHR=2.8, 95% CI (2.0~3.9)].【Conclusion】Betelnut chewing and early smoking are risk factors for the early onset of oral squamous cell carcinoma. and can advance the onset age of OSCC. 2019 Vol. 36 (9): 1684-1687 [Abstract] ( 68 ) HTML (1 KB)  PDF  (0 KB)  ( 9 ) 1688 Detection and Correlation Analysis of CTHRC1, TGF-β1 and Smad7 Expression in Oral Submucous Fibrosis WU Hao, LIU Jian, XIE Hui DOI: 10.3969/j.issn.1671-7171.2019.09.008 【Objective】To investigate the expression of CTHRC1 (collagen triple helix repeat containing 1),TGF-β1 and smad7 in OSF (Oral Submucous Fibrosis) by immunohistochemistry in order to explore the correlation between CTHRC1 and TGF-β1/smad signaling pathway in pathogenesis of OSF. 【Methods】Buccal mucous tissues were obtained from 33 OSF patients (10 cases in the early stage, 13 cases in the middle stage and 10 cases in the late stage) and 10 healthy volunteers' mucous tissues. After paraffin embedding, the expression of CTHRC1,TGF-β1 and smad7 proteins in sections were detected by immunohistochemistry. The correlations between TGF-β1 expression and CTHRC1, smad7 were tested by Pearson software. 【Results】The expression of CTHRC1 in the early, middle and later stage OSF was significantly higher than that in normal oral mucosa(P=0.007,0.002,0.006). SO did the expression of smad7 in all stages of OSF(P=0.032,0.007,0.005). The expression of TGF-β1 was increased in the early and middle stage OSF tissues (P=0.007,0.031), however, there was no significant difference between the late expression and the normal control (P=0.323). There was a positive correlation between TGF-β1 and CTHRC1 expression in OSF lesions (R=0.678,P=0.0010), and there was no significant correlation between TGF-β1 and Smad7 expression (R=0.003,P=0.9908). 【Conclusions】The expression of CTHRC1 increases significantly in all stages of OSF,which is positively correlated with the expression of TGF-β1. CTHRC1 can be a new target for anti-fibrosis. 2019 Vol. 36 (9): 1688-1690 [Abstract] ( 60 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 1691 Effect of Bifidobacterium Tetrad, Zinc Glycyrrhiza Combined with Racecadotril on Diarrhea caused by Rotavirus Infection and its Influence on Serum Inflammatory Factors and Myocardial Enzymes in Children JIANG Chun-hua, ZHANG Hua-qiong DOI: 10.3969/j.issn.1671-7171.2019.09.009 【Objective】To investigate the effect of Bifidobacterium tetrad living bacteria, zinc Glycyrrhiza combined with racecadotril in the treatment of diarrhea caused by rotavirus infection and the effect on serum inflammatory factors and myocardial enzymes in children.【Methods】A total of 136 children with diarrhea due to rotavirus infection who were treated in our hospital from March 2017 to October 2018 were randomly divided into control group and observation group with 68 cases in each group. The control group was treated with live Bifidobacterium tetrad and zinc glycyrrhiza. The observation group was treated with racecadotril on the basis of the control group. Both groups were treated for 3 days. The improvement time of clinical symptoms and signs (antifebrile time, dehydration correction time, stool recovery time, virus negative time, etc.) and serum inflammatory factors (IL-6, TNF-alpha, CRP) and serum myocardial enzymes (LDH) were compared between the two groups. The changes of creatine phosphate kinase (CK), creatine phosphate kinase isoenzyme (CK-MB) and alpha-hydroxybutyrate dehydrogenase (HBDH) were compared between the two groups. 【Results】Before treatment, there was no significant difference in the observation indexes between the two groups (P>0.05). After treatment, the improvement time of clinical symptoms and signs (antipyretic time, dehydration correction time, stool recovery time, virus negative time) in the observation group was shorter than that in the control group (P<0.05); the indexes of serum inflammatory factors (IL-6, TNF-a, CRP) and myocardial zymogram (LDH, CK, CK-MB, HBDH) in the two groups were improved compared with those in the same group before treatment. The improvement degree of the observation group was better than that of the control group (P<0.05), and the total effective rate of the observation group was higher than that of the control group (P<0.05). 【Conclusion】Bifidobacterium tetrad, zinc Glycyrrhiza combined with racecadotril in the treatment of infantile rotavirus-infected diarrhea can improve the clinical efficacy, improve the prognosis of the disease, alleviate the clinical symptoms and signs of children, reduce the degree of inflammation, reduce the level of myocardial enzymes, which is worthy of clinical application. 2019 Vol. 36 (9): 1691-1694 [Abstract] ( 58 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 1694 Application Value of Two-dimensional Strain Imaging in Evaluating Left Atrial Myocardial Function in Elderly Patients with Hypertension and Paroxysmal Atrial Fibrillation WANG Chao, ZHAO Yue-e, ZHENG Bo, et al DOI: 10.3969/j.issn.1671-7171.2019.09.010 【Objective】To evaluate the value of two-dimensional strain imaging in the assessment of left atrial myocardial function in elderly patients who had hypertension complicated with paroxysmal atrial fibrillation.【Methods】A total of 86 patients with hypertension plus paroxysmal atrial fibrillation who were admitted to our hospital from January to December 2018 were enrolled. Patients were divided into different groups according to the number of echocardiographic signs of left ventricular diastolic dysfunction: zero sign group, single sign group and multiple signs group. Myocardial function and left atrial myocardial strain in different groups of patients were compared. 【Results】Based on the number of echocardiographic signs of left ventricular diastolic dysfunction in patients, there were 20 cases (23.3%) in the zero sign group, 35 cases (40.7%) in the single sign group and 31 cases (36.0%) in the multiple signs group. The results showed that LVEF of patients with the zero sign group was higher than that of the single sign and multiple signs group, while LVEDD, LVEDV and LAVI were lower than those of the single sign and multiple signs group. The differences were statistically significant (P<0.05). The strain and strain rate in the middle segment and the middle wall of the left atrial wall of the zero sign group were higher than those of the single sign and multiple signs group; the differences were statistically significant (P<0.05).