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| Expression and Significance of BRAC1 and DIAPH-3 Proteins in Breast Cancer Tissues |
| YANG Chun-shui, LIU Bin, HAN Song-yun,et al |
| Graduate School of Xuzhou Medical University, Xuzhou 221000, Jiangsu Province |
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Abstract 【Objective】To investigate the expression and significance of breast cancer susceptibility gene 1 (BRAC1) and DIAPH-3 protein in breast cancer.【Methods】Immunohistochemical staining was used to detect 92 cases of breast cancer (observation group) and 46 cases of paracancerous tissue specimens (control group). The positive expression rates of DIAPH-3 protein and BRAC1 protein in two groups were compared, and the expression levels of DIAPH-3 protein and BRAC1 protein in patients with different TNM stages, lymph node metastasis, tumor lesion diameter, vascular invasion, histological grade were analyzed. 【Results】The positive rates of DIAPH-3 protein and BRAC1 protein in the breast cancer group were 45.65% (42/92) and 67.39% (62/92), respectively, while those in the paracancerous group were 84.78% (39/46) and 15.22% (7/46), respectively. There was a significant difference between the two groups (P<0.05). The positive expression rates of DIAPH-3 protein in breast cancer patients with different TNM stages and lymph node metastasis were significantly different (P<0.05). The positive expression rate of BRAC1 protein in breast cancer patients with different TNM stages, lymph node metastasis and tumor differentiation was significantly different (P<0.05). 【Conclusion】The down-regulation of DIAPH-3 and up-regulation of BRAC1 in breast cancer are closely related to the occurrence and development of tumor .
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Received: 15 October 2018
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. [J]. JOURNAL OF CLINICAL RESEARCH, 2019, 36(3): 519-520. |
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2019, Vol. 36 