【Conclusion】With the increase in the number of echocardiographic signs of left ventricular diastolic dysfunction, the left atrial myocardial function in hypertension patients complicated with paroxysmal atrial fibrillation was significantly reduced. 2019 Vol. 36 (9): 1694-1696 [Abstract] ( 76 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 1697 Comparison of Clinical Features and Short- and Long-term Prognosis between Simple Cerebral Infarction and Cerebral Infarction with Metabolic Syndrome LI Guo-feng, WEI Yu-qing, JIA Liang,et al DOI: 10.3969/j.issn.1671-7171.2019.09.011 【Objective】To compare clinical characteristics, short-term and long-term prognosis between simple cerebral infarction and cerebral infarction with metabolic syndrome to explore the related factors of prognosis. 【Methods】The clinical data of 328 patients with cerebral infarction admitted to our hospital from May 2010 to May 2016 were retrospectively analyzed. According to whether or not they had metabolic syndrome, they were divided into the metabolic syndrome complication group (182 cases) and simple cerebral infarction group (146 cases), respectively. The clinical characteristics and short-term and long-term prognosis of the two groups were compared and analyzed. The key factors affecting the short-term and long-term prognosis were discussed by logistic regression analysis. 【Results】There were significant differences in gender, age, BMI, prevalence and classification of hypertension, diabetes mellitus, FBG, Fins, HOMA-IRI, HbA1C, blood lipids, HCY, IMT thickening, TOAST classification, complications and LOS between the two groups (P<0.05). However, there were no significant differences of cerebral infarction sites with smoking and drinking (P>0.05).Compared to the simple cerebral infarction group, the short-term effective rate was significantly lower in the cerebral infarction with metabolic syndrome group, while the long-term disability rate and recurrence rate were significantly higher (P<0.05).The Logistic regression analysis showed that hypertension classification (grade three), HbA1C, TOAST classification (LAA), complications (pulmonary embolism) and metabolic syndrome were the key factors affecting the short-term prognosis of cerebral infarction (P<0.05); IMT thickening, infarction site (occipital lobe), complications (pulmonary embolism) and metabolic syndrome were the key factors affecting cerebral infarction disability (P<0.05),and complications (pulmonary embolism) and metabolic syndrome were the key factors affecting the recurrence of cerebral infarction (P<0.05). 【Conclusion】There are significantly different in terms of clinical characteristics and long-term prognosis in patients with simple cerebral infarction and cerebral infarction complicated with metabolic syndrome. The metabolic syndrome is the key factor affecting the prognosis of cerebral infarction. 2019 Vol. 36 (9): 1697-1700 [Abstract] ( 59 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 1700 Serum Level Changes and Significance of CD163, CA125 and GDF-15 in Patients with Chronic Heart Failure LIU Li-li, FENG Lei, WANG Li-jun,et al DOI: 10.3969/j.issn.1671-7171.2019.09.012 【Objective】To investigate the changes and significance of monocyte scavenger receptor (CD163), serum carbohydrate antigen 125 (CA125) and growth differentiation factor-15 (GDF-15) in peripheral blood of patients with chronic heart failure (CHF). 【Methods】A total of 140 patients with CHF diagnosed in our hospital (the CHF group) from March 2017 to May 2018 and 70 healthy volunteers (the control group) from the same period were selected for the study. The levels of peripheral blood CD163, serum CA125 and GDF-15 were compared between the two groups. Cardiac function indicators: left ventricular end-diastolic (LVEDD), left ventricular ejection fraction (LVEF), left ventricular anteroposterior diameter (LAD), left ventricular relative wall thickness (RWT) were compared as well.【Results】The levels of CD163, serum CA125 and GDF-15 in peripheral blood of patients with CHF were significantly higher than those of the control group (P<0.05). The LVEDD and LAD in the observation group were significantly higher than those in the control group, while the LVEF and RWT were significantly lower than those in the control group; And the differences were statistically significant (P<0.05). The value of LVEF was negatively correlated with levels of serum CD163, CA125 and GDF-15 in patients with CHF (rCD163=-0.729, rCA125=-0.638, rGDF-15=-0.552,P<0.05).【Conclusion】The levels of serum CD163, CA125 and GDF-15 in patients with chronic heart failure were significantly increased. The increase was significantly negatively correlated with LVEF values. 2019 Vol. 36 (9): 1700-1702 [Abstract] ( 55 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 1703 Comparison of the Efficacy of Single-port Thoracoscopy and Conventional Video-assisted Thoracoscopy in the Treatment of Traumatic Pneumothorax ZHAO Yong, LUO Xiao-bin, HU Jie-wei,et al DOI: 10.3969/j.issn.1671-7171.2019.09.013 【Objective】To analyze the clinical efficacy of single-port thoracoscopic and video-assisted thoracoscopic surgery for traumatic pneumothorax, and provide more reference for clinical practice. 【Methods】A total of 70 patients with traumatic pneumothorax admitted to our hospital from August 2016 to August 2018 were enrolled. 35 patients underwent single-hole thoracoscopic surgery and 35 patients underwent video-assisted thoracoscopic surgery. The changes of serum inflammatory cytokines and oxidative stress related indicators in the perioperative period, the day of surgery and the 3 days after surgery were compared between the two groups, and the incidence of complication was statistically analyzed. 【Results】The bleeding volume, drainage volume, thoracic tube placement time and hospitalization time of the observation group were less than those of the control group, and the operation time was longer than that of the control group, with statistical significance (P<0.05). On the day after operation, there was no significant difference in serum inflammatory cytokines and oxidative stress related indicators between the two groups (P>0.05); on the 3rd day after operation, the levels of inflammatory cytokines and oxidative stress related indicators in the two groups were lower than those in the day after operation, and the observation group was lower than the control group, the difference was statistically significant (P<0.05). There was no significant difference in the incidence of complications between the two groups (P>0.05). 【Conclusion】Compared with conventional video-assisted thoracoscopy, single-port video-assisted thoracoscopy for traumatic pneumothorax has the characteristics of less trauma, faster recovery, shorter hospitalization time, and can more effectively reduce the inflammatory response and stress response of the body after operation, which is worthy of popularization and application. 2019 Vol. 36 (9): 1703-1706 [Abstract] ( 60 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 1706 Effects of Propofol on Anesthesia and Vasoconstrictor of Patients undergoing Laparoscopic Hysteromyomectomy HU Zhe DOI: 10.3969/j.issn.1671-7171.2019.09.014 【Objective】To analyze the anesthetic effect and post-surgery recovery time of propofol in patients undergoing laparoscopic hysteromyomectomy. 【Methods】A total of 86 cases of uterine myomectomy were randomly divided into the control group (sufentanil alone) and the observation group (sufentanil plus propofol), with 43 in each group. The anesthetic effect of the two groups was analyzed. 【Results】The recovery time and recovery time of spontaneous respiration in the observation group were shorter than those in the control group (P<0.05). Ramsay sedation score was higher in the observation group than the control group. The difference was statistically significant (P<0.05). At 30 min (T0) before operation, there were no significant differences in blood pressure, heart rate (HR) HR, endothelin-1 (ET-1), and angiotensin-Ⅱ (Ang Ⅱ) levels between the two groups (P>0.05). At 30 min (T1) during surgery and 30 min (T2) after surgery, the blood pressure of the observation group was stable compared to the control group (P<0.05), the levels of ET-1 and AngII were lower than the control group (P<0.05), and the HR level was not statistically significant difference with the control group (P>0.05). The incidence of adverse reaction rate was 4.65 (2/43) in the observation group, which was significantly lower than 18.71 in the control group (P<0.05). 【Conclusion】 In the laparoscopic hysteromyomectomy, sufentanil plus propofol has good anesthetic effect with stable vital signs, little influence on ET-1Ang Ⅱ level and high safety. 2019 Vol. 36 (9): 1706-1708 [Abstract] ( 70 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 1709 Early Respiratory Function Exercise Combined with Nasal High Flow Oxygen Therapy on Rehabilitation and Pulmonary Function in Children with Tetralogy of Fallot YANG Gui-hong, XIAO Jian-feng, LUO Jin-wen,et al DOI: 10.3969/j.issn.1671-7171.2019.09.015 【Objective】To explore the effect of early respiratory function training combined with nasal high flow oxygen therapy on the rehabilitation and pulmonary function of children with tetralogy of Fallot (TOF). 【Methods】Eighty-seven children with TOF admitted to our hospital from March 2016 to March 2018 were randomly divided into observation group (n=44) and control group (n=43) according to random number table method. The observation group was treated with early respiratory function exercise combined with nasal high flow oxygen therapy, while the control group was treated with nasal high flow oxygen therapy. The two groups were treated for one month. The changes of SGRQ, blood gas analysis index and pulmonary function before and after treatment were compared between the two groups. 【Results】After treatment, the SGRQ score of the two groups decreased, and the SGRQ score of the observation group was lower than that of the control group (P<0.05). After treatment, the arterial partial pressure of oxygen (PaO2), pH value, pulse oxygen saturation(SpO2 ) increased and the arterial partial pressure of carbon dioxide (PaCO2) decreased in both groups. The PaO2, pH value and SpO2 value in the observation group were higher than those in the control group, and the PaCO2 level was lower than that in the control group (P<0.05). After treatment, the percentage of vital capacity (VC), forced expiratory volume (FEV1), forced vital capacity (FVC), forced expiratory volume (FEV1), forced expiratory volume (FVC), forced expiratory volume (FEV1/FVC) of the two groups increased, and the values of VC, FEV1, FVC and FEV1/FVC of the observation group were higher than those of the control group (P<0.05). 【Conclusion】Early respiratory function exercise combined with nasal high flow oxygen therapy for TOF can effectively improve the quality of life, shorten hospitalization time, improve the blood gas index and pulmonary function of children with TOF, and has high safety. 2019 Vol. 36 (9): 1709-1711 [Abstract] ( 56 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 1712 Expression and Significance of BRAC1 and DIAPH-3 Proteins in Breast Cancer Tissues YANG Chun-shui, LIU Bin, HAN Song-yun,et al DOI: 10.3969/j.issn.1671-7171.2019.09.016 【Objective】To investigate the expression and significance of breast cancer susceptibility gene 1 (BRAC1) and DIAPH-3 protein in breast cancer.【Methods】Immunohistochemical staining was used to detect 92 cases of breast cancer (observation group) and 46 cases of paracancerous tissue specimens (control group). The positive expression rates of DIAPH-3 protein and BRAC1 protein in two groups were compared, and the expression levels of DIAPH-3 protein and BRAC1 protein in patients with different TNM stages, lymph node metastasis, tumor lesion diameter, vascular invasion, histological grade were analyzed. 【Results】The positive rates of DIAPH-3 protein and BRAC1 protein in the breast cancer group were 45.65% (42/92) and 67.39% (62/92), respectively, while those in the paracancerous group were 84.78% (39/46) and 15.22% (7/46), respectively. There was a significant difference between the two groups (P<0.05). The positive expression rates of DIAPH-3 protein in breast cancer patients with different TNM stages and lymph node metastasis were significantly different (P<0.05). The positive expression rate of BRAC1 protein in breast cancer patients with different TNM stages, lymph node metastasis and tumor differentiation was significantly different (P<0.05). 【Conclusion】The down-regulation of DIAPH-3 and up-regulation of BRAC1 in breast cancer are closely related to the occurrence and development of tumor . 2019 Vol. 36 (9): 1712-1714 [Abstract] ( 58 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 1715 Clinical Efficacy of Plasma Exchange Combined with Continuous Blood Purification in Patients with Hepatic Failure DAI Xiao-cai, LIU Di, LIU Qing DOI: 10.3969/j.issn.1671-7171.2019.09.017 【Objective】To analyze the clinical effect of plasma exchange(PE) combined with continuous blood purification(CBP) in the treatment of patients with liver failure(HF). 【Methods】A total of 84 HF patients were divided into two groups; the observation group (n=42 cases, the implementation of PE+CBP) and the control group (n=42 cases, comprehensive intervention of PE treatment). Clinical curative effect, blood biochemical indexes, liver function, cytokines, and adverse reactions were compared between the two groups. 【Results】The effective rate of the observation group was 83.33% (35/42), which was significantly higher than that of the control group 69.05% (29/42), and the difference was significant (P<0.05).TBIL,ALT,AST,PTA, ALB, TBA and CHE in the two groups were significantly improved after treatment (P<0.05). The improvement in the observation group was significantly better than that in the control group (P<0.05). The levels of TNF- alpha and cytokine IL-6 in the observation group were significantly lower than those in the control group, and the difference between the two groups was significant (P<0.05). The effective rate of observation group was significantly higher than that of control group (P<0.05). The adverse reaction rate in the observation group was significantly lower than that in the control group (P<0.05). 【Conclusion】 PE combined with CBP can effectively improve liver function, relieve symptoms, remove inflammatory factors, and reduce complications in patients with liver failure. 2019 Vol. 36 (9): 1715-1717 [Abstract] ( 74 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 1718 Effect of Dexmedetomidine Combined with Ropivacaine on Thoracic Paravertebral Nerve Block in Patients with Esophageal Cancer Resection CHEN Xiao-hong DOI: 10.3969/j.issn.1671-7171.2019.09.018 【Objective】To investigate the effects of dexmedetomidine (Dex) combined with ropivacaine on analgesia, stress reaction and inflammatory reaction through the application of thoracic paravertebral nerve block (TPVB) in patients with esophageal cancer radical resection. 【Methods】A total of 60 patients with esophageal cancer underwent thoracotomy were randomly divided into two groups, with 30 cases in each group. The observation group was given Dex combined with ropivacaine and the control group was given ropivacaine alone for application of TPVB. The MAP, HR and BIS (bispectral index) were recorded before injection (T0), 30min after injection (T1), immediately after endotracheal intubation (T2), excision of tumor (T3) and at the end of operation (T4). The VAS (visual analogue scale) scores and postoperative analgesia pump control delivery times at different time points within 48 h after surgery were compared in the two groups. The concentrations of cortisol, c-reactive protein, TNF- α and IL-6 were measured before surgery and 3h, 24h and 48h after operation. 【Results】There was no difference in MAP and HR at different time points in the two groups (P>0.05). Compared to pre-operation, the BIS of the two groups decreased at T1~T4 (P<0.05).The VAS scores at different time points were lower in observation group than in the control group (P＜0.05). Also, the postoperative analgesia pump control delivery times within 48 h after surgery were lower than those in the control group (P＜0.05). There were no significant differences in preoperative concentrations of cortisol, c-reactive protein , TNF- α and IL-6 between the two groups (P>0.05). The concentrations of the above indexes were significantly increased at 3 h, 24 h and 48 h after surgery. However, the increase of the observation group was lower than that of the control group (P＜0.05). 【Conclusion】Dex combined with ropivacaine in TPVB can significantly prolong the effect of nerve block, improve postoperative analgesia, and decrease the stress reaction and inflammatory reaction in the patients with esophageal cancer undergoing thoracic surgery. 2019 Vol. 36 (9): 1718-1720 [Abstract] ( 59 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 1721 Ultrasonographic Features of Unruptured Tubal Pregnancy and Luteal Cyst of Pregnancy PAN Xiao-qin, XIAO Qing DOI: 10.3969/j.issn.1671-7171.2019.09.019 【Objective】To explore the value of the differential diagnosis of transvaginal ultrasonography by different positions in unruptured tubal pregnancy and luteal cyst of pregnancy.【Methods】Forty-three cases of unruptured tubal pregnancy (group A) and 47 cases of luteal cyst (group B) were selected to compare the size of pregnancy mass and corpus luteum, the thickness of the circumferential wall, the blood flow distribution, the blood flow spectrum and the relationship between the mass or cyst and ovarian position after position change.【Results】In the group A, the size of mass or gestational sac and the thickness of circumferential wall were (2.44 ±1.50) cm and (0.71 ±0.22) cm, respectively. There was no significant difference between the group A and the group B (3.01 ±1.44) cm and (0.68 ±0.23) cm (P>0.05). The blood flow signals in the group A were mostly dot or strip, while those in the group B were mostly circular or semi-circular. There were significant differences in the proportion of circular, dot and strip blood flow signals (P<0.05); the RI value of the group A was (0.49 ± 0.09), which was significantly lower than that of the group B (0.58 ±0.11), and the difference was statistically significant (P<0.05); the blood flow spectrum of the group A was mostly very low resistance or low resistance, while that of the group B was mostly low resistance. The blood flow spectrum of patients showed low resistance and high resistance. The proportion of blood flow spectrum with very low or high resistance was significantly different between the two groups (P<0.05); the position of mass or gestational sac and the ovary of the same side changed in the group A (37/43), while that of the group B and the ovary of the same side remained unchanged (47/47). There was a significant difference between the two groups (P<0.05).【Conclusion】Unruptured tubal pregnancy and luteal cyst of pregnancy have different blood flow signals and spectrum, and the position change is different from the position of the ovary on the same side. Its characteristics are helpful to improve the early detection rate of tubal pregnancy, which is worthy of clinical reference. 2019 Vol. 36 (9): 1721-1723 [Abstract] ( 61 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 1724 Predictive Value of Intracerebral Hemorrhage Score Combined with APACHE Ⅱ Score in the Prognosis of Spontaneous Cerebral Hemorrhage JIANG Wen-tao, HUANG Jian-hua, ZHU Jia-shuang DOI: 10.3969/j.issn.1671-7171.2019.09.020 【Objective】 To explore the predictive value of intracerebral hemorrhage score combined with acute physiology and chronic health score Ⅱ (APACHE Ⅱ) in predicting the prognosis of patients with spontaneous intracerebral hemorrhage (SICH). 【Methods】 Forty-two patients with SICH admitted from November 2015 to December 2018 were selected as subjects. The cerebral hemorrhage score was evaluated at admission, APACHE Ⅱ score was evaluated within 24 hours of admission, and the modified Rankin scale (MRS) score was evaluated at 1 month of onset,poor prognosis was defined as MRS ≥ 4. The prognostic value of cerebral hemorrhage score and APACHE Ⅱ score alone and in combination was evaluated. 【Results】 According to MRS score, 19 cases (45.24%) had poor prognosis and 23 cases (54.76%) had good prognosis. The scores of cerebral hemorrhage and APACHE Ⅱ in poor prognosis group were significantly higher than those in the good prognosis group (P<0.05). The area under ROC curve of cerebral hemorrhage score and APACHE Ⅱ score predicting poor prognosis was 0.841 (95% CI = 0.724~0.958, P<0.001), 0.817 (95% CI = 0.690~0.944, P<0.001), respectively. The combined scheme had the highest specificity, positive predictive value and predictive accuracy, while the single scheme had higher sensitivity and negative predictive value, but the prediction accuracy was the worst.【Conclusion】 Both intracerebral hemorrhage score ≥ 2 and APACHE Ⅱ score ≥ 19 points have good value in predicting the adverse prognosis of SICH patients. Serial connection can improve the predictive specificity, positive predictive value and predictive accuracy. 2019 Vol. 36 (9): 1724-1726 [Abstract] ( 63 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 1727 Evaluation of Group Cognitive Intervention Combined with Scenario Simulation Experience in Elderly Patients with Type 2 Diabetes Mellitus WANG Qing-ju, DU Juan, XU Xiang DOI: 10.3969/j.issn.1671-7171.2019.09.021 【Objective】To investigate the effects of group cognitive intervention combined with scenario simulation experience on disease cognition and self-management ability in elderly patients with type 2 diabetes mellitus(T2DM). 【Methods】A total of 124 elderly patients with T2DM admitted from October 2015 to December 2016 were enrolled. The patients were divided into treatment group and control group with 62 cases in each group by random number table method. The control group received routine nursing interventions including health education, exercise guidance, dietary intervention, and prevention of complications. The treatment group used group cognitive intervention and scenario simulation training. The disease cognition, self-management ability, and blood glucose control were compared between the two groups. 【Results】 Scores of "how much your life affects by diabetes", "How long will your diabetes last?", "How much can you control diabetes?", " How much diabetes treatment can help you ", "How much do you feel about diabetes symptoms?", "How much do you care about diabetes?", "How much do you know about diabetes?" and "How much does diabetes affect your emotions?" of the the treatment group were significantly higher than those of the control group. P<0.05); The diet management, exercise management, blood glucose monitoring, foot care, drug and insulin scores of the treatment group were significantly higher than those of the control group (P<0.05). The blood glucose before meals and the blood glucose 2h after the meal in the treatment group were significantly lower than those in the control group (P<0.05). 【Conclusion】Group cognitive intervention combined with scenario simulation experience can improve the disease cognition level of elderly T2DM patients, promote the development of self-management ability, and control blood sugar levels. 2019 Vol. 36 (9): 1727-1730 [Abstract] ( 67 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 1730 Comparison of B-ultrasonic Hydrostatic Enema and X-ray Air Enema in Treatment of Children Acute Intussusception JIANG Jian-zhong, QIN Dao-rui, HU Jian DOI: 10.3969/j.issn.1671-7171.2019.09.022 【Objective】To compare the efficacy of B-ultrasound-guided hydrostatic enema and X-ray air enema reduction in the treatment of acute intussusception in children. 【Methods】Retrospective analysis of the clinical data of 116 children with acute intussusception admitted to our hospital for enema reduction from February 2017 to February 2018 were studied. According to different enema reductions, patients were divided into the observation group and the control group, with 58 cases in each group. The control group was treated with conventional X-ray air enema, while the observation group was treated with water pressure enema under B-ultrasound monitoring. The reduction rate of intussusception, recurrence rate and complication rate of the two groups were compared. 【Results】The serum C-reactive protein (CRP) level and recovery time of intestinal function in the observation group were significantly lower than those in the control group, while the reduction time of intussusception in the observation group was longer than that in the control group. The difference was statistically significant (P<0.05). The recurrence rate and incidence of complications in the observation group were significantly lower than those in the control group (P<0.05). There was no significant difference in the reduction rate of intussusception between the two groups (P>0.05). The reduction rate of patients who suffered intussusception more than 48 hours in the observation group was higher than that in the control group, and the difference was statistically significant (88.9% vs 72.2%, P<0.05). 【Conclusion】B-ultrasonic hydrostatic enema can be used for early diagnosis of pediatric acute intussusception. It has an obvious reduction effect for intussusception, at the same time, to avoid radiation damage to human body caused by X-ray. It is an effective adjuvant therapy and non-invasive detection method which can reduce the incidence of complications. Therefore it is worthy of clinical application. 2019 Vol. 36 (9): 1730-1732 [Abstract] ( 73 ) HTML (1 KB)  PDF  (0 KB)  ( 15 ) 1733 Changes and Significance of Serum TGF-β1 in Children with Hypoxic Ischemic Encephalopathy HUANG Jian, WU Ji-wei, LUO Rui-bin,et al DOI: 10.3969/j.issn.1671-7171.2019.09.023 【Objective】To investigate the clinical significance of dynamic monitoring of serum TGF-β1 in children with hypoxic ischemic encephalopathy (HIE). 【Methods】A total of 40 children with HIE admitted to the neonatology department of our hospital from January 2017 to December 30, 2018 were enrolled. According to the HIE clinical classification criteria, they were divided into mild group (19 cases), moderate group (19 cases) and severe group (10 cases). Twenty healthy newborns of hospital delivery during the same period were included in the control group. Levels of peripheral blood transforming growth factor-β1 (TGF-β1) were measured and neonatal neurobehavioral assay (NBNA) were examined in all groups. The diagnostic value of TGF-β1 for moderate to severe HIE was analyzed using ROC curves. 【Results】There were no significant differences in gender, gestational age, mode of delivery, maternal primipara, abortion history, intrauterine infection and premature rupture of membranes in the four groups (P>0.05). There were significant differences in TGF-β1 levels between 24 h and 72 h after birth (P<0.05). However, one week after birth, there was no significant difference in TGF-β1 levels in all groups (P>0.05). The decrease of TGF-β1 level and NBNA score of the HIE children reflected the severity of HIE; the difference was statistically significant (P<0.05). At 24 h, 72 h, and 1 week after birth, TGF-β1 levels were positively correlated with NBNA scores (r=0.523, 0.513, 0.428). At 24 h after birth, the optimal critical point for TGF-β1 diagnosis of moderate-severe HIE was 15.6 μg/L, the sensitivity was 71.5%, the specificity was 79.5%, and the area under the AUC curve was 0.78. 【Conclusion】In the order of mild-moderate-severe HIE, TGF-β1 levels decrease and are positively correlated with NBNA scores. 2019 Vol. 36 (9): 1733-1735 [Abstract] ( 60 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 1739 Study on Influencing Factors of Nephropathy in Patients with Type I Diabetes ZHAO Yan DOI: 10.3969/j.issn.1671-7171.2019.09.025 【Objective】To explore the factors that influenced the onset of diabetic nephropathy (DN) in patients with type 1 diabetes. 【Methods】A total of 142 patients admitted to our hospital with type 1 diabetes were selected. According to whether there is DN, patients were divided into DN group and non-DN group. The clinical data of patients were collected, including gender, age, duration of diabetes, blood uric acid. Taking DN as an independent variable and other related indicators as the dependent variable, logistic single factor and multivariate regression analysis were used to explore the factors influencing the pathogenesis of DN in patients with type 1 diabetes 【Results】In the DN group, the duration of diabetes, HbA1C, diastolic blood pressure, blood uric acid and Hb were(8.31±2.28)years,(10.21±3.41)%,(81.59±12.72)mmHg、(306.38±129.02)μmol/L and(116.82±20.31)g/L, respectively, which were significantly higher than those in the non-DN group, i.e.(4.06±1.96)years,(9.41±2.51)%,(75.24±9.61)mmHg,(258.49±92.17)μmol/L and(131.41±14.41)g/L,respectively. The differences between the two groups were statistically significant (P<0.05). Univariate logistic regression analysis showed that the duration of diabetes ≥ 5 years, HbA1C, serum uric acid, diastolic blood pressure, Hb were associated with the onset of DN (P<0.05). Multivariate logistic regression analysis showed that the duration of diabetes ≥5 years, HbA1C, diastolic blood pressure, blood uric acid and Hb were independent risk factors for DN (P<0.05). 【Conclusion】 Diabetes duration ≥ 5 years, HbA1C, diastolic blood pressure, blood uric acid and Hb are independent risk factors for the onset of DN, therefore patients with type 1 diabetes should actively control blood pressure, blood sugar, and uric acid levels. 2019 Vol. 36 (9): 1739-1741 [Abstract] ( 61 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 1741 Clinical Efficacy of Leuprolide Acetate Microspheres for Injection Combined with Levonorgestrel Intrauterine Release System in the Treatment of Adenomyosis WEI Hua-li, NIU Xiu-min, WANG Hong-xia DOI: 10.3969/j.issn.1671-7171.2019.09.024 【Objective】To investigate the clinical effects of leuprolide acetate microspheres combined with levonorgestrel intrauterine delivery system in the treatment of adenomyosis (AMS). 【Methods】Seventy-two patients with AMS in our hospital from December 2014 to December 2017 were selected and divided into observation group and control group according to random number table method, 36 cases in each group. The control group was treated with levonorgestrel intrauterine release system, while the observation group was treated with leuprorelin acetate microspheres for injection on the basis of the control group. The curative effect, uterine volume change, menstrual volume change, dysmenorrhea improvement, serum carcinoembryonic antigen (CA125), quality of life score and incidence of adverse reactions were compared between the two groups before and after treatment. 【Results】The total effective rate of the observation group was 94.44%, which was significantly higher than 77.78% of the control group (P<0.05). After 6 months of treatment, the uterine volume of the observation group was significantly smaller than that of the control group, the dysmenorrhea and menstrual volume score and serum CA125 level were significantly lower than those of the control group (P<0.05), and the quality of life score of the observation group was significantly higher than that of the control group (P<0.05). The incidence of adverse reactions in the observation group was 25.00%, and there was no significant difference between the observation group and the control group (19.44%) (P>0.05).【Conclusion】Levonorgestrel intrauterine release system combined with leuprorelin acetate microspheres for injection in the treatment of AMS patients has a significant effect, can significantly improve the clinical symptoms and quality of life of patients, effectively reduce the level of serum CA125, and has high safety, which is worthy of clinical application. 2019 Vol. 36 (9): 1741-1744 [Abstract] ( 78 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 1742 Effect of Cognitive Behavioral Therapy on Coping Style and Compliance Behavior of Patients with Bladder Cancer after Perfusion Chemotherapy CHE Kun DOI: 10.3969/j.issn.1671-7171.2019.09.026 【Objective】To explore the effect of cognitive behavioral therapy on coping style and compliance behavior of patients with bladder cancer after perfusion chemotherapy. 【Methods】From March 2015 to September 2017, 98 patients with bladder cancer who received perfusion chemotherapy after operation were randomly divided into control group and observation group, 49 cases in each group. The control group was given routine chemotherapy nursing intervention including health education, dietary intervention and prevention of complications, while the observation group was given cognitive behavior intervention. The coping style, compliance behavior and adverse reactions were compared between the two groups.【Results】In the observation group, the scores of perfusion chemotherapy on time, taking medicine according to doctor's advice, good disease awareness, regular review on time, no early discharge of drugs and good living habits were significantly higher than those in the control group (P<0.05); the scores of calmness, optimism and seeking support were significantly higher than those in the control group, while the scores of conservatism, evasion, self-reliance, emotional catharsis and resignation to fate were significantly higher than those in the control group (P<0.05). The incidence of adverse reactions such as hematuria, bladder burning, local infection, adverse reaction of digestive system and bladder irritation sign was significantly lower than that of the control group (P<0.05). 【Conclusion】Cognitive-behavioral therapy can help promote the compliance of doctors with bladder infusion chemotherapy patients and improve the ability to actively respond to behaviors, and reduce the incidence of chemotherapy-related adverse reactions. 2019 Vol. 36 (9): 1742-1745 [Abstract] ( 46 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 1745 Expression of TFF1 and MCP-1 in Urine of Patients with Renal calculi and its Significance ZHANG Jian, CHEN Zhi-qiang, SUN Guo-liang,et al DOI: 10.3969/j.issn.1671-7171.2019.09.027 【Objective】To investigate the levels and significance of trilobal factor 1 (TFF1) and monocyte chemoattractant protein 1 (MCP 1) in urine of patients with renal calculi. 【Methods】From January 2017 to April 2018, 103 patients with renal calculi were selected as observation group and 100 healthy volunteers as control group, serum biochemical parameters such as serum calcium and creatinine in two groups were detected, urine TFF1, MCP-1 and urinary calcium level were detected. 【Results】There was no significant difference in serum calcium, creatinine, uric acid and urea nitrogen between the observation group and the control group (P>0.05). The levels of TFF1 in urine of the observation group were significantly lower than those of the control group, while the levels of MCP-1 and urinary calcium were significantly higher than those of the control group (P<0.05). The estimated glomerular filtration rate (eGFR) of the observation group was (88.10±32.20)[mL/(min·1.73 m2)]. The correlation analysis of urine TFF1, MCP-1, urine calcium and eGFR in the observation group showed that urine TFF1 was negatively correlated with urine calcium (r=-0.433, P<0.05), urine MCP-1 was positively correlated with urine calcium (r=0.404, P<0.05), and negatively correlated with eGFR (r=-0.362, P<0.05).【Conclusion】The level of TFF1 in urine of patients with renal calculi decreases, while the level of MCP-1 increases, which is correlated with urinary calcium and eGFR in patients with renal calculi. 2019 Vol. 36 (9): 1745-1747 [Abstract] ( 53 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 1748 Comparison of MRI and Color Doppler Ultrasonography in the Diagnosis of Placenta Previa in the Posterior Wall of Late Pregnancy XIAO Qing, PAN Xiao-qin, TANG Liang DOI: 10.3969/j.issn.1671-7171.2019.09.028 【Objective】To explore the diagnostic value of MRI and color Doppler ultrasonography in placenta previa posterior wall of uterus in late pregnancy.【Methods】A retrospective analysis was made of 64 cases of placenta previa on the posterior wall of the uterus in late pregnancy from February 2015 to February 2017. Color Doppler ultrasonography was the first choice before operation. For suspected placenta previa patients, the results of cesarean section were used as pathological diagnostic criteria and the diagnostic accuracy of two kinds of detection was evaluated. 【Results】All the patients were confirmed by surgery and pathology. Among the 64 cases of placenta previa, 35 (54.69%) cases were of central type, 9 (14.06%) cases were of partial type, 11 (17.19%) cases were of marginal type, and 9 (14.06%) cases were of low type. The accuracy of MRI in the diagnosis of placenta previa in the posterior wall of the uterus in the third trimester was 98.44%, and only 1 case was misdiagnosed, that is, partial misdiagnosis was central type. The diagnostic accuracy of color doppler ultrasound was 95.31%, and 3 cases were misdiagnosed, among which 2 cases were borderline misdiagnosed as central type and 1 case was partially misdiagnosed as central type. The accuracy of MRI in the diagnosis of placenta previa in the posterior wall of the uterus in the third trimester was slightly higher than that of color doppler ultrasound, but the difference was statistically significant (P>0.05). 【Conclusion】In the clinical diagnosis of placenta previa via the posterior wall of the uterus in the third trimester of pregnancy, color doppler ultrasound is the first choice for detection, and MRI can be performed for those suspected of placenta previa when necessary. The two diagnostic techniques have high accuracy in the diagnosis of placenta previa via the posterior wall of the uterus in the third trimester of pregnancy. 2019 Vol. 36 (9): 1748-1751 [Abstract] ( 57 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 1751 Therapeutic Effect of Sinus Endoscopic Surgery Combined with Chinese Medicine Nasal Lavage on Sinusitis CHEN Hong-chang, LIAO Lei, ZHOU Guang-yao,et al DOI: 10.3969/j.issn.1671-7171.2019.09.029 【Objective】To explore the clinical effect of sinus endoscopy plus traditional Chinese medicine (clearing heat, dampness and phlegm) nasal lavage on sinusitis patients. 【Methods】A total of 82 patients with sinusitis admitted to our hospital from January 2016 to January 2017 were randomly divided into the observation group (n=41, endoscopic sinus surgery combined with Chinese medicine nasal lavage) and the control group (n=41,endoscopic sinus surgery combined with antibiotics saline nasal lavage). The clinical effects of the two groups were compared. 【Results】The nasal airway resistance at 8 and 12 weeks after treatment in the observation group was lower than that in the control group, and the olfactory function score of the observation was also less than that of the control group(P＜0.05).The time of mucosal epithelialization after treatment in the observation group was shorter than that in the control group, so the total effective rate 97.56% of the observation group was higher than that of the control group 85.37%, and the recurrence rate 4.88% of the observation group was lower than that of the control group 21.95% (χ2=3.904、5.144,P＜0.05).The volume of nasal cavity (NCV) and the minimum cross section area of the nasal cavity (NMCA) after treatment in the observation group were more than those of the control group. The total score of quality of life (SNOT-20) score was lower than that of the control group(P＜0.05).【Conclusion】The nasal lavage of traditional Chinese medicine after endoscopic sinus surgery can effectively reduce the nasal airway resistance and improve the patient's sense of smell for patients with sinusitis. The overall effect is good. 2019 Vol. 36 (9): 1751-1753 [Abstract] ( 56 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 1754 Comparison of Clinical Effects of Different Anesthetics on Spinal-epidural Anesthesia in cesarean section LI Ting, CAO Wen-liang, LI Kai,et al DOI: 10.3969/j.issn.1671-7171.2019.09.030 【Objective】To explore the anesthetic effect of ropivacaine and bupivacaine on spinal-epidural anesthesia in cesarean section. 【Methods】A total of 220 cases of cesarean section pregnant women admitted to our hospital were randomly divided into two groups, with 110 cases in each group. The observation group was anesthetized with ropivacaine. the control group was anesthetized with bupivacaine. The anesthesia effect and adverse reactions were observed in the two groups. 【Results】The average arterial pressure and heart rate of the two groups after anesthesia were lower than those before anesthesia (P<0.05). The mean arterial pressure and heart rate at 5 minutes after anesthesia in the observation group were higher than those in the control group (P<0.05). The incidence of adverse reactions and intraoperative hypotension in the observation group were lower than those in the control group (P<0.05). The sensorimotor block in the observation group was better than that in the control group after anesthesia (P<0.05). 【Conclusion】Both ropivacaine and bupivacaine are effective in spinal-epidural anesthesia for cesarean section. However,ropivacaine has less effect on pregnant women, and the incidence of adverse reactions are mild. So it is worthy of popularization. 2019 Vol. 36 (9): 1754-1756 [Abstract] ( 50 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 1756 Effect of L-Carnitine Combined with Astragalus Injection on Serum Myocardical Enzyme Markers in the Treatment of Acute Viral Myocarditis WANG Xiao-xia, LIU Yue-ying, XU Wen-gang DOI: 10.3969/j.issn.1671-7171.2019.09.031 【Objective】To investigate the clinical efficacy of L-carnitine combined with astragalus injection in the treatment of acute viral myocarditis (AVM) and explore its effect on serum myocardial enzyme markers. 【Methods】The clinical data of 104 patients with acute viral myocarditis received admitted our hospital were retrospectively studied. According to the different methods of administration, they were divided into the observation group (L-carnitine combined with Astragalus injection) and the control group (L-carnitine treatment only). There were 52 cases in each group. The therapeutic effects of the two groups were compared. Levels of serum myocardial enzyme markers and incidence of adverse reactions before and after treatment were compared as well. 【Results】After 2 weeks of treatment, the total effective rate of the observation group was 80.7% (42/52), which was higher than that of the control group 59.6% (31/52), and the difference was statistically significant (P<0.05). The levels of serum CK, CK-MB and CTnT in the two groups after treatment were lower than those before treatment; the CK, CK-MB and CTnT levels of the observation group were lower than those of the control group. The difference was statistically significant (P<0.05). There were no significant differences in the incidence of adverse reactions such as headache, allergic reaction, liver and kidney function damage, and dyspnea in the two groups (P>0.05).【Conclusion】L-carnitine combined with astragalus injection is effective in the treatment of acute viral myocarditis. It can effectively improve cardiac function, decrease levels of serum myocardial enzyme markers but not increase drug adverse reactions, which is worthy of clinical application. 2019 Vol. 36 (9): 1756-1758 [Abstract] ( 55 ) HTML (1 KB)  PDF  (0 KB)  ( 10 )

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